Cardiff University is a research university located in the Cathays Park area of Cardiff, Wales, United Kingdom. It received its Royal charter in 1883 and is a member of the Russell Group of Universities. The university is consistently recognised as providing high quality research-based university education in Wales. Wikipedia.
University of Cardiff | Date: 2017-01-11
The invention relates to a device for use in skin improvement or repair, including promoting hair growth, comprising the use of microneedles for the transplantation of cells and a method employing the use of same.
University of Cardiff | Date: 2017-01-30
The disclosure concerns a prognostic method for determining at least one, or a combination, of the following: time to first treatment, response to treatment or overall survival for a patient presenting with a disease including or characterised by telomere shortening, including an assessment of the longest mean telomere length at which telomere end-end fusion events can be detected and then a determination of the mean telomere length in the fusogenic range (i.e. the range below that mean telomere length at which telomere end-end fusion events can be detected) and the subsequent use of the mean telomere length in the fusogenic range as a prognostic indicator.
University of Manchester, U.S. National Institute on Aging, University of Cardiff, VU University Amsterdam, Ucl Business Plc and Hospital District Of Helsinki And Uusimaa | Date: 2017-08-09
The present invention relates to methods of assessing whether a subject has or is likely to develop a neurodegenerative disease comprising determining whether the subject has a mutation in the C9orf72 gene wherein said mutation prevents or disrupts C9orf72 expression relative to expression in a reference from subjects without the mutation.
University of Cardiff | Date: 2017-04-05
A process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral centre of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Ciu Fe, La and Yb.
University of Cardiff | Date: 2017-05-24
The invention relates to a poly(-amino ester (PBAE) or a derivative thereof, for use as a vehicle for transporting an agent into cartilage tissue. In particular, PBAE derivatives are combined with agents and in particular therapeutic agents to form complexes. Certain PBAE derivatives and complexes are novel and these are described and claimed, together with pharmaceutical compositions and methods for using them.
University of Cardiff | Date: 2017-06-07
The present application relates to compounds of any one of Formulae I, Ia, Ib, Ic, Id, Ie, and If. Compounds of Formula (I) have the structure, wherein A, B, Y, Z, R2, R4, R5, R6, Rq and q are as defined herein. The compounds can be used as inhibitors of Bcl-3 and can be used for the treatment of cancer, particularly metastatic cancer.
The Uab Research Foundation, University of Oregon, University of Cardiff and Morehouse School of Medicine | Date: 2016-11-21
Aggleton J.P.,University of Cardiff
Neuroscience and Biobehavioral Reviews | Year: 2012
A review of medial temporal lobe connections reveals three distinct groupings of hippocampal efferents. These efferent systems and their putative memory functions are: (1) The 'extended-hippocampal system' for episodic memory, which involves the anterior thalamic nuclei, mammillary bodies and retrosplenial cortex, originates in the subicular cortices, and has a largely laminar organisation; (2) The 'rostral hippocampal system' for affective and social learning, which involves prefrontal cortex, amygdala and nucleus accumbens, has a columnar organisation, and originates from rostral CA1 and subiculum; (3) The 'reciprocal hippocampal-parahippocampal system' for sensory processing and integration, which originates from the length of CA1 and the subiculum, and is characterised by columnar, connections with reciprocal topographies. A fourth system, the 'parahippocampal-prefrontal system' that supports familiarity signalling and retrieval processing, has more widespread prefrontal connections than those of the hippocampus, along with different thalamic inputs. Despite many interactions between these four systems, they may retain different roles in memory which when combined explain the importance of the medial temporal lobe for the formation of declarative memories. © 2011 Elsevier Ltd.
Linden D.E.J.,University of Cardiff
Neuron | Year: 2012
Neuroimaging is central to the quest for a biological foundation of psychiatric diagnosis but so far has not yielded clinically relevant biomarkers for mental disorders. This review addresses potential reasons for this limitation and discusses refinements of paradigms and analytic techniques that may yield improved diagnostic and prognostic accuracy. Neuroimaging can also be used to probe genetically defined biological pathways underlying mental disorders, for example through the genetic imaging of variants discovered in genome-wide association studies. These approaches may ultimately reveal mechanisms through which genes contribute to psychiatric symptoms and how pharmacological and psychological interventions exert their effects. © 2012 Elsevier Inc.
Carpenter B.K.,University of Cardiff
Chemical Reviews | Year: 2013
Neglect of the excess internal energy, which all nascent reactive intermediates possess in some measure, can lead to serious misinterpretations of their behavior. Most thermal reactions of organic molecules are treated as if they occur on one PE surface, corresponding to the electronic ground states of all species involved. The implication of drawing a PE surface at all is that the Born-Oppenheimer approximation is valid everywhere, that is, that nuclear and electronic coordinates are always separable. However, once a reaction approaches a region on the groundstate PE surface corresponding to a reactive intermediate, this approximation might no longer be safe. In several instances the potential energy surfaces for reactions are actually simplified because ad hoc reaction pathways that may have been added to explain deviations from statistical behavior of reactive intermediates may no longer be necessary.