The University of Duisburg-Essen is a public university in Duisburg and Essen, North Rhine-Westphalia, Germany and a member of the newly founded University Alliance Metropolis Ruhr. It was founded in 1654 and re-established on 1 January 2003 as a merger of the Gerhard Mercator University of Duisburg and the University of Essen. Until 1994 the name of the Gerhard Mercator University was Comprehensive University of Duisburg.With its 12 departments and more than 39,000 students, the University of Duisburg-Essen is among the 10 largest German universities. Many international students study at the University of Duisburg-Essen and give the cities of Duisburg and Essen an international atmosphere. Wikipedia.
University of Duisburg - Essen | Date: 2016-07-28
An anti-CEACAM1 antibody includes at least one antibody heavy chain (V_(H)) domain having antigen binding sites CDR1^(H), CDR2^(H )and CDR3^(H), and at least one antibody light chain (V_(L)) domain having antigen binding sites CDR1^(L), CDR2^(L )and CDR3^(L). The antigen binding site CDR2^(H )has a sequence homology of at least 80% to the amino acid sequence WINTYTGEPT (SEQ ID No. 21).
University of Duisburg - Essen | Date: 2015-06-10
The disclosure relates to a pump for implantation into a vessel or a heart, with the pump being introduced in a first state into the vessel or heart in order then be functionally changed over to a second state in the vessel or in the heart, having
University of Duisburg - Essen | Date: 2017-01-04
For the simplified construction of a dispenser (10) for substances, comprising an outer casing (13) with a deformable outer wall (12), which encloses a deformable container arrangement (11), and also comprising at least one equalizing valve (23) for equalizing air, wherein an air-filled interspace (14) is provided between the outer wall (12) and the container arrangement, and substances are discharged once the outer casing (13) has been subjected to pressure, it is proposed that the container arrangement should have at least two containers (11 a, b) for the separate storage of liquid or pasty substances. For the long-term storage of said substances, in particular the exit region of the container arrangement (11) has a diffusion seal, in particular made of metal, which, just prior to the dispenser (10) being used, is pierced, and opened, from the dispensing head (15), in particular using spikes.
Procaffe S.p.A. and University of Duisburg - Essen | Date: 2017-03-15
An automatic machine (1) for preparing coffee, comprising an infusion assembly (2), a water tank, a heat exchanger with associated pump, and a grinder (3) for grinding coffee beans, the grinder being arranged in line with the infusion assembly (2) and horizontally with respect to a resting surface of the machine, a container (4) adapted to contain coffee beans being connected, in an upper region, to the grinder (3), the grinder (3) being connected to a chamber adapted to contain a scraper (15), the ground coffee being adapted to pass horizontally from the grinder (3) to the scraper (15), in order to accommodate within the scraper (15) a preset dose of ground coffee.
University of Duisburg - Essen | Date: 2017-04-05
The invention relates to a method for holding fish or other species which live in the water in a circulation system (1) comprising at least one holding tank (2), at least one biological filter (3), and optionally other water treatment units (4) for example for a supply of oxygen (5), for sterilization (6), for defoaming (7), for a mechanical filtering process (8), etc. The invention additionally relates to a circulation system. In order to reduce the energy requirement, supply air is supplied to the system by at least one supply air line (60), and exhaust air is discharged by at least one exhaust air line (59). Supply and exhaust air is conducted through a heat exchanger in which heat contained in the exhaust air is transferred to the supply air, and/or the temperature of the supply air is increased to the level of the holding basin.
Neidl Stippler, Kunstwadl and University of Duisburg - Essen | Date: 2017-01-11
The invention relates to a battery or rechargeable battery (8) comprising at least one battery cell (1, 1A,1B,1C,1D,1E) and a temperature control for the battery cells (1, 1A, 1B, 1C, 1D, 1E). The temperature control has: at least one vapour chamber (2, 2A, 2B), a first battery contact surface (4) of which is in direct contact with the surface of the at least one battery cell (1,1A, 1B, 1C, 1D, 1E); and heat pipes (10) which lie partially on a second heat pipe contact surface (4) of the vapour chamber (2, 2A, 2B) and lead out of the battery (8) to a heat exchanger (20).
Schlucker S.,University of Duisburg - Essen
Angewandte Chemie - International Edition | Year: 2014
Surface-enhanced Raman scattering (SERS) has become a mature vibrational spectroscopic technique during the last decades and the number of applications in the chemical, material, and in particular life sciences is rapidly increasing. This Review explains the basic theory of SERS in a brief tutorial and - based on original results from recent research - summarizes fundamental aspects necessary for understanding SERS and provides examples for the preparation of plasmonic nanostructures for SERS. Chemical applications of SERS are the centerpiece of this Review. They cover a broad range of topics such as catalysis and spectroelectrochemistry, single-molecule detection, and (bio)analytical chemistry. Expanding vibrational spectroscopy: Since its first observation in 1973, surface-enhanced Raman scattering (SERS) has developed into a mature vibrational spectroscopic technique. The number of applications in chemistry as well as the material and life sciences is increasing rapidly. This Review summarizes the key concepts behind SERS and provides an overview of current applications in chemistry. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Heusch G.,University of Duisburg - Essen
Circulation Research | Year: 2015
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that by timely reperfusion is needed to reduce infarct size and improve the prognosis of patients with acute myocardial infarction. The conditioning phenomena provide such cardioprotection, insofar as brief episodes of coronary occlusion/reperfusion preceding (ischemic preconditioning) or following (ischemic postconditioning) sustained myocardial ischemia with reperfusion reduce infarct size. Even ischemia/reperfusion in organs remote from the heart provides cardioprotection (remote ischemic conditioning). The present review characterizes the signal transduction underlying the conditioning phenomena, including their physical and chemical triggers, intracellular signal transduction, and effector mechanisms, notably in the mitochondria. Cardioprotective signal transduction appears as a highly concerted spatiotemporal program. Although the translation of ischemic postconditioning and remote ischemic conditioning protocols to patients with acute myocardial infarction has been fairly successful, the pharmacological recruitment of cardioprotective signaling has been largely disappointing to date. © 2015 American Heart Association, Inc.
Heusch G.,University of Duisburg - Essen
The Lancet | Year: 2013
Myocardial infarct size is a major determinant of prognosis. Ischaemic preconditioning with brief coronary occlusion and reperfusion before a sustained period of coronary occlusion with reperfusion delays infarct development. Ischaemic postconditioning uses repetitive brief coronary occlusion during early reperfusion of myocardial infarction and reduces infarct size. Remote ischaemic preconditioning uses brief ischaemia and reperfusion of a distant organ to protect the myocardium. These conditioning protocols recruit a complex signal cascade of sarcolemmal receptor activation, intracellular enzyme activation, and ultimately mitochondrial stabilisation and inhibition of death signalling. Conditioning protocols have been successfully used in patients undergoing elective coronary revascularisation and reperfusion after acute myocardial infarction. Pharmacological recruitment of cardioprotective signalling has also been used to reduce infarct size, but so far without prognostic benefit. Outcomes of cardioprotection are aff ected by age, sex, comorbidities, and drugs, but also by technical issues related to determination of infarct size and revascularisation procedure.
Harder S.,University of Duisburg - Essen
Chemical Reviews | Year: 2010
An extensive review covering all aspects of Calcium-mediated reactions, which include application of calcium compounds as homogeneous catalysts, is presented. Considerable contributions is made to an understanding of Schlenk equilibria in organocalcium chemistry and it is found that the stability of heteroleptic calcium complexes depend on temperature, concentration, presence of polar (co)solvents, amd ligand bulk. Studies also found that the homoleptic complex of calcium is fast in ε-CL polymerization and slow in the polymerization of L-lactide. Investigation of calcium catalysts based on Schiff base ligands shows that polymerizations are initiated either by a salen-Ca complex or by well-defined single-site catalysts. Successful use of organocalcium species as initiators for syndioselective and living styrene polymerization can be attributed to the right balance of Lewis-basic and Lewis acidic properties.