Dhaka, Bangladesh
Dhaka, Bangladesh

The University of Dhaka , is the oldest university in modern Bangladesh. Established during the British Raj in 1921, it gained a reputation as the "Oxford of the East" during its early years and has been a significant contributor to the modern history of Bangladesh. After the partition of India, it became the focal point of progressive and democratic movements in Pakistan. Its students and teachers played a central role in the rise of Bengali nationalism and the independence of Bangladesh.The university's distinguished alumni include Satyendra Nath Bose , Fazlur Rahman Khan , Muhammad Yunus , Vijayaraghavan , Rehman Sobhan , Buddhadeb Bose and Sheikh Mujibur Rahman . It also enjoyed associations with Kazi Nazrul Islam, Rabindranath Tagore and Faiz Ahmed Faiz.Today, it is the largest public university in Bangladesh, with a student body of 33,000 and a faculty of 1,800. It was identified by AsiaWeek as one of the top 100 universities in Asia. However since the 1990s, the university has suffered from intensely politicized, partisan and violent campus politics promoted by Bangladesh's political parties. Wikipedia.

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Fleige E.,Free University of Berlin | Quadir M.A.,University of Dhaka | Haag R.,Free University of Berlin
Advanced Drug Delivery Reviews | Year: 2012

The use of polymeric nanocarriers to transport active compounds like small-molecular drugs, peptides, or genes found an increased attention throughout the different fields of natural sciences. Not only that these nanocarriers enhance the properties of already existing drugs in terms of solubility, bioavailability, and prolonged circulation times, furthermore they can be tailor-made in such a manner that they selectively release their cargo at the desired site of action. For the triggered release, these so-called smart drug delivery systems are designed to react on certain stimuli like pH, temperature, redox potential, enzymes, light, and ultrasound. Some of these stimuli are naturally occurring in vivo, for example the difference in pH in different cellular compartments while others are caused by the disease, which is to be treated, like differences in pH and temperature in some tumor tissues. Other external applied stimuli, like light and ultrasound, allow the temporal and spatial control of the release, since they are not triggered by any biological event. This review gives a brief overview about some types of stimuli-responsive nanocarriers with the main focus on organic polymer-based systems. Furthermore, the different stimuli and the design of corresponding responsive nanocarriers will be discussed with the help of selected examples from the literature. © 2012 Elsevier B.V.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: SSH-2007-4.2-02;SSH-2007-8.0-02 | Award Amount: 723.69K | Year: 2008

Human rights, and especially minority rights, have a clear supranational dimension both in Europe and in South Asia. Europe has made wide use of the mechanisms and soft law approaches developed and implemented at regional level by the OSCE, the Council of Europe and the European Union. In South Asia there is a long tradition of study and robust experience in the field of cultural, religious, linguistic and ethnic management, including the gender dimension, within national boundaries. However, it is only recently that some albeit limited attempts have been made to enhance regional cooperation on these very sensitive issues. Studies carried out by South Asian scholars have created the knowledge base underlying the first rudimentary attempts by the South Asian Association for Regional Cooperation (SAARC) and the foresight initiatives of human rights NGOs and activists. Furthermore, the geopolitical context is now particularly favourable to a supra-national discourse on human and minority rights as a consequence of recently improved relations between India and Pakistan. The overall objective of EURASIA-Net is therefore to enhance the requisite knowledge-base for new policies and instruments to reduce ethnic-religious conflicts and to foster stability and security in South Asia. The specific objectives are: 1. To develop a better understanding of regional South Asian attempts to define (by the research community) and implement (by decision-makers and activists) new supranational instruments for the protection and promotion of human rights, with a particular focus on cross-border minority issues. 2. To sustain Euro-Asiatic research cooperation and exchange on those issues and to enlarge the discussion forum to encompass politicians and human rights activists. 3. To create a framework for future research cooperation between Europe and South Asia that is twofold: (a) a Joint Research Agenda and (b) a modus operandi based on mutual knowledge and understanding.

Nandi S.K.,Chittagong University | Ghosh H.R.,University of Dhaka
Energy | Year: 2010

A pre-feasibility of wind-PV-battery hybrid system has been performed for a small community in the east-southern part of Bangladesh. Solar radiation resources have been assessed from other meteorological parameters like sunshine duration and cloud cover as measured radiation data were not available at the site. The predicted monthly averaged daily global radiation over Chittagong is 4.36 kWh/m2/day. Measured wind speed at the site varies from 3 m/s to 5 m/s. For few months and hours the speed is below the cut in speeds of the available turbines in market. The hybrid system analysis has showed that for a small community consuming 53,317 kWh/year the cost energy is 0.47USD/kWh with 10% annual capacity of shortage and produces 89,151 kWh/year in which 53% electricity comes from wind and the remaining from solar energy. The sensitivity analysis showed that the hybrid system for the community is compatible with the 8 km-12 km grid extension depending on small variation of solar radiation and wind speed over the district whereas the proposed site is more away from the upper limit. Such a hybrid system will reduce about 25 tCO2/yr green house gases (GHG) emission in the local atmosphere. © 2010 Elsevier Ltd.

Lopes L.,University College London | Rahman M.S.,University of Dhaka | Elliott P.,University College London
Heart | Year: 2013

Background: The genetic basis of familial hypertrophic cardiomyopathy (HCM) is well described, but the relation between genotype and clinical phenotype is still poorly characterised. Objective: To summarise and critically review the current literature on genotype-phenotype associations in patients with HCM and to perform a meta-analysis on selected clinical features. Data sources: PubMed/Medline was searched up to January 2013. Retrieved articles were checked for additional publications. Selection criteria: Observational, cross-sectional and prospectively designed English language human studies that analysed the relationship between the presence of mutations in sarcomeric protein genes and clinical parameters. Data extraction and analysis: The pooled analysis was confined to studies reporting on cohorts of unrelated and consecutive patients in which at least two sarcomere genes were sequenced. A random effect meta-regression model was used to determine the overall prevalence of predefined clinical features: age at presentation, gender, family history of HCM, family history of sudden cardiac death (SCD), and maximum left ventricular wall thickness (MLVWT). The I2 statistic was used to estimate the proportion of total variability in the prevalence data attributable to the heterogeneity between studies. Results: Eighteen publications (corresponding to a total of 2459 patients) were selected for the pooled analysis. The presence of any sarcomere gene mutation was associated with a younger age at presentation (38.4 vs 46.0 years, p<0.0005), a family history of HCM (50.6% vs 23.1%, p<0.0005), a family history of SCD (27.0% vs 14.9%, p<0.0005) and greater MLVWT (21.0 vs 19.3 mm, p=0.03). There were no differences when the two most frequently affected genes, MYBPC3 and MYH7, were compared. A total of 53 family studies were also included in the review. These were characterised by pronounced variability and the majority of studies reporting on outcomes analysed small cross-sectional cohorts and were unsuitable for pooled analyses. Conclusions: The presence of a mutation in any sarcomere gene is associated with a number of clinical features. The heterogeneous nature of the disease and the inconsistency of study design precludes the establishment of more precise genotype-phenotype relationships. Large scale studies examining the relation between genotype, disease severity, and prognosis are required.

Ahmed S.M.Z.,University of Dhaka
Electronic Library | Year: 2013

Purpose - The purpose of this paper is to describe the pattern of electronic information resources use and satisfaction with university-paid resources by the faculty members in eight public universities in Bangladesh. Design/methodology/approach - An online questionnaire was used to assess the contemporary use of, and satisfaction with, university subscribed electronic resources by the faculty members. The major constraints faced by them in accessing online resources were also identified. To analyze the influence of demographic characteristics on overall satisfaction with e-resources, Mann-Whitney and Kruskal-Wallis tests were carried out. The constraints faced by the faculty members were tested in relation to their opinions on overall satisfaction using chi-square tests. Findings - The results showed that faculty members are not generally satisfied with the current level of university subscribed e-resources. They identified limited number of titles, limited access to back issues, difficulty in finding information, inability to access from home, limited access to computers and slow download speed as major constraints. These constraints do affect e-resources use in the public universities. However, these constraints are mainly related to the poor IT infrastructure and limited access to e-resources, which may also lead to other constraints such as an unwillingness to use the resources regularly and consequently low satisfaction with such resources. Originality/value - This is the first time an effort has been made to assess the use of university-paid online information resources by the academic community in Bangladesh. This study could be used to assess faculty needs for electronic resources which may also lead to a more dynamic interaction with such resources. Copyright © 2013 Emerald Group Publishing Limited. All rights reserved.

Rukunuzzaman M.,University of Dhaka
Pediatric Gastroenterology, Hepatology and Nutrition | Year: 2015

Purpose: To evaluate clinical and laboratory profile of Wilson's disease (WD) in children. Methods: This cross sectional study was conducted at Bangabandhu Sheikh Mujib Medical University Hospital. Bangladesh, over a period of 3 years. One hundred consecutive children of WD between 3 to 18 years of age were evaluated. Results: Mean age was 8.5±1.5 years. Male female ratio was 2:1. Ninety-one percent of patients were Muslim and 9% Hindu. A total of 53% cases of hepatic WD presented between 5 to 10 years of age and most of the neurologic WD manifested in 10-15 years age group. Sixty-nine children presented only with hepatic manifestations, 6 only with neurological manifestations, 14 with both hepatic and neurological manifestation, 10 children was asymptomatic and 1 patient presented with psychiatric features. WD presented as chronic liver disease (CLD) in 42%, CLD with portal hypertension in 34%, acute hepatitis in 20% and fulminant hepatic failure in 4% cases. Stigmata of CLD were found in 18% patients. Keiser-Fleischser ring was found in 76% total patients. Elevated serum transaminase was found in 85% cases, prolonged prothrombin time in 59% cases and hypoalbuminaemia in 53% cases. A total of 73% patients had low serum ceruloplasmin, basal urinary copper of >100 μg/day was found in 81% cases and urinary copper following penicillamine challenge of >1,200 μg/day was found in 92% cases. Conclusion: Majority of studied WD children presented with hepatic manifestation of which 76% presented with CLD. Any child presented with jaundice after the age of 3 years should be investigated for WD. © 2014 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition.

Sharmin R.,University of Dhaka | Islam A.B.M.M.K.,University of Dhaka
BMC Bioinformatics | Year: 2014

Background: Coronaviruses are the diverse group of RNA virus. From 1960, six strains of human coronaviruses have emerged that includes SARS-CoV and the recent infection by deadly MERS-CoV which is now going to cause another outbreak. Prevention of these viruses is urgent and a universal vaccine for all strain could be a promising solution in this circumstance. In this study we aimed to design an epitope based vaccine against all strain of human coronavirus.Results: Multiple sequence alignment (MSA) approach was employed among spike (S), membrane (M), enveloped (E) and nucleocapsid (N) protein and replicase polyprotein 1ab to identify which one is highly conserve in all coronaviruses strains. Next, we use various in silico tools to predict consensus immunogenic and conserved peptide. We found that conserved region is present only in the RNA directed RNA polymerase protein. In this protein we identified one epitope WDYPKCDRA is highly immunogenic and 100% conserved among all available human coronavirus strains.Conclusions: Here we suggest in vivo study of our identified novel peptide antigen in RNA directed RNA polymerase protein for universal vaccine - which may be the way to prevent all human coronavirus disease. © 2014 Sharmin and Islam; licensee BioMed Central Ltd.

Kabilan M.K.,Universiti Sains Malaysia | Khan M.A.,University of Dhaka
Computers and Education | Year: 2012

Assessment in learning is always of interest to practitioners, academics and researchers, and is always evolving with new implications. Alternative forms of assessment such as e-portfolios have gained recognition in documenting students' learning, as it is synchronous with both product and process. Vast amount of literature narrates the relative advantages of e-portfolios across disciplines, institutions, and applications. In Malaysia, such alternative assessment practices are less explored so far in teacher education. In this study, 55 pre-service TESOL teachers from Universiti Sains Malaysia (USM) are required to create and maintain a personal e-portfolio. The aim of the study is to ascertain the future teachers' practices with e-portfolios in their learning and to determine if these practices lead to teaching competencies. In addition, the study also aims to identify the benefits and challenges of using an e-portfolio as a tool for learning and self-assessment. Findings indicate that participants are appreciative of e-portfolios, as their performance and achievements are traced over time. It is also found that e-portfolios function as a monitoring tool, which helps the teachers recognize their learning and identify their strengths and weaknesses. Challenges are also noted, which include validity and reliability, interrupted Internet connection, negative attitudes participants, time constraints, workload and ethical issues. In terms of teacher competencies, it is found that six competencies emerge from the teachers' practices of e-portfolios - (1) developing understanding of an effective teacher's role; (2) developing teaching approaches/activities; (3) improving linguistic abilities; (4) comprehending content knowledge; (5) gaining ICT skills and; (6) the realization of the need to change mindsets. © 2012 Elsevier Ltd. All rights reserved.

Saha G.,University of Dhaka
International Communications in Heat and Mass Transfer | Year: 2010

A numerical investigation of the steady magnetoconvection in a sinusoidal corrugated enclosure has been performed. In this analysis, two vertical sinusoidal corrugated walls are maintained at a constant low temperature whereas a constant heat flux source whose length is varied from 20 to 80% of the reference length of the enclosure is discretely embedded at the bottom wall. The Penalty finite element method has been used to solve the governing Navier-Stokes and energy conservation equation of the fluid medium in the enclosure in order to investigate the effect of discrete heat source sizes on heat transfer for different values of Grashof number and Hartmann number. The values of the governing parameters are the Grashof number Gr (10 3 to 10 6), Hartmann number Ha (0 to 100) and Prandtl number Pr (0.71). The present numerical approach is found to be consistent and the solution is obtained in terms of stream functions and isotherm contours. © 2009 Elsevier Ltd. All rights reserved.

Hossain M.A.,Universiti Malaysia Sabah | Rahman S.M.M.,University of Dhaka
Food Research International | Year: 2011

Pineapple has several beneficial properties including antioxidant activity. The fruit of pineapple was extracted with ethyl acetate, methanol and water. The phenolic content of the extracts was determined by Folin-Ciocalteu method and antioxidant activity was assayed through some in vitro models such as antioxidant capacity by phosphomolybdenum, β-carotene-linoleate, and radical scavenging activity using α,α-diphenyl-β-picrylhydrazyl (DPPH) method. The phenolic contents of the extracts as caffeic acid equivalents were found to be highest in methanol (51.1%) followed by ethyl acetate (13.8%) and water extract (2.6%). Antioxidant capacity of the extracts as equivalent to ascorbic acid (μmol/g of the extract) was in the order of methanol extract. > ethyl acetate extract. > water extract. In comparison with butylated hydroxyanisole (BHA), at 100. ppm of concentration, the antioxidant and free radical scavenging activities of the extracts assayed through β-carotene-linoleate and DPPH method were also found to be highest with methanol extract followed by ethyl acetate and water extracts. The results indicated that the extent of antioxidant activity of the extract is in accordance with the amount of phenolics present in that extract and the pineapple fruit being rich in phenolics may provide a good source of antioxidant. © 2010 Elsevier Ltd.

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