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Lapid H.,Weizmann Institute of Science | Hummel T.,University of Dresden Medical School
Chemical Senses | Year: 2013

Electro-olfactogram (EOG) represents the sum of generator potentials of olfactory receptor neurons in response to an olfactory stimulus. Although this measurement technique has been used extensively in animal research, its use in human olfaction research has been relatively limited. To understand the promises and limitations of this technique, this review provides an overview of the olfactory epithelium structure and function, and summarizes EOG characteristics and conventions. It describes methodological pitfalls and their possible solutions, artifacts, and questions of debate in the field. In summary, EOG measurements provide a rare opportunity of recording neuronal input from the peripheral olfactory system, while simultaneously obtaining psychophysical responses in awake humans. © The Author 2012. Published by Oxford University Press. All rights reserved.


Ganos C.,University of Hamburg | Roessner V.,University of Dresden Medical School | Munchau A.,University of Hamburg
Neuroscience and Biobehavioral Reviews | Year: 2013

Gilles de la Tourette syndrome (GTS) holds a prime position as a disorder transgressing the brittle boundaries of neurology and psychiatry with an entangling web of motor and behavioral problems. With tics as the disorder's hallmark and myriads of related signs such as echo-, pali- and coprophenomena, paralleled by a broad neuropsychiatric spectrum of comorbidities encompassing attention deficit hyperactivity disorder, obsessive-compulsive disorder and self-injurious behavior and depression, GTS pathophysiology remains enigmatic. In this review, in the light of GTS phenomenology, we will focus on current theories of tic-emergence related to aberrant activity in the basal ganglia and abnormal basal ganglia-cortex interplay through cortico-striato-thalamocortical loops from an anatomical, neurophysiological and functional-neuroimaging perspective. We will attempt a holistic view to the countless major and minor drawbacks of the GTS brain and comment on future directions of neuroscientific research to elucidate this common and complex neuropsychiatric syndrome, which merits scientific understanding and social acceptance. © 2012 Elsevier Ltd.


Iannilli E.,University of Dresden Medical School
Rhinology | Year: 2011

So-called bimodal odorants are able to stimulate the intranasal trigeminal system at relatively low concentrations. Using them as stimuli, the current study focused on the interaction between the olfactory and trigeminal systems at a cerebral level. In the experiment, menthol was used at two concentrations, low and high, and these were delivered to two groups of subjects, a healthy control group and an anosmic group who were unable to perceive smells. A computer-controlled olfactometer based on principles of air-dilution was used to deliver the stimuli, while the brain functions were assessed by a functional magnetic resonance imaging (fMRI) technique. SPM5 was used for data analysis. The results showed that normosmic subjects exhibited activation in the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC), prefrontal cortex (PFC), and cerebellum. Whilst anosmic subjects activated the same area inside the anterior cingulate; moreover a cluster of activation was found in the left parahippocampal gyrus. In controls, an effect of stimulus intensity was localized between the anterior cingulated, the medial frontal gyrus and the cerebellum; such areas could not be found in anosmic subjects. These results suggest that the olfactory system modifies trigeminally mediated information causing an evident effect in the differentiation between stimulus intensities.


Croy I.,Gothenburg University | Maboshe W.,University of Dresden Medical School | Hummel T.,University of Dresden Medical School
International Journal of Psychophysiology | Year: 2013

Objective: The hedonic value of odors is reflected in chemosensory evoked potentials with more salient unpleasant odors being processed differently from pleasant odors. However, it is not known if this effect is stable over time. It was examined if chemosensory evoked potentials towards pleasant and unpleasant odors change with repeated presentation. Methods: 42 participants received two pleasant (Peach and PEA) and one unpleasant (H2S) intensity matched odors in a block design. Intensity and pleasantness were rated after each presentation. Subjective ratings, as well as N1 and P2 of the first stimulus of each block were compared with the two following stimuli of each block. Results: Early and late components of the chemosensory evoked potentials had shorter latencies in response to the unpleasant H2S compared to PEA and Peach. Pleasantness ratings for H2S increased with repeated presentation but were far below neutral even for the third stimulus in a row. In line with this, for H2S only, the P2 amplitude diminished with repeated presentation. Conclusion: We assume that unpleasant stimuli catch more attention first hand. However, repeated presentation leads to reduced emotional salience of unpleasant stimuli only, which is mirrored in a decrease of neuronal activation. © 2013 Elsevier B.V..


Schriever V.A.,University of Dresden Medical School
Rhinology | Year: 2012

Olfactory dysfunction is a common complaint in a large number of people. As the aetiologies of olfactory dysfunction vary greatly so do the treatment approaches. The aim of this retrospective study was to evaluate treatment with systemic corticosteroids, particularly focusing on its effectiveness on the different olfactory dysfunction aetiologies. Although a prospective randomized control trail is preferred for such an investigation, using the current approach, we were able to test a very large patient population. A total of 425 patients with olfactory dysfunction were treated with systemic corticosteroids for 14 days. Olfactory performance was measured using the `Sniffin` Sticks` battery before and after the treatment. The treatment with systemic corticosteroids significantly increased the performance on the TDI score and on each of the three subtests; threshold, discrimination and identification. In 26.6% of the patients improvement of more than six points of the TDI score was observed. The treatment proved to be more effective in patients with sinunasal olfactory dysfunction, where this percentage increased to 36.7, compared to other aetiologies. In addition, the increase in olfactory function was negatively correlated with the TDI score before the treatment. This study confirms the effectiveness of systemic corticosteroids on olfactory dysfunction in a large patient population. Specifically, the results show that treatment is: (a) more effective in patients with sinunasal than in patients with idiopathic olfactory dysfunction, (b) most effective in patients with sinunasal disease with nasal polyps, and (c), at best, effective in half of the patients. The current study may provide help in counselling patients.

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