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Duisburg, Germany

The University of Duisburg-Essen is a public university in Duisburg and Essen, North Rhine-Westphalia, Germany and a member of the newly founded University Alliance Metropolis Ruhr. It was founded in 1654 and re-established on 1 January 2003 as a merger of the Gerhard Mercator University of Duisburg and the University of Essen. Until 1994 the name of the Gerhard Mercator University was Comprehensive University of Duisburg.With its 12 departments and more than 39,000 students, the University of Duisburg-Essen is among the 10 largest German universities. Many international students study at the University of Duisburg-Essen and give the cities of Duisburg and Essen an international atmosphere. Wikipedia.

Heusch G.,University of Duisburg - Essen
Circulation Research | Year: 2015

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that by timely reperfusion is needed to reduce infarct size and improve the prognosis of patients with acute myocardial infarction. The conditioning phenomena provide such cardioprotection, insofar as brief episodes of coronary occlusion/reperfusion preceding (ischemic preconditioning) or following (ischemic postconditioning) sustained myocardial ischemia with reperfusion reduce infarct size. Even ischemia/reperfusion in organs remote from the heart provides cardioprotection (remote ischemic conditioning). The present review characterizes the signal transduction underlying the conditioning phenomena, including their physical and chemical triggers, intracellular signal transduction, and effector mechanisms, notably in the mitochondria. Cardioprotective signal transduction appears as a highly concerted spatiotemporal program. Although the translation of ischemic postconditioning and remote ischemic conditioning protocols to patients with acute myocardial infarction has been fairly successful, the pharmacological recruitment of cardioprotective signaling has been largely disappointing to date. © 2015 American Heart Association, Inc. Source

Behrens M.,University of Duisburg - Essen
Angewandte Chemie - International Edition | Year: 2014

Combined experimental and theoretical approaches resulted in a better understanding of the hydrogenation of CO2 to methanol on copper-based catalysts. These results highlight the important role of the reducible oxide promoter for CO2 activation. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Arndt M.,University of Vienna | Hornberger K.,University of Duisburg - Essen
Nature Physics | Year: 2014

Quantum physics has intrigued scientists and philosophers alike, because it challenges our notions of reality and locality-concepts that we have grown to rely on in our macroscopic world. It is an intriguing open question whether the linearity of quantum mechanics extends into the macroscopic domain. Scientific progress over the past decades inspires hope that this debate may be settled by table-top experiments.© 2014 Macmillan Publishers Limited. Source

Horsthemke B.,University of Duisburg - Essen
Journal of Pathology | Year: 2014

Genomic imprinting is an epigenetic process by which the male and the female germline confer different DNA methylation marks and histone modifications onto specific gene regions, so that one allele of an imprinted gene is active and the other one is silent. Since the dosage of imprinted genes is important for normal development, growth and behaviour, the loss or duplication of the active allele can cause disease. Copyright © 2014 Pathological Society of Great Britain and Ireland. Source

Despite the recent success of MAPK signaling-targeted drugs in melanoma, the majority of patients with metastatic melanoma still undergo disease progression after initial tumor shrinkage indicating gradually developing therapy resistance. This review will give an overview on currently suggested concepts of resistance to MAPK pathway inhibitors in melanoma with particular focus on inter- and intraindividual as well as intratumor heterogeneity. The high plasticity of melanoma cells promotes both the clonal evolution of genetic resistance, for example, because of mutations in the MAPK or PI3K/AKT/PTEN pathways, and the emergence of cell phenotypes that functionally and metabolically overcome MAPK inhibition. Like a 'moving target', melanoma cells are shifting between different metabolic, cell cycle and differentiation states reflecting a highly dynamic potential to adapt to exogenous stressors including drugs. The introduction of MAPK inhibitors into the clinics has tremendously pushed the field of melanoma research not just because of the historic therapeutic success but also by providing a new tool to study human melanoma in its natural microenvironment. © 2015 Macmillan Publishers Limited. Source

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