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Oulehlova A.,University of Defence at Brno
Risk, Reliability and Safety: Innovating Theory and Practice - Proceedings of the 26th European Safety and Reliability Conference, ESREL 2016 | Year: 2017

The article deals with impacts of carried out research into electricity blackout on other sectors with the emphasis on the environment. Electricity blackout represents one of the most serious anthropogenic threats to current society. Long-term electricity blackout brings impacts on society, property as well as environment; therefore the critical factor is to ensure protection, reliability and functionality of the critical infrastructure. Within the research into the relations between the sectors of critical infrastructure, energy sector has been identified as crucial for ensuring the functionality of related critical infrastructure. © 2017 Taylor & Francis Group, London.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: SEC-2007-6.2-01 | Award Amount: 2.72M | Year: 2009

Security-centered training course curricula on disaster management for first responders (FR)* in EU member states will be comparatively assessed with a specially developed matrix-based software: (1) for all EU member states (2) as derived from international best practices in the US, Russia, and Israel as countries with extensive experience in this field. The comparative assessment will cover: (a) Didactic areas (electronic and hardcopy teaching materials used, computer modelling, field exercises); (b) Subject areas (terror threats to FR; risk assessment and -management; catastrophic terrorism; weapons of mass destruction, -mass killing, -mass disturbance; synchronization of response staff; (c) comparative evaluation of training course curricula by virtual reality safety training with biofeedback. Representatives of FR organisations and SMEs in security technology will be involved throughout the assessment. This new integrative approach reflects the necessity of the integretive operation of end-users and representatives of the research and development community to enhance European joint security capabilities.The results of the assessment will be used to: (1) Establish an EU- security curricula database; (2) Identify potentially existing gaps in the EU training curricula; (3) Recommend an Action Plan for eliminating training deficiencies; (4) Develop a standardized security-centered training curriculum for first responders on disaster management; (5) Enhance the implementation of technology-based security programs into FR organisations


Khateb F.,Brno University of Technology | Biolek D.,University of Defence at Brno
Circuits, Systems, and Signal Processing | Year: 2011

Low-voltage (LV) low-power (LP) integrated circuit design is becoming a leading trend in VLSI technology, particularly in special portable applications. In this paper the principle of a bulk-driven MOS transistor is employed in the design of a novel LV LP current differencing transconductance amplifier (CDTA). Designs in the 0.25 μm CMOS technology have been verified via PSpice simulation. The supply voltages are only ±0.6 V. © 2011 Springer Science+Business Media, LLC.


Valis D.,University of Defence at Brno | Pietrucha-Urbanik K.,Rzeszow University of Technology
Eksploatacja i Niezawodnosc | Year: 2014

Assessing the vulnerability of critical infrastructure objects is of major concern when dealing with the process of dependability and risk management. Special attention is paid to the objects of higher interest, such as nuclear power plants. In spite of the protection of these objects, there is still a certain level of a potential threat. The aim of the paper is to describe a possible way of attacking on the object in order to get into a particular part of it. Several characteristics of an adversarýs attempt were obtained. For this reason as well as for modelling adversarýs behaviour diffusion processes have been used.


Stefek A.,University of Defence at Brno
Proceedings of 14th International Conference on Mechatronics, MECHATRONIKA 2011 | Year: 2011

It is short history when many heuristic optimization methods appear. As example Particle swarm optimization method (PSO) or Repulsive particle swarm optimization method (RPSO), Gravitational search algorithm (GSA), Central force optimization (CFO), Harmony search algorithm (HAS) etc. Those methods are working differently but all of them can optimize same problems. There is general question: Exists any standard benchmark which can be used for individual methods comparing? It is a bit hard to answer this question because it is possible to find some optimization problems which are widely used along some papers but in fact there does not exists summary which can be uses for standard evaluation of optimization process. This paper will describe set of benchmarks which can be used for evaluation of optimization process. As a part of paper some results of optimization and utilization of optimization methods will be included. © 2011 Univ of Trencin.


Tichy A.,University of Defence at Brno
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové | Year: 2010

Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, cell-cycle progress, and apoptosis. Here we describe its main signalling targets and discuss its importance in DNA repair as well as novel findings linked to this key regulatory enzyme in the terms of ionizing radiation-induced DNA damage.


Tichy A.,University of Defence at Brno
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové | Year: 2012

In this paper we describe the influence of NU7026, a specific inhibitor of DNA-dependent protein kinase, phosphoinositide 3-kinase, and ATM-kinase on molecular and cellular mechanisms triggered by ionising irradiation in human T-lymphocyte leukaemic MOLT-4 cells. We studied the effect of this inhibitor (10 1microM) combined with gamma-radiation (1 Gy) leading to DNA damage response and induction of apoptosis. We used methods for apoptosis assessment (cell viability count and flow-cytometric analysis) and cell cycle analysis (DNA content measurement) and we detected expression and post-translational modifications (Western blotting) of proteins involved in DNA repair signalling pathways. Pre-treatment with NU7026 resulted into decreased activation of checkpoint kinase-2 (Thr68), p53 (Ser15 and Ser392), and histone H2A.X (Ser139) 2 hours after irradiation. Subsequently, combination of radiation and inhibitor led to decreased amount of cells in G2-phase arrest and into increased apoptosis after 72 hours. Our results indicate that in leukaemic cells the pre-incubation with inhibitor NU7026 followed by low doses of ionising radiation results in radio-sensitising of MOLT-4 cells via diminished DNA repair and delayed but pronounced apoptosis. This novel approach might offer new strategies in combined treatment of leukaemia diseases.


Bajgar J.,University of Defence at Brno
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové | Year: 2010

The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present. Though the research is very intensive, unfortunately, up to now, there is not universal or significantly better reactivator sufficiently effective against all nerve agents/OP when compared with presently available oximes (pralidoxime, methoxime, obidoxime, trimedoxime, HI-6). The use of the most effective reactivator (HI-6) using simple type of autoinjector (e.g. ComboPen) is strictly limited because of decomposition of HI-6 in solution. Thanks to better solubility it is clear that another salt of HI-6 (dimethanesulfonate, HI-6 DMS) is more convenient for the use as antidote against nerve agents in the autoinjector than HI-6 chloride (Cl). It was clearly demonstrated that reactivation potency of HI-6 DMS in comparison with HI-6 Cl in vivo was the same and bioavailability of HI-6 DMS is better than that of HI-6 Cl. Three chambered autoinjector allows administration of all three antidotes (atropine, reactivator, diazepam) simultaneously. Moreover, the content of chambers can be changed according to proposed requirements. Possible way to solve the problem of universal reactivator could be the use of two reactivators. Three chambered autoinjector is an ideal device for this purpose.


Zaplatilek K.,University of Defence at Brno
Proceedings of the European Computing Conference, ECC '11 | Year: 2011

The article deals with various ways of memristor modeling and simulation in the MATLAB®&Simulink® environment. Recently used and published mathematical memristor model serves as a base, regarding all known features of its behavior. Three different approaches in the MATLAB&Simulink system are used for the differential and other equations formulation. The first one employs the standard system core offer for the Ordinary Differential Equations solutions (ODE) in the form of an m-file. The second approach is the model construction in Simulink environment. The third approach employs so-called physical modeling using the built-in Simscape™ system. The output data are the basic memristor characteristics and appropriate time courses. The features of all models are discussed, especially regarding the computer simulation. Possible problems that may occur during modeling are pointed.


Hoskova-Mayerova S.,University of Defence at Brno
Computers and Mathematics with Applications | Year: 2012

Hypergroups are generalizations of groups. If this binary operation is taken to be multivalued, then we arrive at a hypergroup. The motivation for generalization of the notion of group resulted naturally from various problems in non-commutative algebra, another motivation for such an investigation came from geometry. In various branches of mathematics we encounter important examples of topologico-algebraical structures like topological groupoids, groups, rings, fields etc. In this contribution various kinds of continuity of hyperoperations will be introduced, namely pseudocontinuous, strongly pseudocontinuous and continuous hyperoperations. Further, the relationship between them is studied. Our aim is to generalize the concept of topological groupoid to topological hypergroupoid. © 2012 Elsevier Ltd. All rights reserved.

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