Davis, CA, United States

University of California at Davis

www.ucdavis.edu
Davis, CA, United States

The University of California, Davis , is a public research university located in Davis, California, just west of Sacramento. It encompasses 5,300 acres of land, making it the second largest UC campus in terms of land ownership, after UC Merced. UC Davis also has the third-largest enrollment in the UC System after UCLA and UC Berkeley.The 2015 U.S. News & World Report college rankings named UC Davis as the 9th best public university, 38th nationally, and 4th of the UC schools, following UC Berkeley, UCLA, and UC San Diego. UC Davis is one of 62 members in the Association of American Universities.The Carnegie Foundation classifies UC Davis as a comprehensive doctoral research university with a medical program, and very high research activity. UC Davis faculty includes 23 members of the National Academy of science, 25 members of the American Academy of Arts and science, 17 members of the American Law Institute, 14 members of the Institute of Medicine, and 14 members of the National Academy of Engineering. Among other honors, university faculty, alumni, and researchers have won the Nobel Peace Prize, Presidential Medal of Freedom, Pulitzer Prize, MacArthur Fellowship, National Medal of Science, and Presidential Early Career Award in Science and Engineering.The university has expanded over the past century to include graduate and professional programs in medicine , law, veterinary medicine, education, nursing, and business management, in addition to 90 research programs offered by UC Davis Graduate Studies. UC Davis' School of Veterinary Medicine is the largest in the United States and is ranked second in the nation.The UC Davis Aggies athletic teams compete in the NCAA Division I level, primarily in the Big West Conference as well as the Big Sky Conference and the Mountain Pacific Sports Federation. In its first year of full Division I status, 11 UC Davis teams qualified for NCAA post-season competition. Wikipedia.

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Friedman J.R.,University of California at Davis | Nunnari J.,University of California at Davis
Nature | Year: 2014

Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within eukaryotic cells radically changed. Recent advances have revealed how the organelle's behaviour has evolved to allow the accurate transmission of its genome and to become responsive to the needs of the cell and its own dysfunction. © 2014 Macmillan Publishers Limited. All rights reserved.


Luck S.J.,University of California at Davis | Vogel E.K.,University of Oregon
Trends in Cognitive Sciences | Year: 2013

Visual working memory capacity is of great interest because it is strongly correlated with overall cognitive ability, can be understood at the level of neural circuits, and is easily measured. Recent studies have shown that capacity influences tasks ranging from saccade targeting to analogical reasoning. A debate has arisen over whether capacity is constrained by a limited number of discrete representations or by an infinitely divisible resource, but the empirical evidence and neural network models currently favor a discrete item limit. Capacity differs markedly across individuals and groups, and recent research indicates that some of these differences reflect true differences in storage capacity whereas others reflect variations in the ability to use memory capacity efficiently. © 2013 Elsevier Ltd.


Henderson J.M.,University of California at Davis
Trends in Cognitive Sciences | Year: 2017

The recent study of overt attention during complex scene viewing has emphasized explaining gaze behavior in terms of image properties and image salience independently of the viewer's intentions and understanding of the scene. In this Opinion article, I outline an alternative approach proposing that gaze control in natural scenes can be characterized as the result of knowledge-driven prediction. This view provides a theoretical context for integrating and unifying many of the disparate phenomena observed in active scene viewing, offers the potential for integrating the behavioral study of gaze with the neurobiological study of eye movements, and provides a theoretical framework for bridging gaze control and other related areas of perception and cognition at both computational and neurobiological levels of analysis. © 2016 Elsevier Ltd


McAllister A.K.,University of California at Davis
Biological Psychiatry | Year: 2014

Although the etiology of schizophrenia (SZ) remains unknown, it is increasingly clear that immune dysregulation plays a central role. Genome-wide association studies reproducibly indicate an association of SZ with immune genes within the major histocompatibility complex (MHC). Moreover, environmental factors that increase risk for SZ, such as maternal infection, alter peripheral immune responses as well as the expression of immune molecules in the brain. MHC class I (MHCI) molecules might mediate both genetic and environmental contributions to SZ through direct effects on brain development in addition to mediating immunity. MHCI molecules are expressed on neurons in the central nervous system throughout development and into adulthood, where they regulate many aspects of brain development, including neurite outgrowth, synapse formation and function, long-term and homeostatic plasticity, and activity-dependent synaptic refinement. This review summarizes our current understanding of MHCI expression and function in the developing brain as well as its involvement in maternal immune activation, from the perspective of how these roles for MHCI molecules might contribute to the pathogenesis of SZ. © 2014 Society of Biological Psychiatry.


Hell J.W.,University of California at Davis
Neuron | Year: 2014

While CaMKII has long been known to be essential for synaptic plasticity and learning, recent work points to new dimensions of CaMKII function in the nervous system, revealing that CaMKII also plays an important role in synaptic organization. Ca2+-triggered autophosphorylation of CaMKII not only provides molecular memory by prolonging CaMKII activity during long-term plasticity (LTP) and learning but also represents a mechanism for autoactivation of CaMKII's multifaceted protein-docking functions. New details are also emerging about the distinct roles of CaMKIIα and CaMKIIβ in synaptic homeostasis, further illustrating the multilayered and complex nature of CaMKII's involvement in synaptic regulation. Here, I review novel molecular and functional insight into how CaMKII supports synaptic function. © 2014 Elsevier Inc.


Potassium channels (KChs) are the most diverse ion channels, in part due to extensive combinatorial assembly of a large number of principal and auxiliary subunits into an assortment of KCh complexes. Their structural and functional diversity allows KChs to play diverse roles in neuronal function. Localization of KChs within specialized neuronal compartments defines their physiological role and also fundamentally impacts their activity, due to localized exposure to diverse cellular determinants of channel function. Recent studies in mammalian brain reveal an exquisite refinement of KCh subcellular localization. This includes axonal KChs at the initial segment, and near/within nodes of Ranvier and presynaptic terminals, dendritic KChs found at sites reflecting specific synaptic input, and KChs defining novel neuronal compartments. Painting the remarkable diversity of KChs onto the complex architecture of mammalian neurons creates an elegant picture of electrical signal processing underlying the sophisticated function of individual neuronal compartments, and ultimately neurotransmission and behavior. © 2015 Elsevier Inc.


Louie A.,University of California at Davis
Chemical Reviews | Year: 2010

The design and challenges in multimodality imaging techniques are studied. One of the conceptually simplest approaches to generating multimodal contrast agents is to encapsulate more than one type of contrast agent into the aqueous phase of liposomes. Each approach relies on some method to disperse the lipid in a solution, typically after drying the lipids, so that the lipids may self-assemble into various forms of lipid spheres with aqueous centers. Tissue penetration can be achieved by modifying the lipid composition to one that allows uptake by cells or fusion to cell membranes and release of core contents. In addition to the use of synthetic lipids to form liposomal carriers, multimodal probes have been constructed by loading multiple types of probes to a naturally occurring lipoprotein vehicle, including low-density lipoprotein (LDL) 20 and high density lipoproteins (HDL). One of the most active areas of multimodality probe research has been in nanomaterials, which have proven to lend themselves well to the mixing required to generate multimodal functionality.


Syvanen M.,University of California at Davis
Annual Review of Genetics | Year: 2012

The flow of genes between different species represents a form of genetic variation whose implications have not been fully appreciated. Here I examine some key findings on the extent of horizontal gene transfer (HGT) revealed by comparative genome analysis and their theoretical implications. In theoretical terms, HGT affects ideas pertaining to the tree of life, the notion of a last universal common ancestor, and the biological unities, as well as the rules of taxonomic nomenclature. This review discusses the emergence of the eukaryotic cell and the occurrence of HGT among metazoan phyla involving both transposable elements and structural genes for normal housekeeping functions. I also discuss the bacterial pangenome, which provides an important case study on the permeability of species boundaries. An interesting observation about bdelloid rotifers and their reversion to asexual reproduction as it pertains to HGT is included. © 2012 by Annual Reviews.


Crutchfield J.P.,University of California at Davis
Nature Physics | Year: 2012

What is a pattern? How do we come to recognize patterns never seen before? Quantifying the notion of pattern and formalizing the process of pattern discovery go right to the heart of physical science. Over the past few decades physics' view of nature's lack of structure-its unpredictability-underwent a major renovation with the discovery of deterministic chaos, overthrowing two centuries of Laplace's strict determinism in classical physics. Behind the veil of apparent randomness, though, many processes are highly ordered, following simple rules. Tools adapted from the theories of information and computation have brought physical science to the brink of automatically discovering hidden patterns and quantifying their structural complexity.


Power P.P.,University of California at Davis
Chemical Reviews | Year: 2012

A study was conducted to investigate stable two-coordinate, open-shell (d 1-d 9) transition metal complexes. Investigations revealed that such two-coordinate complexes were gaining popularity due to their magnetic properties. The first structural characterization of a two-coordinate molecular species in the solid state was investigated in 1985 when the synthesis and structure of the dialkyl Mn{C(SiMe 3) 3} 2 were published. The d 1-d 9 electron configurations predicted on the basis of a simple ligand field approach in linear coordination were demonstrated along with their ground states. Investigations of such two-coordinate transition metal hydrides and halides also provided important insights that were applicable to stable two-coordinate complexes.

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