Center Regional Of Lutte Contre Le Cancer Francois Baclesse, University of Caen Lower Normandy and Institute Of Cancerologie Of Louest Rene Gauducheau | Date: 2015-03-03
The invention relates to compounds of formula (I), and to their therapeutic use in the treatment of cancer:
University of Caen Lower Normandy | Date: 2015-02-25
Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against Enterococcus.
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.45M | Year: 2013
Neuroinflammation is a hallmark of multiple sclerosis and ischemic stroke. Investigating neuroinflammation as a common theme in neurological disorders, this ITN will focus in particular on myeloid cells, microglia, and endothelial cells. Sixteen partners from the academic and private sector with complementary scientific background join forces to train 13 ESRs in neuroinflammatory concepts and technologies that are valid across specific disease entities. Using an interdisciplinary and intersectorial approach the training will promote technical expertise, insight into entrepreneurship, as well as leadership and communication skills and lay the foundation for a successful career of ESRs either in the academic or private sector.
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.4-3 | Award Amount: 7.65M | Year: 2013
Resilience-Increasing Strategies for Coasts toolKIT (RISC-KIT) will deliver ready-to-use methods, tools and management approaches to reduce risk and increase resilience to low-frequency, high-impact hydro-meteorological events. The open-source and free-ware RISC-KIT tool kit will consist of a Coastal Risk Assessment Framework (CRAF) which - at the regional scale (100s km) - can quickly assess present and future hot spot areas of coastal risk due to multi-hazards a quantitative, high-resolution Early Warning and Decision Support System (EWS/DSS) for use on these hot spots (with a scale of 10s of km) and a web-based management guide offering innovative, cost-effective, ecosystem-based DRR measures; and a Coastal Risk Database of present and historic socio-economic and physical data. These tools will enable Europes coastal managers, decision-makers and stakeholders to identify hot spot areas; produce timely forecasts and early warnings; evaluate the effect of climate-related, socio-economic and cultural changes on coastal risk; and choose the best prevention, mitigation and preparedness measures for their coast. The toolkit will be tested using data collected on ten diverse case study sites along each of Europes regional seas and one international site. The toolkits performance will be evaluated with an End-User Board of coastal managers, civil protection agencies and local governments with a vested interest in each of these case study sites. The RISC-KIT products will help to achieve rapid attainment of UNISDR Disaster Reduction Goals and promote EU-consistent methods through innovative e-learning and open access publication. RISC-KIT will have an active synergy with Belmont Forum projects, related EU projects and an International Expert Board with members from third countries experiencing similar types of threats.
French National Center for Scientific Research, University of Caen Lower Normandy and Joseph Fourier University | Date: 2016-09-02
Agency: European Commission | Branch: H2020 | Program: ERC-STG | Phase: ERC-StG-2014 | Award Amount: 1.15M | Year: 2015
Complex Stein spaces may be thought of as analytic analogues of the affine schemes of algebraic geometry. They may be characterized in several manners: using convergence of holomorphic functions, topological properties or potential-theoretic properties, for instance. Especially useful for applications is the fact that their coherent cohomology vanishes. Despite the crucial importance of this theory in complex analytic geometry, its p-adic counterpart has hardly been sketched. In the setting of Berkovich geometry (one among the several notions of p-adic geometry), recent developments have enabled to get a fine understanding of the topology of the spaces (work of Berkovich and Hrushovski-Loeser) and to define the basic tools of potential theory (work of Baker-Rumely, Thuillier, Boucksom-Favre-Jonsson and Chambert-Loir-Ducros). The conditions for a comprehensive study of p-adic Stein spaces are now met; this will be our first goal. The theory will then be used to investigate envelopes of holomorphy and meromorphy. As an application, I plan to derive rationality criteria for power series over function fields. The second part of the project is devoted to the theory of Stein spaces for Berkovich spaces over rings of integers of number fields (where all the places appear on an equal footing). Those spaces have hardly been studied and only a very small part of the usual analytic machinery is available in this setting. Here, my main goal will consist in proving the basic and fundamental fact that relative polydisks are Stein spaces (in the cohomological sense). This will allow a deeper investigation of rings of convergent arithmetic power series (i.e. with integral coefficients) and will lead up to properties related to commutative algebra but also to the inverse Galois problem. Knowing that the coherent cohomology of polydisks vanishes also opens the road towards computing global cohomology groups for projective analytic spaces over ring of integers of number fields.
Catholic University of Leuven and University of Caen Lower Normandy | Date: 2015-02-09
Disclosed herein is a bispecific inhibitor for use in treating thrombotic disorders, such as acute thrombotic disorders like stroke and thromboembolism. The bispecific inhibitor is based on monoclonal antibodies targeting TAFI and PAI-1, and shows efficacy in the presence or the absence of plasminogen activators such as tissue-type plasminogen activator (tPA).
University of Caen Lower Normandy | Date: 2014-05-19
Compounds are provided according to Formula (I) as well as their enantiomers and their racemics, their acid salts, their hydrates or their solvation products. Among a large number of possible meanings, X represents a halogen, Y an oxygen atom; all of the coefficients m, n, r and s have the value 1, R represents an ethyl and R a cycloalkyl. The invention also includes Methods of preparing the above compounds and the pharmaceutical compositions containing them also are provided.
French Institute of Health, Medical Research and University of Caen Lower Normandy | Date: 2015-12-17
The present invention relates to mutated tissue plasminogen activators, and their use for treating thrombotic diseases.
Cahu J.,University of Caen Lower Normandy
Cell death & disease | Year: 2012
The molecular mechanisms underlying cancer resistance remain elusive. One possible explanation is that cancer stem cells (CSCs) elude drug treatment, emerge and reproduce a tumor. Using multiple myeloma as a paradigm, we showed that cancer stem-like cells (CSLCs) appear after genotoxic stress because of their intrinsic properties. However, these properties do not drive the emergence of the CSLCs. Following genotoxic stress, remaining DNA damages lead to a senescence-associated secretory phenotype (SASP). Senescent cells, which are the non-CSLCs, secrete chemokines contributing to the emergence, maintenance and migration of CSLCs. Downregulation of checkpoint protein 2, a key player of SASP, significantly reduced the emergence of CSLCs. Our results unravel a novel molecular mechanism by which SASP might promote malignancy, underlining the dual role of senescence in tumorigenesis. This mechanism, based on mutual cooperation among tumor cells, illustrates how cancer may relapse; its targeting could represent new therapeutic opportunities.