Cardiff University is a research university located in the Cathays Park area of Cardiff, Wales, United Kingdom. It received its Royal charter in 1883 and is a member of the Russell Group of Universities. The university is consistently recognised as providing high quality research-based university education in Wales. Wikipedia.
University of Cardiff | Date: 2014-07-03
The present application relates to therapeutics and pharmaceutical compositions, their use and also methods for preventing post-traumatic osteoarthritis, early or late stage, using compounds which inhibit either, or both, AMPA and KA glutamate receptors (Glu Rs).
University of Cardiff | Date: 2017-04-05
A process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral centre of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Ciu Fe, La and Yb.
The Uab Research Foundation, University of Oregon, University of Cardiff and Morehouse School of Medicine | Date: 2016-11-21
University of Cardiff | Date: 2017-01-30
The disclosure concerns a prognostic method for determining at least one, or a combination, of the following: time to first treatment, response to treatment or overall survival for a patient presenting with a disease including or characterised by telomere shortening, including an assessment of the longest mean telomere length at which telomere end-end fusion events can be detected and then a determination of the mean telomere length in the fusogenic range (i.e. the range below that mean telomere length at which telomere end-end fusion events can be detected) and the subsequent use of the mean telomere length in the fusogenic range as a prognostic indicator.
University of Cardiff | Date: 2017-01-11
The invention relates to a device for use in skin improvement or repair, including promoting hair growth, comprising the use of microneedles for the transplantation of cells and a method employing the use of same.
University of Cardiff | Date: 2017-06-07
The present application relates to compounds of any one of Formulae I, Ia, Ib, Ic, Id, Ie, and If. Compounds of Formula (I) have the structure, wherein A, B, Y, Z, R2, R4, R5, R6, Rq and q are as defined herein. The compounds can be used as inhibitors of Bcl-3 and can be used for the treatment of cancer, particularly metastatic cancer.
University of Cardiff | Date: 2017-05-24
The invention relates to a poly(-amino ester (PBAE) or a derivative thereof, for use as a vehicle for transporting an agent into cartilage tissue. In particular, PBAE derivatives are combined with agents and in particular therapeutic agents to form complexes. Certain PBAE derivatives and complexes are novel and these are described and claimed, together with pharmaceutical compositions and methods for using them.
Owen M.J.,University of Cardiff
Neuron | Year: 2014
Recent findings in psychiatric genetics have crystallized concerns that diagnostic categories used in the clinic map poorly onto the underlying biology. If we are to harness developments in genetics and neuroscience to understand disease mechanisms and develop new treatments, we need new approaches to patient stratification that recognize the complexity and continuous nature of psychiatric traits and that are not constrained by current categorical approaches. Recognizing this, the National Institute for Mental Health (NIMH) has developed a novel framework to encourage more research of this kind. The implications of these recent findings and funding policy developments for neuroscience research are considerable. © 2014 Elsevier Inc.
Burnett A.K.,University of Cardiff
Blood | Year: 2013
Better treatment is required for older patients with acute myeloid leukemia (AML) not considered fit for intensive chemotherapy. We report a randomized comparison of low-dose Ara-C (LDAC) vs the novel nucleoside, clofarabine, in untreated older patients with AML and high-risk myelodysplastic syndrome (MDS). A total of 406 patients with de novo (62%), secondary disease (24%), or high-risk MDS (>10% marrow blasts) (15%), median age 74 years, were randomized to LDAC 20 mg twice daily for 10 days every 6 weeks or clofarabine 20 mg/m(2) on days 1 to 5, both for up to 4 courses. These patients had more adverse demographics than contemporaneous intensively treated patients. The overall remission rate was 28%, and 2-year survival was 13%. Clofarabine significantly improved complete remission (22% vs 12%; hazard ratio [HR] = 0.47 [0.28-0.79]; P = .005) and overall response (38% vs 19%; HR = 0.41 [0.26-0.62]; P < .0001), but there was no difference in overall survival, explained by poorer survival in the clofarabine patients who did not gain complete remission and also following relapse. Clofarabine was more myelosuppressive and required more supportive care. Although clofarabine doubled remission rates, overall survival was not improved overall or in any subgroup. The treatment of patients of the type treated here remains a major unmet need.
Carpenter B.K.,University of Cardiff
Chemical Reviews | Year: 2013
Neglect of the excess internal energy, which all nascent reactive intermediates possess in some measure, can lead to serious misinterpretations of their behavior. Most thermal reactions of organic molecules are treated as if they occur on one PE surface, corresponding to the electronic ground states of all species involved. The implication of drawing a PE surface at all is that the Born-Oppenheimer approximation is valid everywhere, that is, that nuclear and electronic coordinates are always separable. However, once a reaction approaches a region on the groundstate PE surface corresponding to a reactive intermediate, this approximation might no longer be safe. In several instances the potential energy surfaces for reactions are actually simplified because ad hoc reaction pathways that may have been added to explain deviations from statistical behavior of reactive intermediates may no longer be necessary.