The University of California, Berkeley , is a public research university located in Berkeley, California. According to the 2014 Academic Ranking of World Universities, the University of California, Berkeley is the fourth best university in the world. It is the most selective – and highest ranked in U.S. News and ARWU – public university in the world for undergraduate education. Aside from its academic prestige, UC Berkeley is also well known for producing a high number of entrepreneurs.The university occupies 1,232 acres on the eastern side of the San Francisco Bay with the central campus resting on 178 acres . Berkeley is the flagship institution of the 10 campus University of California system and one of only two UC campuses operating on a semester calendar, the other being UC Merced.Established in 1868 as the result of the merger of the private College of California and the public Agricultural, Mining, and Mechanical Arts College in Oakland, Berkeley is the oldest institution in the UC system and offers approximately 350 undergraduate and graduate degree programs in a wide range of disciplines. The University of California has been charged with providing both "classical" and "practical" education for the state's people. Cal co-manages three United States Department of Energy National Laboratories, including the Los Alamos National Laboratory, Lawrence Livermore National Laboratory and Lawrence Berkeley National Laboratory for the U.S. Department of Energy.Berkeley faculty, alumni, and researchers have won 72 Nobel Prizes , 9 Wolf Prizes, 7 Fields Medals, 18 Turing Awards, 45 MacArthur Fellowships, 20 Academy Awards, and 11 Pulitzer Prizes. To date, UC Berkeley scientists have discovered 6 chemical elements of the periodic table . Along with Berkeley Lab, UC Berkeley researchers have discovered 16 chemical elements in total – more than any other university in the world. Berkeley is a founding member of the Association of American Universities and continues to have very high research activity with $730.7 million in research and development expenditures in the fiscal year ending June 30, 2014. Berkeley physicist J. Robert Oppenheimer was the scientific director of the Manhattan Project that developed the first atomic bomb in the world, which he personally headquartered at Los Alamos, New Mexico, during World War II. Faculty member Edward Teller was the "father of the hydrogen bomb". Former United States Secretary of Energy and Nobel laureate Steven Chu , was Director of Berkeley Lab, 2004–2009.The athletic teams at UC Berkeley are known as the California Golden Bears and are members of both the Pacific-12 Conference and the Mountain Pacific Sports Federation in the NCAA. Wikipedia.
Komander D.,Medical Research Council Laboratory of Molecular Biology |
Rape M.,University of California at Berkeley
Annual Review of Biochemistry | Year: 2012
The posttranslational modification with ubiquitin, a process referred to as ubiquitylation, controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a single moiety or in the form of polymeric chains in which successive ubiquitin molecules are connected through specific isopeptide bonds. Reminiscent of a code, the various ubiquitin modifications adopt distinct conformations and lead to different outcomes in cells. Here, we discuss the structure, assembly, and function of this ubiquitin code. © 2012 by Annual Reviews. All rights reserved.
O'Rourke D.,University of California at Berkeley
Science | Year: 2014
Recent advances in the science and technology of global supply chain management offer near-real-time demand-response systems for decision-makers across production networks. Technology is helping propel "fast fashion" and " lean manufacturing," so that companies are better able to deliver products consumers want most. Yet companies know much less about the environmental and social impacts of their production networks. The failure to measure and manage these impacts can be explained in part by limitations in the science of sustainability measurement, as well as by weaknesses in systems to translate data into information that can be used by decision-makers inside corporations and government agencies. There also remain continued disincentives for firms to measure and pay the full costs of their supply chain impacts. I discuss the current state of monitoring, measuring, and analyzing information related to supply chain sustainability, as well as progress that has been made in translating this information into systems to advance more sustainable practices by corporations and consumers. Better data, decision-support tools, and incentives will be needed to move from simply managing supply chains for costs, compliance, and risk reduction to predicting and preventing unsustainable practices.
Rabosky D.L.,University of California at Berkeley
Nature communications | Year: 2013
Several evolutionary theories predict that rates of morphological change should be positively associated with the rate at which new species arise. For example, the theory of punctuated equilibrium proposes that phenotypic change typically occurs in rapid bursts associated with speciation events. However, recent phylogenetic studies have found little evidence linking these processes in nature. Here we demonstrate that rates of species diversification are highly correlated with the rate of body size evolution across the 30,000+ living species of ray-finned fishes that comprise the majority of vertebrate biological diversity. This coupling is a general feature of fish evolution and transcends vast differences in ecology and body-plan organization. Our results may reflect a widespread speciational mode of character change in living fishes. Alternatively, these findings are consistent with the hypothesis that phenotypic 'evolvability'-the capacity of organisms to evolve-shapes the dynamics of speciation through time at the largest phylogenetic scales.
Guzman M.G.,University of California at Berkeley
Lancet | Year: 2015
Dengue viruses have spread rapidly within countries and across regions in the past few decades, resulting in an increased frequency of epidemics and severe dengue disease, hyperendemicity of multiple dengue virus serotypes in many tropical countries, and autochthonous transmission in Europe and the USA. Today, dengue is regarded as the most prevalent and rapidly spreading mosquito-borne viral disease of human beings. Importantly, the past decade has also seen an upsurge in research on dengue virology, pathogenesis, and immunology and in development of antivirals, vaccines, and new vector-control strategies that can positively impact dengue control and prevention. Copyright © 2015 Elsevier Ltd. All rights reserved.
Komeili A.,University of California at Berkeley
FEMS Microbiology Reviews | Year: 2012
Magnetotactic bacteria (MB) are remarkable organisms with the ability to exploit the earth's magnetic field for navigational purposes. To do this, they build specialized compartments called magnetosomes that consist of a lipid membrane and a crystalline magnetic mineral. These organisms have the potential to serve as models for the study of compartmentalization as well as biomineralization in bacteria. Additionally, they offer the opportunity to design applications that take advantage of the particular properties of magnetosomes. In recent years, a sustained effort to identify the molecular basis of this process has resulted in a clearer understanding of the magnetosome formation and biomineralization. Here, I present an overview of MB and explore the possible molecular mechanisms of membrane remodeling, protein sorting, cytoskeletal organization, iron transport, and biomineralization that lead to the formation of a functional magnetosome organelle. © 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd.
Bachtrog D.,University of California at Berkeley
Nature Reviews Genetics | Year: 2013
The human Y chromosome is intriguing not only because it harbours the master-switch gene that determines gender but also because of its unusual evolutionary history. The Y chromosome evolved from an autosome, and its evolution has been characterized by massive gene decay. Recent whole-genome and transcriptome analyses of Y chromosomes in humans and other primates, in Drosophila species and in plants have shed light on the current gene content of the Y chromosome, its origins and its long-term fate. Furthermore, comparative analysis of young and old Y chromosomes has given further insights into the evolutionary and molecular forces triggering Y-chromosome degeneration and into the evolutionary destiny of the Y chromosome. © 2013 Macmillan Publishers Limited. All rights reserved.
Lisch D.,University of California at Berkeley
Nature Reviews Genetics | Year: 2013
For decades, transposable elements have been known to produce a wide variety of changes in plant gene expression and function. This has led to the idea that transposable element activity has played a key part in adaptive plant evolution. This Review describes the kinds of changes that transposable elements can cause, discusses evidence that those changes have contributed to plant evolution and suggests future strategies for determining the extent to which these changes have in fact contributed to plant adaptation and evolution. Recent advances in genomics and phenomics for a range of plant species, particularly crops, have begun to allow the systematic assessment of these questions. © 2013 Macmillan Publishers Limited.
Levine M.,University of California at Berkeley
Cell | Year: 2011
The textbook view of gene activation is that the rate-limiting step is the interaction of RNA polymerase II (Pol II) with the gene's promoter. However, studies in a variety of systems, including human embryonic stem cells and the early Drosophila embryo, have begun to challenge this view. There is increasing evidence that differential gene expression often depends on the regulation of transcription elongation via the release of Pol II from the proximal promoter. I review the implications of this mechanism of gene activation with respect to the orderly unfolding of complex gene networks governing animal development. © 2011 Elsevier Inc.
Ingolia N.T.,Carnegie Institution |
Ingolia N.T.,University of California at Berkeley
Nature Reviews Genetics | Year: 2014
Genome-wide analyses of gene expression have so far focused on the abundance of mRNA species as measured either by microarray or, more recently, by RNA sequencing. However, neither approach provides information on protein synthesis, which is the true end point of gene expression. Ribosome profiling is an emerging technique that uses deep sequencing to monitor in vivo translation. Studies using ribosome profiling have already provided new insights into the identity and the amount of proteins that are produced by cells, as well as detailed views into the mechanism of protein synthesis itself. © 2014 Macmillan Publishers Limited. All rights reserved.
Hartwig J.F.,University of California at Berkeley
Accounts of Chemical Research | Year: 2012
Methods that functionalize C-H bonds can lead to new approaches for the synthesis of organic molecules, but to achieve this goal, researchers must develop site-selective reactions that override the inherent reactivity of the substrates. Moreover, reactions are needed that occur with high turnover numbers and with high tolerance for functional groups if the C-H bond functionalization is to be applied to the synthesis of medicines or materials. This Account describes the discovery and development of the C-H bond functionalization of aliphatic and aromatic C-H bonds with borane and silane reagents. The fundamental principles that govern the reactivity of intermediates containing metal-boron bonds are emphasized and how an understanding of the effects of the ligands on this reactivity led us to broaden the scope of main group reagents that react under mild conditions to generate synthetically useful organosilanes is described. Complexes containing a covalent bond between a transition metal and a three-coordinate boron atom (boryl complexes) are unusually reactive toward the cleavage of typically unreactive C-H bonds.Moreover, this C-H bond cleavage leads to the formation of free, functionalized product by rapid coupling of the hydrocarbyl and boryl ligands. The initial observation of the borylation of arenes and alkanes in stoichiometric processes led to catalytic systems for the borylation of arenes and alkanes with diboron compounds (diborane(4) reagents) and boranes. In particular, complexes based on the Cp*Rh (in which Cp is the cyclopentadienyl anion) fragment catalyze the borylation of alkanes, arenes, amines, ethers, ketals, and haloalkanes. Although less reactive toward alkyl C-H bonds than the Cp*Rh systems, catalysts generated from the combination of bipyridines and iridium(I)-olefin complexes have proven to be the most reactive catalysts for the borylation of arenes. The reactions catalyzed by these complexes form arylboronates from arenes with site-selectivity for C-H bond cleavage that depends on the steric accessibility of the C-H bonds. These complexes also catalyze the borylation of heteroarenes, and the selectivity for these substrates ismore dependent on electronic effects than the borylation of arenes. The products from the borylation of arenes and heteroarenes are suitable for a wide range of subsequent conversions to phenols, arylamines, aryl ethers, aryl nitriles, aryl halides, arylboronic acids, and aryl trifluoroborates. Studies of the electronic properties of the ancillary ligand on the rate of the reaction show that the flat structure and the strong electron-donating property of the bipyridine ligands, along with the strong electron-donating property of the boryl group and the presence of a p-orbital on the metal-bound atom, lead to the increased reactivity of the iridium catalysts. Based on this hypothesis, we studied catalysts containing substituted phenanthroline ligands for a series of additional transformations, including the silylation of C-H bonds. A sequence involving the silylation of benzylic alcohols, followed by the dehydrogenative silylation of aromatic C-H bonds, leads to an overall directed silylation of the C-H bond ortho to hydroxyl functionality. © 2011 American Chemical Society.