The University of British Columbia, commonly referred to as UBC, is a public research university with campuses and facilities in the province of British Columbia, Canada.Founded in 1908 as the McGill University College of British Columbia, the university became independent and adopted its current name in 1915. It is the oldest institution of higher learning in British Columbia and enrolls over 58,000 students at its Vancouver and Okanagan Valley campuses. UBC's 4.02 km2 Vancouver campus is located within the University Endowment Lands, about 10 km from Downtown Vancouver. The 2.09 km2 Kelowna campus, acquired in 2005, is located in the Okanagan Valley.UBC is ranked 30th in the world according to U.S. News & World Report 's 2015 rankings and eighth among universities outside the United States by Newsweek. UBC faculty, alumni, and researchers have won seven Nobel Prizes, 68 Rhodes Scholarships, 65 Olympic medals, 180 fellowships to the Royal Society of Canada, and alumni include two Canadian prime ministers. UBC is a research-intensive university that funds more than 8,000 projects with its $519 million research budget.UBC is a non-sectarian and coeducational institution, with more than 275,000 living alumni in 120 countries. The university is a member of Universitas 21, the Association of Universities and Colleges of Canada, the Association of Southeast Asian Institutions of Higher Learning, the International Association of Universities, the U15 and the only Canadian member of the Association of Pacific Rim Universities. The university's varsity teams, known as the Thunderbirds in Vancouver and the Heat in the Okanagan, compete in the Canada West Universities Athletic Association of the Canadian Interuniversity Sport. Wikipedia.
University of British Columbia | Date: 2016-04-18
This invention provides the use of a polymer comprising a hyperbranched polyether polyol such as hyperbranched polyglycerol as a serum albumin substitute. Also provided are high molecular weight hyperbranched polyglycerol polymers suitable for a variety of medical and non-medical uses including methods for making such high molecular weight polymers.
University of British Columbia | Date: 2016-07-14
The present invention provides methods for inhibiting complement activation and uses thereof. More specifically, the present invention provides methods for inhibiting complement activation using inorganic polyphosphates of at least 10 phosphate units. The polyphosphates inhibit complement activation by one or more of: binding to the C6 complement protein, C1-esterase inhibitor (C1-inh), factor H or factor B; enhancing the activity of C1-inh; interfering with C1s-mediated cleavage of C2; destabilizing the C5b-6 complement protein complex; interfering with C5b,6 interaction with C7; interfering with binding of C5b-7 to a cell membrane; interfering with integration of C5b-7 into a cell membrane; interfering with binding of C5b-8 to a cell membrane; interfering with integration of C5b-8 into a cell membrane; destabilizing the membrane attack complex (MAC); or reducing the amount of C5b-9 deposited on a cell surface.
Michigan State University, Wisconsin Alumni Research Foundation and University of British Columbia | Date: 2017-03-08
The invention relates to nucleic acids encoding a feruloyl-CoA:monolignol transferase and the feruloyl-CoA:monolignol transferase enzyme that enables incorporation of monolignol ferulates, for example, including p-coumaryl ferulate, coniferyl ferulate, and sinapyl ferulate, into the lignin of plants.
University of British Columbia | Date: 2017-01-11
Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
University of British Columbia | Date: 2017-03-29
Provided herein are high-throughput sequencing methods to study the diversity and functionality of lymphocyte receptor chains and pairing of the same. Specifically, the methods provided herein are used to identify with confidence one or more lymphocyte receptor chain pairs in a sample, for example one or more functional chain pairs.
University of British Columbia | Date: 2017-02-08
A method and system for for reducing ion concentration of a solution and converting gas. The system comprising a multi-chamber unitary dialysis cell comprising a gas chamber, a product chamber, and an acid chamber. Ion exchange barriers separate the chambers of the dialysis cell. A first anion exchange barrier is positioned between the product chamber and the acid chamber and a first cation exchange barrier is positioned between the product chamber and the gas chamber. Anions from the solution being treated associate with cations from the acid chamber to form an acid solution in the acid chamber, and cations from the solution being treated associate with anions from the fluid comprising gas to form salt, thereby reducing the ion concentration of the solution being treated and converting at least a portion of the gas into salt.
University of British Columbia | Date: 2016-05-23
The present invention provides a method for treating a mammalian subject affected by prostate cancer comprising i) an oligonucleotide which reduces clusterin expression and ii) a Heat Shock Protein 90 (Hsp90) inhibitor each in an amount that when in combination with the other is effective to treat the mammalian subject. The present invention also provides pharmaceutical compositions comprising an amount of an oligonucleotide which reduces clusterin expression, and a Hsp90 inhibitor for use in treating a mammalian subject affected by prostate cancer. Also provided are oligonucleotides which reduce clusterin expression for use in combination with a Hsp90 inhibitor in treating a mammalian subject affected by prostate cancer, and a composition for treating a mammalian subject affected by prostate cancer comprising i) an oligonucleotide which reduces clusterin expression and ii) a Hsp90 inhibitor each in an amount that when in combination with the other is effective to treat the mammalian subject.
University of British Columbia | Date: 2017-01-04
The invention provides a method of preparing a metal / metal oxide material. In one aspect, a nanostructure is provided, the nanostructure comprising a first metal to form the metal oxide, and a reaction surface with a reducing agent on the reaction surface. A second metal is deposited onto the reaction surface to form a bimetallic product. The bimetallic product is calcined to form the metal / metal oxide material.
University of British Columbia, University of Toronto, French Institute for Research in Computer Science and Automation | Date: 2017-02-22
A method is for estimating a three-dimensional (3D) representation of a set of two-dimensional (2D) curves of a concept drawing, the estimate of the 3D representation corresponding to a 3D object underlying the concept drawing. The method comprises: obtaining a representation of a set of 2D curves a concept drawing that represent a 3D object underlying the concept drawing; determining an energy function based on the set of 2D curves, the energy function comprising one or more terms, each term reflective of a preference for a 3D representation based on a characteristic of the 2D curves which reflects how concept drawings are commonly perceived to represent 3D objects; and performing an optimization which minimizes the energy function to thereby determine the 3D representation.
Boston University and University of British Columbia | Date: 2017-01-19
The invention described herein relates to methods of treating emphysema and COPD with a GHK tripeptide. The invention further relates to methods of determining the state of the lungs using biomarkers described herein.