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Amin N.C.,Max Mousseron Institute of Biomolecules | Amin N.C.,University Of Cocody Ufr Science Pharmaceutiques | Blanchin M.-D.,Max Mousseron Institute of Biomolecules | Ake M.,University Of Cocody Ufr Science Pharmaceutiques | Fabre H.,Max Mousseron Institute of Biomolecules
Journal of Chromatography A | Year: 2012

This paper presents an overview on the current status of enantiomeric and diastereomeric separations of chiral antimalarials and derivatives by capillary electrophoresis (CE). The wide variety of chiral selectors which have been employed to resolve successfully antimalarial enantiomers: oligosaccharides (cyclodextrins, oligomaltodextrins), neutral (amylose, dextrin and dextran) and charged (chondroitin sulfate, heparin, dextran sulfate) polysaccharides and proteins are reviewed. Cyclodextrins were the most employed. Chiral additives added to the background electrolyte often facilitated separations of quinine/quinidine and cinchonine/cinchonidine diastereomers. However, in a few cases, using micellar electrokinetic capillary chromatography or non aqueous CE, resolution of diastereomers could be achieved without additives. Quantitative applications of CE to the quality control of antimalarial drugs and their analysis in biological and food matrices are presented. © 2012 Elsevier B.V. Source


Amin N.C.,Max Mousseron Institute of Biomolecules | Amin N.C.,University Of Cocody Ufr Science Pharmaceutiques | Blanchin M.-D.,Max Mousseron Institute of Biomolecules | Ake M.,University Of Cocody Ufr Science Pharmaceutiques | Fabre H.,Max Mousseron Institute of Biomolecules
Journal of Chromatography A | Year: 2013

An exhaustive review of applications of achiral capillary electrophoresis methods to the analysis of antimalarials is presented. It covers quality control of formulations, analysis in biological fluids and food, determination of physico-chemical properties (pKa, partition coefficient and interaction studies). Miscellaneous applications are also considered. © 2013. Source

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