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Calgary, Canada

The University of Calgary is a public research university located in Calgary, Alberta, Canada. Founded in 1966 the University of Calgary is composed of 14 faculties and more than 85 research institutes and centres.More than 25,000 undergraduate and 6,000 graduate students are currently enrolled. The University of Calgary has graduated over 155,000 alumni in 152 countries, including the current Prime Minister of Canada, Stephen Harper, and Canadian astronaut Robert Thirsk.The University of Calgary is one of Canada’s top research universities and is a member of the U15 .The University of Calgary is the birthplace of a number of important inventions, including the neurochip. The university's sponsored research revenue of $352 million, with total revenues exceeding $1.1 billion, is one of the highest in the country. Being in Calgary, with Canada's highest concentration of engineers and geoscientists, the Faculty of Science, Department of Geoscience and the Schulich School of Engineering maintain ties to the petroleum and geoscience industry.The main campus is located in the north-west quadrant of Calgary, near the Bow River, and covers more than 200 hectares or 494.2 acre. Wikipedia.

Zamponi G.W.,University of Calgary
Nature Reviews Drug Discovery | Year: 2016

Voltage-gated calcium channels are important regulators of brain, heart and muscle functions, and their dysfunction can give rise to pathophysiological conditions ranging from cardiovascular disorders to neurological and psychiatric conditions such as epilepsy, pain and autism. In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors. © 2016 Macmillan Publishers Limited. All rights reserved. Source

Fox J.W.,University of Calgary
Trends in Ecology and Evolution | Year: 2013

A leading idea about how disturbances and other environmental fluctuations affect species diversity is the intermediate disturbance hypothesis (IDH). The IDH states that diversity of competing species is, or should be expected to be, maximized at intermediate frequencies and/or intensities of disturbance or environmental change. I argue that the IDH has been refuted on both empirical and theoretical grounds, and so should be abandoned. Empirical studies only rarely find the predicted humped diversity-disturbance relationship. Theoretically, the three major mechanisms thought to produce humped diversity-disturbance relationships are logically invalid and do not actually predict what they are thought to predict. Disturbances and other environmental fluctuations can affect diversity, but for different reasons than are commonly recognized. © 2012 Elsevier Ltd. Source

Marrink S.J.,Zernike Institute for Advanced Materials | Tieleman D.P.,University of Calgary
Chemical Society Reviews | Year: 2013

The Martini model, a coarse-grained force field for biomolecular simulations, has found a broad range of applications since its release a decade ago. Based on a building block principle, the model combines speed and versatility while maintaining chemical specificity. Here we review the current state of the model. We describe recent highlights as well as shortcomings, and our ideas on the further development of the model. © 2013 The Royal Society of Chemistry. Source

Sui R.,University of Calgary | Charpentier P.,University of Western Ontario
Chemical Reviews | Year: 2012

A study was conducted to demonstrate synthesis of metal oxide nanostructures by direct sol-gel chemistry in supercritical fluids (SCF). The emphasis of the investigations was on the physics, chemistry, and engineering aspects of the polycondensation of metal oxide precursors in SCFs, while highlighting the mechanisms of the chemical reactions and nanostructure formation. SCF drying circumvented the liquid-gas interface during vaporization due to its single phase nature, preventing collapse of the solid network from capillary forces during the drying process. The latest developments in the sol-gel technology were marked by the use of organic solvents or SCFs for synthesizing a variety of metal oxides. Another major advantage of using SCFs as reaction media for sol-gel reactions relied on the fact that the resulting materials were readily dried after SCF venting. Source

Santamaria P.,University of Calgary
Immunity | Year: 2010

Autoimmune diseases with high population prevalence such as type 1 diabetes (T1D) develop as a result of ill-defined interactions between putative environmental triggers and a constellation of genetic elements scattered throughout the genome. In T1D, these interactions somehow trigger a loss of tolerance to pancreatic β cells, manifested in the form of a chronic autoimmune response that mobilizes virtually every cell type of the immune system and progressively erodes the host's β cell mass. The five accompanying review articles focus on key areas of T1D research, ranging from genetics and pathogenesis to prediction and therapy. Here, I attempt to integrate and bring into focus the most salient points of these reviews in the context of other findings, with an emphasis on identifying knowledge gaps and research opportunities. © 2010 Elsevier Inc. Source

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