Time filter

Source Type

Geneva, Switzerland

The University of Geneva is a public research university located in Geneva, Switzerland. It was founded in 1559 by John Calvin, as a theological seminary and law school. It remained focused on theology until the 17th century, when it became a center for Enlightenment scholarship. In 1873, it dropped its religious affiliations and became officially secular. Today, the university is the second-largest university in Switzerland by number of students. In 2009, the University of Geneva celebrated the 450th anniversary of its founding.UNIGE has programs in various fields but has academic and research programs in international relations , law, astrophysics, astronomy, genetics . The university holds and actively pursues teaching, research, and community service as its primary objectives. In 2011, it was ranked 73rd worldwide by the Academic Ranking of World Universities, and 69th in the QS World University Rankings.UNIGE is a member of the League of European Research Universities, the Coimbra Group and the European University Association. Wikipedia.

Wehrle-Haller B.,University of Geneva
Current Opinion in Cell Biology | Year: 2012

Integrin-dependent cell adhesions come in different shapes and serve in different cell types for tasks ranging from cell-adhesion, migration, and the remodeling of the extracellular matrix to the formation and stabilization of immunological and chemical synapses. A major challenge consists in the identification of adhesion-specific as well as common regulatory mechanisms, motivating the need for a deeper analysis of protein-protein interactions in the context of intact focal adhesions. Specifically, it is critical to understand how small differences in binding of integrins to extracellular ligands and/or cytoplasmic adapter proteins affect the assembly and function of an entire focal adhesion. By using the talin-integrin pair as a starting point, I would like to discuss how specific protein-protein and protein-lipid interactions can control the behavior and function of focal adhesions. By responding to chemical and mechanical cues several allosterically regulated proteins create a dynamic multifunctional protein network that provides both adhesion to the extracellular matrix as well as intracellular signaling in response to mechanical changes in the cellular environment. © 2011 Elsevier Ltd. Source

Rochaix J.-D.,University of Geneva
Annual Review of Plant Biology | Year: 2014

Photosynthetic organisms are continuously subjected to changes in light quantity and quality, and must adjust their photosynthetic machinery so that it maintains optimal performance under limiting light and minimizes photodamage under excess light. To achieve this goal, these organisms use two main strategies in which light-harvesting complex II (LHCII), the light-harvesting system of photosystem II (PSII), plays a key role both for the collection of light energy and for photoprotection. The first is energy-dependent nonphotochemical quenching, whereby the high-light-induced proton gradient across the thylakoid membrane triggers a process in which excess excitation energy is harmlessly dissipated as heat. The second involves a redistribution of the mobile LHCII between the two photosystems in response to changes in the redox poise of the electron transport chain sensed through a signaling chain. These two processes strongly diminish the production of damaging reactive oxygen species, but photodamage of PSII is unavoidable, and it is repaired efficiently. Copyright © 2014 by Annual Reviews. Source

Wehrle-Haller B.,University of Geneva
Current Opinion in Cell Biology | Year: 2012

The formation of tissues and organs requires cells to adhere to each other and/or to migrate and polarize in contact with components of the extracellular matrix. The connection between the cytoskeleton and the extracellular environment is provided by heterodimeric transmembrane receptors of the integrin family. In response to extracellular ligand binding, integrins undergo a conformational switch that permits the recruitment of cytoplasmic adapter proteins, eventually linking the integrin receptors to the actin cytoskeleton, progressively forming highly complex cell-matrix adhesions. A major challenge in the field consists in identifying the regulatory mechanisms, which drive the assembly of cell-matrix adhesions as they are based on posttranslational modifications as well as allosteric conformational changes caused by protein-protein as well as protein-lipid interactions. In response to mechanical tension, generated either by intra-cellular acto-myosin contraction, shear stress or mechanical strain on the extracellular scaffold, the composition and signaling of cell-matrix adhesion changes, leading either to increased anchorage or controlled disassembly of cell matrix adhesions, both processes critically involved in cell migration. The aim of this review is to provide insight into the mechanisms leading to the progressive assembly of focal adhesions, how they are modulated in response to mechanical challenges and which mechanisms are used for their disassembly. © 2012 Elsevier Ltd. Source

Rodriguez I.,University of Geneva
Cell | Year: 2013

Understanding the mechanisms of monogenic and monoallelic transcription of the large repertoire of olfactory receptor genes represents a challenging task. A picture is now emerging in which odorant receptor choice and stabilization involve an escape from silencing followed by the activation of an unconventional feedback loop. © 2013 Elsevier Inc. Source

Chiaradia M.,University of Geneva
Nature Geoscience | Year: 2014

Porphyry copper systems supply about 75% of the world's copper. They form above subduction zones and are preferentially associated with calc-alkaline magmas. Such magmas result from continuous iron depletion during differentiation, in contrast to tholeiitic magmas that show initial iron enrichment during differentiation. The formation of calc-alkaline magmas is favoured by high water content and oxygen fugacity. These characteristics, as well as magmatic metal contents, are thought to be imparted in the mantle source by fluids of the subducted slab. Yet this process does not explain why porphyry copper systems preferentially occur in thicker arcs. Here I present a statistical assessment of more than 40,000 published geochemical analyses of magmatic rocks from 23 Quaternary-aged volcanic arcs worldwide. I find that magmas of thicker arcs are systematically more calc-alkaline and more depleted in copper than magmas of thinner arcs. This implies that the missing copper in the former accumulates as copper sulphides within or at the base of thicker arcs. Such copper accumulations are an essential step in forming porphyry systems. These results suggest that the thickness of the overriding plate provides a more important control on magma differentiation than the composition of the mantle source, and can explain the preferential association of porphyry copper systems with calc-alkaline magmas and thicker arcs. © 2014 Macmillan Publishers Limited. Source

Discover hidden collaborations