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Bonn, Germany

The University of Bonn is a public research university located in Bonn, Germany. Founded in its present form in 1818, as the linear successor of earlier academic institutions, the University of Bonn is today one of the leading universities in Germany. The University of Bonn offers a large number of undergraduate and graduate programs in a range of subjects. Its library holds more than two million volumes. The University of Bonn has 525 professors and 31,000 students. Among its notable alumni and faculty are seven Nobel Laureates, two Fields Medalists, twelve Gottfried Wilhelm Leibniz Prize winners, Prince Albert, Pope Benedict XVI, Frederick III, Karl Marx, Heinrich Heine, Friedrich Nietzsche, Konrad Adenauer, and Joseph Schumpeter. In the years 2010, 2011 and 2013, the Times Higher Education ranked the University of Bonn as one of the 200 best universities in the world. The University of Bonn is ranked 94th worldwide according to the ARWU University ranking. Wikipedia.

The Janus kinase (JAK)-inhibitor ruxolitinib decreases constitutional symptoms and spleen size of myelofibrosis (MF) patients by mechanisms distinct from its anticlonal activity. Here we investigated whether ruxolitinib affects dendritic cell (DC) biology. The in vitro development of monocyte-derived DCs was almost completely blocked when the compound was added throughout the differentiation period. Furthermore, when applied solely during the final lipopolysaccharide-induced maturation step, ruxolitinib reduced DC activation as demonstrated by decreased interleukin-12 production and attenuated expression of activation markers. Ruxolitinib also impaired both in vitro and in vivo DC migration. Dysfunction of ruxolitinib-exposed DCs was further underlined by their impaired induction of allogeneic and antigen-specific T-cell responses. Ruxolitinib-treated mice immunized with ovalbumin (OVA)/CpG induced markedly reduced in vivo activation and proliferation of OVA-specific CD8+ T cells compared with vehicle-treated controls. Finally, using an adenoviral infection model, we show that ruxolitinib-exposed mice exhibit delayed adenoviral clearance. Our results demonstrate that ruxolitinib significantly affects DC differentiation and function leading to impaired T-cell activation. DC dysfunction may result in increased infection rates in ruxolitinib-treated patients. However, our findings may also explain the outstanding anti-inflammatory and immunomodulating activity of JAK inhibitors currently used in the treatment of MF and autoimmune diseases. Source

Langer N.,University of Bonn
Annual Review of Astronomy and Astrophysics | Year: 2012

Understanding massive stars is essential for a variety of branches of astronomy including galaxy and star cluster evolution, nucleosynthesis and ernovae, pulsars, and black holes. It has become evident that massive star evolution is very diverse, being sensitive to metallicity, binarity, rotation, and possibly magnetic fields. Although the problem to obtain a good statistical observational database is alleviated by current large spectroscopic surveys, it remains a challenge to model these diverse paths of massive stars toward their violent end stage. I show that the main sequence stage offers the best opportunity to gauge the relevance of the various possible evolutionary scenarios. This also allows sketching the post-main-sequence evolution of massive stars, for which observations of Wolf-Rayet stars give essential clues. Recent ernova discoveries owing to the current boost in transient searches allow tentative mappings of progenitor models with ernova types, including pair-instability ernovae and gamma-ray bursts. Copyright © 2012 by Annual Reviews. Source

Grimme S.,University of Bonn
Chemistry - A European Journal | Year: 2012

The equilibrium association free enthalpies ΔGa for typical supramolecular complexes in solution are calculated by ab initio quantum chemical methods. Ten neutral and three positively charged complexes with experimental ΔGa values in the range 0 to -21 kcal mol -1 (on average -6 kcal mol-1) are investigated. The theoretical approach employs a (nondynamic) single-structure model, but computes the various energy terms accurately without any special empirical adjustments. Dispersion corrected density functional theory (DFT-D3) with extended basis sets (triple-ζ and quadruple-ζ quality) is used to determine structures and gas-phase interaction energies (ΔE), the COSMO-RS continuum solvation model (based on DFT data) provides solvation free enthalpies and the remaining ro-vibrational enthalpic/entropic contributions are obtained from harmonic frequency calculations. Low-lying vibrational modes are treated by a free-rotor approximation. The accurate account of London dispersion interactions is mandatory with contributions in the range -5 to -60 kcal mol-1 (up to 200 % of ΔE). Inclusion of three-body dispersion effects improves the results considerably. A semilocal (TPSS) and a hybrid density functional (PW6B95) have been tested. Although the ΔGa values result as a sum of individually large terms with opposite sign (ΔE vs. solvation and entropy change), the approach provides unprecedented accuracy for ΔG a values with errors of only 2 kcal mol-1 on average. Relative affinities for different guests inside the same host are always obtained correctly. The procedure is suggested as a predictive tool in supramolecular chemistry and can be applied routinely to semirigid systems with 300-400 atoms. The various contributions to binding and enthalpy-entropy compensations are discussed. Unprecedented accuracy for computed association free enthalpies of supramolecular host-guest complexes (some examples are shown here) in solution has been achieved by a combination of high-level quantum chemical procedures. The approach is quite general, includes all basic physical effects quantitatively and requires no special empirical adjustments. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

The present invention relates to a nucleic acid carrier molecule, comprising the general formula M-S

University of Bonn and University of Cologne | Date: 2014-07-10

The invention pertains to a method for diagnosing or detecting lung cancer in human subjects based on ribonucleic acid (RNA) expression, in particular based on RNA from blood. The invention discloses 361 genes which are differentially expressed in blood from lung cancer patients and discloses that at least 4 of the mRNAs must be determined in order to have an AUC of at least 0.8.

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