The University of Duisburg-Essen is a public university in Duisburg and Essen, North Rhine-Westphalia, Germany and a member of the newly founded University Alliance Metropolis Ruhr. It was founded in 1654 and re-established on 1 January 2003 as a merger of the Gerhard Mercator University of Duisburg and the University of Essen. Until 1994 the name of the Gerhard Mercator University was Comprehensive University of Duisburg.With its 12 departments and more than 39,000 students, the University of Duisburg-Essen is among the 10 largest German universities. Many international students study at the University of Duisburg-Essen and give the cities of Duisburg and Essen an international atmosphere. Wikipedia.
University of Duisburg - Essen | Date: 2016-07-28
An anti-CEACAM1 antibody includes at least one antibody heavy chain (V_(H)) domain having antigen binding sites CDR1^(H), CDR2^(H )and CDR3^(H), and at least one antibody light chain (V_(L)) domain having antigen binding sites CDR1^(L), CDR2^(L )and CDR3^(L). The antigen binding site CDR2^(H )has a sequence homology of at least 80% to the amino acid sequence WINTYTGEPT (SEQ ID No. 21).
University of Duisburg - Essen | Date: 2017-01-04
For the simplified construction of a dispenser (10) for substances, comprising an outer casing (13) with a deformable outer wall (12), which encloses a deformable container arrangement (11), and also comprising at least one equalizing valve (23) for equalizing air, wherein an air-filled interspace (14) is provided between the outer wall (12) and the container arrangement, and substances are discharged once the outer casing (13) has been subjected to pressure, it is proposed that the container arrangement should have at least two containers (11 a, b) for the separate storage of liquid or pasty substances. For the long-term storage of said substances, in particular the exit region of the container arrangement (11) has a diffusion seal, in particular made of metal, which, just prior to the dispenser (10) being used, is pierced, and opened, from the dispensing head (15), in particular using spikes.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-15-2016-2017 | Award Amount: 18.70M | Year: 2017
Big Data will have a profound economic and societal impact in the mobility and logistics sector, which is one of the most-used industries in the world contributing to approximately 15% of GDP. Big Data is expected to lead to 500 billion USD in value worldwide in the form of time and fuel savings, and savings of 380 megatons CO2 in mobility and logistics. With freight transport activities projected to increase by 40% in 2030, transforming the current mobility and logistics processes to become significantly more efficient, will have a profound impact. A 10% efficiency improvement may lead to EU cost savings of 100 BEUR. Despite these promises, interestingly only 19 % of EU mobility and logistics companies employ Big Data solutions as part of value creation and business processes. The TransformingTransport project will demonstrate, in a realistic, measurable, and replicable way the transformations that Big Data will bring to the mobility and logistics market. To this end, TransformingTransport, validates the technical and economic viability of Big Data to reshape transport processes and services to significantly increase operational efficiency, deliver improved customer experience, and foster new business models. TransformingTransport will address seven pilot domains of major importance for the mobility and logistics sector in Europe: (1) Smart High-ways, (2) Sustainable Vehicle Fleets, (3) Proactive Rail Infrastructures, (4) Ports as Intelligent Logistics Hubs, (5) Efficient Air Transport, (6) Multi-modal Urban Mobility, (7) Dynamic Supply Chains. The TransformingTransport consortium combines knowledge and solutions of major European ICT and Big Data technology providers together with the competence and experience of key European industry players in the mobility and logistics domain.
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: ICT-17-2016-2017 | Award Amount: 4.94M | Year: 2017
The mission of BDVe is to support the Big Data Value PPP in realizing a vibrant data-driven EU economy or said in other words, BDVe will support the implementation of the PPP to be a SUCCESS. Behind that mission, there are multiple goals to achieve, which should be taken into full consideration when defining the directions of the PPP. Some of the most challenging ones are: (1) achieving a more competitive landscape of European Big Data providers, leading to bigger market share; (2) creating the context for a more competitive EU industry (transport, manufacturing, public sector, agrifood, media, energy) in the advent of a data-driven revolution where many traditional players will have to transform their processes and re-think their business if they want to remain completive or in some cases, just to survive-; (3) ensuring the sustainability of the investments and actions triggered by the PPP. BDVe has broken down those high-level goals into 7 major priorities for the project: Being accurately informed about most important facts in Big Data so that we have a solid basis to support the decision-making process in the PPP Supporting the implementation of the Big Data PPP from an operational point of view Developing a vibrant community around the PPP Supporting the development of a European network of infrastructures and centers of excellence around Big Data Setting-up a professional Communications strategy Setting up a framework that supports the acceleration of data-driven businesses, and Ensuring the sustainability of the investments and actions triggered by the PPP. The BDVe consortium includes a set of partners that have shown commitment and dedication to the success of the PPP for several years. They have already invested and they have committed to invest along the coming years. We believe that this CSA cannot be a neutral action that offers operational support without further commitment.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-06-2016 | Award Amount: 5.00M | Year: 2017
Secure cloud computing is key for business success and end-user adoption of federated and decentralized cloud services and thus essential to stimulate the growth of the European Digital Single Market. RestAssured will provide solutions to specific technical concerns of data protection in the cloud (such as geo-location restrictions on personal data), which are imposed by the dynamic, multi-stakeholder and decentralized nature of federated cloud systems. These concerns mean that privacy and security by design approaches will no longer be sufficient, due to uncertainty at design time of how the cloud and privacy requirements may dynamically evolve and change at run time. To this end, RestAssured provides novel mechanisms and cloud architectures for the runtime detection, prediction and prevention of data protection violations. RestAssured will assure the protection of sensitive business and citizen data in the cloud by combining four pillars of innovation: (1) combination of fully homomorphic encryption to process data without decryption with cloud enablement of SGX hardware for protected data processing, (2) sticky policies for decentralized data lifecy-cle management, (3) models@runtime for data protection assurance, and (4) automated risk management for run-time data protection. The applicability and usefulness of the RestAssured solutions will be demonstrated through three use cases driven by project partners and involving other stakeholders from outside the consortium; High Performance Computing for commercial enterprises; Pay As You Drive usage based insurance; and self-directed Social care for vulnerable adults and social care providers. The main impact of RestAssured will be to enable the free and seamless movement of data within the EU, whilst assuring conformance to data protection regulations, such as the EU Data Protection Directive and its successor the General Data Protection Regulation.
Schlucker S.,University of Duisburg - Essen
Angewandte Chemie - International Edition | Year: 2014
Surface-enhanced Raman scattering (SERS) has become a mature vibrational spectroscopic technique during the last decades and the number of applications in the chemical, material, and in particular life sciences is rapidly increasing. This Review explains the basic theory of SERS in a brief tutorial and - based on original results from recent research - summarizes fundamental aspects necessary for understanding SERS and provides examples for the preparation of plasmonic nanostructures for SERS. Chemical applications of SERS are the centerpiece of this Review. They cover a broad range of topics such as catalysis and spectroelectrochemistry, single-molecule detection, and (bio)analytical chemistry. Expanding vibrational spectroscopy: Since its first observation in 1973, surface-enhanced Raman scattering (SERS) has developed into a mature vibrational spectroscopic technique. The number of applications in chemistry as well as the material and life sciences is increasing rapidly. This Review summarizes the key concepts behind SERS and provides an overview of current applications in chemistry. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Heusch G.,University of Duisburg - Essen
Circulation Research | Year: 2015
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that by timely reperfusion is needed to reduce infarct size and improve the prognosis of patients with acute myocardial infarction. The conditioning phenomena provide such cardioprotection, insofar as brief episodes of coronary occlusion/reperfusion preceding (ischemic preconditioning) or following (ischemic postconditioning) sustained myocardial ischemia with reperfusion reduce infarct size. Even ischemia/reperfusion in organs remote from the heart provides cardioprotection (remote ischemic conditioning). The present review characterizes the signal transduction underlying the conditioning phenomena, including their physical and chemical triggers, intracellular signal transduction, and effector mechanisms, notably in the mitochondria. Cardioprotective signal transduction appears as a highly concerted spatiotemporal program. Although the translation of ischemic postconditioning and remote ischemic conditioning protocols to patients with acute myocardial infarction has been fairly successful, the pharmacological recruitment of cardioprotective signaling has been largely disappointing to date. © 2015 American Heart Association, Inc.
Arndt M.,University of Vienna |
Hornberger K.,University of Duisburg - Essen
Nature Physics | Year: 2014
Quantum physics has intrigued scientists and philosophers alike, because it challenges our notions of reality and locality-concepts that we have grown to rely on in our macroscopic world. It is an intriguing open question whether the linearity of quantum mechanics extends into the macroscopic domain. Scientific progress over the past decades inspires hope that this debate may be settled by table-top experiments.© 2014 Macmillan Publishers Limited.
Heusch G.,University of Duisburg - Essen
The Lancet | Year: 2013
Myocardial infarct size is a major determinant of prognosis. Ischaemic preconditioning with brief coronary occlusion and reperfusion before a sustained period of coronary occlusion with reperfusion delays infarct development. Ischaemic postconditioning uses repetitive brief coronary occlusion during early reperfusion of myocardial infarction and reduces infarct size. Remote ischaemic preconditioning uses brief ischaemia and reperfusion of a distant organ to protect the myocardium. These conditioning protocols recruit a complex signal cascade of sarcolemmal receptor activation, intracellular enzyme activation, and ultimately mitochondrial stabilisation and inhibition of death signalling. Conditioning protocols have been successfully used in patients undergoing elective coronary revascularisation and reperfusion after acute myocardial infarction. Pharmacological recruitment of cardioprotective signalling has also been used to reduce infarct size, but so far without prognostic benefit. Outcomes of cardioprotection are aff ected by age, sex, comorbidities, and drugs, but also by technical issues related to determination of infarct size and revascularisation procedure.
Harder S.,University of Duisburg - Essen
Chemical Reviews | Year: 2010
An extensive review covering all aspects of Calcium-mediated reactions, which include application of calcium compounds as homogeneous catalysts, is presented. Considerable contributions is made to an understanding of Schlenk equilibria in organocalcium chemistry and it is found that the stability of heteroleptic calcium complexes depend on temperature, concentration, presence of polar (co)solvents, amd ligand bulk. Studies also found that the homoleptic complex of calcium is fast in ε-CL polymerization and slow in the polymerization of L-lactide. Investigation of calcium catalysts based on Schiff base ligands shows that polymerizations are initiated either by a salen-Ca complex or by well-defined single-site catalysts. Successful use of organocalcium species as initiators for syndioselective and living styrene polymerization can be attributed to the right balance of Lewis-basic and Lewis acidic properties.