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Bologna, Italy

The University of Bologna is a university in Bologna, Italy, founded in 1088. As of 2013 the University's crest carries the motto Alma mater studiorum and the date A.D. 1088. The University has about 85,000 students in its 23 schools. It has branch centres in Imola, Ravenna, Forlì, Cesena and Rimini and a branch center abroad in Buenos Aires. It also has a school of excellence named Collegio Superiore di Bologna. It is recognised as the oldest university in continuous operation, considering that it was the first to use the term universitas for the corporations of students and masters which came to define the institution.The publisher of the University of Bologna is Bononia University Press S.p.A . Wikipedia.

Maroney M.J.,University of Massachusetts Amherst | Ciurli S.,University of Bologna
Chemical Reviews | Year: 2014

The knowledge of the biochemistries, structures, and reaction mechanisms of enzymes whose active sites require nickel, and utilize it in a nonredox role, are reviewed. The selection of nickel as a catalytic center for biological reactions is related to its flexible coordination geometry, which makes this metal a very versatile element for biological applications. The biological roles of nickel enzymes are conveniently divided into redox and nonredox roles. S-donor ligands are strongly associated with Ni redox enzymes, which include a novel superoxide dismutase, and several other enzymes including hydrogenase and COdehydrogenase/acetyl coenzyme. An alternative reaction mechanism has been proposed that features different roles for the two Ni(II) ions, with Ni1 binding and activating urea, and Ni2 binding and activating the nucleophilic water by turning it into a hydroxide ion. Thus, the proposed Fe-ARD mechanism relies on transient redox chemistry, while Ni(II) is a simple Lewis acid.

Palareti G.,University of Bologna
Blood | Year: 2014

Thromboses limited to infrapopliteal leg deep veins (isolated distal deep vein thrombosis [IDDVT]) are frequently diagnosed in subjects with suspected pulmonary embolism or DVT and account for one-fourth to one-half of all diagnosed leg DVTs. Despite their frequency, the natural history of IDDVTs and their real risk of thromboembolic complications are still uncertain because of the scarcity of prospective, blind, nonintervention studies. Therefore it is still debated whether they warrant diagnosis and treatment. Diagnosis is based on ultrasonographic examination, which is more operator dependent and less sensitive in distal than in proximal veins. The available data seem to support the view that most IDDVTs are self-limiting and inconsequential for patients, though in some cases they can be associated with complications and warrant diagnosis and treatment. The available guidelines for treatment of IDDVTs give different indications ranging from serial imaging of the deep veins for 2 weeks to detect and treat only in case of proximal extension, to giving oral anticoagulation in all IDDVT patients for 3 months. I review this issue, focusing on possible and suggested treatments in symptomatic IDDVT patients, and describe our current therapeutic approach to these patients. © 2014 by The American Society of Hematology.

Bandini M.,University of Bologna
Chemical Society Reviews | Year: 2011

Synthetic organic chemistry has been markedly affected by the booming of gold catalysis over the past decade. The renaissance of this coinage metal allowed unprecedented transformations to be realized in a highly selective manner and rendered "old chemistry" more accessible from a practical point of view. Particularly, organic compounds containing C-C multiple bonds benefited from the high carbophilicity of gold species, that opened access to a great chemical diversity through direct and selective π-electrophilic activations. Nowadays, the complexity of naturally occurring compounds based on functionalized aromatic frameworks continues to inspire and influence developments in synthetic chemistry. Furthermore, the ubiquitous presence of arene-based systems in pharmaceuticals, agrochemicals, and functional organic materials warrants the growing demand for mild, selective and sustainable synthetic routes to their preparation. In this context, although the peculiar aptitude of gold salts/complexes for interaction with aromatic compounds (auration process) has long been known, the direct catalytic gold decoration of arenes, has risen to prominence only recently. Here, the extensive use of electrophilic activation of C-C multiple bonds by gold species deserves a prominent mention, and the great strides made in the field over the last few years are described in this tutorial review. © 2011 The Royal Society of Chemistry.

Bandini M.,University of Bologna
Angewandte Chemie - International Edition | Year: 2011

Simple, selective, and sustainable: The optimization of the economic and the environmental impact of an organic reaction is one of the most demanding issues of modern organic synthesis. The use of allylic alcohols in catalytic stereoselective alkylation reactions provides an outstanding example of how these problems can be successfully addressed (see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Pediatric cytogenetically normal acute myeloid leukemia (CN-AML) is a heterogeneous subgroup of myeloid clonal disorders that do not harbor known mutations. To investigate the mutation spectrum of pediatric CN-AML, we performed whole-transcriptome massively parallel sequencing on blasts from 7 CN-AML pediatric patients. In 3 patients we identified a recurrent cryptic inversion of chromosome 16, encoding a CBFA2T3-GLIS2 fusion transcript. In a validation cohort of 230 pediatric CN-AML samples we identified 17 new cases. Among a total of 20 patients with CBFA2T3-GLIS2 fusion transcript out of 237 investigated (8.4%), 10 patients (50%) did not belong to the French-American-British (FAB) M7 subgroup. The 5-year event-free survival for these 20 children was worse than that for the other CN-AML patients (27.4% vs 59.6%; P = .01). These data suggest that the presence of CBFA2T3-GLIS2 fusion transcript is a novel common feature of pediatric CN-AML, not restricted to the FAB M7 subtype, predicting poorer outcome.

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