Delhi, India

University of Delhi

du.ac.in
Delhi, India

The University of Delhi is a public central university located in Delhi, India. It is the premier university of the country and is known for its high standards in teaching and research, as well as the eminent scholars it attracts to its faculty.It was established in 1922 as a unitary, teaching and residential university by an Act of the then Central Legislative Assembly. The President of India is the Visitor, the Vice President is the Chancellor and the Chief Justice of the Supreme Court of India is the Pro-Chancellor of the University. Ever since its inception, a strong commitment to excellence in teaching and research has made the University of Delhi a role-model and path-setter for other universities in the country. Its rich academic tradition has always attracted the most talented students who later on go on to make important contributions to their society. Wikipedia.

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University of Delhi and The Mclean Hospital Corporation | Date: 2017-01-12

Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and aminoacridine based hybrids, and methods of using such compounds for diagnosing and/or treating infections, neurodegenerative diseases or disorders, inflammation, inflammation associated diseases and disorders, and/or diseases or disorders that are treatable with dopamine agonists such as the restless leg syndrome.


Mustard, a crop whose seeds and oil are traditionally used in everyday cooking in India, is coming closer to being the country’s first transgenic food crop. India’s top biotechnology regulator earlier this month approved the commercial cultivation of genetically modified (GM) mustard. However, before the seeds are released for sowing, India’s environment minister will have to approve the May 11 recommendation of the Genetic Engineering Appraisal Committee, the government body that evaluates GM crops. The University of Delhi’s Centre for Genetic Manipulation of Crop Plants developed the GM mustard. The goal is to allow plant breeders to develop higher-yielding hybrids of the largely self-pollinating crop. One strain of the bioengineered mustard contains genes from a soil bacterium that cause male flowers to be sterile. Breeders can then pollinate these plants with a strain genetically modified to restore fertility in the resultant hybrids. India’s Supreme Court is hearing a case seeking a moratorium on commercial release of the mustard. The Ministry of Environment, Forest & Climate Change has stated it will abide by the court’s decision. If accepted, the mustard will be the second GM crop to be approved for cultivation and the first GM food crop. India approved the cultivation of transgenic cotton in 2002. Currently, India depends heavily on imports to meet its enormous demand for edible oils, including mustard oil.


The International Association of HealthCare Professionals is pleased to welcome Arun Chawla, MD, Nephrologist to their prestigious organization with his upcoming publication in The Leading Physicians of the World. Dr. Arun Chawla is a highly trained and qualified nephrologist with a vast expertise in all facets of his work, especially glomerulonephritis, hypertension and chronic kidney disease. Dr. Chawla has been in practice for more than a decade, and is currently serving patients within Advocare Nephrology of South Jersey at their Voorhees, Sicklerville, and Williamstown locations. Dr. Chawla was educated at the University of Delhi, Maulana Azad Medical College in New Delhi, India, where he graduated with his Medical Degree. Upon relocating to the United States, he completed his internal medicine residency at the University of Rochester School of Medicine and Dentistry Rochester General Hospital in New York. He then undertook his fellowship training at Hofstra North Shore Long Island Jewish School of Medicine. Dr. Chawla is board certified in both Internal Medicine and Nephrology by the American Board of Internal Medicine. To keep up to date with the latest advances and developments in his field, Dr. Chawla maintains a professional membership with the National Kidney Foundation. He believes that patient education, awareness, and strong communication skills are essential for providing the highest quality of care to his patients. He attributes his success to his exceptional training and mentors, as well as his hard work and persistence. In his free time, Dr. Chawla enjoys studying world history and various cultures, spending time with his family, and playing tennis. Learn more about Dr. Chawla here: http://www.advocarenephrologysj.com and be sure to read his upcoming publication in The Leading Physicians of the World. FindaTopDoc.com is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics.  Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review.  FindaTopDoc.com features each doctor’s full professional biography highlighting their achievements, experience, patient reviews and areas of expertise.  A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life.  For more information about FindaTopDoc, visit http://www.findatopdoc.com


Ray R.S.,University of Delhi | Katyal A.,University of Delhi
Neuroscience and Biobehavioral Reviews | Year: 2016

Neurodegenerative conditions present a group of complex disease pathologies mostly due to unknown aetiology resulting in neuronal death and permanent neurological disability. Any undesirable stress to the brain, disrupts homeostatic balance, through a remarkable convergence of pathophysiological changes and immune dysregulation. The crosstalk between inflammatory and oxidative mechanisms results in the release of neurotoxic mediators apparently spearheaded by myeloperoxidase derived from activated microglia, astrocytes, neurons as well as peripheral inflammatory cells. These isolated entities combinedly have the potential to flare up and contribute significantly to neuropathology and disease progression. Recent, clinicopathological evidence support the association of myeloperoxidase and its cytotoxic product, hypochlorous acid in a plethora of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Multiple sclerosis, Stroke, Epilepsy etc. But the biochemical and mechanistic insights into myeloperoxidase mediated neuroinflammation and neuronal death is still an uncharted territory. The current review outlines the emerging recognition of myeloperoxidase in neurodegeneration, which may offer novel therapeutic and diagnostic targets for neurodegenerative disorders. © 2016 Elsevier Ltd


Pratap R.,University of Delhi | Ram V.J.,University of Lucknow
Chemical Reviews | Year: 2014

A study focuses on providing information about the natural products of chromene, furochromenes, pyranochromenes, and benzochromene ring systems, along with the synthesis of various aromatized and partially reduced chromenes, benzo-, and naphtho-fused chromenes, thiochromenopyrans, and their applications in synthetic organic chemistry for the construction of numerous diverse compounds. It is demonstrated that the presence of nitro group at C-5 in XVIIa,b affects the chemical shifts of H-4 and H-6 protons, and they resonate downfield as compared to respective protons of XVIIc due to the presence of electron-withdrawing substituents. It has also been observed that various substituted 2H-chromenes isolated from the leaves of Orthosiphom aristatus have been used as traditional medicine for the treatment of hypertension and diabetes.


Kamei R.G.,University of Delhi
Proceedings. Biological sciences / The Royal Society | Year: 2012

The limbless, primarily soil-dwelling and tropical caecilian amphibians (Gymnophiona) comprise the least known order of tetrapods. On the basis of unprecedented extensive fieldwork, we report the discovery of a previously overlooked, ancient lineage and radiation of caecilians from threatened habitats in the underexplored states of northeast India. Molecular phylogenetic analyses of mitogenomic and nuclear DNA sequences, and comparative cranial anatomy indicate an unexpected sister-group relationship with the exclusively African family Herpelidae. Relaxed molecular clock analyses indicate that these lineages diverged in the Early Cretaceous, about 140 Ma. The discovery adds a major branch to the amphibian tree of life and sheds light on both the evolution and biogeography of caecilians and the biotic history of northeast India-an area generally interpreted as a gateway between biodiversity hotspots rather than a distinct biogeographic unit with its own ancient endemics. Because of its distinctive morphology, inferred age and phylogenetic relationships, we recognize the newly discovered caecilian radiation as a new family of modern amphibians.


Jain A.K.,University of Delhi
Journal of Bone and Joint Surgery - Series B | Year: 2010

The dismal outcome of tuberculosis of the spine in the pre-antibiotic era has improved significantly because of the use of potent antitubercular drugs, modern diagnostic aids and advances in surgical management. MRI allows the diagnosis of a tuberculous lesion, with a sensitivity of 100% and specificity of 88%, well before deformity develops. Neurological deficit and deformity are the worst complications of spinal tuberculosis. Patients treated conservatively show an increase in deformity of about 15°. In children, a kyphosis continues to increase with growth even after the lesion has healed. Tuberculosis of the spine is a medical disease which is not primarily treated surgically, but operation is required to prevent and treat the complications. Panvertebral lesions, therapeutically refractory disease, severe kyphosis, a developing neurological deficit, lack of improvement or deterioration are indications for surgery. Patients who present with a kyphosis of 60° or more, or one which is likely to progress, require anterior decompression, posterior shortening, posterior instrumented stabilisation and anterior and posterior bone grafting in the active stage of the disease. Late-onset paraplegia is best prevented rather than treated. The awareness and suspicion of an atypical presentation of spinal tuberculosis should be high in order to obtain a good outcome. Therapeutically refractory cases of tuberculosis of the spine are increasing in association with the presence of HIV and multidrug-resistant tuberculosis. ©2010 British Editorial Society of Bone and Joint Surgery.


Kalia V.C.,University of Delhi
Biotechnology Advances | Year: 2013

Excessive and indiscriminate use of antibiotics to treat bacterial infections has lead to the emergence of multiple drug resistant strains. Most infectious diseases are caused by bacteria which proliferate within quorum sensing (QS) mediated biofilms. Efforts to disrupt biofilms have enabled the identification of bioactive molecules produced by prokaryotes and eukaryotes. These molecules act primarily by quenching the QS system. The phenomenon is also termed as quorum quenching (QQ). In addition, synthetic compounds have also been found to be effective in QQ. This review focuses primarily on natural and synthetic quorum sensing inhibitors (QSIs) with the potential for treating bacterial infections. It has been opined that the most versatile prokaryotes to produce QSI are likely to be those, which are generally regarded as safe. Among the eukaryotes, certain legumes and traditional medicinal plants are likely to act as QSIs. Such findings are likely to lead to efficient treatments with much lower doses of drugs especially antibiotics than required at present. © 2012 Elsevier Inc.


Kumar A.,University of Delhi | Venkatesu P.,University of Delhi
Chemical Reviews | Year: 2012

An overview of the stability of α-Chymotrypsin (CT) in different solvent media is studied. The degree of stabilization of CT depends on the type of the solvent and the additive and is related to the form of the enzyme (soluble or immobilized) existing in the system. Organic solvents influenced the 3D structure of the CT thereby affecting the stability of the enzyme. If the enzyme exists in immobilized form, its stability depends also on the nature of the support. Protein functional groups in aqueous solution are surrounded by a hydration shell, which is composed of water molecules attached to the protein surface. Solvent hydrophobicity and polarity indirectly influence enzyme activity by affecting the hydration level of the enzyme. It is possible that the ILs reinforce CT structure such that it is able to perform its function more readily, which would account for the most effective stabilizing agents. However, ILs differ in the length of the alkyl group attached to the imidazolium cation, thus presumably differing in their hydrophobicity and ability to interact with the enzyme.


Gopalaiah K.,University of Delhi
Chemical Reviews | Year: 2013

Asymmetric metal-catalytic reactions can produce large quantities of chiral products with a very high efficiency using small amounts of chiral metal catalysts. Much of the work in asymmetric metal catalysis has been performed using noble metals based on rhodium, palladium, ruthenium, and iridium complexes. The next phase of development is the application of iron catalysis in asymmetric synthesis. There are significant developments in the design and use of chiral iron catalysts beginning with Groves discovery of catalytic asymmetric epoxidations with chiral iron-porphyrins in 1983. Cytochromes are redox enzymes, distributed widely in all living cells. They are conjugated proteins having an iron-porphyrin as prosthetic group. Cytochrome c and cytochrome P-450 are the most extensively studied oxidases. They bring about a wide range of stereoselective transformations, such as epoxidations, hydroxylations and others.

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