The University of Coimbra dɨ kuˈĩbɾɐ]) is a Portuguese public university in Coimbra, Portugal. Established in 1290, it is one of the oldest universities in continuous operation in the world, the oldest university of Portugal, and one of its largest higher education and research institutions. It is organized into eight different faculties according to a wide range of fields, granting academic bachelor's , master's and doctorate degrees in arts, engineerings, humanities, mathematics, natural science, social science, sports and technologies. It is a founding member of the Coimbra Group, a group of leading European research universities, whose inaugural meeting it hosted. The University of Coimbra has approximately 20,000 students, and hosts one of the largest communities of international students in Portugal, being the most cosmopolitan Portuguese university.On 22 June 2013, UNESCO added the university to its World Heritage List. Wikipedia.
News Article | May 17, 2017
The increasing growth of the automotive industry demands the development of groundbreaking solutions, innovative technologies and disruptive products, services and business models. New industrial players must constantly invest in R&D and look one step forward into the future, which was in fact the main objective of the International Industry Roundtable (IIR) promoted by the MIT Portugal Program, which took place on Monday, May 15th, at the RÓMULO - Centro Ciência Viva from the University of Coimbra. The auto industry has some of the largest industrial R&D investors in the world. Typically, the annual investment in R&D surpasses 30 billion in Europe only. The automotive industry is also one of the most important industries in Portugal, being a top contributor for value creation and generation of jobs. It represents around 8% of the country's GDP, 11% of the country exports and more than 30.000 direct jobs. This Roundtable brought together more than 80 industry leaders, entrepreneurs, expert researchers and graduate students in a look ahead to the next 5-10 years of the industry. The Session allowed participants to discuss common objectives, share new technologies and ideas, and promoted networking and potential collaborations between participants from academia and industry. The initiative counted on the participation of speakers from emerging companies based in Portugal such as the Fraunhofer Institute, Magnum Cap, AFIA, Brisa, Ceiia, TU Delft, Bosch, Caetano Bus, Uber, BMWi and Ubiwhere, and representatives of MIT Portugal, University of Coimbra, University of Minho, and University of Lisbon. The International Industry Roundtables (IIR) are an ongoing initiative of the MIT Portugal Program in collaboration with multiple academic and business entities and this is the second edition dedicated to Cities, Energy and Transportation. The IIR aim is to use the neutral grounds of academia to bring together entrepreneurs, company executives, policy makers, scientists, engineers and graduate students around topics where cutting-edge technology is put at the service of sustainable economic and social development. The focus is to bridge views and find common objectives between industry and academia, as well as within industry and within academia.
Alves J.L.,University of Coimbra
Journal of Neuroscience Research | Year: 2014
The blood-brain barrier (BBB) is an anatomical microstructural unit, with several different components playing key roles in normal brain physiological regulation. Formed by tightly connected cerebrovascular endothelial cells, its normal function depends on paracrine interactions between endothelium and closely related glia, with several recent reports stressing the need to consider the entire gliovascular unit in order to explain the underlying cellular and molecular mechanisms. Despite that, with regard to traumatic brain injury (TBI) and significant events in incidence and potential clinical consequences in pediatric and adult ages, little is known about the actual role of BBB disruption in its diverse pathological pathways. This Mini-Review addresses the current literature on possible factors affecting gliovascular units and contributing to posttraumatic BBB dysfunction, including neuroinflammation and disturbed transport mechanisms along with altered permeability and consequent posttraumatic edema. Key mechanisms and its components are described, and promising lines of basic and clinical research are identified, because further knowledge on BBB pathological interference should play a key role in understanding TBI and provide a basis for possible therapeutic targets in the near future, whether through restoration of normal BBB function after injury or delivering drugs in an increased permeability context, preventing secondary damage and improving functional outcome. © 2013 Wiley Periodicals, Inc.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-4-2014 | Award Amount: 16.42M | Year: 2015
PRACE, the Partnership for Advanced Computing, was established in May 2010 as a permanent pan-European High Performance Computing service providing world-class systems for world-class science. Six systems at the highest performance level (Tier-0) are deployed by Germany, France, Italy and Spain providing researchers with over 9 billion core hours of compute time. HPC experts from twenty-five member states - funded in part in three implementation projects - enabled users from academia and industry to ascertain leadership and remain competitive in the Global Race. Currently PRACE is preparing for PRACE 2.0, the successor of the initial five year period. The objectives of PRACE-4IP are to build on and seamlessly continue the successes of PRACE and start new innovative and collaborative activities proposed by the consortium. These include: assisting the transition to PRACE 2.0; strengthening the internationally recognised PRACE brand; continuing advanced training which so far provided more than 15.000 person-training days to over 4700 persons, preparing strategies and best practices towards exascale computing, coordinating and enhancing the operation of the multi-tier HPC systems and services, and supporting users to exploit massively parallel systems and novel architectures. The proven project structure will be used to achieve each of the objectives in six dedicated work packages. The project will continue to be managed by Jlich. The activities are designed to increase Europes research and innovation potential especially through: seamless and efficient Tier-0 services and a pan-European HPC ecosystem including national capabilities; promoting take-up by industry and special offers to SMEs; analysing new flexible business models for PRACE 2.0; proposing strategies for deployment of leadership systems; collaborating with the ETP4HPC, the coming CoEs and other European and international organisations on future architectures, training, application support and policies.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-11-2016 | Award Amount: 16.11M | Year: 2017
PRACE, the Partnership for Advanced Computing is the permanent pan-European High Performance Computing service providing world-class systems for world-class science. Systems at the highest performance level (Tier-0) are deployed by Germany, France, Italy and Spain providing researchers with over 11 billion core hours of compute time. HPC experts from 25 member states enabled users from academia and industry to ascertain leadership and remain competitive in the Global Race. Currently PRACE is in transition to PRACE 2, the successor of the initial five year period. The objectives of PRACE-5IP are to build on and seamlessly continue the successes of PRACE and start new innovative and collaborative activities proposed by the consortium. These include: assisting the transition to PRACE 2 including an analysis of Trans National Access; strengthening the internationally recognised PRACE brand; continuing and extend advanced training which so far provided more than 18 800 persontraining days; preparing strategies and best practices towards Exascale computing; coordinating and enhancing the operation of the multi-tier HPC systems and services; and supporting users to exploit massively parallel systems and novel architectures. A high level Service Catalogue is provided. The proven project structure will be used to achieve each of the objectives in 6 dedicated work packages. The activities are designed to increase Europes research and innovation potential especially through: seamless and efficient Tier-0 services and a pan-European HPC ecosystem including national capabilities; promoting take-up by industry and new communities and special offers to SMEs; implementing a new flexible business model for PRACE 2; proposing strategies for deployment of leadership systems; collaborating with the ETP4HPC, CoEs and other European and international organisations on future architectures, training, application support and policies. This will be monitored through a set of KPIs.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: REV-INEQUAL-06-2016 | Award Amount: 5.00M | Year: 2017
ISOTIS addresses the nature, causes and impact of early emerging social and educational inequalities in the context of socioeconomic, cultural and institutional processes. The aim is to contribute to effective policy and practice development to combat inequalities. Quasi-panels and pooled longitudinal datasets will be used to examine the variation in early educational gaps and developmental trajectories across countries, systems and time. To disentangle the complex interactions between characteristics of systems and target groups, ISOTIS will study significant immigrant, indigenous ethnic-cultural and low-income native groups, associated with persistent educational disadvantages. ISOTIS will examine current resources, experiences, aspirations, needs and well-being of children and parents in these groups in the context of acculturation and integration, and in relation to local and national policies. ISOTIS aims to contribute to effective policy and practice development by generating recommendations and concrete tools for (1) supporting disadvantaged families and communities in using their own cultural and linguistic resources to create safe and stimulating home environments for their children; for (2) creating effective and inclusive pedagogies in early childhood education and care centres and primary schools; for (3) professionalization of staff, centres and schools to improve quality and inclusiveness; for (4) establishing inter-agency coordination of support services to children and families; and for (5) developing policies to combat educational inequalities. ISOTIS will develop inter-linked programmes for parents, classrooms and professionals using Virtual Learning Environments for working in linguistically diverse contexts. All this work together is expected to support the education practice and policy field in Europe in meeting the challenges of reducing social and educational inequalities.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-24-2015 | Award Amount: 4.34M | Year: 2016
Manufacturing competitiveness depends largely on its productivity, flexibility and agility to react to market demands. Robots are a key element to achieve such competitiveness, especially if they are able to collaborate with humans in a shared workspace in the shop-floor, creating a co-working partnership. The paradigm for robot usage has changed from an idea in which robots work with complete autonomy to a scenario in which robots collaborate with humans. This means taking the best of each partner, human and robot, by exploring the cognitive and dexterity capabilities of humans (focus on value-added tasks) and the capacity of robots to produce repetitive work and provide assistance. ColRobot combines cutting-edge European robot technology and end-user requirements for assembly processes to create an integrated system for collaborative robotics in which a mobile manipulator acts as a third hand by delivering kits, tools, parts, and holding work pieces while the operator works on it. Humans will cognitively and physically interact with ColRobot robots using gestures, touch commands and demonstrations. The robot will be able to navigate autonomously in the factory floor to pick up the required parts and tools, and prepare kits for assembly. A safety system that pushes the limits of standardization in collaborative robotics supervises the process. The technology readiness level (TRL) will be increased by means of continuous iterative real world testing (performance, usability, relevance in manufacturing), validation and improvement. Two use cases in automobile and aerospace industry will be implemented and validated in real world operational environments. The ColRobot vision and the consortium competences in technology transfer will allow to reduce the technological innovation gap that halts the transition from science to economic and social impact.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: WASTE-6b-2015 | Award Amount: 4.97M | Year: 2016
The scope of the project is to develop and test methods for designing and implementing innovative and sustainable Strategic Plans for Waste Prevention and Management in various urban contexts that will enhance urban environmental resilience and guarantee progress towards more sustainable production and consumption patterns together with improvements waste recovery and recovered materials use. Urban_Wins will define a data set, based on material flow indicators, capable of supporting and orienting decision making processes for urban waste prevention and management. Knowledge of the factors that influence the metabolism of cities will be improved together with the understanding of how those factors can be transformed in positive drivers of technological, non-technological and governance changes. The information set produced by the consortium will also focus on how a more efficient use of resources and a better management of waste can improve urban quality and citizens welfare, key points for urban stakeholders involvement, both in the planning and implementation of actions. The proposal reunites diverse actors such as cities, research institutes and universities, environmental NGOs, IT&C, technological innovation and waste management companies, professional associations that represent EU regions, sectors and levels of governance. The complex partnership guarantees that advancement in EU research in the field of urban metabolism and waste management strategies is directly linked to stakeholder engagement and mutual learning and contributes to the achievement of resource efficiency and waste management objectives. Urban_Wins analytical tools will be built on the base of datasets and experiences of 24 EU cities from 6 European countries and the Strategic Plans will be tested by 8 EU cities and will encompass regulatory measures, educational initiatives and sector specific actions.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-09-2016 | Award Amount: 6.20M | Year: 2017
Due to lack of targeted interventions, compliance issues, insufficient effect sizes and a high non-responder rate to currently available interventions, there is an urgent need to develop innovative and new interventions for chronic paediatric neuropsychiatric disorders, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). Transcranial direct current stimulation (tDCS) has been shown to be an innovative, effective and safe alternative treatment approach for neuropsychiatric disorders in adults. Here, for the first time, the effect of tDCS on core neurocognitive and behavioral outcomes will be proven in children and adolescents. First, effect sizes and safety of standard tDCS in the clinical setting targeting core brain regions and disorder specific cognitive tasks will be established by three phase-IIa randomized, double blind, sham-controlled studies in ADHD and ASD. Second, the impact of brain development and age-dependent anatomical / functional features on effects of tDCS will be studied systematically using methods of modern neurophysiology, neuroimaging and electric current modeling. This involves an additional phase-I clinical trial. Third, mechanisms of tDCS on brain function will be studied, and biomarkers will be developed in order to predict individual response to standard and individualized stimulation protocols. Finally, the applicability of tDCS in children and adolescents will be improved by developing an innovative personalized home-based treatment option in combination with a telemental health service, which will be tested by a fifth, phase-IIa clinical trial. Throughout the entire project, ethical concerns of the target population will be addressed. This project opens a new avenue for the application of tDCS as an alternative treatment for a great number of chronic neuropsychiatric disorders in children and adolescents and will allow flexible integration of tDCS in the daily routine of families.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: DS-03-2015 | Award Amount: 8.11M | Year: 2016
Over recent years, Industrial and Automation Control Systems (IACS) adopted in Critical Infrastructures (CIs) have become more complex due to the increasing number of interconnected devices, and to the large amount of information exchanged among system components. With the emergence of such an Internet of Things generation of IACS, the boundaries to be protected have grown well beyond that of the single or aggregated-plant, typical of the mono-operator or silos vision. That poses new challenges, as more operators become involved in a scenario that naturally demands the introduction of multi-tenancy mechanisms. New ICT paradigms, where virtualization is playing an important role, provide innovative features for flexible and efficient management, monitoring and control of devices and data traffic. With the OT/IT convergence, OT (Operation Technologies) will benefit from IT innovation, but at the same time, they will also inherit new IT threats that can potentially impact CIs. ATENA project, with reference to the above-mentioned interdependent scenario, aims at achieving the desired level of Security and Resilience of the considered CIs, while preserving their efficient and flexible management. ATENA, leveraging the outcomes of previous European Research activities, particularly the CockpitCI and MICIE EU projects, will remarkably upgrade them by exploiting advanced features of ICT algorithms and components, and will bring them at operational industrial maturity level; in this last respect, ATENA outcomes will be tailored and validated in selected Use Cases. In particular, ATENA will develop a Software Defined Security paradigm combining new anomaly detection algorithms and risk assessment methodologies within a distributed environment, and will provide a suite of integrated market-ready ICT networked components and advanced tools embedding innovative algorithms both for correct static CI configuration and for fast dynamic CI reaction in presence of adverse events.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EUB-1-2015 | Award Amount: 1.50M | Year: 2016
EUrope-BRAzil Collaboration on BIG Data Scientific REsearch through Cloud-Centric Applications aims at providing services in the cloud for the processing of massive data coming from highly connected societies, which impose multiple challenges on resource provision, performance, Quality of Service and privacy. Processing those data require rapidly provisioned infrastructures customised to Big Data requirements. The three main aims of the proposal will be: - The development of innovative Big Data services for capturing, federating and annotating on the order of PB of data on top of efficient programming models. Despite that MapReduce is a successful model in BigData (with a high impact on massive Geo-spatial and textual data), it has many limitations specially when dealing with real-time transactions or streamed data, the proposal would aim to introduce innovative evolutions on the capture, federation & annotation experience it can bring to the table with its partners. - The Development of advanced cloud services to support Big Data. This cloud services will address three main challenges: a) the advance on SLAs to support privacy (boundaries of protected data to be moved) and performance restrictions (convenience of moving data to computing resources or vice-versa); b) Quality of Service (vertical and horizontal elastic adjustment of resources allocates to meet deadlines and dynamic adjustment of workloads); and c) Business models (price-based dynamic re-scheduling of data searching for the best usage of resources invested). - The demonstration of such services on applications with high social and business impact, addressing main scenarios of high interest for both Europe and Brazil.