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Caraffa di Catanzaro, Italy

Aurisicchio L.,Takis | Ciliberto G.,University of Catanzaro
Expert Opinion on Biological Therapy | Year: 2012

Introduction: The recent approval of the first therapeutic cancer vaccine by the US Regulatory Agency represents a breakthrough event in the history of cancer treatment. The past scepticism towards this type of therapeutic intervention is now replaced by great expectations. The field is now moving towards the development of alternative vaccination technologies, which are capable of generating stronger, more durable and efficient immune responses against specific tumour-associated antigens (TAAs) in combination with cheaper and more standardised manufacturing. Areas covered: In this context, genetic vaccines are emerging among the most promising methodologies. Several evidences point to combinations of different genetic immunisation modalities (heterologous prime/boost) as a powerful approach to induce superior immune responses and achieve greater clinical efficacy. In this review, we provide an overview of the current status of development of genetic cancer vaccines with particular emphasis on adenoviral vector prime/DNA boost vaccination schedules. Expert opinion: We believe that therapeutic genetic cancer vaccines have the strong potential to become an established therapeutic modality for cancer in next coming years, in a manner similar to what have now become monoclonal antibodies. © 2012 Informa UK, Ltd. Source

Pietropaolo A.,University of Catanzaro | Nakano T.,Hokkaido University
Journal of the American Chemical Society | Year: 2013

Helical polymers with switchable screw sense are versatile frameworks for chiral functional materials. In this work, we reconstructed the free energy landscape of helical poly(2,7-bis(4-tert-butylphenyl)fluoren-9-yl acrylate) [poly(BBPFA)], as its racemization is selectively driven by light without any rearrangement of chemical bonds. The chirality inversion was enforced by atomistic free energy simulations using chirality indices as reaction coordinates. The free energy landscape reproduced the experimental electronic circular dichroism spectra. We propose that the chirality inversion of poly(BBPFA) proceeds from a left-handed 31 helix via multistate free energy pathways to reach the right-handed 31 helix. The inversion is triggered by the rotation of biphenyl units with an activation barrier of 38 kcal/mol. To the best of our knowledge, this is the first report on the chiral inversion mechanism of a helical polymer determined in a quantitative way in the framework of atomistic free energy simulations. © 2013 American Chemical Society. Source

Small S.L.,University of California at Irvine | Buccino G.,University of Catanzaro | Solodkin A.,University of California at Irvine
Nature Reviews Neurology | Year: 2013

Following stroke, patients are commonly left with debilitating motor and speech impairments. This article reviews the state of the art in neurological repair for stroke and proposes a new model for the future. We suggest that stroke treatment - from the time of the ictus itself to living with the consequences - must be fundamentally neurological, from limiting the extent of injury at the outset, to repairing the consequent damage. Our model links brain and behaviour by targeting brain circuits, and we illustrate the model though action observation treatment, which aims to enhance brain network connectivity. The model is based on the assumptions that the mechanisms of neural repair inherently involve cellular and circuit plasticity, that brain plasticity is a synaptic phenomenon that is largely stimulus-dependent, and that brain repair required both physical and behavioural interventions that are tailored to reorganize specific brain circuits. We review current approaches to brain repair after stroke and present our new model, and discuss the biological foundations, rationales, and data to support our novel approach to upper-extremity and language rehabilitation. We believe that by enhancing plasticity at the level of brain network interactions, this neurological model for brain repair could ultimately lead to a cure for stroke. © 2013 Macmillan Publishers Limited. All rights reserved. Source

Amato F.,University of Catanzaro | Ariola M.,Parthenope University of Naples | Cosentino C.,University of Catanzaro
IEEE Transactions on Automatic Control | Year: 2010

The note deals with the finite-time analysis and design problems for continuous-time, time-varying linear systems. Necessary and sufficient conditions and a sufficient condition for finite-time stability are devised. Moreover, sufficient conditions for the solvability of both the state and the output feedback problems are stated. Such results require the feasibility of optimization problems involving Differential Linear Matrix Inequalities. Some numerical examples illustrate the effectiveness of the proposed approach. © 2006 IEEE. Source

Amato F.,University of Catanzaro | Ariola M.,Parthenope University of Naples | Cosentino C.,University of Catanzaro
Automatica | Year: 2010

In this paper we deal with some finite-time control problems for discrete-time, time-varying linear systems. First we provide necessary and sufficient conditions for finite-time stability; these conditions require either the computation of the state transition matrix of the system or the solution of a certain difference Lyapunov inequality. Then we address the design problem. The proposed conditions allow us to find output feedback controllers which stabilize the closed loop system in the finite-time sense; all these conditions can be expressed in terms of LMIs and therefore are numerically tractable, as shown in the example included in the paper. © 2010 Elsevier Ltd. All rights reserved. Source

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