The University of Birmingham is a red brick university located in the city of Birmingham, United Kingdom. It received its royal charter in 1900 as a successor to Queen's College, Birmingham and Mason Science College . Birmingham was the first red brick university to gain a charter. It is a founding member of both the Russell Group of British research universities and the international network of research universities, Universitas 21.The University of Birmingham was ranked 11th in the UK and 64th in the world by QS World University Rankings. In 2013, Birmingham was named 'University of the Year 2014' in the Times Higher Education awards. Birmingham is also ranked 4th in the UK for Graduate Prospects in The Times and The Sunday Times Good University Guide 2015.The student population includes around 19,000 undergraduate and 9,000 postgraduate students, which is the 11th largest in the UK. The annual income of the institution for 2010–11 was £470.7 million, with an expenditure of £443.7 million.The university is home to the Barber Institute of Fine Arts, housing works by Van Gogh, Picasso and Monet, the Lapworth Museum of Geology, the Cadbury Research Library home to the Mingana Collections of Middle Eastern manuscripts and the Chamberlain Collection, and the Joseph Chamberlain Memorial Clock Tower, which is a prominent landmark visible from many parts of the city. Academics and alumni of the university include former British Prime Ministers Neville Chamberlain, and Stanley Baldwin, and eight Nobel laureates. Wikipedia.
University of Birmingham | Date: 2015-05-06
The invention provides an emulsion comprising: (a) a continuous phase; (b) a dispersed phase comprising an active compound (1); and (c) colloidal particles located at the interface between the continuous phase and the dispersed phase. These are particularly useful with one or more agrochemicals or food additives as an active compound.
University of Birmingham and The Secretary Of State For Defence Of The United Kingdom Of Great Britain And Northern Ireland | Date: 2015-02-25
The invention relates to an antimicrobial surface, in particular a surface functionalised with a peptide comprising an antimicrobial moiety. The invention comprises a surface functionalised with a peptide comprising an antimicrobial moiety and a binder moiety, wherein the peptide is immobilized on the surface by electrostatic interactions between the binder moiety and the surface. Further provided is a medical device, a peptide and a method for the immobilization of a peptide.
University of Birmingham | Date: 2017-03-08
The invention provides an agent for preventing or treating a condition characterised by the presence of unwanted cells, the agent comprising:(i) a targeting moiety that is capable of targeting to the unwanted cells; and(ii) a T cell antigen,wherein the T cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent in the vicinity of the unwanted cells.
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.61M | Year: 2017
Though Big Data has become common in many domains nowadays, the challenges to develop efficient and automated mining of the ever increasing data sets by new generations of data scientists are eminent. These challenges span wide swathes of society, business and research. Astronomers with their high-tech observatories are historically at the forefront of this field, but obviously, the impact in e.g. commercial applications, security, environmental monitoring and experimental research is immense. We aim to contribute to this general discussion by training a number of young scientists in the fields of computer science and astronomy, focussing on techniques of automated learning from large quantities of data to answer fundamental questions on the evolution of properties of galaxies. While these techniques will lead to major advances in our understanding of the formation and evolution of galaxies, we will also promote, in collaboration with industry, much more general applications in society, e.g. in medical imaging or remote sensing. We have put together a team of astronomers and computer scientists, from academic and private sector partners, to develop techniques to detect and classify ultra-faint galaxies and galaxy remnants in a deep survey of the Fornax cluster, and use the results to study how galaxies evolve in the dense environment of galaxy clusters. With a team of young researchers we will develop novel computer science algorithms addressing fundamental topics in galaxy formation, such as the huge dark matter fractions inferred by theory, and the lack of detected angular momentum in galaxies. The collaboration is unique - it will develop a platform for deep symbiosis of two radically different strands of approaches: purely data-driven machine learning and specialist approaches based on techniques developed in astronomy. Young scientists trained with such skills are highly demanded both in research and business.
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.91M | Year: 2017
The EU currently is negotiating a controversial Transatlantic Trade and Investment Partnership (TTIP) agreement with the USA, the main features of which will be the abolition of tariffs, the reduction of non-tariff barriers to trade between the EU and the USA and the introduction of a dispute settlement mechanism. The objective of the proposed TTIP Innovative Training Network (TTIP-ITN) is to foster interdisciplinary research into TTIP with a view to create a significantly increased European knowledge base and research capacity on TTIP, thus helping Europe to reap the benefits of TTIP (wealth, jobs, etc.) while addressing its challenges (democracy, accountability, environmental- and labour standards, etc.).The network is an interdisciplinary, intersectoral collaboration pooling world-leading researchers and practitioners from all relevant disciplines of law - EU constitutional, internal market, and external relations law, international trade law, and international law, as well as political science, international relations, business studies, and economics. TTIP-ITN fully integrates non-academic Beneficiaries and Partner Organisations, including think tanks, lobbyists, regulatory bodies, law firms, US academic institutions, and an international organisation. Furthermore, the network will support and enhance the process of converting research results into policy papers through partnership with high-impact policy research units at the forefront of European policy research and policy making. The work package consists of 3 substantive work packages on (1) transatlantic governance, (2) transatlantic regulation, and (3) multilateralism and regionalism. 15 PhD research projects will be supervised by academics of the 11 Beneficiaries with an interdisciplinary training programme covering the legal, political and economic foundations of TTIP and an interdisciplinary and intersectoral programme of secondments involving 22 Partner Organisations.
HarmonicSS - HARMONIzation and integrative analysis of regional, national and international Cohorts on primary Sjgrens Syndrome (pSS) towards improved stratification, treatment and health policy making
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC1-PM-04-2016 | Award Amount: 10.19M | Year: 2017
HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along with methods to make results of analyses and outcomes comparable across centers and sustainable through Rheumatology associations. The overall idea of the HarmonicSS project is to bring together the largest well characterized regional, national and international longitudinal cohorts of patients with Primary Sjgrens Syndrome (pSS) including those participating in clinical trials, and after taking into consideration the ethical, legal, privacy and IPR issues for sharing data from different countries, to semantically interlink and harmonize them into an integrative pSS cohort structure on the cloud. Upon this harmonized cohort, services for big data mining, governance and visual analytics will be integrated, to address the identified clinical and health policy pSS unmet needs. In addition, tools for specific diagnostic procedures (e.g. ultrasonography image segmentation), patient selection for clinical trials and training will be also provided. The users of the HarmonicSS platform are researchers (basic/translational), clinicians, health policy makers and pharma companies. pSS is relevant not only due to its clinical impact but also as one of the few model diseases to link autoimmunity, cancer development (lymphoproliferation) and the pathogenetic role of infection. Thus, the study of pSS can facilitate research in many areas of medicine; for this reason, the possibility for sustainability and expandability of the platform is enhanced. Moreover, pSS has a significant impact on the healthcare systems, similar to that of rheumatoid arthritis.
Rickinson A.B.,University of Birmingham
Seminars in Cancer Biology | Year: 2014
Epstein-Barr virus (EBV) is aetiologically linked to a wide range of human tumours. Some arise as accidents of the virus' lifestyle in its natural niche, the B lymphoid system; these include B-lymphoproliferative disease of the immunocompromised, Hodgkin Lymphoma, Burkitt Lymphoma and particular forms of diffuse large B cell lymphoma. Interestingly, HIV infection increases the incidence of each of these B cell malignancies, though by different degrees and for different reasons. Other EBV-associated tumours arise through rare viral entry into unnatural target tissues; these include all cases of nasal T/NK cell lymphoma and of undifferentiated nasopharyngeal carcinoma plus a small but significant subset of gastric carcinomas, a tumour type more generally associated with chronic Helicobacter pylori infection. Understanding EBV's involvement in the pathogenesis of these different malignancies is an important long-term goal. This article focuses on two overlapping, but relatively neglected, areas of research that could contribute to that goal. The first addresses the mechanisms whereby coincident infections with other pathogens increase the risk of EBV-positive malignancies, and takes as its paradigm the actions of holoendemic malaria and HIV infections as co-factors in Burkitt lymphomagenesis. The second widens the argument to include both infectious and non-infectious sources of chronic inflammation in the pathogenesis of EBV-positive tumours such as T/NK cell lymphoma, nasopharyngeal carcinoma and gastric carcinoma. © 2014.
Turner B.M.,University of Birmingham
Trends in Genetics | Year: 2012
This review examines the proposition that the nucleosome, in addition to its role as a DNA packaging device, is a signaling module through which changing environmental and metabolic conditions can influence genomic functions. The role of enzyme-catalyzed post-translational modifications of the core histones is critically assessed, leading to the conclusion that they play varied, often crucial and sometimes causative roles in this signaling process. © 2012 Elsevier Ltd.
Mendes P.M.,University of Birmingham
Chemical Society Reviews | Year: 2013
Recently, there has been an outburst of research on engineered cell-material interfaces driven by nanotechnology and its tools and techniques. This tutorial review begins by providing a brief introduction to nanostructured materials, followed by an overview of the wealth of nanoscale fabrication and analysis tools available for their development. This background serves as the basis for a discussion of early breakthroughs and recent key developments in the endeavour to develop nanostructured materials as smart interfaces for fundamental cellular studies, tissue engineering and regenerative medicine. The review covers three major aspects of nanostructured interfaces-nanotopographical control, dynamic behaviour and intracellular manipulation and sensing-where efforts are continuously being made to further understand cell function and provide new ways to control cell behaviour. A critical reflection of the current status and future challenges are discussed as a conclusion to the review. © 2013 The Royal Society of Chemistry.
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.93M | Year: 2017
Train2Target is a multidisciplinary European Training Network built to address the challenge of the discovery of alternative antimicrobials. Innovative strategies to deliver a next generation of drugs are urgently needed. The alarming threats and spread of multi-drug resistant bacteria is currently leaving clinicians with very limited options to combat infections especially those from Gram-negative pathogens. The Train 2Target research programme focuses on the assembly of the well-known bacterial cell envelope from a new perspective. Indeed it aims to inhibit novel targets in envelope biogenesis by altering the function and misbalancing the coordination of envelope assembly machines, which build and assemble the Gram-negative bacterial envelope. A wide variety of chemical classes and compounds sources will be screened using innovative biochemical, biophysical and genetic assays to identify valuable hit scaffolds to be optimized into druggable leads. The high quality and credibility of our consortium is ensured by a strong interdisciplinary academia-industry partnership to encompass different complementary expertise ranging from microbiology, bacterial genetics, biochemistry, cell imaging, structural biology, biophysics and chemical synthesis. Our 9 academic groups are all renowned leaders in the cell envelope biogenesis field, whereas the complementary 5 SMEs and 3 Industry partners are specialised in drug discovery and development of novel anti-infective drugs. This unique combination of scientific excellence and industrial know-how in drug discovery covers the entire process from the design to the implementation of innovative antibacterial strategies and lead identification. Train2Target also represents a unique research platform to train 15 Early Stage Researchers and equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the pharma/biotech job market.