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El Taref Province, Algeria

Merzoug S.,Annaba University | Merzoug S.,University of El-Tarf | Toumi M.L.,Annaba University | Boukhris N.,Annaba University | And 3 more authors.
Pharmacology Biochemistry and Behavior | Year: 2011

Chemotherapeutic regimens have been indicated to negatively impact the quality of life for patients. Adriamycin (ADR) is an effective chemotherapeutic agent widely employed for the treatment of human's malignancies; however, it may cause serious side effects. The present study was aimed at investigating the effects of acute administration of ADR on cognitive alterations, brain oxidative status and immune dysregulation in male Wistar rats. Treated animals received a single intraperitoneal injection of ADR (7 mg/kg). Control ones received physiological saline only. Behavioral effects were tested in the elevated plus-maze and the open field which showed that drug-treated rats displayed anxious behavior and deteriorations in the locomotive and exploratory activities over the 72 h following ADR injection as compared to controls. Assessment of brain antioxidant capacity in ADR-injected animals revealed an increase in glutathione-S-transferase activities and malondialdehyde levels while a decrease in glutathione concentrations when compared with the vehicle-treated group. Our results indicated that ADR administration decreased total leukocyte, lymphocyte and granulocyte counts, while enhanced monocyte levels. Moreover, white blood cells (WBC) relative counts in ADR-treated rats showed a significant increase in monocytes and granulocytes and a decrease in lymphocytes as compared to controls. This study suggests that ADR-related cognitive impairments are associated with brain oxidative stress and myelosuppression. © 2011 Elsevier Inc. All rights reserved. Source

Toumi M.L.,Annaba University | Merzoug S.,Annaba University | Merzoug S.,University of El-Tarf | Baudin B.,University Paris Est Creteil | Tahraoui A.,Annaba University
Pharmacology Biochemistry and Behavior | Year: 2013

This study was performed in rats to investigate the effect of a psychogenic stress during late gestation on the immediate behavior and brain oxidative status in dams as well as on the immune cell counts in their offspring up to weaning. Besides, the ability of quercetin (a natural flavonoid) to prevent stress effects was evaluated. Quercetin was orally administered for 6 consecutive days before the pregnant rats were acutely exposed to predator stress on gestational day 19. Post-stress corticosterone level, brain oxidative stress parameters and anxiety-like behavior were assessed in dams, whereas immune cell counts were postnatally determined in both male and female pups. Predator stress caused an oxidative stress in the brain and elicited an elevation in plasma corticosterone with concomitant behavioral impairment in dams. Prenatally-stressed pups mainly showed a decrease in total leukocytes and lymphocytes along with monocytosis and granulocytosis, but these changes were sex-dependent throughout the postnatal period studied. Quercetin pretreatment blocked the stress-induced corticosterone release and alleviated the brain oxidative stress with the maternal anxiety measures being slightly attenuated, whereas its effects on the offspring immune cell counts were mostly revealed at birth. Our findings suggest that late gestational exposure to traumatic events may cause anxiety symptoms in dams, in which corticosterone and brain oxidative stress play a certain role, and trigger negative immune changes in the early postnatal life of progeny. Notably, quercetin intake before such adverse events seems to be beneficial against negative outcomes in both dams and offspring. © 2013 Elsevier Inc. Source

Ilyes M.,Oran University of Science and Technology - Mohamed Boudiaf | Ahmed B.,University of El-Tarf
International Journal of Poultry Science | Year: 2013

A study was carried out on 144 local chickens (Gallus gallus domesticus), from rural area of El-Tarf to determine the prevalence of cestode parasites in the intestinal tract of the chickens. The overall prevalence rate was 88.19%, in the El-Tarf poultry. At least one species of cestodes was found on every chicken examined. Seven species of cestodes were identified in all; they had the following prevalences: Raillietina echinobothrida (83.33%), Raillietina tetragona (68.75%), Raillietina cesticillus (29.16%), Hymenolepis carioca (12.5%), Choanotaenia infundibulum (11.8%), Davainea proglottina (11.11%) and Amoebotaenia cuneata (4.16%). This study showed that there was no significant difference (p>0.05) between the prevalence of cestodes in relation to age and sex. © Asian Network for Scientific Information, 2013. Source

Merzoug S.,Annaba University | Merzoug S.,University of El-Tarf | Toumi M.L.,Annaba University | Toumi M.L.,Dr. Yahia Fares University Center of Medea | Tahraoui A.,Annaba University
Naunyn-Schmiedeberg's Archives of Pharmacology | Year: 2014

This study was designed to evaluate the effect of quercetin, a natural flavonoid, on behavioral alterations, brain oxidative stress, and immune dysregulation caused by a chemotherapeutic agent, Adriamycin (ADR; 7 mg/kg of body weight). Different subsets of male Wistar rats were used to determine the benefit of quercetin on ADR-related depression-like and anxiety-like behaviors in the forced swim test, open field, and elevated plus maze, respectively. Quercetin (60 mg/kg of body weight) was administered 24, 5, and 1 h before the test session of forced swim test (FST) or at the same time points before the elevated plus maze/open field (EPM/OF) tests. Other subsets of rats were sacrificed after quercetin injections to assess the plasma corticosterone level, the brain oxidative status, and the immune cell count. Our results indicate that quercetin alleviated the anxio-depressive-like behavior, attenuated the brain oxidative stress, and suppressed the corticosterone excess that appeared following ADR treatment. The ADR-induced immune disturbance was slightly diminished after quercetin administration, especially for the lymphocyte count. This study suggests that quercetin can mitigate the neurobehavioral and immunological impairments that manifest in ADR-treated rats. Therefore, the combination of quercetin treatment with the chemotherapeutic regimen seems to be beneficial against chemotherapy-related complications. © 2014 Springer-Verlag Berlin Heidelberg. Source

Angucl F.,University of El-Tarf | Amirat A.,Universite Mohamed Cherif Messaadia de Souk-Ahras | Bounour N.,Annaba University
Proceedings of the 2013 11th International Symposium on Programming and Systems, ISPS 2013 | Year: 2013

Model Driven Software Engineering has matured over the last few years and is now becoming an established technology. As a consequence dealing with evolving metamodels and the necessary co-evolution of instances of this metamodel is becoming increasingly important. Several approaches have been proposed to solve model co-evolution problem. In this paper, Firstly, existing approaches in this area are analyzed to define requirements of our approach, namely automaticity, reuse, expressiveness and intelligence. After that we present a new approach CBRMig towards a solution to metamodel and model co-evolution problem. The core of our proposal is using a case based reasoning system that automates the process of creation and selection of cases to assist with the generation of a migration algorithm used for adapting models in response to metamodel evolution. © 2013 IEEE. Source

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