The University of Bologna is a university in Bologna, Italy, founded in 1088. As of 2013 the University's crest carries the motto Alma mater studiorum and the date A.D. 1088. The University has about 85,000 students in its 23 schools. It has branch centres in Imola, Ravenna, Forlì, Cesena and Rimini and a branch center abroad in Buenos Aires. It also has a school of excellence named Collegio Superiore di Bologna. It is recognised as the oldest university in continuous operation, considering that it was the first to use the term universitas for the corporations of students and masters which came to define the institution.The publisher of the University of Bologna is Bononia University Press S.p.A . Wikipedia.
Italian Institute of Technology and University of Bologna | Date: 2015-06-12
The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.
University of Bologna and Glassup S.R.L. | Date: 2015-03-27
The invention describes augmented reality glasses (1) for medical applications configured to be worn by a user, comprising a frame (15) that supports a glasses lens (2a, 2b), wherein the frame (15) comprises an RGB lighting system comprising RGB-emitting devices (16a, 16b, 16c) configured to emit light beams (B1, B2, B3); first optical systems (17a, 17b, 17c) configured to collimate at least partially said beams (B1, B2, B3) into collimated beams (B1c; B2c; B3c); wherein the frame (15) further comprises a display (3) configured to be illuminated by the RGB lighting system (16) by means of the collimated beams (B1c; B2c; B3c); to receive first images (I) from a first processing unit (10); to emit the first images (I) as second images (IE1) towards the glasses lens (2a, 2b), wherein the lens (2a, 2b) is configured to reflect the second images (IE1) coming from the display (3) as images projected (IP) towards an internal zone (51) of the glasses corresponding to an eye position zone of the user who is wearing the glasses in a configuration for use of the glasses. The invention moreover describes an augmented reality system for medical applications on a user comprising the augmented reality glasses (1) of the invention, biomedical instrumentation (100) configured to detect biomedical and/or therapeutic and/or diagnostic data of a user and to generate first data (D1) representative of operational parameters (OP_S) associated with the user, transmitting means (101) configured to transmit the first data (D1) to the glasses (1); wherein the glasses (1) comprise a first processing unit (10) equipped with a receiving module (102) configured to receive the first data (D1) comprising the operational parameters (OP_S) associated with the user.
BRESMEDICAL PTY Ltd and University of Bologna | Date: 2015-03-27
A computer-implemented method for surgical planning and/or surgical navigation. A surgical navigation and/or planning system is also provided, that can include aspects of the computer-implemented method, which allows virtual implant planning, and receives real-time data from a tracker. The system can also include one or more hardware components which allow real-time imaging of one or more surgical instruments onto, relative to or over a patients anatomy. The system and computer-implemented method improve the precision and safety of image based surgery, for example precision placement of bone implants during surgery. A software application is used to manage drill-guide assisted surgery and image-guided surgery. This provides a method and system for Computer Assisted Surgery (CAS) which improves accuracy and safety of a variety of surgical procedures.
Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016
This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship.
Mandelli L.,University of Bologna |
Serretti A.,University of Bologna
Neuroscience and Biobehavioral Reviews | Year: 2013
Increasing evidence supports the involvement of both heritable and environmental risk factors in major depression (MD) and suicidal behavior (SB). Studies investigating gene-environment interaction (G. ×. E) may be useful for elucidating the role of biological mechanisms in the risk for mental disorders. In the present paper, we review the literature regarding the interaction between genes modulating brain functions and stressful life events in the etiology of MD and SB and discuss their potential added benefit compared to genetic studies only. Within the context of G. ×. E investigation, thus far, only a few reliable results have been obtained, although some genes have consistently shown interactive effects with environmental risk in MD and, to a lesser extent, in SB. Further investigation is required to disentangle the direct and mediated effects that are common or specific to MD and SB. Since traditional G. ×. E studies overall suffer from important methodological limitations, further effort is required to develop novel methodological strategies with an interdisciplinary approach. © 2013 Elsevier Ltd.
Stirpe F.,University of Bologna
Toxicon | Year: 2013
Ribosome-inactivating proteins (RIPs) either single-chain (type 1) or two-chain (type 2) are frequent in plants, often in multiple forms. They are RNA N-glycosidases, have antiviral, antifungal and insecticidal activity. Their expression in plants is increased under stressful conditions. They are investigated for practical applications in medicine and in agriculture. In medicine, RIPs have been linked to, or fused with, appropriate antibodies or other carriers to form " immunotoxins" or other conjugates specifically toxic to the cells target of the carrier, with the aim of eliminating malignant or other undesired cells. In agriculture, it has been observed that an enhanced expression of RIPs confers to plants an increased resistance to viruses, fungi, insects, and also to drought and salinity. © 2013 Elsevier Ltd.
Contestabile A.,University of Bologna
Behavioural Brain Research | Year: 2011
The cholinergic hypothesis of cognitive impairment and Alzheimer's disease has been for decades a " polar star" for studies on dementia and neurodegenerative diseases. Aim of the present article is to briefly summarize its birth and its evolution throughout years and discoveries. Putting the cholinergic hypothesis in an historical perspective, allows to appreciate the enormous amount of experimental and clinical research that it has stimulated over years and the impressive extent of knowledge generated by this research. While some of the assumptions at the basis of its original formulation are disputable in the light of recent developments, the cholinergic hypothesis has, however, constituted an invaluable stimulus to better understand not only the anatomy and the biochemistry of the cholinergic systems of brain connections but also its developmental biology, its complex relationships with trophic factors, its role in cognitive functions. Thus, rather than being consigned to history, the cholinergic hypothesis will likely contribute to further understanding dementia and neurodegenerative diseases and will hopefully be integrated in novel therapies and treatments. © 2010.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: NMBP-18-2016 | Award Amount: 7.30M | Year: 2017
In the GRIDABLE project we will introduce novel thermoplastic polymer composite materials to enhance performance of essential components of smart grid infrastructure. We have proven in laboratory scale that the polypropylene-silica nanocomposite brings considerable improvements especially in dielectric breakdown strength. When applied as insulator in high-voltage direct current (HVDC) cable and in DC capacitors, the composite will bring significant enhancement at device level compared to the state-of-the-art. Cost and physical size of the capacitors will be reduced. Thermoplastic composite will enable cost effective production of cables by extrusion. Additionally, enhanced dielectric properties will increase HVDC transfer capacity. This will result in more efficient use of energy and materials. In the GRIDABLE project we will up-scale production of novel dielectric nanocomposite for electrical insulation applications. We will transfer materials high performance from laboratory scale to pre-production scale. This will be proven by relevant demonstrators and prototypes. The technical advances gained with novel dielectric material will facilitate to enhance power supply reliability. The new level of dielectric characteristics will help to manage volatility of the grid considering variety of power sources. Thus grid efficiency can be increased. The new HVDC cables will allow efficient electricity transfer over very long distances, e.g., from remote low-carbon power plants. This will also ease utilisation of distributed and intermittent renewable energy sources.