Belgrade, Serbia
Belgrade, Serbia

The University of Belgrade is the oldest and largest university in Serbia.Founded in 1808 as the Belgrade Higher School in revolutionary Serbia, by 1838 it merged with the Kragujevac-based departments into a single university. The University has nearly 90,000 students and over 4,200 members of teaching staff. Since its founding, the University has educated more than 330,000 bachelors, around 21,300 magisters, 29,000 specialists and 12,600 doctors. The University comprises 31 faculties, 11 research institutes, the university library, and 7 university centres. The faculties are organized into 4 groups: social science and humanities; medical science; natural science and mathematics; and technological science.The University of Belgrade has found its place amongst the top 400 universities in the world, according to the most recent global ranking carried out by the Shanghai List. In the area of mathematics, it is ranked among the top 150 universities in the world. Wikipedia.

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Jojic D.,University of Banja Luka | Vrecica S.T.,University of Belgrade | Zivaljevic R.T.,Serbian Academy of Science and Arts
Journal of Combinatorial Theory. Series A | Year: 2017

Following Karaguezian, Reiner and Wachs we study the connectivity degree and shellability of multiple chessboard complexes. Our central new results provide sharp connectivity bounds relevant to applications in Tverberg type problems where multiple points of the same color are permitted. The results presented in this paper also serve as a foundation for the new results of Tverberg–van Kampen–Flores type, as described in the sequel to this paper. © 2016 Elsevier Inc.

Ostojic S.M.,University of Novi Sad | Ostojic S.M.,University of Belgrade
Clinical Science | Year: 2016

Beneficial effects of physical activity on mitochondrial health are well substantiated in the scientific literature, with regular exercise improving mitochondrial quality and quantity in normal healthy population, and in cardiometabolic and neurodegenerative disorders and aging. However, several recent studies questioned this paradigm, suggesting that extremely heavy or exhaustive exercise fosters mitochondrial disturbances that could permanently damage its function in health and disease. Exercise-induced mitochondrial dysfunction (EIMD) might be a key proxy for negative outcomes of exhaustive exercise, being a pathophysiological substrate of heart abnormalities, chronic fatigue syndrome (CFS) or muscle degeneration. Here, we overview possible factors that mediate negative effects of exhaustive exercise on mitochondrial function and structure, and put forward alternative solutions for the management of EIMD. © 2016 The Author(s).

Doljak D.,Serbian Academy of Science and Arts | Popovic D.,University of Belgrade | Kuzmanovic D.,Civil Engineering Institute IG Banja Luka
Renewable and Sustainable Energy Reviews | Year: 2017

Photovoltaic power plants represent a good solution concerning electric energy supply under the condition that there are sufficiently available and suitable areas for their mounting. This study supports an opinion hypothesis that the City of Požarevac has at its disposal a considerable potential for energy production by photovoltaic power plants at the degraded areas. The geographic information systems were used to identify and create polygons for degraded areas, and the Energy capacity assessment tool was used in order to estimate the solar potential for this areas. The results showed that it would be possible to generate about 43% of the electric energy produced by thermal power plants “Kostolac A” and “Kostolac B” by construction and work of photovoltaic power plants in proposed locations. For a long-term standpoint, this project would prevent the emission of over 30 million tons of CO2 into the atmosphere. This study should contribute to the better understanding of local authorities regarding the potential for the use of solar energy, as well as, define of better principles, measures, instruments and policy to stimulate the application of solar energy to secure the requirements for electric energy. © 2017 Elsevier Ltd

Bodrozic J.N.,University of Belgrade
Blood Coagulation and Fibrinolysis | Year: 2017

Severe form of haemophilia in women is an extremely rare condition. Owing to the rarity of the disease there are no precise recommendations concerning the optimal management of pregnancy and delivery in these patients. We are reporting the clinical course and management of a 30-year-old woman with a severe form of haemophilia A (factor VIII <1?IU/dl) during her first pregnancy and delivery. Antepartum, she was treated on demand by FVIII concentrate and she delivered at 37 weeks of gestation by cesarean section. In postpartal period an excellent control of bleeding was obtained by regularly administering FVIII concentrate for several days as well by concomitant use of tranexamic acid and oral contraceptive pills in the next 6 weeks. Copyright © 2017 YEAR Wolters Kluwer Health, Inc. All rights reserved.

The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: First ever randomized trial in the setting of aortic stenosis has been started in an attempt to adequately address this 'burning issue'. In light of this fact it is important to identify biomarkers which might help in risk stratification of these patients, not only in the referring physician's office during a routine exam, but also for preoperative patients scheduled for surgical replacement/transcatheter aortic valve implantation. This report is focusing on novel laboratory parameters which might be helpful in this risk stratification. © 2017 Future Medicine Ltd.

Unic-Stojanovic D.,University of Belgrade
Signa Vitae | Year: 2015

Carotid endarterectomy (CEA) is a surgical procedure performed to reduce the incidence of embolic and thrombotic stroke. Although only a preventive procedure, CEA carries the risk of perioperative complications. There is constant searching for an optimal anesthetic technique. There are pros and cons for both anesthetic techniques used: regional (RA) and general anesthesia (GA). A large number of studies have compared RA and GA techniques in CEA surgery patients. The primary outcome was the proportion of patients with stroke, myocardial infarction, or death. However, neither the GALA trial nor the pooled analysis was adequately powered to reliably detect an effect of type of anesthesia on mortality. It may therefore be appropriate to consider other additional parameters (stress response, incidence of postoperative delirium and cognitive impairment, functional recovery, total surgery time, intensive care unit requirement, hospital stay, hospital costs and patients satisfaction) when comparing the outcomes of the two techniques. Although, the debate continues as to whether regional anesthesia or general anesthesia is safer, the choice of anesthetic technique is a complex decision and surgical teams should be able to offer both RA and GA. The individual approach is the ideal choice and should be determined at the discretion of the surgeon, anesthetist and patient depending on the clinical situation and own preferences. © 2015 Signa Vitae. All rights reserved.

Frittella S.,CNRS Laboratory of Fundamental Informatics of Marseille (LIF) | Greco G.,Technical University of Delft | Kurz A.,University of Leicester | Palmigiano A.,Technical University of Delft | Sikimic V.,University of Belgrade
Journal of Logic and Computation | Year: 2016

In the present article, we introduce a multi-type display calculus for dynamic epistemic logic, which we refer to as Dynamic Calculus. The display approach is suitable to modularly chart the space of dynamic epistemic logics on weaker-than-classical propositional base. The presence of types endows the language of the Dynamic Calculus with additional expressivity, allows for a smooth proof-theoretic treatment, and paves the way towards a general methodology for the design of proof systems for the generality of dynamic logics, and certainly beyond dynamic epistemic logic. We prove that the Dynamic Calculus adequately captures Baltag-Moss-Solecki's dynamic epistemic logic, and enjoys Belnap-style cut elimination. © The Author, 2014. Published by Oxford University Press. All rights reserved.

Frittella S.,CNRS Laboratory of Fundamental Informatics of Marseille (LIF) | Greco G.,Technical University of Delft | Kurz A.,University of Leicester | Palmigiano A.,Technical University of Delft | Sikimic V.,University of Belgrade
Journal of Logic and Computation | Year: 2016

The present article provides an analysis of the existing proof systems for dynamic epistemic logic from the viewpoint of proof-theoretic semantics. Dynamic epistemic logic is one of the best known members of a family of logical systems that have been successfully applied to diverse scientific disciplines, but the proof-theoretic treatment of which presents many difficulties. After an illustration of the proof-theoretic semantic principles most relevant to the treatment of logical connectives, we turn to illustrating the main features of display calculi, a proof-theoretic paradigm that has been successfully employed to give a proof-theoretic semantic account of modal and substructural logics. Then, we review some of the most significant proposals of proof systems for dynamic epistemic logics, and we critically reflect on them in the light of the previously introduced proof-theoretic semantic principles. The contributions of the present article include a generalization of Belnap's cut-elimination metatheorem for display calculi, and a revised version of the display-style calculus D.EAK [30]. We verify that the revised version satisfies the previously mentioned proof-theoretic semantic principles, and show that it enjoys cut-elimination as a consequence of the generalized metatheorem. © The Author, 2014. Published by Oxford University Press. All rights reserved.

Guzina J.,University of Belgrade | Djordjevic M.,University of Belgrade
BMC Evolutionary Biology | Year: 2017

Background: Transcription initiation is in bacteria exhibited by different σ factors, most of which fall within σ70 family. This family is diverse, ranging from the housekeeping Group I (RpoDs), to Group IV (ECF) σ factors, that transcribe smaller regulons under more stringent conditions. RpoDs employ a kinetic mix-and-match mechanism, where promoter elements complement each other binding strengths in achieving sufficient transcription activity. On the other hand, it is assumed that ECF σs, which are the most distant from the housekeeping σ factors, cannot exhibit mix-and-matching. However, mix-and-matching for ECF σ factors was not quantitatively checked before, and recent results show a much larger flexibility in the promoter recognition by the members of this group. Results: To this end, we quantitatively investigate mix-and-matching in two canonical ECF σ family members (σE and σW), for which we use a biophysics based model of transcription initiation. For σE, we perform a separate analysis for in-vitro active and in-vitro inactive promoters, which allows us investigating how mix-and-matching depends on the external factors that may control transcription activity in the in-vitro inactive set. We show that the promoter elements of canonical ECF σs significantly complement each other strengths, where such mix-and-matching is in the in-vitro active set even stronger compared to the correlations observed for the housekeeping σs. This complementation however significantly decreases for the in-vitro inactive set, which we propose is due to mix-and-matching with regulatory sequences outside of the canonical promoter elements. In line with this proposition, we show that a conserved spacer element, which appears in the in-vitro inactive promoter set, significantly increases the promoter element complementation. While RpoD promoter elements mix-and-match to achieve sufficient total transcription activity, for σE they complement each other to achieve sufficiently strong total binding affinity, which we relate to differences in physiological responses between the two groups of σ factors. Conclusion: Despite a common notion that smaller σ factor specificity leads to a larger mix-and-matching, we here obtain a larger promoter element complementation for σE compared to RpoDs. Finally, to explain this finding, we propose a simple model which relates the size of σ factor regulon with the extent of mix-and-matching, based on an assumption of a selection pressure on promoters that are near the non-specific binding boundary to remain functional. © 2017 The Author(s).

Trivic D.D.,University of Belgrade
Chemistry Education Research and Practice | Year: 2016

This paper presents a pedagogical experiment with parallel groups through which the effectiveness of the cognitive apprenticeship model of dealing with the teaching topic Carboxylic acids and their derivatives was compared with the traditional approach to the elaboration of this topic. This experiment featured the participation of 241 students aged 17, attending their third year of grammar school, natural sciences stream. The experimental group consisted of 118 students, whereas the control group was made up of 123 students. Within the framework of the experiment, a pre-test consisting of items that resembled regular textbook items was used as an instrument for checking how balanced the previously acquired knowledge concerning the teaching topic Carboxylic acids and their derivatives of the students in the two groups was. A post-test was used as an instrument for comparing the effectiveness of the two approaches, and it mostly consisted of items that required the application of the knowledge concerning the teaching topic Carboxylic acids and their derivatives in solving real-life problems. In the pre-test, no statistically significant difference in the overall percentage of correct answers given by the two groups of students was established. In the post-test, the students from the experimental group scored a statistically significant higher percentage of correct answers compared to the students from the control group. On the basis of this, it can be concluded that the applied cognitive apprenticeship approach has the potential to improve the level of students' understanding of the concepts from the topic Carboxylic acids and their derivatives, as well as the students' ability to apply the knowledge on the examples from real life. © 2016 The Royal Society of Chemistry.

Terzic A.,Serbian Institute for Testing of Materials IMS | Pezo L.,University of Belgrade | Andric L.,Serbian Institute for Technology of Nuclear and Other Mineral Raw Materials
Composites Part B: Engineering | Year: 2017

Natural zeolites of clinoptilolite type from seven deposits were submitted to mechano-chemical activation in a Retsch ultra-centrifugal mill. The zeolite types and activation parameters were altered during the experiment with an aim to determine the optimal combination that would produce powder with adequate physico-chemical and microstructural properties for application as a binder replacement and an ion-exchanger in the construction composites. The effects of input variables (chemical composition of the samples) and process parameters (the rotor velocity and the activation period) on the efficiency of zeolite activation were investigated in terms of dependent parameters such as: specific surface area, grain size distribution, cation exchange capacity, melting point, compression strength, shrinking, water absorption and apparent porosity. Cluster analysis, Principal component analysis and Standard score analysis were applied in the assessment of the acquired product quality. Artificial neural networks (ANN) were developed in mathematical modeling of observed responses. Subsequently the ANN was compared to experimental results and the developed second order polynomial models. Developed models showed r2 values in the 0.822–0.998 range, meaning that they were able to predict the observed responses in a wide range of processing parameters. ANN models performed high prediction accuracy (0.975–0.993) and can be considered as precise and very useful for response variables prediction. The combination of the conducted mathematical analyses isolated Z5 zeolite as a preferable type, and 20000 rpm and 30 min as an optimal activation set of parameters. Mathematically derived conclusions were confirmed by results of instrumental analyses (XRD, DTA/TG, SEM). © 2016 Elsevier Ltd

Grujic N.,University of Belgrade | Radivojevic M.,University of Belgrade
Nematology | Year: 2017

Annual decline rates of potato cyst nematode (PCN) populations have been extensively studied. They vary considerably due to many factors, including potato cultivar, initial PCN density and climatic factors. Information is needed on PCN decline in potato fields in the specific conditions of Western Serbia, which is the centre for most of the local potato production, especially seed potato. We investigated the decline of Globodera rostochiensis over 1 or 2 years under the influence of PCN-resistant potato cv. Agria in the field and microplots. Decline was compared with fallow in Ponikve, near the original record of G. rostochiensis. Population decline in the field after cv. Agria was approximately 80%. In two parts of the field where potato cv. Agria was cropped once or twice with fallow before and after, the viable PCN population declined over 9 years to about 1% of initial Pi values. In a third part of the field, left fallow for 9 years, 15% of the initial population was still viable, after an annual decline rate of 9.4%. The influence of volunteer potatoes on maintaining PCN populations was also examined. In the microplots, with a higher density of volunteers compared to the field, PCN decline under resistant potato cv. Agria was 70%. At crop harvest a new generation was recorded, suggesting its possible formation on susceptible volunteer potato. The full cysts represented 1% of all cysts examined and 13% of total second-stage juveniles found in the samples. The information will be useful for improvement of management procedures. © 2017 Copyright 2017 by Koninklijke Brill NV, Leiden, The Netherlands.

Jankovic V.,University of Belgrade | Vukmirovic N.,University of Belgrade
Physical Review B - Condensed Matter and Materials Physics | Year: 2017

We present a detailed investigation of ultrafast (subpicosecond) exciton dynamics in the lattice model of a donor/acceptor heterojunction. Exciton generation by means of a photoexcitation, exciton dissociation, and further charge separation are treated on equal footing. The experimentally observed presence of space-separated charges at 100fs after the photoexcitation is usually attributed to ultrafast transitions from excitons in the donor to charge-transfer and charge-separated states. Here, we show, however, that the space-separated charges appearing on 100-fs time scales are predominantly directly optically generated. Our theoretical insights into the ultrafast pump-probe spectroscopy challenge usual interpretations of pump-probe spectra in terms of ultrafast population transfer from donor excitons to space-separated charges. ©2017 American Physical Society.

Vujovic D.,University of Belgrade | Protic M.,Hydrometeorological Service of Serbia
Atmospheric Research | Year: 2017

Deep convection yielding severe weather phenomena (hail, flash floods, thunder) is frequent in Serbia during the warmer part of the year, i.e. April to September. As an effort to mitigate any potential damage to material goods, agricultural crops and vegetation from larger hailstones, cloud seeding is performed. In this paper, we analyzed 29 severe hailstorms seeded by silver iodide. From these, we chose five intense summer thunderstorm cells to analyze in detail the influence of silver-iodide cloud seeding on the radar parameters. Four of them were seeded and one was not. We also used data from firing stations (hail fall occurrence, the size of the hailstones). The most sensitive radar parameter in seeding was the height where maximum reflectivity in the cloud was observed. Its cascade appeared in every case of seeding, but was absent from the non-seeded case. In the case of the supercell, increase and decrease of the height where maximum reflectivity in the cloud was observed occurred in almost regular intervals, 12 to 15 min. The most inert parameter in seeding was maximum radar reflectivity. It changed one to two dBz during one cycle. The height of the top of the cloud and the height of the zone exhibiting enhanced radar echo both had similar behavior. It seems that both increased after seeding due to a dynamic effect: upward currents increasing due to the release of latent heat during the freezing of supercooled droplets. Mean values of the height where maximum reflectivity in the cloud was observed, the height of the top of the cloud and the height of the zone exhibiting enhanced radar echo during seeded period were greater than during unseeded period in 75.9%, 72.4% and 79.3% cases, respectively. This is because the values of the chosen storm parameters were higher when the seeding started, and then those values decreased after the seeded was conducted. © 2017 Elsevier B.V.

Pajic-Lijakovic I.,University of Belgrade | Milivojevic M.,University of Belgrade
Journal of Biological Physics | Year: 2017

The mean features of cell surface rearrangement during cell aggregate rounding after uni-axial compression between parallel plates are considered. This is based on long-time rheological modeling approaches in order to shed further light on collective cell migration. Many aspects of cell migration at the supra-cellular level, such as the coordination between surrounding migrating cell groups that leads to uncorrelated motility, have remained unclear. Aggregate shape changes during rounding are considered depending on the size and homogeneity of 2-D and 3-D cell aggregates. Cell aggregate shape changes that are taking place during successive relaxation cycles have various relaxation rates per cycle. Every relaxation rate is related to the corresponding cell migrating state. If most of the cells migrate per cycle, the relaxation rate is maximal. If most of the cells are in a resting state per cycle, the relaxation rate is nearing zero. If some cell groups migrate while the others, at the same time, stay in a resting state, the relaxation rate is lower than that obtained for the migrating cells. The relaxation rates per cycles are not random, but they have a tendency to gather around two or three values indicating an organized cell migrating pattern. Such behavior suggests that uncorrelated motility during collective cell migration in one cycle induces a decrease of the relaxation rate in the next cycle caused by an accumulation of cells in the resting state. However, cells have the ability to overcome these perturbations and re-establish an ordered migrating trend in the next cycle. These perturbations of the cell migrating state are more pronounced for: (1) more mobile cells, (2) a heterogeneous cell population, and (3) a larger cell population under the same experimental conditions. © 2017 Springer Science+Business Media Dordrecht

Ivkovic M.,University of Belgrade | Konjevic N.,University of Belgrade
Spectrochimica Acta - Part B Atomic Spectroscopy | Year: 2017

In this work we summarize, analyze and critically evaluate experimental procedures and results of LIBS electron number density plasma characterization using as examples Stark broadened Si I and Si II line profiles. Selected publications are covering the time period from very beginning of silicon LIBS studies until the end of the year 2015. To perform the analysis of experimental LIBS data, the testing of available semiclassical theoretical Stark broadening parameters for Si I and Si II lines was accomplished first. This is followed by the description of experimental setups, results and details of experimental procedure relevant for the line shape analysis of spectral lines used for plasma characterization. Although most of results and conclusions of this analysis are related to the application of silicon lines for LIBS characterization they are of general importance and may be applied to other elements and different low-temperature plasma sources. The analysis of experimental procedures used for LIBS diagnostics from emission profiles of non-hydrogenic spectral lines is carried out in the following order: the influence of laser ablation and crater formation, spatial and temporal plasma observation, line self-absorption and experimental profile deconvolution, the contribution of ion broadening in comparison with electron impacts contributions to the line width in case of neutral atom line and some other aspects of line shape analysis are considered. The application of Stark shift for LIBS diagnostics is demonstrated and discussed. Finally, the recommendations for an improvement of experimental procedures for LIBS electron number density plasma characterization are offered. © 2017

Zuidam N.J.,Unilever | Nedovic V.A.,University of Belgrade
Encapsulation Technologies for Active Food Ingredients and Food Processing | Year: 2010

Consumers prefer food products that are tasty, healthy and convenient. Encapsulation is an important way to meet these demands by delivering food ingredients at the right time and right place. For example, encapsulates may allow flavour retention, mask bad tasting or bad smelling components, stabilize food ingredients and/or increase their bioavailability. Encapsulation may also be used to immobilise cells or enzymes in the production of food materials or products, such as fermentation or metabolite production. This book provides a detailed overview of technologies for preparing and characterisation of encapsulates for food active ingredients to be used in food products, food processing or food production. The book is aimed to inform people who work in the academia or R&D of companies on delivery of food compounds via encapsulation and on food processing using immobilized cells or enzymes, with both a limited and an advantaged knowledge of the field. The structure of the book is according to the use of encapsulates for a specific application. Emphasis has been put to strategy, since encapsulation technologies may change. Most chapters include application possibilities of the encapsulation technologies in specific food products or processes. The first part of the book reviews general technologies, food-grade materials and characterization methods for encapsulates. The second part of the book, discusses encapsulates of active ingredients (i.e. aroma, fish oil, minerals, vitamins, peptides, proteins, probiotics) for specific food applications. The last part of the book describes immobilization technologies of cells and enzymes for use within food fermentation processes (like beer, wine, dairy and meat) and food production (e.g., sugar conversion, production of organic acids or amino acids, and hydrolysis of triglycerides). Edited by two leading experts in the field, Encapsulation Technologies for Food Active Ingredients and Food Processing will be a valuable reference source for those working in the academia or food industry. The editors work either in industry or university, and they have brought together in this book contributions from both fields. Dr. Nicolaas Jan (Klaas-Jan) Zuidam is leading the skillbase group 'Controlled Delivery of Food Actives' and is a member of the management team of the Flavour Generation & Delivery department within Unilever Research and Development in Vlaardingen, The Netherlands. Since 1990, he has been working on encapsulation, respectively, in the area of pharmaceutics, gene therapy, laundry and foods. He is an author of more than 35 peer-reviewed articles and book chapters, and holds 2 patents. Dr. Viktor A. Nedovic is an associate professor at the Department of Food Technology and Biochemistry, Faculty of Agriculture, University of Belgrade, Belgrade, Republic of Serbia. Since 1989, he has been working on immobilisation, co-immobilisation, encapsulation and bioreactor system design in the fields of food production and fermentation processes. He is an author of around 200 articles published in journals, books and proceedings. He has also served as co-editor of two important books on cell immobilisation: Fundamentals of Cell Immobilisation Biotechnology (Kluwer Academic Publisher, 2004) and Applications of Cell Immobilisation Biotechnology (Springer, 2005). © Springer Science+Business Media, LLC 2010 All rights reserved.

Bjegovic-Mikanovic V.,University of Belgrade | Otok R.,Association of Schools of Public Health in the European Region ASPHER
Frontiers in Public Health | Year: 2017

The public health profession in Europe has a leadership role for ensuring European's health in the twenty-first century and therefore must assume responsibility for advancing education for research and practice. Three fundamental questions are explored: (1) What are the main public health problems facing public health professionals; (2) What are their existing competencies after training; and (3) What competencies do European employers expect? The European Schools of Public Health assessed their best success to be in the field of health promotion, followed by disease prevention including identification of priority health problems, and elimination of health hazards in the community. Conversely, they see the least success in dealing with preparedness and planning for public health emergencies. From an employer's perspective, significant gaps between current and desired levels of performance at the job exist for all Essential Public Health Operations of World Health Organization. Based on prior research and recent European surveys of Schools and Departments of Public Health, the following recommendations are made, which emphasize the leadership role of the European public health community: (1) the preparation of public health professionals requires an interface between public health functions, competencies, and performance; (2) competence-based education is important and allows debates on the scope of the required education; (3) governments have to realize that the present lack of infrastructure and capacity is detrimental to the people's health; (4) as public health challenges are increasingly global, educational institutions have to look beyond the national boundaries and participate in European and global networks for education, research, and practice. © 2017 Bjegovic-Mikanovic and Otok.

Smiljanic J.,University of Belgrade | Dankulov M.M.,University of Belgrade
PLoS ONE | Year: 2017

The affiliation with various social groups can be a critical factor when it comes to quality of life of each individual, making such groups an essential element of every society. The group dynamics, longevity and effectiveness strongly depend on group's ability to attract new members and keep them engaged in group activities. It was shown that high heterogeneity of scientist's engagement in conference activities of the specific scientific community depends on the balance between the numbers of previous attendances and non-attendances and is directly related to scientist's association with that community. Here we show that the same holds for leisure groups of the Meetup website and further quantify individual members' association with the group. We examine how structure of personal social networks is evolving with the event attendance. Our results show that member's increasing engagement in the group activities is primarily associated with the strengthening of already existing ties and increase in the bonding social capital. We also show that Meetup social networks mostly grow trough big events, while small events contribute to the groups cohesiveness. © 2017 Smiljaniæ, Mitroviæ Dankulov. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Berec V.,Vinča Institute of Nuclear Sciences | Berec V.,University of Belgrade
European Physical Journal: Special Topics | Year: 2017

Complexity is highly susceptible to variations in the network dynamics, reflected on its underlying architecture where topological organization of cohesive subsets into clusters, system’s modular structure and resulting hierarchical patterns, are cross-linked with functional dynamics of the system. Here we study connection between hierarchical topological scales of the simplicial complexes and the organization of functional clusters – communities in complex networks. The analysis reveals the full dynamics of different combinatorial structures of q-th-dimensional simplicial complexes and their Laplacian spectra, presenting spectral properties of resulting symmetric and positive semidefinite matrices. The emergence of system’s collective behavior from inhomogeneous statistical distribution is induced by hierarchically ordered topological structure, which is mapped to simplicial complex where local interactions between the nodes clustered into subcomplexes generate flow of information that characterizes complexity and dynamics of the full system. © 2017 EDP Sciences and Springer

Tomovska R.,Mit University | Radivojevic A.,University of Belgrade
Journal of Cleaner Production | Year: 2017

This paper examines the sustainable design strategies of the Balkan vernacular architecture in the example of the traditional Ohrid house. The approach regarding the problem of resource conservation which is present in the selected examples of vernacular architecture offers the possibility of analysing and discussing the building strategies of the past, which are still considered to be relevant in terms of sustainability and environmental design. The subject of this research is the sustainable design strategies that refer to the reuse of building material and the measures regarding waste reduction in the form of its incorporation into new building materials. The research points to sustainable solutions regarding on-site minimisation of construction waste in the example of the traditional Ohrid house during the following three phases of the life cycle of both the material and the building: pre-building, building, and post-building phase. The applied on-site waste minimisation measures and the principle of using materials with low-embodied energy, identified in the example of the traditional Ohrid house, can be understood as the conceptual basis for finding more efficient solutions in today's material and energy conservation practices, proving that sustainable architecture could be achieved by a simple and thoughtful application of local materials and building techniques. © 2017 Elsevier Ltd

Stevanovic V.D.,University of Belgrade | Hrnjak P.,University of Illinois at Urbana - Champaign | Hrnjak P.,Cts Inc.
Applied Thermal Engineering | Year: 2017

This paper presents a three-dimensional model of the refrigerant-oil two phase flow developed with the aim of predicting the oil retention in evaporators of air-conditioning systems. The developed model is based on the two-fluid model approach. The governing mass, momentum and energy balance equations are written for each phase. The gas phase is the refrigerant vapor, while the liquid phase is the mixture of liquid refrigerant and oil. The balance equation for the oil mass fraction in the mixture with liquid refrigerant is included. Transfer processes at the vapor-liquid interfaces and on the flow channel walls are predicted with closure laws. The model is solved by the in-house computer code based on the SIMPLE type numerical procedure. The model is validated by comparing numerically predicted refrigerant mass and oil retention data in a brazed plate and fin evaporator, typically used in automotive applications, against measured values. Two sets of experiments performed with refrigerants R134a and R1234yf in the mixture with PAG oil are simulated. The numerical results provide a complete picture of the two-phase flow structure in the evaporator. Model predicts that oil is mainly retained in the bottom header and in smaller amounts in the top header and in parallel evaporating channels with upward refrigerant flow. The developed three-dimensional modeling and numerical approach has the advantage of being more reliable for the prediction of oil retention than existing one-dimensional models. © 2017 Elsevier Ltd

Maluckov C.A.,University of Belgrade
IEEE Transactions on Dielectrics and Electrical Insulation | Year: 2016

The results of investigations of influences of electrode conditions on the electrical breakdown mechanisms are presented. Investigations are performed measuring the time delays on gas tube filled with nitrogen at 400 Pa. The analysis indicates necessity of the certain number of breakdowns for conditioning of electrode surfaces. The main finding is decrease of the minimal number of pre-conditioning breakdowns for stable electrode conditions with increase of the value of the relaxation time. In the cases where stationary conditions have not been established yet the asymmetry of the time delay distribution for short relaxation times is shown to be related with the number of measurements. In addition, the approach developed here is shown significant to clarify the properties of the time delay distributions. © 2016 IEEE.

Carruba V.,Paulista University | Novakovic B.,University of Belgrade | Aljbaae S.,Paulista University
Monthly Notices of the Royal Astronomical Society | Year: 2017

The Hoffmeister family is a C-type group located in the central main belt. Dynamically, it is important because of its interaction with the ν1C nodal secular resonance with Ceres, which significantly increases the dispersion in inclination of family members at a lower semimajor axis. As an effect, the distribution of inclination values of theHoffmeister family at a semimajor axis lower than its centre is significantly leptokurtic, and this can be used to set constraints on the terminal ejection velocity field of the family at the time it was produced. By performing an analysis of the time behaviour of the kurtosis of the νW component of the ejection velocity field [γ 2(νW)], as obtained from Gauss' equations, for different fictitious Hoffmeister families with different values of the ejection velocity field, we were able to exclude that the Hoffmeister family should be older than 335 Myr. Constraints from the currently observed inclination distribution of the Hoffmeister family suggest that its terminal ejection velocity parameter VEJ should be lower than 25ms-1. Results of aYarko-YORP Monte Carlo method to family dating, combined with other constraints from inclinations and γ 2(νW), indicate that the Hoffmeister family should be 220-40 +60 Myr old, with an ejection parameter VEJ = 20 ± 5 m s-1. © 2016 The Authors.

Pejovic P.,University of Belgrade
2016 International Symposium on Industrial Electronics, INDEL 2016 - Proceedings | Year: 2016

In this paper, experiences from founding and teaching a course Software Tools in Electronics are presented. The course teaches students to use basic software tools to document their work, to draw circuit diagrams, to do numeric and symbolic computing, to provide graphical presentation of data, and finally teaches Python both as a programming language and as a tool for numeric computing, symbolic computing, and graphical presentation of data. The course covers only the tools that are free software, and in introductory part of the course licensing and social issues are covered. Tools taught at the course are listed, the reasons behind their choice are explained, and teaching experiences and impressions are stated. © 2016 IEEE.

Radosavljevic J.,University of Belgrade
Peanuts: Consumption, Allergies and Nutritional Content | Year: 2016

Allergic reactions to peanuts are a major cause of food-induced anaphylaxis, both in children and adults. It is estimated that approximately 1% of the world’s population developed allergy to peanuts and the prevalence is exhibiting an increasing trend. Sensitization by peanut proteins is suspected to develop directly by ingestion of food containing peanuts or processed peanut proteins or through skin, using cosmetic products containing peanut oil and some peanut proteins. In this chapter, biochemical properties of major peanut allergens (Ara h 1, Ara h 2, Ara h 3 and Ara h 6) are thoroughly reviewed with emphasis on structural similarity to proteins from other sources which is frequently resulting in cross-reactivity. Recently reported peanut proteins are briefly described (Ara h 7-17). Methodologies for detecting minute amounts of peanuts in different sources will be improved by further advancement of knowledge on peanut allergens. Hopefully, the potential threat to peanut-allergic persons produced by contamination of food by trace amounts of peanuts and their proteins will be diminished. © 2017 by Nova Science Publishers, Inc. All rights reserved.

Nikolic S.,University of Belgrade | Zivkovic V.,University of Belgrade
Medicine, Science and the Law | Year: 2017

Herein, a potentially dangerous explosive home-made device used for fun and entertainment is described. It consists of two iron parts connected with a U-shaped thick wire: a wedge about 8 cm in length, which fits into a hollow cylinder, filled with a small amount of nitre (the mineral form of potassium nitrate). Striking the device onto a hard surface creates a spark inside it, which burns the nitre, producing a very loud bang. We are in possession of such device in our forensic museum collection. We present a case from 1937 related to the use of this explosive home-made device. A boy was injured using it, as the wedge hit him in the left temporal region and entered his skull. The major initial consequence was a localised brain injury, without any bleeding. Delayed presentation resulted in intracranial infection – purulent meningitis due to open craniocerebral injury, which was the cause of death three months later. The potentially dangerous home-made explosive iron device presented here was in use mostly by children from the end of the 19th century until the early 1970s, when it was replaced with less dangerous and cheaper Chinese firecrackers and fireworks. © 2016, © The Author(s) 2016.

Stamenkovic D.,University of Belgrade | Popovic V.,University of Belgrade | Vorotovic G.,University of Belgrade
Refrigeration Science and Technology | Year: 2015

Yugoslavia was one of the first countries to accede to ATP agreement in 1975. The Republic of Serbia confirmed the Agreement on 5 December 2011 and was the first in the region to implement it in practice. Implementation of the Agreement could not be carried out without the birth pangs, for many reasons - old equipment, absence of road checks, counterfeit certificates and more. However, the number of equipment registered or built in Serbia and complying with the Agreement is getting bigger every day. This paper presents the experiences of Serbia's only ATP testing station obtained through testing of the equipment in use. Furthermore, 117 collected times needed for special equipment to reach the temperature declared by their class are analysed and compared between the boxes of different ages, taking into account the capacity of the refrigeration unit.

Andric F.,University of Belgrade | Heberger K.,Hungarian Academy of Sciences
Journal of Chromatography A | Year: 2017

Comparison and selection of chromatographic columns is an important part of development as well as validation of analytical methods. Presently there is abundant number of methods for selection of the most similar and orthogonal columns, based on the application of limited number of test compounds as well as quantitative structure retention relationship models (QSRR), from among Snyder's hydrophobic-subtraction model (HSM) have been most extensively used.Chromatographic data of 67 compounds were evaluated using principal component analysis (PCA), hierarchical cluster analysis (HCA), non-parametric ranking methods as sum of ranking differences (SRD) and generalized pairwise correlation method (GPCM), both applied as a consensus driven comparison, and complemented by the comparison with one variable at a time (COVAT) approach. The aim was to compare the ability of the HSM approach and the approach based on primary retention data of test solutes (log. k values) to differentiate among ten highly similar C18 columns.The ranking (clustering) pattern of chromatographic columns based on primary retention data and HSM parameters gave different results in all instances. Patterns based on retention coefficients were in accordance with expectations based on columns' physicochemical parameters, while HSM parameters provided a different clustering.Similarity indices calculated from the following dissimilarity measures: SRD, GPCM Fisher's conditional exact probability weighted (CEPW) scores; Euclidian, Manhattan, Chebyshev, and cosine distances; Pearson's, Spearman's, and Kendall's, correlation coefficients have been ranked by the consensus based SRD. Analysis of variance confirmed that the HSM model produced statistically significant increases of SRD values for the majority of similarity indices, i.e. HS transformation of original retention data yields significant loss of information, and finally results in lower performance of HSM methodology. The best similarity measures were obtained using primary retention data, and derived from Kendal's and Spearman's correlation coefficients, as well as GPCM and SRD score values. Selectivity function, Fs, originally proposed by Snyder, demonstrated moderate performance. © 2017 Elsevier B.V.

Ostojic S.M.,University of Novi Sad | Ostojic S.M.,University of Belgrade
Theranostics | Year: 2017

More than 400 original articles have been published from 2007 onwards evaluating therapeutic potential of molecular hydrogen (H2), the youngest member of medical gases family with selective anti-oxidative properties. However, recent studies suggest that H2 may tackle other mitochondrial processes besides oxidative stress, including metabolic pathways that drive cellular energy. © Ivyspring International Publisher.

Batos B.,Institute of Forestry | Miljkovic D.,University of Belgrade
Archives of Biological Sciences | Year: 2017

The variability of viability (germination rate and the length of pollen tubes) of fresh pedunculate oak (Quercus robur L.) pollen grains was studied in vitro on a medium containing 15% sucrose. Spatial variability was studied by sampling fresh pollen grains from a total of thirteen trees at four different sites in the area of Belgrade (Košutnjak, Banovo Brdo, Ada Ciganlija and Bojcin Forest) in a single year (2011). In order to assess temporal variability and determine the effects of climate change on a small time scale, we studied the viability of the pollen grains collected from one tree at the Banovo Brdo site in six different years (2004, 2005, 2006, 2007, 2011 and 2012). Interindividual variability was tested on the pollen grains sampled from eight trees at Ada Ciganlija in 2004. The percentage values of the pollen grain germination rate and the pollen tube length showed no statistically significant differences between the sites. However, the studied characteristics of the pollen grain viability (germination rate and pollen tube length) showed statistically significant differences in both temporal (between the pollen collection years) and interindividual variability. This type of research makes a valuable contribution to pedunculate oak breeding programs through the identification of trees with stable production and a good quality of pollen. Furthermore, it can be important in defining the patterns of spatial, temporal and individual variability of pollen grain viability under the influence of climate factors, which are showing compelling changing trends from year to year. © 2017 by the Serbian Biological Society.

Fotev V.G.,University of Belgrade | Dinulovic M.,University of Belgrade
FME Transactions | Year: 2017

This paper presents performed 3D CFD simulation of burner start-up and finding the maximal temperature difference through mantle thickness which induces maximal thermal stress. The process is unsteady, beginning from the mantle room temperature and ending with its steady state condition. The behavior of burner is simulated for minimal thermal power, i.e., for critical conditions from the mantle temperature standpoint. © 2017, Faculty of Mechanical Engineering, Belgrade.

Zivanovic S.T.,University of Belgrade | Vasilic G.V.,University of Belgrade
FME Transactions | Year: 2017

A new programmnig method of CNC Machine tools, which is developing as an alternative to G code, is AP238 protocol or STEP-NC, according to ISO 10303 standard. In this paper, a comparation between classical (G code) and new way of programming (STEP-NC ) is given. A structure of ecquipment needed for new programming metod, program structure and current scenario for imlementation of STEP-NC are shown. Verification of the above scenarios using the STEP-NC, is realized through three examples. © 2017, Faculty of Mechanical Engineering, Belgrade.

Backalov I.,University of Belgrade | Rudakovic S.,University of Belgrade
FME Transactions | Year: 2017

Freeboard assignment for seagoing vessels is carried out according to the deterministic provisions of the International Convention on Load Lines. In present investigation, however, an attempt is made to evaluate the influence of freeboard on the dynamic stability of ships in storms using a probabilistic approach. The probability of a stability failure of a small multipurpose cargo ship exposed to irregular beam waves and stochastic beam wind is estimated in a series of numerical experiments, whereby the freeboard of the exafmined vessel is systematically varied. The effect of freeboard is quantified in terms of a range of metacentric heights ensuring sufficient stability from the probabilistic point of view. The paper presents a step towards a procedure that could enable a better balance of safety and cost-efficiency in the ship design framework. © 2017, Faculty of Mechanical Engineering, Belgrade.

Stevanovic I.,University of Belgrade | Rasuo B.,University of Belgrade
FME Transactions | Year: 2017

The paper explains the fundamentals of bionics. Using the basic principles of bionics, an analysis was made of the movement of legged biological systems on the basis of laboratory observations and measurements, in which they studied the movement of biological systems moving with the help of its legs. Then the 3D model of the robot is designed inspired with insects with six legs and using two of the four basic principles of movement with the help of legs. 3D model was created with the of Solidworks software package. A mathematical model with Matlab Simulink - SimMechanic Software. Using modern software tools like Solidworks and Matlab Simulink a mathematical analysis of its mechanism for movement in a 3D environment is performed. It is shown that the Bionics with the help of modern software engineering can be a powerful tool, but to get complete results it is necessary to apply all the principles that is obtained by the analysis. © 2017, Faculty of Mechanical Engineering, Belgrade.

Jovanovic R.Z.,University of Belgrade | Sretenovic A.A.,University of Belgrade
FME Transactions | Year: 2017

For the prediction of heating energy consumption of university campus, neural network ensemble is proposed. Actual measured data are used for training and testing the models. Improvement of the predicton accuracy using k-means clustering for creating subsets used to train individual radial basis function neural networks is examined. Number of clusters is varying from 2 to 5. The outputs of ensemble members are aggregated using simple, weighted and median based averaging. It is shown that ensembles achieve better prediction results than the individual network. © 2017, Faculty of Mechanical Engineering, Belgrade.

Peco-Antic A.,University of Belgrade
Srpski Arhiv za Celokupno Lekarstvo | Year: 2016

The hemolytic–uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI). The major cause of HUS in childhood (>90%) is infection with verocytotoxin (Shiga-like toxin – “Stx”)-producing bacteria, usually enterohemorrhagic Escherichia coli (VTEC/STEC). The infection may be transmitted by the consumption of undercooked meat, pasteurized dairy products, contaminated vegetables, fruits and water, or by contact with STEC diarrhea. After an incubation period of three to eight days, patients commonly develop bloody diarrhea followed in 5–22% by HUS that may be complicated by central nervous system, pancreatic, skeletal, and myocardial involvement. HUS is one of the main causes of AKI in children in Europe. The management of HUS includes the usual treatment of children with AKI. Transfusion with packed red blood cells is needed in case of a severe anemia, while platelet transfusions are limited to the need for a surgical procedure or in active bleeding. Currently, there is no consensus on the use of antibiotic therapy. Treatment with plasma and/or plasma exchange has not been proven beneficial in STEC-HUS. Eculizumab has been used for the treatment of STEC-HUS, but the value of this treatment remains to be determined. The mortality of HUS is reported to be 3–5%. About 12% of patients will progress to end-stage renal failure within four years and about 25% will have long-term complications, including hypertension, proteinuria, renal insufficiency, and insulin-dependent diabetes mellitus. Transplantation can be performed without increased risk for the recurrence of the disease. ©2016, Serbia Medical Society. All rights reserved.

Sosic D.,University of Belgrade | Stefanov P.,University of Belgrade
IET Conference Publications | Year: 2016

Feeder reconfiguration is defined as altering the topological structures of distribution feeders by changing the open/closed states of the sectionalizing and tie switches. One of the main goals of the reconfiguration of the distribution network is to reduce active power losses. This is a complex combinatorial optimization problem because there are multiple constraints, which must not be violated while finding an optimal or near-optimal solution to the distribution network reconfiguration problem. In order to avoid time-consuming optimization in this paper heuristic approach will be used for solving reconfiguration. The selection of tie switch that will open depends on the voltage difference at its ends. This can result in finding local minima, but the process of obtaining results is significantly faster. The proposed algorithm will be tested on modified IEEE 123-bus three phase unbalanced distribution system. Due to the adopted modifications backup supply of consumers were enabled. In order to maintain the radial network condition two switches are added to the feeder halves. This change enables formation of radial network regardless of the choice of supply nodes. Only by using an unbalanced three-phase model of network elements is possible to get the exact configuration of the distribution network that has a minimum losses. In addition to active power losses reduction, there is a reduction of the voltage unbalance as a result of reconfiguration.

Tripkovic B.,University of Belgrade | Penezic K.,University of Belgrade
Quaternary International | Year: 2017

The end of Neolithic is in western Serbia marked with a specific type of sites not known in other parts of the central Balkan area. These are small tell-like mounds, usually up to 50 m in diameter, called Obrovac-type settlements (meaning – surrounded by a ditch) according to the toponyms of some of them. The main argument in previous interpretations concerning the origin and function of the mounds was the necessity for local inhabitants to adapt to marshy and floodplain environment of the Mačva region (western Serbia). Therefore, the aim of this paper is to use the results of the recently conducted geoarchaeological coring in carefully selected locations on- and off-the sites to obtain a preliminary picture of the palaeoenvironment of western and north-western Serbia as well as to explore the implications for the formation of these enigmatic settlements. We first provide an overview of the geographical and pedological history of the region; this is followed by a detailed description of the research aims and methods. Finally, we present and discuss the results of geoarchaeological coring at six selected Obrovac-type sites. © 2015 Elsevier Ltd and INQUA

Kotur D.,University of Belgrade | Rajakovic N.,University of Belgrade
IET Conference Publications | Year: 2016

Reconfiguration is one of the main applications for the reduction of power losses in the distribution system. By determining the optimal topology of the distribution network, it is possible to provide the electricity to all consumers with minimal power losses. With the advent of distributed and renewable energy sources, in addition to the local production of active power it is possible to get the local production of reactive power with the help of power electronics devices. Such nodes are called prosumer nodes. By controlling the reactive power flow in the distribution network it is possible further to reduce active power losses. In this paper, an analysis of the optimal reconfiguration of distribution networks in the presence of prosumer nodes is carried out. The goal of the paper is to develop a methodology by which it is possible to determine the optimal reconfiguration of the distribution network, as well as the optimal values of generating reactive power of prosumers nodes. The results obtained in this paper indicate that the combination of these two techniques can significantly reduce losses in the distribution network.

Zarkovic M.,University of Belgrade | Sosic D.,University of Belgrade
IET Conference Publications | Year: 2016

In this paper, the use of artificial neural networks (ANN) is proposed for solving the impact of distributed generation (DG) on electric power systems (EPS). Developed models of ANN evaluate the steady state of EPS and are a fundamental for planning, operation and control of modern power systems with DG. The mathematical model of the harmonic power flow comprises a set of non-linear algebraic equations traditionally solved with some iteration method. Variable consumption in the system and variable production of DG must be taken into account of power flow. In order to take into account this fact, we used a Monte Carlo simulation (MCS) to create different situations in the EPS. Using MCS we got a database that is essential for the creation of ANN. Outputs of our database are impacts of DG: active power losses, voltage drops, maximum of voltage drops and total harmonic distortion (THD). The proposed ANN methodology has been successfully tested using the IEEE-33 bus system without DG. Then the same system with DG in different nodes is used for testing created ANN models.

Stojkovic J.,University of Belgrade | Rajakovic N.,University of Belgrade
IET Conference Publications | Year: 2016

The aim of this paper is to analyze the potential of demand response as one of the participants in the frequency control. Thermostatically controlled refrigerator model along with control algorithm that modifies its consumption is described in this paper. The algorithm allows a controlled reduction or increase of the aggregated active power consumption of a large set of refrigerators by changing bounds temperatures that depend on frequency deviation as well as the speed of frequency deviation. With this methodology, aggregated group of refrigerators acts like a virtual distributed energy storage providing the frequency reserve that depends on the size of deviation as well as the speed of deviation. This approach is very simple and it does not violate the user comfort. Refrigerator model along with control algorithm is implemented in DIgSILENT software and it is validated on Serbian power system during characteristic disturbances in the power network. The impact of demand response is quantified by comparative analysis when the thermostatic devices participate and don't participate in frequency control. Simulation results have shown that developed demand response model can provide a reliable reserve for frequency control.

Dokic S.,University of Belgrade | Ratkovic Z.,PE Srbijagas
IET Conference Publications | Year: 2016

Unplanned and abrupt disconnections of high-power gas plants from the Electricity Transmission System (ETS) poses a problem for network balancing and may disrupt the operation of ETS, due to the incapacity to duly respond and provide sufficient volumes of energy reserve to meet the consumption. With a view to improving the performance of gas power plants and achieving a greater reliability of ETS, the solution to this problem lies in the installation of sensors that will monitor the gas pipeline's working parameters (pressure, temperature and flow rate) at multiple points, control elements (block valves), and in equipping of gas pipeline installations in the gas power plant with intelligent instrumentation. Signals from these devices are sent to the dispatch centre of the ETS Operator, where the management software identify alarming conditions, monitors and calculates the gas parameters in the pipeline and at gas turbine inlet, as well as monitor electrical parameters in plant. Using simulation software Operator can simulate behaviour of plant and output value according to change of input variable. This allows for a continual monitoring of the gas power plant's and gas pipeline installations' performance.

Rajic T.,University of Belgrade | Stojanovic Z.,University of Belgrade
IET Conference Publications | Year: 2016

This paper explains the algorithm for the longitudinal differential protection of transmission lines. In case of current transformer saturation, conventional stabilization is insufficient for avoiding an unnecessary protection tripping. Such a problem may occur due to a fault outside the protected zone of the transmission line. In such cases, additional stabilization ought to be implemented as well. The paper presents simulations of various potential faults, and offers a comparison of relay operation with and without additional stabilization.

Krstivojevic J.,University of Belgrade | Djuric M.,University of Belgrade
IET Conference Publications | Year: 2016

A new algorithm for avoiding maloperation of transformer differential protection during external faults caused by current transformer (CT) saturation is presented. The algorithm is based on the time-domain phase comparison of the primary and secondary currents of power transformer (PT). The algorithm serves for identification of faults which occurred outside the protected zone. The presented algorithm could be used as an additional criterion for operation of transformer differential protection. Its application would greatly improve the correct operation of differential protection and so increase its security. The required input signals for testing the algorithm have been generated by computer simulations. The paper presents the algorithm and results of the performed tests.

Rakovic D.,University of Belgrade
2016 13th Symposium on Neural Networks and Applications, NEUREL 2016 | Year: 2016

The subject of this paper is quantum-informational Hopfield-like holographic framework for integrative medicine and transpersonal psychology, and the related bioresonant electromagnetic patterns-qua-attractors and healing boundary conditions. In the focus of their holistic methods are body's acupuncture system and consciousness, with underlying bioresonant electromagnetic patterns-qua-attractors and healing boundary conditions. The presented quantum-holographic framework for psychosomatics might have significant holistic implications, providing better understanding of the nature of psychosomatic diseases. © 2016 IEEE.

Jankovic B.,University of Belgrade | Marinovic-Cincovic M.,Vinča Institute of Nuclear Sciences | Jankovic M.,Vinča Institute of Nuclear Sciences
Food Chemistry | Year: 2017

Kinetics of degradation for Aronia melanocarpa fresh fruits in argon and air atmospheres were investigated. The investigation was based on probability distributions of apparent activation energy of counterparts (εa). Isoconversional analysis results indicated that the degradation process in an inert atmosphere was governed by decomposition reactions of esterified compounds. Also, based on same kinetics approach, it was assumed that in an air atmosphere, the primary compound in degradation pathways could be anthocyanins, which undergo rapid chemical reactions. A new model of reactivity demonstrated that, under inert atmospheres, expectation values for εa occured at levels of statistical probability. These values corresponded to decomposition processes in which polyphenolic compounds might be involved. εa values obeyed laws of binomial distribution. It was established that, for thermo-oxidative degradation, Poisson distribution represented a very successful approximation for εa values where there was additional mechanistic complexity and the binomial distribution was no longer valid. © 2017 Elsevier Ltd

Krmar J.,University of Belgrade | Papic V.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

Recognition of humans based on characteristic eye features has taken a significant place in security and identification systems in the past two decades. The complex pattern of the iris, that is unique to an eye, makes iris a great biometric descriptor. The first step in the process of the biometric identification based on iris is its localization in an image. The shape of the iris, its size, position, shades from the light sources and eyelashes make this process difficult. It is reported that most failures to match in iris recognition system result from inaccurate segmentation. This paper will analyze statistical characteristics of iris texture with an attempt to improve the process of segmentation. © 2016 IEEE.

Ninkovic N.M.,University of Belgrade | Stojanovic M.D.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

Quality of Service (QoS) has held a pivotal role in achieving network performance, but recent advents of software defined networking (SDN), mobility and virtualization require that certain architectural modifications are considered. Domain boundaries are blurred by the fact that end-to-end (E2E) performance should be guaranteed within and beyond domain boundaries. Our work aims to address the limitations of the existing QoS architectures deployed within the domain and to propose solutions to overcome challenges associated with interdomain QoS delivery. We have thoroughly analyzed packet dispersion mechanism as a quality improvement methodology for QoS strict services, whereas our main focus of interdomain E2E performance relies on service class mapping between domains. In the context of class mapping, our work has yielded two mapping algorithms with superior performance in comparison to the existent algorithm. Furthermore, implementation aspect of the proposed algorithms has been considered as a part of third party (3P) service negotiation model, a promising approach to interdomain QoS delivery. © 2016 IEEE.

Perovic J.,University of Belgrade | Olcan D.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

We present an approximation formula and numerical results for the excess attenuation of electric field of a wave propagating within deciduous forest. The formula is tuned to fit averaged attenuation obtained by full-wave simulations of stochastic 3D and 2D models of forests. The electric field was either vertically or horizontally polarized, at frequencies 30 MHz, 60 MHz and 100 MHz. The formula predicts the excess attenuation within several decibels, up to at least 100 MHz. © 2016 IEEE.

Rakas S.V.B.,University of Belgrade | Stojanovic M.D.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

In this paper, we propose a policy-based model to achieve end-to-end (E2E) service negotiation among multiple domains that constitute E2E path. The model relies on a centralized approach, realized via the third party (3P) agent, which acts as a proxy server for local (per-domain) management entities. We demonstrate the proposed model on the implementation of policies for allocation of performance impairment budgets among domains, and present the appropriate software design. © 2016 IEEE.

Savic S.V.,University of Belgrade | Ilic M.M.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

A summery review of several topics in higher order computational electromagnetic (CEM) are presented. First, constant speed parametrization (CSP) mapping between the parent and the final computational domain is presented. Next, we construct, numerically model, and analyze transformation-based metamaterial invisibility cloaks. These cloaks are continuously inhomogeneous and anisotropic. Finally, we nonrigorously implement symmetric second-order absorbing boundary condition (ABC) coupled with higher order curl-conforming basis functions and curved finite elements. We point out the differences that exist when the second-order ABC is used in low-and high-order CEM. Each topic is covered by at least one numerical example. © 2016 IEEE.

Cica Z.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

In modern communication networks, the security aspect is very important. Encryption algorithms are used to protect user communication from eavesdropping. Symmetric key algorithms must be used to achieve high speed secured communication. In this paper, we propose and evaluate the pipelined implementation of the Camellia encryption algorithm which has been approved for use by the ISO/IEC. Camellia algorithm achieves the same level of security as the AES while having similar hardware complexity. © 2016 IEEE.

Zekovic A.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

In this paper, 3D video formats: Frame Compatible (FC) side-by-side (SBS) representation format, Frame Sequential (FS) format, and multiview (MV) video format are analyzed, using the publicly available long frame size video traces. Given the complexity of these signals multifractal analysis is chosen and performed using the method of moments and the histogram method. Results of the analyses show the highest complexity of the structure in the case of MV 3D video, while the lowest for the FS video. Additionally, different streaming approaches of the video are analyzed showing lower complexity of the structure in these cases. © 2016 IEEE.

Batanovic V.,University of Belgrade | Nikolic B.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

Sentiment classification of texts written in Serbian is still an under-researched topic. One of the open issues is how the different forms of morphological normalization affect the performances of different sentiment classifiers and which normalization procedure is optimal for this task. In this paper we assess and compare the impact of lemmatizers and stemmers for Serbian on classifiers trained and evaluated on the Serbian Movie Review Dataset. © 2016 IEEE.

Radak Z.,Serbia Broadband Srpske Kablovske Mreze | Dogatovic V.R.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

In this paper we point out the possibility of establishing a flexible charging of phone services towards the needs of business customers. This research describes the specific case of two business customers who are ready to change their charging options with aim to achieve savings. Also, it presents comparative analysis of the costs generated with the current and a new charging option. Cost analysis is not as important as it is important to emphasize the existence of mechanisms for adapting rigid system of charges. © 2016 IEEE.

Durkovic S.,University of Belgrade | Cica Z.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

Load balanced Birkhoff-von Neumann (BvN) switches are very popular due to low hardware complexity and high performance. But, for some traffic scenarios, the achieved throughput can be severely decreased. We propose a novel load balanced BvN based switch that is non-blocking (achieves 100% throughput) for any admissible traffic scenario. The proposed switch implements only one switch stage because the deflection mechanism is used. The delay and buffer bounds are analyzed using the network calculus theory. © 2016 IEEE.

Radosavljevic Z.,University of Belgrade | Kovacevic B.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

The Integrated Track Splitting (ITS) filter is a method for automatic target tracking in clutter. The ITS filter models each track as a set of components, where each component is defined with a unique measurement history which consists of zero or one measurement received each scan. Regarding to clutter density and tracking parameters, a component merging is used for the reason of computational complexity reducing. For each component the state estimate and the a-posteriori probability of component existence are computed recursively. The probability of the new component existence is the probability that the parent component exists and that the measurement used to create the new component is the target measurement. The probability of target existence, mean and covariance of the state estimate for the track are then calculated and used for track maintenance and track output. Using an extensive Monte Carlo simulation, the various parameters (probability of track elimination and confirmation, probability of detection) are changed to obtain the optimal depth of component merging history (CMH), numbers of confirmed false track or lost tracks that each produces. The article is having a practical contribution while approve which depth of CMH is needed for the specific tracking situation. © 2016 IEEE.

Miletic M.F.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

This paper presents results for numerical analysis of three electrostatic problems by using four MoM (method of moments) formulations while exploiting the rotational symmetry of the analyzed structures. These results are mutually compared, but also compared to the results obtained by the electrostatic solver where rotational symmetry is not considered. It is observed that exploiting the rotational symmetry reduces the number of unknowns needed for the analysis. © 2016 IEEE.

Bobic V.,University of Belgrade | Graovac S.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

In this paper, eye tracking methodology is presented. It is a commercial camera based system for detection of eye pupil, its trajectory and classification of eye movements that led to the formation of assessed eye path. Methodology was examined on 10 subjects, who performed specified series of eye movements. Video frames were segmented and coordinates of eye pupil were found. Modified velocity threshold method for classification of eye movements was performed, achieving accuracy of 96.25%. © 2016 IEEE.

Celebonovic V.,University of Belgrade
Journal of Physics: Conference Series | Year: 2017

John Hubbard proposed "his model" (HM) nearly sixty years ago, and one could be tempted to expect that everything (or almost so) about it is well known. Quite to the contrary, the HM is still arising interest and its applicability seems to be rising. The aim of this paper is to discuss several examples of new or already existing but improved results concerning the 2D HM and its applicability to nanomaterials. The following issues will be discussed: increasing the number of terms in various expressions used in calculating the conductivity; introducing the strain in these expressions ( which is important for experiments under high pressure); defining the pressure in a 2D system and calculating the reflectivity but taking into account the imaginary part of the conductivity. © Published under licence by IOP Publishing Ltd.

Brodic D.,University of Belgrade | Amelio A.,University of Calabria
Measurement Science Review | Year: 2017

Human exposure to extremely low frequency magnetic field represents a risk to their health. This paper takes into consideration the level of an extremely low-frequency magnetic field between 30 and 300 Hz emitted by an AC laptop adapter. The experiment consists of testing 17 different AC adapters for laptops. During the testing, laptops are operated in a normal operating conditions as well as under heavy load. The magnetic field measurement is conducted in the area around the AC adapter. Obtained data is evaluated according to the critical level of the magnetic field proposed by safety standards. Furthermore, data is classified by a K-medians method in order to determine the critical levels of the magnetic field exposure in the nearby area of the AC adapter. Obtained classifications are evaluated according to safety standards, giving a critical analysis of magnetic field areas at risk. Due to emission of a very strong magnetic field in certain areas, a recommendation for safety use of the AC adapter is proposed. © 2017 Darko Brodić et al., published by De Gruyter Open.

Cirkovic P.,University of Belgrade
EPJ Web of Conferences | Year: 2017

The latest results of searches for the standard model Higgs boson produced in association with a top quark-antiquark pair (tt H), where Higgs decays into photons, bottom quark-antiquark pair or leptons via WW, ZZ and ττ are presented. The analyses have been performed using the 13 TeV pp collisions data recorded by the CMS experiment in 2015 and part of 2016. The results are presented in the form of the best fit to the signal strength (μ = σ/σSM) measured with respect to the Standard Model prediction and its expected and observed 95% CL upper limits. © The Authors, published by EDP Sciences, 2017.

Batas-Bjelic I.,University of Belgrade | Rajakovic N.,University of Belgrade
IET Conference Publications | Year: 2016

The incidence of catastrophic events like Southeastern Europe Floods 2014 and other extreme weather conditions may be increased in future which, as consequence, demand more resilient smart municipal energy grids. The decentralized multi-energy smart systems with islanding capability that has significant advantages in critical events may be modelled with Hybrid Optimization of Multiple Energy Resources (HOMER) simulation tool. In this paper the results obtained by employing the HOMER simulation tool are presented with the techno-economic feasibility study of a resilient and not resilient smart municipal energy grid, with a case study with nine (9) scenarios for one community in Republic of Serbia, to show economic effects on: (a) levelized costs of energy, (b) net national grid purchases, (c) total net present costs and reliability effects on: d) investment costs for the targeted reliability level, (e) operational payments due to shortages of supply, and (f) net present cost of the critical infrastructure load resulting from these precaution measures. In the conclusion the pathway from present national grid to more resilient multi-energy system, based on locally available renewable energy sources and responsive demand has been shown.

Novakovic N.,University of Belgrade
Journal of Craniofacial Surgery | Year: 2017

BACKGROUND:: Having in mind the importance of reconstruction of the calvaria, our goal was to compare the complication rates following the use of autologous bone and methylmethacrilate grafts, and explain the factors influencing them. METHODS:: The authors collected information of all the patients undergoing cranial reconstructive surgery (N?=?149) at the Military Medical Academy in Belgrade. Procedures were performed either using a craniotomy bone flap, removed and replaced in the same act, or using methylmethacrilate. These 2 groups were compared using the Chi-squared test, controlling for the confounding influence of the size of the defect. RESULTS:: Intracranial neoplasms were the cause for the reconstruction in 71.1% of patients. The total complication rate was 7.4%, while the infection rate was 5.4%. The infection rate was significantly higher in those procedures done using methylmethacrilate (11.3% compared with 2.1%, P?=?0.017), but when controlling for the confounding effect of the size of the defect treated, the difference in infection rate was significant only in large defects (13.9% compared with 2%, P?=?0.031), while for small defects the difference was not statistically significant. CONCLUSIONS:: Our study suggests that the material used for reconstruction of calvaria influences the infection rate only in large and complicated defects. Considering the importance of the reconstruction, further studies should explore and confirm the role of material type on the rate of complications. © 2017 by Mutaz B. Habal, MD.

Pajevic T.,University of Belgrade | Glisic B.,University of Belgrade
Archives of Oral Biology | Year: 2017

Objective Anthropological studies have reported that tooth size decreases in the context of diet changes. Some investigations have found a reverse trend in tooth size from the prehistoric to the modern times. The aims of this study were to analyze tooth size in skeletal samples from Mesolithic–Neolithic Age, Bronze Age, and Roman to Medieval times to determine sex differences and establish a temporal trend in tooth size in the aforementioned periods. Design Well-preserved permanent teeth were included in the investigation. The mesiodistal (MD) diameter of all teeth and buccolingual (BL) diameter of the molars were measured. Effects of sex and site were tested by one-way ANOVA, and the combined effect of these factors was analyzed by UNIANOVA. Results Sexual dimorphism was present in the BL diameters of all molars and MD diameters of the upper first and the lower third molar. The lower canine was the most dimorphic tooth in the anterior region. The MD diameter of most teeth showed no significant difference between the groups, (sample from: Mesolithic–Neolithic Age-group 1; Bronze Age-group 2; Roman times-group 3; Medieval times-group 4), whereas the BL diameters of the upper second and the lower first molar were the largest in the first group. Multiple comparisons revealed a decrease in the BL diameter of the upper second and the lower first molar from the first to the later groups. Lower canine MD diameter exhibited an increase in the fourth group compared to the second group. Conclusion On the basis of the MD diameter, a temporal trend could not be observed for most of the teeth. The lower canine exhibited an increase in the MD diameter from the prehistoric to the Medieval times. Changes of BL diameter were more homogeneous, suggesting that the temporal trend of molar size decreased from the Mesolithic–Neolithic to Medieval times in Serbia. © 2017

Marcikic I.J.,University of Belgrade | Paunovic M.V.,University of Belgrade
FME Transactions | Year: 2017

In a special way, "Cézanne's wedge" allows the model of inverse perspective to be used for the representation of space and objects in painting. As a bridge between the ancient style of "dividing" construction and Renaissance perspective, inverse perspective as an important projection model, due to the fact that it represents an object with the minimum of hidden parts, compared to representation in any other system of projection. The optical-physiological properties of the optic apparatus, the fact that we perceive space from two points, inverse perspective, which implies a multiocular view with many binocular pairs of points, are close to natural vision. Popular-culture's need for the sensation of 3D space in a picture separates artistic creativity from the individual expression of the artist, his intuitive geometry and its spirit of revised reality, which are important characteristics of every masterpiece. This paper analyses the inverse perspective and its effects in the representation of space in Cézanne's paintings. © Faculty of Mechanical Engineering, Belgrade. All rights reserved.

Nikolic B.,University of Belgrade | Sazdovic B.,University of Belgrade
European Physical Journal C | Year: 2017

In this article we offer a new interpretation of the T-dualization procedure of type II superstring theory in the double space framework. We use the ghost free action of type II superstring in pure spinor formulation in approximation of constant background fields up to the quadratic terms. T-dualization along any subset of the initial coordinates, xa, is equivalent to the permutation of this subset with subset of the corresponding T-dual coordinates, ya, in double space coordinate ZM= (xμ, yμ). Requiring that the T-dual transformation law after the exchange xa↔ ya has the same form as the initial one, we obtain the T-dual NS–NS and NS–R background fields. The T-dual R–R field strength is determined up to one arbitrary constant under some assumptions. The compatibility between supersymmetry and T-duality produces a change of bar spinors and R–R field strength. If we dualize an odd number of dimensions xa, such a change flips type IIA/B to type II B/A. If we T-dualize the time-like direction, one imaginary unit i maps type II superstring theories to type II ⋆ ones. © 2017, The Author(s).

Ignjatovic I.S.,University of Belgrade | Marinkovic S.B.,University of Belgrade | Tosic N.,University of Belgrade
Engineering Structures | Year: 2017

An experimental study of the shear behaviour of recycled aggregate concrete (RAC) beams with and without shear reinforcement is presented. Nine full-scale simply supported beams were loaded in four-point bending tests until failure. Three different replacement ratios of coarse natural with coarse recycled concrete aggregate (0%, 50% and 100%), and three different shear reinforcement ratios (0%, 0.14% and 0.19%) were the main parameters. All natural aggregate concretes (NAC) and recycled aggregate concretes (RAC) were designed and experimentally verified to have similar compressive strength and workability. It was found that the shear behaviour and the shear strength of the beams with 50% and 100% of recycled concrete aggregate were very similar to that of the corresponding natural aggregate concrete beams. The applicability of different code provisions for shear strength predictions of the RAC beams with and without shear reinforcement was tested by comparison with test results obtained on 85 beams, 58 RAC and 27 corresponding NAC beams. The shear strength of RAC50 and RAC100 beams with and without shear reinforcement was conservatively predicted by the analyzed codes with similar reliability as for the corresponding NAC beams shear strength. At this state-of-knowledge, the application of the analyzed codes’ provisions for NAC beams shear strength can be recommended both for the RAC50 and the RAC100 beams. © 2017

Peric S.,University of Belgrade
European Journal of Human Genetics | Year: 2017

Variants in the TTN gene have been associated with distal myopathies and other distinctive phenotypes involving skeletal and cardiac muscle. Through whole-exome sequencing we identified a novel stop-gain variant (c.107635C>T, p.(Gln35879Ter)) in the TTN gene, coding a part of the M-line of titin, in 14 patients with autosomal recessive distal myopathy and Serbian ancestry. All patients share a common 1 Mb core haplotype associated with c.107635C>T, suggesting a founder variant. In compound heterozygotes, nine other TTN variants were identified: four stop-gain, three frameshift, one missense and one splice donor variant. Patients homozygous for the common variant did not show significant clinical differences to the compound heterozygous patients. The clinical presentation of all patients was an adult onset distal myopathy with predominant lower limb involvement. In addition, most patients had normal to mildly elevated serum creatine kinase levels, myopathic electromyograms, normal cardiologic and respiratory tests and muscle pathology consistent with a dystrophic process. In this study, we describe a distinct phenotype for patients with distal myopathy associated with novel recessive TTN variants including a Serbian founder variant. Our results expand the phenotypic and genetic spectrum of titinopathies and will facilitate the diagnosis of this condition in patients of Serbian origin.European Journal of Human Genetics advance online publication, 15 March 2017; doi:10.1038/ejhg.2017.16. © 2017 Macmillan Publishers Limited, part of Springer Nature.

Bojkovic Z.,University of Belgrade | Milovanovic D.,University of Belgrade
Lecture Notes in Electrical Engineering | Year: 2017

5G is now the next generation of wireless communication systems. The general demonstration of one technology vision for fifth generation mobile networks is presented in this work. The vision of 5G technology provides guidance for the definition of requirements, architecture, and other aspects. By expanding the performances limits of mobile networks, it is necessary for the 5G to include a flexible designing which can optimize network utilization with large range of examples for partnership and business models. The 5G should include flexibility to optimize the network usage by design. Modular network functions with the ability of on demand deployment and scaling capabilities need to be included in the architecture. The purpose of this inclusion would be to handle the accommodation of various demands in a cost-effective and agile manner. Direct communication in D2D services is one of the new 5G networks characteristics. Advanced technologies such as massive MIMO and millimeter-wave radio systems have significant impact on design of cellular architecture. It is crucial for 5G technology to maintain a massive traffic volume owing to increase efficiency of radio link and density of cells. Also, it is necessary for the network to be transformed in a cloud architecture, which coordinates radio resources of multi-radio access, and inter-cell interference during network deployment. Research trends in 5G tell us that using an aggregation of technologies, it is possible to realize numerous goals. Our use case study for the perspective period post-2020 shows extremely broad variety of applications and their attributes performance. © Springer International Publishing AG 2017.

Matijevic D.V.,University of Belgrade | Popovic V.M.,University of Belgrade
FME Transactions | Year: 2017

This paper presents certain considerations related to noise, vibration and harshness issues on modern motor vehicles. The first, practical aspect was used toward structuring of the acquired knowledge and relationships, required for proper problem diagnosis. On the other hand, advanced signal analyses are considered. The influence on human body is processed and certain noise and vibration analyzers are presented. This synergy of scientific and applicative approach represents a basis for further research related to this important automotive branch. © Faculty of Mechanical Engineering, Belgrade. All rights reserved.

Punt M.M.,University of Belgrade
24th Telecommunications Forum, TELFOR 2016 | Year: 2016

Applications developed in an integrated environment consisting of digital TV, mobile devices and internet can offer users novel human-computer interaction scenarios compared to the scenarios that a single device could offer. In this paper the SHARP development framework is presented. The framework allows efficient implementation of distributed systems in an integrated environment. The field of game development was chosen as the target domain to verify the benefits of the framework. Conclusions on how the users accepted the identified scenarios were made by examining the experience of test users interacting with the developed applications. The SHARP framework was verified by comparing size, complexity and responsiveness of the applications developed using the framework and without using the framework. © 2016 IEEE.

Rakic V.,University of Belgrade
Medicine, Health Care and Philosophy | Year: 2017

The question will be raised whether oxytocin can serve as an effective moral enhancer. Different types of moral enhancement will be addressed, one of them being compulsory moral enhancement. It will be argued that oxytocin cannot serve as an effective moral enhancer if its use is being made compulsory. Hence, compulsory administration of oxytocin does not result in genuine moral enhancement. In order to demonstrate this, a stipulation of the main potentially beneficial outcomes of using oxytocin as a moral enhancer will be offered, as well as a discussion of objections to the notion that oxytocin can be an effective moral enhancer. It will be concluded that mandatory administration of oxytocin is ineffective because of a combination of two reasons: (1) mandatory administration of oxytocin renders moral reflection practically superfluous; (2) without moral reflection the beneficial outcomes of the use of oxytocin do not outweigh its drawbacks to the degree that we could speak of effective moral enhancement. © 2017 Springer Science+Business Media Dordrecht

Kotur D.,University of Belgrade | urisic Z.,University of Belgrade
Renewable Energy | Year: 2017

The increase in installed capacity of renewable energy sources (RES) has a positive effect on the development of smart grids and demand side management (DSM). The reason for this is the intermittent nature of renewable energy, which is directly related to the problem of balancing the production and consumption of power within the power system. By using the DSM, the power consumption in the system comprising RES can be easier adjusted to the power production. The paper proposes an improved concept of DSM through the spatial and temporal DSM. The optimal spatial and temporal DSM aims at determining the power diagram of each individual load bus in order to achieve the optimal state in the whole system. The optimal state of the system can be quantified through the minimum daily energy losses or minimum daily operating costs. A mathematical definition of the optimal spatial and temporal DSM problem is presented as well as the algorithm for its solution. The proposed methodology has been tested by three test networks. The results confirm the overall system performance improvements that include: reduction of energy losses in the system, reduction of the operating costs and the increase of the voltage quality within the system. © 2017 Elsevier Ltd

Messina R.,University of Lorraine | Stankovic I.,University of Belgrade
Physica A: Statistical Mechanics and its Applications | Year: 2017

The assembly in two dimensions of spherical magnets in strong magnetic field is addressed theoretically. It is shown that the attraction and assembly of parallel magnetic chains is the result of a delicate interplay of dipole–dipole interactions and short ranged excluded volume correlations. Minimal energy structures are obtained by numerical optimization procedure as well as analytical considerations. For a small number of constitutive magnets Ntot≤26, a straight chain is found to be the ground state. In the regime of larger Ntot≥27, the magnets form two touching chains with equally long tails at both ends. We succeed to identify the transition from two to three touching chains at Ntot=129. Overall, this study sheds light on the mechanisms of the recently experimentally observed ribbon formation of superparamagnetic colloids via lateral aggregation of magnetic chains in magnetic field (Darras et al., 2016). © 2016 Elsevier B.V.

Geschke R.H.,Stellenbosch University | Jokanovic B.,University of Belgrade | Meyer P.,Stellenbosch University
IEEE Transactions on Microwave Theory and Techniques | Year: 2011

A configuration of composite resonators consisting of three split-ring resonators is proposed to obtain a triple-band response with two transmission zeros between the passbands. Two new topologies are presented to design triple-band filters with controllable responses. A systematic filter design approach is presented based on a filter coupling model. The model is established to enable triple-band filter design with controlled passbands. Two methods are proposed and compared for the extraction of filter parameters. Coupling between nonadjacent elements is considered in the model and shown to have a significant effect. By changing the orientation of the coupled composite resonators, it is possible to introduce additional transmission zeros. Two sixth-order filter examples illustrate the use of the coupling model with the filter design approach to design filters with specified responses. The limitations of this filter topology are discussed. © 2006 IEEE.

Potpara T.S.,University of Belgrade | Lip G.Y.H.,University of Birmingham
International Journal of Clinical Practice | Year: 2014

Atrial fibrillation (AF) sometimes develops in younger individuals without any evident cardiac or other disease. To refer to these patients who were considered to have a very favourable prognosis compared with other AF patients, the term 'lone' AF was introduced in 1953. However, there are numerous uncertainties associated with 'lone' AF, including inconsistent entity definitions, considerable variations in the reported prevalence and outcomes, etc. Indeed, increasing evidence suggests a number of often subtle cardiac alterations associated with apparently 'lone' AF, which may have relevant prognostic implications. Hence, 'lone' AF patients comprise a rather heterogeneous cohort, and may have largely variable risk profiles based on the presence (or absence) of overlooked subclinical cardiovascular risk factors or genetically determined subtle alterations at the cellular or molecular level. Whether the implementation of various cardiac imaging techniques, biomarkers and genetic information could improve the prediction of risk for incident AF and risk assessment of 'lone' AF patients, and influence the treatment decisions needs further research. In this review, we summarise the current knowledge on 'lone' AF, highlight the existing inconsistencies in the field and discuss the prognostic and treatment implications of recent insights in 'lone' AF pathophysiology. © 2013 John Wiley & Sons Ltd.

Loncar N.,University of Belgrade | Fraaije M.W.,University of Groningen
Applied Microbiology and Biotechnology | Year: 2015

Catalases represent a class of enzymes which has found its place among industrially relevant biocatalysts due to their exceptional catalytic rate and high stability. Textile bleaching prior to the dyeing process is the main application and has been performed on a large scale for the past few decades. Their limited substrate scope has not prevented the development of various other catalase-based applications. Newly developed approaches continue to exploit their excellent catalytic potential to degrade hydrogen peroxide while (per)oxidase activity of catalases is opening a new range of possibilities as well. This review provides an overview of applications that involve heme-containing catalases that have been demonstrated in recent years. © 2015, Springer-Verlag Berlin Heidelberg.

Vidovic D.,Jaroslav Cerni Institute for the Development of Water Resources | Dimkic M.,Jaroslav Cerni Institute for the Development of Water Resources | Pusic M.,University of Belgrade
Journal of Computational Physics | Year: 2011

A non-linear finite volume method with monotone matrix for the diffusion equation is presented. It does not extrapolate the primary variable to Neumann boundaries, as this was previously done in similar methods. This change results in faster convergence. Computation time is significantly shortened further using the reduced rank extrapolation method (RRE), and imposing an upper limit on the number of linear iterations per non-linear step. Second-order accuracy and performance improvement are demonstrated by numerical examples. © 2011 Elsevier Inc.

Matauek M.R.,University of Belgrade
Journal of Process Control | Year: 2010

The proposed method for designing multivariable controller is based on ideal decoupler D(s) and PID controller optimization under constraints on the robustness and sensitivity to measurement noise. The high closed-loop system performance and robustness are obtained using the same controller in all loops. The method is effective despite the values and positions of the right half plane zeros and dead-times in the process transfer function matrix Gp(s). The validity of the proposed multivariable control system design and tuning method is confirmed using a test batch consisting of Two-Input Two-Output (TITO) stable, integrating and unstable processes, and one Three-Input Three-Output (TITO) stable process. © 2010 Elsevier Ltd. All rights reserved.

Antonijevic M.,University of Belgrade | Alagic S.,University of Belgrade
Environmental Science and Pollution Research | Year: 2013

The copper production in Bor (East Serbia) during the last 100 years presents an important source of the pollution of environment. Dust, waste waters, tailing, and air pollutants influence the quality of soil, water, and air. Over 2,000 ha of fertile soil have been damaged by the flotation tailing from Bor's facilities. The goal of the present work has been to determine the content of Pb, Cu, and Fe in wild plants (17 species) naturally growing in the damaged soil and in fodder crops (nine species) planted at the same place. The content of Pb, Cu, and Fe has been analyzed in damaged soil as well. This study has also searched for native (wild) and cultivated plants which are able to grow in contaminated soil in the area of the intense industrial activity of copper production in Bor, which means that they can accumulate and tolerate heavy metals in their above-ground tissues. It has been found out that the content of all metals in contaminated soil decreases considerably at the end of the experiment. As it has been expected, all plant species could accumulate investigated metals. All tested plants, both wild-growing and cultivated plants, seem to be quite healthy on the substrate which contained extremely high concentrations of copper. © 2012 Springer-Verlag.

Nesic A.D.,Institute IMTEL | Nesic D.A.,University of Belgrade
IEEE Antennas and Wireless Propagation Letters | Year: 2012

A new type of printed millimeter planar antenna with circular polarization for 60-GHz range is proposed. Radiation elements with two open tape rings are arranged in a two-dimensional 8 × 8 antenna array. Feeding is synphase network with tapered symmetrical (balanced) microstrip in the same plane as the radiation elements. The 8×8 array is fabricated in the conventional technology. To test reproducibility, three samples are fabricated. Measured $S 11 (VSWR), gain, and axial ratio (AR) are very good and in very good agreement between all three samples: AR <3 dB about 25% and gain near 20 dBi. © 2011 IEEE.

Potpara T.S.,University of Belgrade | Marinkovic J.M.,University of Belgrade | Prostran M.S.,University of Belgrade | Lip G.Y.H.,University of Birmingham
Circulation: Arrhythmia and Electrophysiology | Year: 2012

Background-The CHA 2DS 2-VASc (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke/transient ischemic attack [TIA], Vascular disease, Age 65-74 years, and Sex category [female gender]) schema recently has been introduced to complement the CHADS 2 (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, and previous stroke or TIA) score and improve the identification of atrial fibrillation (AF) patients at "truly low risk" for thromboembolism. We tested the predictive ability of the CHA 2DS 2-VASc, CHADS 2, and van Walraven risk stratification schemes in a cohort of "lone" AF patients with a 12-year follow-up. Methods and Results-We conducted a registry-based, observational cohort study of 345 patients initially diagnosed with "lone" AF between 1992 and 2007. At baseline, all patients had the CHADS 2 and van Walraven scores of 0, and 262 (75.9%) had a CHA 2DS 2-VASc score of 0. During follow-up (or within a year prior to stroke), 228 (66.1%), 234 (67.8%), and 150 patients (43.5%) retained the CHADS 2, van Walraven, and CHA 2DS 2-VASc scores of 0, respectively. The overall rate of ischemic stroke was 0.19 (95% CI: 0.18-0.20) per 100 patient years. In the multivariable analysis, only the CHA 2DS 2-VASc score of 0 was significantly related to the absence of stroke (odds ratio 5.1, 95% CI: 1.5-16.8, P=0.008). Only the CHA 2DS 2-VASc score had a significant prediction ability (c-statistic 0.72 [0.61- 0.84], P<0.031). Conclusions-The CHA 2DS 2-VASc score reliably identified the "lone" AF patients who were at "truly low risk" for thromboembolism, and was the only tested risk stratification scheme with a significant predictive ability for thromboembolism among lone AF patients. © 2012 American Heart Association, Inc.

Vukosavic S.N.,University of Belgrade
IET Electric Power Applications | Year: 2011

This study presents a novel algorithm for the induction motor torque control in field-weakening region. The proposed method insures maximum DC bus utilisation and extends the torque-speed curve up to the system limits. Controller is based on the stator voltage angle control. It provides full DC-link disturbance rejection and offers the torque response time sufficient for most applications. The algorithm is simple, without neither the outer flux loop nor the inner current loop. Dynamic response is preserved over wide speed range by means of gain-scheduling. Simulations and experiments prove an ease of implementation and the robustness of the proposed solution. This study comprises analytical considerations, simulation results, a detailed description of implementation steps and extensive experimental results. © The Institution of Engineering and Technology 2011.

Janevic T.,Yale University | Jankovic J.,University of Belgrade
International Journal of Public Health | Year: 2012

Objective: Roma experience high levels of discrimination and social exclusion. Our objective was to examine differences in self-rated health (SRH) between Roma and non-Roma in Serbia. Methods: Using data from the 2007 Living Standards Measurement Survey in Serbia (n = 14,313), we used binomial regression to estimate the relative risk (RR) of poor (SRH) among Roma (n = 267) relative to non-Roma. We additionally conducted group comparisons of combinations of Romani ethnicity, poverty, and gender, relative to the baseline group of non-Roma males not in poverty. Results: Adjusting for age, Roma were more than twice as likely as non-Roma to report poor SRH (RR = 2.3, 95% Confidence Interval (CI) = 1.8, 2.8). After adjustment for household consumption, employment, and education, the RR was reduced to 1.6 (95% CI = 1.3, 2.0). Romani women, regardless of whether they were living in poverty or not, experienced the greatest risk of poor SRH, with risks relative to non-Roma males not in poverty of 3.2 (95% CI = 2.3, 4.2) and 3.1 (95% CI = 2.4, 4.0), respectively. Conclusion: Roma in Serbia are at increased risk of poor SRH; Romani women experience the greatest burden of poor SRH. © 2011 Swiss School of Public Health.

Jovanovic R.,Qatar Environment and Energy Research Institute | Jovanovic R.,University of Belgrade | Voss S.,University of Hamburg
Computers and Industrial Engineering | Year: 2014

In the Blocks Relocation Problem (BRP) one is given a block retrieval sequence and is concerned with determining a relocation pattern minimizing the total number of moves required to enforce the given retrieval sequence. The importance of the BRP has been constantly growing in recent years, as a consequence of its close connection with the operations inside of a container terminal. Due to the complexity of the BRP, a large number of methods has been developed for finding near optimal solutions. These methods can be divided in two main categories greedy heuristics and more complex methods. The latter achieve results of higher quality, but at the cost of very long execution times. In many cases, this increased calculation time is not an option, and the fast heuristic methods need to be used. Greedy heuristic approaches, in general, apply the heuristic based only on the properties of the block that is being relocated and the current state of the bay. In this paper we propose a new heuristic approach in which when deciding where to relocate a block we also take into account the properties of the block that will be moved next. This idea is illustrated by improving the Min-Max heuristic for the BRP. We compare the new heuristic to several existing methods of this type, and show the effectiveness of our improvements. The tests have been conducted on a wide range of sizes of container bays, using standard test data sets. © 2014 Elsevier Ltd. All rights reserved.

Batas Bjelic I.,University of Belgrade
Renewable and Sustainable Energy Reviews | Year: 2014

With the Law on Energy and its acceptance by the Covenant of Mayors, local authorities in Serbia are obliged to prepare action plans for the development of distributed generation and energy efficiency measures aiming at reducing CO2 emissions. The development of distributed generation (wind, photovoltaic, hydro and combined heat and power plant) is an asset to the local authorities wishing to become energy independent microgrids that could relieve the national transmission grid in the way of reducing amount of electricity to be transported from centralized generation to the end-user. Using the simulation tool HOMER, an optimal configuration plan of the municipal microgrids for Serbia has been drawn, in order to obtain the lowest total net present costs during the planning period under various levels of CO2 reduction constraint. The increase of the end-user specific costs for energy has been quantified in a sensitivity analysis based on this constraint in the local authority microgrid. © 2014 Elsevier Ltd.

Kesic V.,University of Belgrade | Poljak M.,University of Ljubljana | Rogovskaya S.,Moscow Medical Academy
Cancer Epidemiology Biomarkers and Prevention | Year: 2012

Cervical cancer is an important public health care problem in Europe. The overall incidence rate of cervical cancer in Europe is 10.6 per 100,000. However, within Europe, the incidence rates significantly differ, being lower in Western Europe where prevention programs are better developed. Significantly higher are the incidence and mortality rates in Central and Eastern Europe, being in close correlation to the intensity of organized screening. Human papillomavirus (HPV) vaccines are being delivered to the low-incidence populations that already have extensive screening programs, whereas the high-incidence countries have not implemented the vaccination programs yet. The resolution of the problem of cervical cancer control in Europe will be a matter of the implementation of public health care programs across the whole continent. © 2012 AACR.

Patients with migraine with aura often experience a variety of visual and somatosensory phenomena and disturbances of higher cortical functions. Analysis of these alterations may provide important information about the involvement of different cortical regions in cortical spreading depression (CSD).We report five cases of migraineurs who experience unusually abundant clinical phenomena during auras. These patients were selected from a cohort of migraine with aura patients who were interviewed, using a specially designed questionnaire, to evaluate the presence of higher cortical dysfunctions. On the basis of the aura symptoms they reported, we attempted to infer the origin and the possible paths of CSD in each patient. According to their reported symptoms, CSD could begin in the primary visual cortex, in the primary somatosensory cortex or simultaneously in both, and propagate to the posterior parietal cortex, the temporal lobe and Broca’s area. We believe that clinical descriptions of aura could play an important role in further investigations of the pathophysiology of migraine. © 2014, CIC Edizioni Internazionali s.r.l., Inc. All rights reserved.

Jecmenica-Lukic M.,University of Belgrade | Poewe W.,University of Innsbruck | Tolosa E.,University of Barcelona | Wenning G.K.,University of Innsbruck
The Lancet Neurology | Year: 2012

Diagnostic criteria for multiple system atrophy are focused on motor manifestations of the disease, in particular ataxia and parkinsonism, but these criteria often cannot detect the early stages. Non-motor symptoms and signs of multiple system atrophy often precede the onset of classic motor manifestations, and this prodromal phase is estimated to last from several months to years. Autonomic failure, sleep problems, and respiratory disturbances are well known symptoms of established multiple system atrophy and, when presenting early and preceding ataxia or parkinsonism, should be regarded as evidence of premotor multiple system atrophy. An early and accurate diagnosis is becoming increasingly important as new neuroprotective agents are developed. © 2012 Elsevier Ltd.

Upton P.J.,Open University Milton Keynes | Borjan Z.,University of Belgrade
Physical Review B - Condensed Matter and Materials Physics | Year: 2013

The universal scaling function W+-(y) of the Casimir force (y is a temperature-dependent variable) away from the critical point for thermodynamic systems in the Ising universality class confined between two parallel plates with antisymmetric boundary conditions [denoted (ab)=(+-)] has been analyzed using the extended de Gennes-Fisher local-functional method. Results on the universal function W+-(y) are presented in spatial dimension d=3 applying the extended sine parametric model for temperatures T>TR, where TR is the critical temperature of the roughening transition. The asymptotic behavior of W+-(y) for large values of the scaling variable y, y→±∞, is analyzed in general dimension d for Tâ‰Tc, where Tc is the bulk critical temperature, and in d≥3 for Tâ‰TR. © 2013 American Physical Society.

Golic K.,Union University of Serbia | Kosoric V.,SEEEA D.o.o. | Furundzic A.K.,University of Belgrade
Renewable and Sustainable Energy Reviews | Year: 2011

The building sector, which accounts for about 40% of total energy consumption in Europe, offers various possibilities for achieving higher energy efficiency by introducing distributed RES. As 20% of total energy consumption in this sector is used for water heating, it follows that 8% of total energy in Europe is consumed for water heating purposes, which provides great opportunities for energy savings. Solar water heating systems (SWHSs) are a suitable technology for renewable energy source (RES) exploitation to be applied in residential building refurbishment that generate both fossil fuel savings and reductions in CO2 emissions. Due to its complexity, SWHS integration requires a comprehensive approach including consideration of the functional and aesthetic, energy performance, and economic and ecological aspects from conceptual design through to design realization. This article defines a general model of SWHS integration in residential building refurbishment. The model is divided into several basic phases in order to facilitate problem-solving and to enable the individual optimization processes for variant design. The phases are systematically analyzed and a proper procedure and/or methods are established to solve them. At the very beginning of the suggested problem-solving procedure, the measures 'Building Potential', P̃B, and 'Degree of Feasibility', pB, are first introduced in order to estimate the suitability of SWHS integration. A Multi-Criteria compromise ranking method, is recommended for a comprehensive evaluation of design variants and for the selection of the optimal SWHS integration Design Variant. The proposed general model is also applied for solving a real problem - namely, the integration of SWHS through the refurbishment of residential buildings in the suburb of "Konjarnik" in Belgrade, Serbia, which is one of the many that were built in Belgrade after the Second World War. © 2010 Elsevier Ltd.

Nikolic M.,University of Belgrade
Pediatric Dermatology | Year: 2014

Pustular psoriasis (PP) is rare in children. The small number of reported cases makes deciding on treatment and follow-up challenging. The current study was an evaluation of treatment approaches and courses of PP in 18 children diagnosed and followed over a 20-year period. From 1992 to 2011 we treated 1,447 children with psoriasis, 18 of whom had PP. Follow-up was 2 to 19 years. At the time of initial manifestation of PP, our patients were 1.5 months to 16 years old. Seven patients had a previous history of psoriasis vulgaris. Three children entered long-term remission after one pustular attack, 10 developed psoriasis vulgaris, 2 are currently under treatment, and 3 were lost to follow-up. Treatment with acitretin, cyclosporine, or methotrexate was efficacious and well tolerated. PP is rare, but according to our experience, it has a good prognosis in children. © 2014 Wiley Periodicals, Inc.

Rajic N.,University of Belgrade | Obradovic B.,University of Belgrade
Journal of Hazardous Materials | Year: 2012

Removal of heavy metal ions from aqueous solutions using zeolites is widely described by pseudo-second order kinetics although this model may not be valid under all conditions. In this work, we have extended approaches used for derivation of this model in order to develop a novel kinetic model that is related to the ion exchange mechanism underlying sorption of metal ions in zeolites. The novel model assumed two reversible steps, i.e. release of sodium ions from the zeolite lattice followed by bonding of the metal ion. The model was applied to experimental results of Cu(II) sorption by natural clinoptilolite-rich zeolitic tuff at different initial concentrations and temperatures and then validated by predictions of ion exchange kinetics of other divalent heavy metal ions (i.e. Mn(II), Zn(II) and Pb(II)). Model predictions were in excellent agreements with experimental data for all investigated systems. In regard to the proposed mechanism, modeling results implied that the sodium ion release rate was constant for all investigated metals while the overall rate was mainly determined by the rate of heavy metal ion bonding to the lattice. In addition, prediction capabilities of the novel model were demonstrated requiring one experimentally determined parameter, only. © 2012 Elsevier B.V.

Filipovic M.,University of Belgrade | Kamberovic Z.,University of Belgrade
Materials and Design | Year: 2013

The microstructure and properties of 17wt.% Cr-2.9wt.% C cast irons with up to 3.17wt.% Nb additions, in both as-cast and heat treated state, have been studied. Also the influence of titanium and cerium on the structure and properties of 17wt.% Cr-2.9wt.% C-2wt.% Nb alloys are examined. NbC carbides present in the structure of tested alloys, due to their characteristic morphology, show higher wear resistance and toughness than M7C3 carbides. Increasing amount of this type of carbides, caused by the increase of niobium in Fe-Cr-C-Nb alloys, contributes to the improvement of wear resistance and dynamic fracture toughness. The alloy containing approximately 3% Nb gives the best compromise between wear resistance and fracture toughness. This alloy shows about 30% greater dynamic fracture toughness and about 30% greater abrasion wear resistance than the basic Fe-Cr-C alloy. Titanium and cerium affect the crystallisation process of Fe-Cr-C-Nb alloys and the transformation of austenite during the cooling after solidification. The addition of 0.26% Ti results in a substantial change in the morphology and distribution of NbC carbides. The secondary carbides which precipitate in the matrix regions of the tested 17wt.% Cr-2.9wt.% C-2wt.% Nb white iron containing titanium has an impact on the abrasion behaviour and fracture toughness. The alloy containing 0.28% Ti and 0.19% Ce has pearlite-austenitic matrix microstructure in as-cast condition. The pearlite, due to its high microhardness, improves the wear resistance under low-stress abrasion conditions, but drastically reduces the toughness of tested alloy. © 2012 Elsevier Ltd.

Damjanov N.,University of Belgrade
Biologics: Targets and Therapy | Year: 2015

Over the past decade, the use of biologics has significantly changed the management of rheumatoid arthritis (RA). Biologics selectively target components of the immune system, resulting in better disease control. However, the growing use of biologics in RA has increased safety concerns among rheumatologists. Randomized controlled trials (RCTs) and registries are the most reliable sources of clinical safety data. Although safety data from RCTs provide certain insights into the clinical safety profile of an agent, strict constraints in study design (eg, exclusion criteria and restrictive treatment protocols) often do not accurately reflect possible safety issues in the use of the agent, either in the clinical setting or over long-term treatment. Registries, on the other hand, are not restrictive regarding patient enrollment, making them more reliable in evaluating long-term safety. A number of registries have been established globally: in Europe, the United States, and Asia. However, the availability of registry data from Eastern Europe is lacking. The notable exceptions so far are registries from the Czech Republic (ATTRA, a registry of patients treated with anti-tumor necrosis factor-alpha drugs) and Serbia (National registry of patients with rheumatoid arthritis in Serbia [NARRAS]). The current report provides an overview of safety data with biologics in RA from RCTs and registries. Availability of regional safety data from Eastern Europe is of great importance to its clinicians for making evidence-based treatment decisions in RA. © 2015 Codreanu and Damjanov.

Zarkovic M.,University of Belgrade
Journal of Thyroid Research | Year: 2012

Graves' disease is a most common cause of hyperthyroidism. It is an autoimmune disease, and autoimmune process induces an inflammatory reaction, and reactive oxygen species (ROSs) are among its products. When balance between oxidants and antioxidants is disturbed, in favour of the oxidants it is termed "oxidative stress" (OS). Increased OS characterizes Graves' disease. It seems that the level of OS is increased in subjects with Graves' ophthalmopathy compared to the other subjects with Graves' disease. Among the other factors, OS is involved in proliferation of orbital fibroblasts. Polymorphism of the 8-oxoG DNA N-glycosylase 1 (hOGG1) involved in repair of the oxidative damaged DNA increases in the risk for developing Grave's disease. Treatment with glucocorticoids reduces levels of OS markers. A recent large clinical trial evaluated effect of selenium on mild Graves' ophthalmopathy. Selenium treatment was associated with an improved quality of life and less eye involvement and slowed the progression of Graves' orbitopathy, compared to placebo. © 2012 Miloš arković.

Tadic M.,University of Belgrade | Tadic M.,University of Sfax
Journal of Clinical Ultrasound | Year: 2015

Despite several limitations, two-dimensional echocardiography (2DE) is the standard method for assessing the right atrium (RA) in everyday clinical routine. Cardiac magnetic resonance remains the current "gold standard" for RA visualization and volume quantification. The development of 2DE-derived strain imaging has enabled assessing RA deformation and phasic function in various pathologic conditions. Three-dimensional echocardiography was demonstrated to be more accurate and reproducible than 2DE for cardiac chamber quantification, while also allowing the evaluation of RA phasic function without geometric assumption. The purpose of this review is to summarize currently available data about RA anatomy, phasic function, and mechanics acquired by different imaging modalities. © 2015 Wiley Periodicals, Inc.

Potpara T.S.,University of Belgrade
Postgraduate Medicine | Year: 2014

Vascular endothelium has important regulatory functions in the cardiovascular system and a pivotal role in the maintenance of vascular health and metabolic homeostasis. It has long been recognized that endothelial dysfunction participates in the pathogenesis of atherosclerosis from early, preclinical lesions to advanced, thrombotic complications. In addition, endothelial dysfunction has been recently implicated in the development of insulin resistance and type 2 diabetes mellitus (T2DM). Considering that states of insulin resistance (eg, metabolic syndrome, impaired fasting glucose, impaired glucose tolerance, and T2DM) represent the most prevalent metabolic disorders and risk factors for atherosclerosis, it is of considerable scientific and clinical interest that both metabolic and vascular disorders have endothelial dysfunction as a common background. Importantly, endothelial dysfunction has been associated with adverse outcomes in patients with established cardiovascular disease, and a growing body of evidence indicates that endothelial dysfunction also imparts adverse prognosis in states of insulin resistance. In this review, we discuss the association of insulin resistance and T2DM with endothelial dysfunction and vascular disease, with a focus on the underlying mechanisms and prognostic implications of the endothelial dysfunction in metabolic and vascular disorders. We also address current therapeutic strategies for the improvement of endothelial dysfunction. © Postgraduate Medicine.

Tadic M.,University of Belgrade | Cuspidi C.,University of Milan Bicocca
European Journal of Internal Medicine | Year: 2013

The cluster of metabolic and hemodynamic abnormalities which characterize the metabolic syndrome (MS) is responsible for subclinical cardiac and extra-cardiac damage such as left ventricular hypertrophy, diastolic dysfunction, carotid atherosclerosis and microalbuminuria. The development of different non-invasive imaging methods enabled a detail investigation of right ventricular structure and function, and revealed that right ventricular remodeling followed changes in the left ventricular structure and function in patients with arterial hypertension, diabetes or obesity. Previous investigations also reported that the coexistence of two components of the MS induced more significant cardiac remodeling than the presence of only one MS risk-factor. The relationship between different components of the MS (increased blood pressure, abdominal obesity, increased fasting glucose level and dyslipidemia) and right ventricular remodeling could be explained by several hemodynamic and non-hemodynamic mechanisms. However, the association between right ventricular remodeling and the MS has not been sufficiently investigated so far. The aim of this article was to review recent articles focusing on the association between metabolic syndrome components and the metabolic syndrome itself with impairments in right ventricular structure and function assessed by different imaging techniques. © 2013 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Potpara T.S.,University of Belgrade | Lip G.Y.H.,University of Birmingham | Apostolakis S.,University of Birmingham
Heart | Year: 2012

Warfarin has long been the 'gold standard' of oral anticoagulation for stroke prevention in atrial fibrillation (AF). Recently, the oral direct thrombin inhibitors and direct factor Xa inhibitors have emerged as attractive alternatives to warfarin and have already changed the landscape of stroke prevention in AF. The new anticoagulants have important advantages over warfarin. Despite their impressive performance in clinical trials, their long-term efficacy and safety still require evaluation in 'real-world' clinical practice. In this review, the emerging role of the new oral anticoagulants for stroke prevention in patients with AF is discussed.

Stankov L.,Singapore National Institute of Education | Saucier G.,University of Oregon | Knezevic G.,University of Belgrade
Psychological Assessment | Year: 2010

In the present article, the authors report on the development of a scale for the measurement of the militant extremist mind-set. A previous pilot study identified 56 statements selected from writings of various terrorist groups as well as from psychological, historical, and political texts on terrorism. These statements, together with measures of personality, social attitudes, values, and social cynicism, were administered to participants from 9 countries (N = 2,424). A series of exploratory factor analyses of 56 statements produced 3 factors: Proviolence, Vile World, and Divine Power. Correlations of these factors with external variables indicate that Divine Power is a traditional religiosity scale, whereas Proviolence and Vile World scales cannot be accounted for by the existing psychological constructs. The distribution of scores on the Proviolence scale is skewed, indicating that the majority of participants disapprove of this attitude. The authors also present means for the countries included in the analysis. Participants from Malaysia endorse Vile World and Divine Power statements stronger than participants from other countries. The 3 Asian countries (China, Korea, and Malaysia) endorse Proviolence more strongly than countries from other parts of the world. © 2010 American Psychological Association.

Potpara T.S.,University of Belgrade | Lip G.Y.H.,University of Birmingham
Best Practice and Research: Clinical Haematology | Year: 2013

Atrial fibrillation (AF) confers a significant risk of stroke or systemic thromboembolism. Oral anticoagulation is the most effective therapy for AF-related stroke prevention. A decision to advise oral anticoagulation should be based upon the individual absolute risks of stroke and bleeding, and almost all AF patients with ≥1 stroke risk factors have a positive net clinical benefit of oral anticoagulation. The novel oral anticoagulants (NOACs) dabigatran, rivaroxaban and apixaban are more convenient, and are at least equally effective and safer (regarding bleeding complications) for stroke prevention compared with vitamin K antagonists (VKAs). Availability of NOACs and improved stroke and bleeding risks assessment should increase the number of AF patients who receive adequate thromboprophylaxis. In this review article, we present an overview of the clinical phase III trials with NOACs for stroke prevention and discuss the contemporary principles of thromboprophylaxis in AF patients with various stroke and bleeding risk profiles, as well as practical aspects of NOACs therapy. © 2013 Elsevier Ltd. All rights reserved.

Ilic A.,University of Niš | Krtinic D.,University of Belgrade
Match | Year: 2010

Let G be a simple undirected n-vertex graph with the characteristic polynomial of its Laplacian matrix L(G), det(λI - L(G)) = Σk=0 n(-1)kckλn-k. Laplacian-like energy of a graph is newly proposed graph invariant, defined as the sum of square roots of Laplacian eigenvalues. For bipartite graphs, the Laplacian-like energy coincides with the recently defined incidence energy IE(G) of a graph. In [D. Stevanovic, Laplacian-like energy of trees, MATCH Commun. Math. Comput. Chem. 61 (2009), 407-417.] the author introduced a partial ordering of graphs based on Laplacian coefficients. We point out that original proof was incorrect and illustrate the error on the example using Laplacian Estrada index. Furthermore, we found the inverse of Jacobian matrix with elements representing derivatives of symmetric polynomials of order n, and provide a corrected elementary proof of the fact: Let G and H be two n-vertex graphs; if for Laplacian coefficients holds Ck(G) ≤ ck(H) for k = 1,2,...,n - 1, then LEL(G) ≤ LEL(H). In addition, we generalize this theorem and provide a necessary condition for functions that satisfy partial ordering based on Laplacian coefficients.

Miletic N.,Fruit Research Institute | Nastasovic A.,University of Belgrade | Loos K.,University of Groningen
Bioresource Technology | Year: 2012

Biotechnology also holds tremendous opportunities for realizing functional polymeric materials. Biocatalytic pathways to polymeric materials are an emerging research area with not only enormous scientific and technological promise, but also a tremendous impact on environmental issues. Many of the enzymatic polymerizations reported proceed in organic solvents. However, enzymes mostly show none of their profound characteristics in organic solvents and can easily denature under industrial conditions.Therefore, natural enzymes seldom have the features adequate to be used as industrial catalysts in organic synthesis. The productivity of enzymatic processes is often low due to substrate and/or product inhibition. An important route to improving enzyme performance in non-natural environments is to immobilize them.In this review we will first summarize some of the most prominent examples of enzymatic polymerizations and will subsequently review the most important immobilization routes that are used for the immobilization of biocatalysts relevant to the field of enzymatic polymerizations. © 2011 Elsevier Ltd.

Carrizosa E.,University of Seville | Drazic M.,University of Belgrade | Drazic Z.,University of Belgrade | Mladenovic N.,Brunel University
Computers and Operations Research | Year: 2012

Variable Neighborhood Search (VNS) has shown to be a powerful tool for solving both discrete and box-constrained continuous optimization problems. In this note we extend the methodology by allowing also to address unconstrained continuous optimization problems. Instead of perturbing the incumbent solution by randomly generating a trial point in a ball of a given metric, we propose to perturb the incumbent solution by adding some noise, following a Gaussian distribution. This way of generating new trial points allows one to give, in a simple and intuitive way, preference to some directions in the search space, or, contrarily, to treat uniformly all directions. Computational results show some advantages of this new approach. © 2011 Elsevier Ltd.

Pamucar D.S.,University of Belgrade | Pejcic-Tarle S.,University of Belgrade
Expert Systems with Applications | Year: 2014

Local city authorities are making a serious effort to expand the number of low-greenhouse gas vehicles (green vehicles) at home. There is no reliable methodology, however, to support the implementation of this passenger transportation concept. In order to optimize the green capacity, a system has been developed to support decision making in urban green vehicle routing. The objective of this paper is to propose a green vehicle distribution model in a public transportation network. The problem has been defined as a problem of non-linear optimization with dispersed input parameters, requiring neuro-fuzzy logic. An adaptive neural network was developed, taking into account the costs to be borne by operators and users, and the environmental parameters along the observed vehicle route. Each input parameter of the neuro-fuzzy model has been placed in a complex context. They were divided into the elements describing in more detail the environmental status, the operator and passenger costs. The advantage of the model is that several factors shaping the input parameters have been taken into consideration. On the other hand, the complexity of urban systems management makes it a considerable challenge, and the surrounding circumstances are difficult to predict accurately. Accordingly, the inputs of the green vehicle model were fuzzified. The Index of Performance (IP) is the output, associated with each branch of the passenger transportation network. The model has been tested on a part of the public transport system in central Belgrade. The results have proven a practical application possible, and a calibration of input parameters allows for full implementation in public transport vehicle routing. © 2013 Elsevier Ltd. All rights reserved.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2009.8.1.1 | Award Amount: 8.47M | Year: 2010

Primary aluminium production industry is the worlds larger industrial consumer of energy and ranked among the most CO2 intensive industries. It also generates enormous quantities of wastes that further decrease the exergy efficiency of its production process. However, this industry is one of the most vital sectors from economic and social point of view, not only for EU but also for the entire world. In order to remain viable and competitive, primary aluminium industry has to operate in a smarter way, be more energy efficient and meet the environmental requirements of our times. This can be achieved only through radical new technologies and novel business strategies, which will enable the industry to maintain its competitiveness and fasten its viability in the worlds markets, and explore new business opportunities. The main goal of this project is to provide primary aluminium industry with green innovative technological and economical solutions, focusing on the: (i) significant improvement of energy and exergy efficiencies of the production process; (ii) substantial reduction of GHG emissions; and (iii) complete elimination of the solid wastes. In order to achieve this goal within the project, novel technologies for the reduction of alumina to aluminium and the complete utilization of the red mud will be demonstrated and validated in pilot-scale. These technologies are energy-efficient and environmental-friendly, ensuring the competitiveness of the industry. A site optimization study of the new industry, integrating the novel technologies, is expected to achieve further reduction of energy and CO2 emissions and improve the energy and exergy efficiency of the whole process. It is aimed that the novel technologies will play a key-role on the sustainability, competitiveness and viability of primary aluminium production industry, so as to render it a leader industry for energy-efficient technologies and products in Europe and worldwide.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: SC5-13a-2014 | Award Amount: 2.09M | Year: 2015

The exploitation of minerals in Europe is an indispensable activity to ensure that the present and future needs of the European society can be met. This means that sufficient access is required to explore and exploit minerals. At the same time the mineral needs of our society must be met without compromising the ability of future generations to meet their own needs. Accordingly exploitable mineral deposits (known deposits, abandoned mines and historical mining sites) need to be assessed against other land uses, taking into account criteria such as habitats, other environmental concerns, priorities for settlements, etc. Access to mineral deposits, on the other hand, also meets public interests such as raw materials security (compared with many international access options). The deliberation between these diverse land uses requires adequate consideration of the exclusiveness, reversibility, and consequences on the surrounding. The overall objective of MINATURA 2020 is to develop a concept and methodology (i.e. a harmonised European regulatory/guidance/policy framework) for the definition and subsequent protection of mineral deposits of public importance in order to ensure their best use in the future. Providing a policy planning framework that comprises the sustainability principle for mining is the key driving force behind MINATURA.

Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2012-IAPP | Award Amount: 467.60K | Year: 2013

CONPRA project, with its Consortium composition and program, tries to answer some major challenges in the development driven archaeology. With its particular focus on economic and technological circumstances in emerging markets, the major issue is increasing the capacities of SMEs in facing new and changing conditions in their respective countries, and in reinforcing the capacity of academia towards more competitive role in heritage industry. CONPRA will join 4 partners (2 universities and 2 SMEs) from 4 different countries (Slovakia, Czech Republic, Slovenia, Serbia). All 4 partners could be considered as leading institutions in their fields of expertise in their countries. All partners intend to employ secondees on their regular projects providing so the major field for gaining new knowledge and skills, as well as to exchange experienced researchers aiding the partner institutions on the spot. ULJ will involve secondees from SMEs into its program of aerial schools (in Slovenia and elsewhere) planned for 2013. The major working of the UBG will be archaeological site of Vina (10 m deep Neolithic site of extreme international importance for the appearance of early farming in Europe). VIA MAGNA will focus on testing of use of the 3D photogrammetry on selected sites with presence of torsal architecture in the landscape context and TerraVerita will work on the evaluation of archaeological data, acquired by non-destructive research, and their value for archaeological prediction in relation to the management of landscape transects research. Each WP will produce a manual that will containing knowledge, experience, proved methodologies and techniques in the above mentioned fields of archaeology. The project and its outputs will positively influence the quality of research of all participating partners, especially their potential and capacities for applicative research tasks and projects.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: ENV.2008. | Award Amount: 1.14M | Year: 2009

This proposal puts forward plans to establish a research network of experts on noise and health in Europe. This network will establish future research directions and policy needs in Europe. The network will review the existing literature on environmental noise exposure and health focussing on the consolidation of existing state of the art knowledge and the identification of gaps in the evidence and future research needs and hypotheses to be tested. In the network we will train junior researchers in noise and health through setting up an exchange network across Europe. The network will focus on noise exposure assessment in health studies in order to build more complex analytical models of noise and health effects that take into account moderating factors including the joint effects of air pollution and noise. A specific function of the network will be to establish communication between researchers on noise and researchers on air pollution. We will improve the measurement of health outcomes relevant to noise research and strengthen the available methodologies for future research, by extending analyses on existing research taking advantage of the large EU-funded RANCH and HYENA studies and relevant national studies. We will develop novel designs for research on noise and health to provide to the EU a new strategy for the development of noise and health research in the future. We will disseminate the results to the EU, to national governments, to fellow researchers, and other stakeholders.

Agency: European Commission | Branch: H2020 | Program: SESAR-RIA | Phase: Sesar-01-2015 | Award Amount: 599.87K | Year: 2016

Automation effects on arousal could be predicted differently depending on the Attentional Theory. The classical Theory (Kahneman, 1973) considers the level of arousal reliant only on psychological factors (stress, fatigue and emotions). Automation would only affect the task complexity by allocating part of the cognitive processing to the system. Alternative theories such as Malleable Attentional Resources Theory (MART) (Young and Stanton, 2002) assumes that automation would also affect the level of arousal and be dependent on controllers expectations: when the ATCo expects that the task is easy in the near future, she/he will reduce the arousal levels and get bored or sleepy (overconfidence on automation). On the contrary, fears of automation failing would increase stress and also the level of arousal causing disorientation, overacting or erratic behaviour. Based on these theories, AUTOPACE proposes basic research on a Psychological Model to quantitatively predict how automation would impact on human performance based on cognitive resources modeling (demanded and available), tasks characteristics (automation), psychological factors modeling (fatigue, stress and emotions) and ATCo expectations (overconfidence vs fears of automation). A catalogue of training strategies to support the controller being in-the-loop will be explored. For the classical Theory, the strategies only for keeping attention on the main task avoiding out-of-the-loop effect. For the MART the coach will be also for coping with stress. A reviewed Curricula and ATCo Selection will be initiated. Expert Judgment from Psychologists, ATM Experts and Controllers Trainers supported by Literature Research will look at future competences and training strategies. The research on Psychological Modeling will be also sustained with Analytical Studies by using an existing prototype for demanded resources. AUTOPACE points at research paths suggested in Ergonomics in design Issue (Hancock et all, April 2013).

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: SEC-2011.6.1-1 | Award Amount: 2.20M | Year: 2012

Our objective in this project is to explore and compare relevant cultural phenomena and legal determinations of civil security across Europe, taking into account the existing significant differences between countries and regions. We start by creating a framework that can be used to carry out a comparative analysis. We develop definitions of security effectiveness and efficiency that can be put into practice with the available data and in the context of the widely varying security systems in Europe. We consider a representative sample of selected countries, embodying the diverse regional security architectures, with regard to the sharing of responsibilities between public and private bodies and the role that citizens and their awareness play in regional security architectures. We study how the identified differences affect the effectiveness and efficiency of different kinds of security systems in these countries and regions. We determine what works and what doesnt work with regard to particular types of risks, crises and disasters, and countries and regions. Finally we give specific advice, based on consensually agreed upon objective indicators and analysis, about what changes or modifications might result in improvements to the security situation in regions or countries where this is desired by EU policymakers. Consequently, we achieve the expected impact of giving the EU a clear view of which kind of systems that could successfully enhance the security in certain regions, and contribute and give EU-added value to the debate concerning not one security fits all.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-03a-2014 | Award Amount: 6.92M | Year: 2015

This proposal SFS-03a-2014-aligned focuses to minimize the risk of introduction/impact of emerging pests threatening EU agriculture and forestry. The targets are: 1) Xylella fastidiosa and its vectors in olive, grapevine, citrus, stone fruit, ornamentals and landscape trees of high socio-economic importance; 2) Ca. Liberibacter solanacearum and its vectors affecting a number of strategic crops such as potato, tomato and carrot; and 3) Hymenoscyphus pseudoalbidus (anomorph. Chalara fraxinea) and Phytophtora spp. seriously affecting broadleaf and conifer species in forest ecosystems. Targeted pests, their vectors and the host response will be explored using innovative approaches (NGS, transcriptomic). Diseases surveillance and epidemiology given by current methods will integrate improved survey protocols and remote sensing. Innovative IPM will include studies of microbiome to develop sustainable solutions in line with the EU plant health legislation. New knowledge gained with POnTE will result in an outcome-based pest prevention and management work plan to: a) implement area-wide pest risk assessments; b) prevent the entry and develop surveillance and early detection tools (diagnostic kits, lab-on-chip, new biomarkers); c) mitigate the spread and reduce the socio-economic impact; d) IPM based on disease resistance, disease-free seeds, cultural practices and physical environmentally-friendly treatments; e) support knowledge-based decision-making policies at EU level. The proposal fosters and promotes a multi-actor approach and transnational research collaborations among 25 Partners at the forefront of research in plant protection, agro-engineering and economics. It involves key industries/SMEs that develop diagnostic kits and services, agrochemical and seed companies, stakeholder groups. End-users will participate in the development of the project and immediately implement the practical solutions derived from the outcomes to solve these serious emerging diseases.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-13-2015 | Award Amount: 6.43M | Year: 2016

MycoKey aims to generate innovative and integrated solutions that will support stakeholders in effective and sustainable mycotoxin management along food and feed chains. The project will contribute to reduce mycotoxin contamination mainly in Europe and China, where frequent and severe mycotoxin contaminations occur in crops, and where international trade of commodities and contaminated batches are increasing. MycoKey will address the major affected crops maize, wheat and barley, their associated toxigenic fungi and related mycotoxins (aflatoxins, deoxynivalenol, zearalenone, ochratoxin A, fumonisins). The project will integrate key information and practical solutions for mycotoxin management into a smart ICT tool (MycoKey App), providing answers to stakeholders, who require rapid, customized forecasting, descriptive information on contamination risk/levels, decision support and practical economically-sound suggestions for intervention. Tools and methodologies will be strategically targeted for cost-effective application in the field and during storage, processing and transportation. Alternative and safe ways to use contaminated batches will be also delivered. The focus of Mycokey will be: i) innovating communications of mycotoxin management by applying ICT, providing input for legislation, enhancing knowledge and networks; ii) selecting and improving a range of tools for mycotoxin monitoring; iii) assessing the use of reliable solutions, sustainable compounds/green technologies in prevention, intervention and remediation. The multi-disciplinary consortium, composed by scientific, industrial and association partners (32), includes 11 Chinese institutions and will conduct the 4 years programme in a framework of international networks.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: RUR-08-2016 | Award Amount: 6.39M | Year: 2016

The main goal of AGROinLOG is the demonstration of Integrated Biomass Logistic Centres (IBLC) for food and non-food products, evaluating their technical, environmental and economic feasibility. The project is based on three agro-industries in the fodder (Spain), olive oil production (Greece) and cereal processing (Sweden) sectors that are willing to deploy new business lines in their facilities to open new markets in bio-commodities (energy, transport and manufacturing purposes) and intermediate bio-products (transport and biochemicals). These sectors represent over 10% turnover of agro-food industries and 30% of those with inherent synergies to integrate food and non-food business taking advantage of their existing equipment, seasonality and established food logistics. The synergies of applying IBLCs business in existing agro-industries can have a positive impact over 18% in final product price, giving a clear competitive strength to a wide segment of agro-industries, which can exploit this privileged situation compared to a new biomass supply business built from scratch. The project is built on these agro-industries that will achieve a TRL7-8 in their facilities, guaranteeing operation under real conditions and with big amounts of production compared to the current activity, ensuring proximity to real market at the end of the project. Main challenges are based on being able to integrate logistics, harvesting and equipment in food and non-food applications, where the project is focused; ensuring marketability of the final bio-commodities. Besides, AGROinLOG will apply a multi-actor approach to attain experiences and knowledge of the sectors and agro-industries, enhancing the accuracy of the business models and developing effective and friendly guidelines of best practices to replicate and spread IBLC concept in Europe. This project will contribute towards employment stability seasonality avoidance-, rural development and bio-economy goals.

Loncar N.,University of Groningen | Loncar N.,University of Belgrade | Fraaije M.W.,University of Groningen
Applied Microbiology and Biotechnology | Year: 2015

Thermobifida fusca is a mesothermophilic organism known for its ability to degrade plant biomass and other organics, and it was demonstrated that it represents a rich resource of genes encoding for potent enzymes for biocatalysis. The thermostable catalase from T. fusca has been cloned and overexpressed in Escherichia coli with a yield of 400 mg/L. Heat treatment of disrupted cells at 60 °C for 1 h resulted in enzyme preparation of high purity; hence, no chromatography steps are needed for large-scale production. Except for catalyzing the dismutation of hydrogen peroxide, TfuCat was also found to catalyze oxidations of phenolic compounds. The catalase activity was comparable to other described catalases while peroxidase activity was quite remarkable with a kobs of nearly 1000 s−1 for catechol. Site directed mutagenesis was used to alter the ratio of peroxidase/catalase activity. Resistance to inhibition by classic catalase inhibitors and an apparent melting temperature of 74 °C classifies this enzyme as a robust biocatalyst. As such, it could compete with other commercially available catalases while the relatively high peroxidase activity also offers new biocatalytic possibilities. © 2014, Springer-Verlag Berlin Heidelberg.

Petronijevic M.,Medicines and Medical Devices Agency of Serbia | Ilic K.,University of Belgrade
Journal of Clinical Pharmacology | Year: 2013

Patient gender and age are considered to be the risk factors for developing drug-induced liver injury (DILI). The aim of this study was to analyze gender and age differences in reporting of drug-induced hepatic failure (HF) to the VigiBase. VigiBasewas screened for the HF reports submitted from 2000 to 2009. The information retrieved referred to the suspected drug, age, gender, and a reporting country. Variables were examined by using descriptive statistics and the binomial test. During the 10-year period there were in total 6 370 HF reports from 38 countries. After the exclusion of cases with missing gender data (379 cases), females counted for 54.03%. The largest portion of HF cases referred to age <55 (42.57%) with female predominance (56.81%), whereas age 55 (32.57%) showed almost even gender distribution. Overall, there were 941 different drugs or their combinations reported. Females significantly predominated in HF cases associated with analgesics, antiepileptics, antiinflamatory and antirheumatic drugs, psychoanaleptics, antibacterials for systemic use, and antidiabetic drugs. Males were significantly overrepresented in HF cases associated with antivirals for systemic use. Differences between genders and/or age groups in the reporting of drug-induced HF depend on drug and/or drug class but may be influenced by multiple factors. © The Author(s) 2013.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2012.2.5-03 | Award Amount: 3.70M | Year: 2013

General objective of the project is to integrate advancement in scientific knowledge about the impact of food chains with application of knowledge to practice to increase food chains sustainability through public policies and private strategies. This general objective will be pursued through the following specific objectives: To develop and validate a performance criteria matrix for assessment and comparison of food chains operating at a range of geographical scales through analysis of how food chain impacts are communicated in different spheres of society. To build a database of quantifiable indicators of impact and a set of 20 case studies aimed at understanding how impacts are generated within specific food chains. To advance knowledge on methodological problems and trade-offs arising when measuring and comparing the impact of food chains within and between sectors. To assess how performance is perceived by stakeholders in different national contexts through participatory assessment and multicriteria analysis of the different typologies of food chains. To assess the actual and potential role of public and private policies addressing food chains and to turn assessment into policy recommendations. To build a network that turns the advancement of scientific knowledge into decision making tools for domestic and public consumers, producers, citizens, scientists, policy makers, civil society organizations. The project will be developed around the following assumptions: Costs and benefits analysis needs methodological update: for this reason the broader concept of performance is used The performance of food chains has multiple dimensions (economic, social, environmental, health, ethical) To turn knowledge into practice a demand-driven approach is necessary, focusing on how food choice affects the five dimensions of impact The complexity of impacts of food chains requires plurality of methods and transdisciplinarity

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: TPT-2008.0.0.8 | Award Amount: 1.63M | Year: 2010

TransNEW is a Horizontal Activity for the implementation of the Transport Programme. It is a Coordinating and Support Action aimed at supporting transport research activities in the New Member States. It contributes to the implementation of the Framework Programme and to the preparation of future Community research and technological development. It also stimulates, encourages and facilitates the participation of the New Member States and particularly SMEs in those countries in national, regional and European research. TransNEW has one primary focus to assess, analyse and define strategies for realising New Member and Associated States potentials in transport research. This is absolutely in line with the Integration/Efficiency Topic TPT.2008.8. TransNEW aims to map the transport research capacities in new Member States (and Associated States) by analysing their transport research activities to establish their recent patterns of collaboration. With this information evaluated by Mode and by Activity this will then be used to maximise the benefits of transport research at regional level and at a mode level. TransNEW covers all the transport modes including Aeronautics and aims to evaluate research capability in order to support the involvement of New Member States in a number of topics and potentially exploit the synergies between Air transport and surface transport modes. Through mode evaluation, TransNEW will assess the research actors who can make an active contribution to the common (transport research) objectives of advancing competitiveness, anticipating and responding to the socio-economic and environmental challenges of the transport system. TransNEW will cluster the research capacity results by Activities. The five Activities are: 1. Greening - environmental impacts of transport and climate change 2. Enhanced integration of transport modes 3. Safety and Security 4. Transport system efficiency and Mobility 5. Competitiveness

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST.2008.3.1.1. | Award Amount: 2.86M | Year: 2009

Pubtrans4all will develop a prototype vehicle-based boarding assistance system that can be built into new rail vehicles or retrofitted into existing rail vehicles to improve accessibility for all persons. Accessibility for rail vehicles is particularly problematic since rail vehicles have a long service life and so many currently inaccessible vehicles will remain in service well into the future. PubTrans4all will help make existing public transport systems more accessible, improving service for everyone. The PubTrans4all projects objective is to develop a standard boarding assistance system that can be used on many different types of rolling stock and infrastructures. The boarding assistance system will not simply be a device, but rather include contributing elements that make it possible to effectively use the device to access rail vehicles. The prototype will be developed by a multi-disciplinary consortium including users, public transport operators, academic researchers and manufacturers. As part of the process of developing the prototype boarding assistance system, the project will survey state of the art accessibility devices and make recommendations for best practices in the use and operation of these existing devices. The project will include an extensive dissemination program designed to communicate study results widely, but also to help inform the general public and decision-makers about the importance and challenges in providing accessibility for all. The PubTrans4all project will be completed by a well balanced and geographically diverse consortium. Especially beneficial is the participation of several Eastern European partners since accessibility is not sufficiently recognized as a problem in many of these countries. Accessibility for all is critical to creating an equitable, effective and efficient transport system. The project PubTrans4all will help build a fully accessible rail network.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.2.5-01 | Award Amount: 11.91M | Year: 2013

The AQUAVALENS consortium has brought together SMEs, Industries, Universities and Research Institutes with the mission of protecting the health of European Citizens from contaminated drinking water and water used in food processing. We will achieve this by developing sustainable technologies to enable water system managers whether in large or small water systems or within food growers or manufacturers to better control the safety of their water supplies. The work of the project is divided into four main clusters of work packages that sequentially lead to the development of appropriate technologies. These four clusters are: 1. Platform targets, 2. Platform development, 3. Field studies in European drinking water systems, and 4. Improving Public Health through safer water. In cluster 1 we shall generate new knowledge on the molecular genetics of viral, bacterial and parasitic waterborne pathogens. This will enable us to identify gene targets for the identification, and characterisation of these pathogens, that will also enable the determination of their virulence for humans. In cluster 2 we shall use the knowledge gained to develop new technologies that integrate sample preparation and detection into a single platform. These platforms will then be subject to a rigorous process of validation and standardisation. In cluster 3 we will use the validated platforms to undertake a series of field studies in large and small drinking water systems, and in food production. These field studies will generate new knowledge about the risk to public health from waterborne pathogens in Europe and also test the value of the technologies in the field. Finally in cluster 4 we test how these technologies can be used to protect human health, though improving the effectiveness of Water Safety Plans, adaptation to climate change, and control of outbreaks of infectious disease. We will also determine the sustainability and potential economic impacts of these technologies.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-FCH | Phase: SP1-JTI-FCH.2011.3.1 | Award Amount: 6.30M | Year: 2012

EURECA develops the next generation of -CHP systems based on advanced PEM stack technology. The idea is to overcome the disadvantages of complex gas purification, gas humidification and the low temperature gradient for the heat exchangers in a heating system. EURECA will develop a new stack generation based on PEM technology with operating temperatures of 90C to 120C. Thus results in a less complicated and therefore in a more robust -CHP system with reduced costs. The development of a new stack generation includes various parallel working tasks. EURECA will optimize materials to operate in that temperature range including membrane and bipolar plate materials. Also the catalyst will be improved with a lower platinum loading design target < 0.2g/kW. The stack design and the flow field of the bipolar plates will be optimized for the operating conditions. All development steps will be supported by state-of-the-art modeling. As the final step the developed stack will be integrated in an adapted -CHP system to achieve proof-of-concept in the target application. Important part of the project is the validation of the design targets. The -CHP system including the reformer is expected to operate at an electrical efficiency of 40%. Lifetime tests with defined test procedures on single cells and short stacks will indicate a stack lifetime of approx. 12.000 h. In all development processes the partners have agreed to a design-to-cost approach. This includes the producibility in series production processes. A cost assessment will indicate the cost savings by the less complicated system. The consortium is well balanced along the supply chain. Component suppliers and system designers are backed by research institutions. High quality of the development process is of top priority to all partners. Therefore the consortium will agree at the beginning of EURECA on specific quality and management procedures - including contingency planning measurements.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: REGPOT-2007-3-01 | Award Amount: 1.18M | Year: 2008

The main objectives of the project are improving, building, fostering and disseminating the wireless sensor networking (WSN) expertise in the WBC region. The human and infrastructure research capabilities of two WBC research centres (Skopje and Belgrade) will be improved to enable them to drive WSN research in the region and actively collaborate with research institutions from the EU. A sustainable cooperation framework that will support continuous collaboration of research institutions in WBC and the EU will be built through a two-way exchange of researchers, students, knowledge and know-how and joint research and educational actions. The fostering relates to the promotion of WSN research on the research and educational agendas of the WBC institutions and influencing national government bodies to support WSN research as an area of strategic interest. Finally, the dissemination targets the distribution of the economic and social benefits of potential key applications for the region and identifying newly accessible market niches to generate interest and opportunities for the local WBC industry and particularly SMEs. The main course of action is to leverage already achieved results and continue building established relationship between the WBC and the EU researchers on a larger scale through collaboration on selected use cases (personal health monitoring and emergency/disaster recovery) and active and organized exchange of researchers, scientific know-how and RTD results relying on expertise of the EUs convergence region and Member States partners. The consortium consists of highly skilled and competent WSN researchers from the EU institutions. A portion of the EU part of the consortium consists of people originating from the WBC. The project is also supported by six highly regarded world WSN experts who will take active part in project events.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SEC-2012.5.2-1 | Award Amount: 4.78M | Year: 2013

Public Protection and Disaster Relief (PPDR) agencies in EC member states are relying on digital Private Mobile Radio (PMR) networks for mission-critical voice and data communication. These networks are highly resilient and properly dimensioned to cope with crisis and emergency handling, and are well protected against monitoring and intrusion by means of encryption, authentication and integrity. The two main standards for digital PMR networks in Europe are TETRA (TErrestrial Trunked RAdio) and TETRAPOL.The majority of these networks are based on mature technology, requiring old-fashion synchronous links (backbone), and using proprietary hardware solutions that eventually become obsolete. These networks also provide limited inter-technology coverage providing very ineffective management of emergency events, both at the national level and in cross-border regions. The main goal of SALUS is to design, implement and evaluate a next generation communication network for Public Protection and Disaster Relief (PPDR) agencies, supported by network operators and industry, which will provide security, privacy, seamless mobility, QoS and reliability support for mission-critical PMR voice and broadband data services. The project covers the full techno-economic scope regarding development and deployment of the next generation PPDR networks by focusing on the integration with / migration to 4G wireless communications developments targeting three critical scenarios 1) city security, 2) disaster recovery, and 3) temporary protection. Salus will address key research challenges such as enterprise architectures, economic and business analysis, and a number of technical aspects concerning QoS, resilience, inter-systems handover (secure, seamless and fast), enhanced security, privacy mechanisms in heterogeneous network infrastructure, and multicast broadband PPDR services.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.4.3 | Award Amount: 2.93M | Year: 2009

The project will develop intelligent technologies to support learning and knowledge-building (LKB) activities in Intelligent Learning Extended Organisation (IntelLEO), a new paradigm representing a community that emerges as a temporal integration of two or more different business and educational communities and organizational cultures (industrial, research and educational).\nThe objective is to explore how the responsiveness of the LKB environments in an IntelLEO, aiming to enhance motivation of learners, proactively encouraging them to take part in LKB activities, can be radically enhanced by advanced technology exploiting a synergy between services for\n- efficient management of collaborative LKB activities and access to and supply of shared content, and\n- harmonisation of individual and organisational objectives.\nThe project will develop:\n\ta new Implementation Framework on how to exploit this synergy, taking into account the best social constructivist and situated learning practices in collaborative LBK for an IntelLEO\n\tan innovative ontological framework for context capturing which includes learners, context and collaboration models, serving to achieve the targeted synergy\n\t generic and widely applicable synergetic services, fitting SOA principles, for managing collaborative LKB activities and contents within an IntelLEO, such as services for:\no\tManagement of Social Interactions,\no\tProvision of learning resources,\no\tProvision of the most appropriate LKB path for individuals/groups,\no\tScaffolding of the learning process of individuals in accordance with organisation objectives & policy.\nThe new services will be validated within three IntelLEOs each involving various configurations of business and educational organisations, made to share resources, skills and costs in supporting LKB activities. An analysis of socio-economic context regarding applicability/ usefulness of the approach proposed and services will be provided.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: EE-07-2015 | Award Amount: 1.55M | Year: 2016

40% of all energy consumption and 36% of CO2 emissions in the European Union arise in private and public buildings. Thus, major advancements have to be made in this sector to reach the EUs climate and energy targets. Energy-efficient buildings will also contribute to the vision of secure, affordable and climate-friendly energy for citizens and businesses as well as generating additional societal, environmental and economic benefits. To strengthen policies that promote retrofitting and modernizing existing buildings, the EU has adopted the Directive 2012/27/EU on Energy Efficiency (EED). It requires EU Member States and candidate countries to establish a long-term strategy for mobilizing investment in the renovation of the national building by 30 April 2014, and every 3 years thereafter. These action plans are an integral part of a countrys National Energy Efficiency Action Plans. As of May 2015, 27 EU Member States have adhered to the requirement of Article 4, EED, and submitted their national building renovation strategy, albeit most did not meet the April deadline and some submitted their strategies as late as March 2015. However, the requirements to prepare these renovation strategies appear to have overburdened most EU member states. According to an analysis conducted by the Buildings Performance Institute Europe, only five countries have at least adequately complied with the five core elements described in Article 4 of the EED. To date, no renovation strategy has been submitted that can count as a best practice and provide orientation for other countries. The project EmBuild (Empower public authorities to establish a long-term strategy for mobilizing investment in the energy efficient renovation of the building stock) is designed to empower public authorities at local, regional and national level, to formulate renovation strategies for the building sector that foster deep renovation and facilitate the acceleration of the renovation.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-17-2015 | Award Amount: 9.63M | Year: 2016

The share of renewable energy is growing rapidly driven by the objective to reduce greenhouse gas emissions. The amount of electric power which can be supplied to the grid depends on the time of the day and weather conditions. A conventional fleet of thermal power plants is required to compensate for these fluctuations before large scale energy storage technologies will be mature and economically viable. All power market projections expect this to be the case for the next 50 years at least. For a strong expansion of renewables, this fleet has to operate flexibly at competitive cost. Current power plants cannot fill this role immediately without impeding their efficiency and engine lifetime through increased wear and damage induced by the higher number of (shorter) operating/loading cycles. New technologies need to be introduced to balance demand peaks with renewable output fluctuations at minimal fuel consumption and emissions without negative effects on cycling operation. The FLEXTURBINE partners have developed a medium to long term technology roadmap addressing future and existing power plants. The FLEXTURBINE project presented hereafter is the first step in such technology roadmap and consists of: (1) new solutions for extended operating ranges to predict and control flutter, (2) improved sealing and bearing designs to increase turbine lifetime and efficiency by reducing degradation/damages, and (3) an improved lifecycle management through better control and prediction of critical parts to improve competitive costs by more flexible service intervals and planned downtime, and by reducing unplanned outages. In all areas, individual technologies will be developed from TRL 3 to TRL 4-6. FLEXTURBINE brings together the main European turbine manufacturers, renowned research institutes and universities. It involves plant and transmission system operators to include user feedback and to prepare the take-up of the FLEXTURBINE technologies in power plants world-wide.

Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2011.3.3 | Award Amount: 551.87K | Year: 2011

The EU and the Western Balkan Countries face common challenges in the very important area of Monitoring and Control (M&C) that create a favourable environment for strategic collaboration in both research and industrial level. BALCON will act as a major driver for the reinforcement of EUWBC cooperation in M&C research, and as such, boost concrete EU-WBC R&D activities among the M&C key research and industrial leaders of the two regions. The project will achieve its objectives via a wide range of activities that include the:\n- Assessment of the EU-WBC research collaboration potential in the broader field of M&C to conclude on the EU-WBC research areas of common interest in the field of M&C, including a set of indicative courses of action to enhance EU-WBC RTD cooperation in the M&C area.\n- Setting up of a consultation and validation mechanism (EU-WBC High-level Working Group in M&C area) that will engage key recognised stakeholders of both regions in project activities to increase the project outcomes visibility and credibility, facilitate consensus building and finally their acceptance by the wider EU-WBC community in the area of Monitoring and Control.\n- Organisation of a variety of networking, training and awareness raising activities to bring closer the research & industrial actors of the two regions, thus, preparing the ground for advanced support services towards the realisation of concrete EU-WBC RTD activities in the M&C area.\n- Deployment of a variety of dissemination actions, as well as preparing post-project exploitation activities for project outcomes and reassure their sustainability beyond project life-time. BALCON project mobilises a multi-disciplinary consortium of 8 partners: 3 from EU countries (Greece and France) and 5 from Western Balkan Countries (Serbia, Croatia, Montenegro, FYROM and Bosnia and Herzegovina). Albania and Kosovo (under UNSC Resolution 1244/99) will also be addressed under project activities through the extensive network and contacts that BALCON WBC partners posses in the broader region.

Rajilic-Stojanovic M.,University of Belgrade | Rajilic-Stojanovic M.,Wageningen University | Shanahan F.,Alimentary Pharmabiotic Center | Shanahan F.,University College Cork | And 3 more authors.
Inflammatory Bowel Diseases | Year: 2013

Background: Presence of intestinal microbes is a prerequisite for the development of ulcerative colitis (UC), although deviation of the normal intestinal microbiota composition, dysbiosis, is presumably implicated in the etiology of UC. Methods: The fecal microbiota of 30 UC samples obtained from 15 patients who were sampled twice and from 15 healthy control subjects originating from 2 geographic locations was analyzed using highly reproducible phylogenetic microarray that has the capacity for detection and quantification of more than 1000 intestinal bacteria in a wide dynamic range. Results: The fecal microbiota composition is not significantly influenced by geographic location, age, or gender, but it differs significantly between the patients with UC and the control subjects (P 1/4 0.0004). UC-associated microbiota is stable during remission and similar among all patients with UC. Significant reduction of bacterial diversity of members of the Clostridium cluster IV and significant reduction in the abundance of bacteria involved in butyrate and propionate metabolism, including Ruminococcus bromii et rel. Eubacterium rectale et rel., Roseburia sp., and Akkermansia sp. are markers of dysbiosis in UC. Increased abundance of (opportunistic) pathogens including Fusobacterium sp., Peptostreptococcus sp., Helicobacter sp., and Campylobacter sp. as well as Clostridium difficile were found to be associated with UC. Conclusions: Dysbiosis in UC is stable in time and shared between patients from different geographic locations. The microbial alterations offer a mechanistic insight into the pathogenesis of the disease. Copyright © 2013 Crohn's & Colitis Foundation of America, Inc.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-07a-2014 | Award Amount: 3.40M | Year: 2015

Research and development activities are proposed for the benefit of sustainable pork chains based on European local pig breeds and their production systems. Workprogramme is planned to respond to consumer demands for quality and healthiness of pork products with regional identity and societal demands for environment preservation and development of local agro-economy. Description and evaluation of local pig breeds, with an emphasis on untapped ones will be performed using novel genomic tools. Performance of local pig breeds will be evaluated in contrasted agro-geo-climatic conditions and production systems (indoor, outdoor, organic). Focus will be on pig feeding and management strategies and on the use of locally available feeding resources. Intrinsic quality of traditional and new regional high quality pork products and attitudes of consumers from various market areas will be assessed; in particular the motives for the choice and willingness to pay such products. Marketing strategies will be adressed in particular short chain distribution channels. All activities will be driven from the perspective of sustainability (environmental impact, animal welfare, product quality, consumer acceptability and market potential). The activities will engage innovative approaches to answer socio-economic demands of regional pork chains involving partners from different sectors. The ambition is to enhance existing and create new networks between academia and non-academia partners, within and between regions and to tackle the value chain for regional high quality pork products, focusing on diverse and so far untapped pig breeds, their production systems and pork products. Cross-fertilising interactions between research, local agriculture, businesses and end-users will be achieved with partners from these complementary sectors in all research and development activities.

Agency: European Commission | Branch: FP7 | Program: CP-SICA | Phase: KBBE-2007-2-1-02 | Award Amount: 3.04M | Year: 2008

The general objective of the FOCUS-BALKANS project is to improve competencies and understanding in the field of consumer food science in the Western Balkan countries (WBC). The scientific results of the research will make important contribution to the public health and consumer protection and to the achievement of the objectives within the FP7. The specific objectives are to: - Develop a network of universities, institutes, high schools, consumer organisations, NGOs and private enterprises active in the field of food consumer science with are able to develop joint-research activities; - Have a better understanding of food consumers in the WBCs, with a focus on products with positive nutritional properties (fruits and health / diet foods) and / or sustainability (organic and traditional food products). Formal training will be organised for key research organisations in the WBCs to enable them to become familiar with state of the art methodologies, practical techniques and theories. The training activities, organised in each WBC-country, target a wide range of organisations from the public and private research sectors, NGOs & consumer associations. 6 regional training meetings will be designed by the project partners and associated organisations. Four studies on niche markets plus one quantitative survey will systematically be conducted by WBC organisations as a mechanism for learning-by-doing. Two open seminars will bring together a wider spectrum of stakeholders including food supply chains representatives and policy-makers. Altogether, these actors will be invited to participate in the Food Consumer Science Balkan Network, which will seek to stimulate regional and interdisciplinary co-operation. The research, training and networking activities are intimately interlinked and will have strong synergies.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.4.3-1 | Award Amount: 8.25M | Year: 2012

Background: A significant proportion of pre-diabetics, show macro and micro vascular complications associated with hyperglycaemia. Although many trials have demonstrated the efficacy of lifestyle and pharmaceutical interventions in diabetes prevention, no trial has evaluated the extent to which mid- and long-term complications can be prevented by early interventions on hyperglycaemia. Aims: To assess the long-term effects on multiple complications of hyperglycaemia of early intensive management of hyperglycaemia with sitagliptin, metformin or their combination added to lifestyle intervention (LSI) (diet and physical activity), compared with LSI alone in adults with non-diabetic intermediate hyperglycaemia (IFG, IGT or both). Study Design: Long-term, multi-centre, randomised, partially double blinded, placebo controlled, phase-IIIb clinical trial with prospective blinded outcome evaluation. Participants will be randomised to four parallel arms: 1) LSI \ 2 placebo tablets/day; 2) LSI \ 2 Metformin tablets of 850 mg/day; 3) LSI \ 2 Sitagliptin tablets of 50 mg/day; 4) LSI \ 2 tablets of a fixed-dose combination of Sitagliptin 50mg and Metformin 850 /day. Active intervention will last for at least 3 years, and additional follow-up up to 5 years. Setting and population: Males and Females with pre-diabetes (IFG, IGT or both) aged 45 to 74 years selected from primary care screening programs in 15 clinical centres from 12 countries: Australia, Austria, Bulgaria, Germany, Greece, Italy, Lithuania, Poland, Serbia, Spain, Switzerland and Turkey. (N=3000) Main Outcomes: The primary endpoint is a combined continuous variable: the microvascular complication ndex (MCI) composed by a linear combination of the Early Treatment Diabetic Retinopathy Study Scale (ETDRS) score (based on retinograms), the level of urinary albumin to creatinine ratio, and a measure of distal small fibre neuropathy (sudomotor test by SUDOSCAN), measured during baseline visit and at 36th and 60th month visits after randomisation. In addition, this project will include the evaluation of early novel serological biomarkers of systemic inflammation, early micro-vascular damage, non-alcoholic fatty liver disease, insulin sensitivity and insulin secretion, and measures of quality of life, sleep quality (somnograms) and neuropsychological evaluation. Vascular function and structure will be evaluated in a subset of participants (n=1000), including cIMT and microvascular endothelial function measured by EndoPAT. Expected results: By evaluating the effect of aggressive treatments in pre-diabetes for the early prevention of diabetes complication, this project has the potential of changing the current paradigm of early management of hyperglycaemia. The ultimate goal is the development of a standardized core protocol for the early prevention of microvascular and other complications, impacting social cost as a result not only in health care, but also in disabilities at work.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: ENV.2010.4.1.4-1 | Award Amount: 1.22M | Year: 2010

Balkan countries do not have a coherent and continuous approach towards the challenge of implementing integrated Earth Observation (EO) applications in environmental monitoring and management. It should be mentioned that the Balkan countries, except Greece, are not ESA members. Besides, Albania, Serbia, Bulgaria, FYROM, Montenegro and Bosnia Herzegovina are also not members of the GEO. The defect in the implementation of EO applications and their use in the environmental decision making are manifested through the limited synergies among national and regional institutions, ineffective technological means and discontinuous record of participation to international organizations and committees. On the other hand, the increasing importance of a common approach towards effective environmental monitoring practices, for the benefit of the societal web of the broader Balkan region, calls for immediate action, setting as a starting point the built up of regional institutional capacity and spillage of technology transfer. The aim of the OBSERVE project is to collect and compile all the necessary information for delivering an integrated analysis on the current status of EO activities and networks in the Balkans regarding environmental monitoring, the potential benefit from the full exploitation of an integrated capacity building strategy and the prospect of creating a relevant permanent EO Community in the broader region. OBSERVE project has the ultimate goal to raise awareness and establish firm links with the regional decision making bodies on the importance of a mutual and enhanced EO application network on environmental monitoring according to the principles of the GEO. The OBSERVE project consortium consists of 15 institutions from 13 different countries, 8 of which belong to the Balkan region. 10 of the partners are Universities/Research Organizations while the other 5 are from private sector.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: KBBE-2007-1-4-05 | Award Amount: 1.14M | Year: 2008

AgriPolicy builds on the results of the previous FP6 project CEEC AGRI POLICY ( which was awarded financial support by DG Research in 2004 following the call FP6-2003-SSP-3. The overall objective of the proposal is to support the formulation of Community agricultural policies. AgriPolicy has 4 specific objectives: 1. Networking and information sharing The objective is to stimulate the networking and the sharing of information between organisations involved in agri-economics analysis. The networking will be stimulated through the organisation of 3 symposia and 6 workshops and the development of a dynamic web site including an up-dated directories of experts and organisations. 2. Provide scientific input for policy making The objective is to provide analyses on a number of specific topics (8-monthly as well as report on demand). 3. Prepare future analysis The objective is to prepare for future policy and sectoral analyses and research by collecting quantitative and qualitative information. In the NMS, 3 monitoring reports of agricultural and rural will be prepared. In the WBC, a study on the existing availability of key agricultural and rural statistics will be prepared. 4. Develop analytical capacities The objective is to strengthen the analytical capabilities of the research organisations involved in the project in the field of policy evaluation and foresight analysis. This will be achieved by implementing training sessions as well as conducting pilot studies. AgriPolicy will be implemented by a team of experts from 24 organisations from 24 countries. The team is composed of the partners of the former project, augmented with new competencies from the old Member States (IAMO in Germany and LEI in the Netherlands), from Malta and from Albania, FYROM, Kosovo and Montenegro.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ISIB-04a-2014 | Award Amount: 5.00M | Year: 2015

Europes bioeconomy is expected to foster economic growth and to tackle significant societal challenges with less harmful environmental effects through innovative, sustainable and inclusive use of European forest resources. Increasing demand for biomass and other ecosystem goods and services calls for changes in forest-related policies at different levels and across different sectors. Accordingly, the recent Forest Strategy provides clear signals towards the need for harmonised information for mapping and assessing the dynamic state of forest ecosystems and their services. Building upon scientific advances in COST E4, 39, 43, USEWOOD, FORSYS, ORCHESTRA; the networks ENFIN, EFFIS, SOSIN; the FP7 EUFODOS, S2BIOM, INTEGRAL, SIMWOOD, FIRE PARADOX the project DIABOLO aims to: i) strengthen the methodological framework towards more accurate, harmonised and timely forest information, e.g. on growing stock and stock changes, biomass, carbon, NWFP; enable the analysis of sustainable biomass supply derived from multipurpose and multisource national forest inventories; and facilitate near real-time forest disturbance monitoring, e.g. on forest fires, storm, drought, insect outbreaks; ii) support EU policy processes, international reporting obligations, forest administration and forest planning entities with new methodologies and EU-wide consistent forest information; iii) make innovative use of existing field-collected data and EC space-based applications of EO and satellite positioning systems with reference to INSPIRE and GEOSS, and global monitoring systems such as REDD\, FLEGT and UNFF. To deliver high impact, beyond state-of-the-art work within the ecological and socio-economic diversity in Europe, the trans-disciplinary DIABOLO involves experts in quantitative modelling, policy science and NFIs, from 26 European countries, committed to provide new methodologies and information for various end-uses, including EFDAC (FISE) at JRC, GLOBIOM at IIASA and work at FAO/UNECE.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: ENV.2010.1.1.6-2 | Award Amount: 1.06M | Year: 2011

The projects aims are the development and evaluation of mitigation/adaptation (M/A) policy portfolios and the prioritization of research needs and gaps for twelve (12) countries (Albania, Armenia, Azerbaijan, Bulgaria, Estonia, Kazakhstan, Moldova, Romania, Russian Federation, Serbia, Turkey and Ukraine) characterized as emerging economies. The achievement of these aims is ensured through seven (7) work packages (WP) corresponding to the following projects main objectives, Evaluation of available data and information (WP1), Choice and implementation of models (WP2), Scenarios and policy portfolios (WP3), Evaluation of policy portfolios (WP4), Prioritization of research gaps and needs (WP5), Training Dissemination (WP6), Management (WP7). The overall strategy is based on Development (WP1, WP2, and WP3), Implementation (WP3), Evaluation (WP4) and Knowledge Transfer (WP6) towards scientists and decision makers of both public and private sectors from the aforementioned emerging economies; scientific research needs and gaps (WP5) will be identified and listed in an inventory as well. The knowledge transfer (training dissemination) includes a combination of training and of a continuous flow of information to decision makers of the public and private sectors of the participating emerging economies. Training includes tele-teaching and one case study seminar (in-situ) plus the provision of the necessary means (data base, software licenses plus the instruction material that will be developed during the relevant tasks of the project). Scientists and decision makers of both the public and private sector will be encouraged to participate in the training procedures and benefit from the projects dissemination activities. The dissemination activities include official presentations and deliberations with the governmental bodies of the Black Sea Economic Cooperation Organization (BSEC) (Ministerial Meetings, Working Groups on Environment, Energy, Science and Technology, etc), the national competent authorities and relevant stakeholders, twelve (12) national workshops, a final international conference, a world wide disseminated newsletter, a main website with fifteen (15) linked websites, papers in scientific journals and conferences, editions. A close cooperation, at regional and national level with the BSEC Permanent Secretariat (PERMIS), the Business Council (BC-BSEC), the relevant ministries and local market forces (Industry, SMEs, banking sector, NGOs, etc) will enhance the socio-economic impact of the project. Additional efforts will be carried out for coordinated action with the United Nations Development Programme (UNDP) and other international programmes in the region. The projects duration is 36 months and the budget 961,455.00

Agency: European Commission | Branch: FP7 | Program: CP-IP-SICA | Phase: KBBE-2009-2-5-01 | Award Amount: 7.58M | Year: 2010

VEG-i-TRADE provides platforms to identify impacts of anticipated climate change and globalisation on food safety, microbiological and chemical hazards, of fresh produce and derived food products. Control measures of managerial and technological nature will be developed in the supply chain of crop production, post-harvest processing and logistics to minimize food safety risks. The assessment of the performance of horticultural safety management systems by a novel diagnostic instrument at EU level exemplified by several countries in Europe and tailored on a global level including major EU trade partners from various climate zones will lead to recommendations on European and global level on quality assurance and the setting of science-based performance objectives. VEG-i-TRADE will pro-actively invest in problem solving technologies for safe produce investigating aspects of water quality and water treatment, horticultural production practices, disinfection treatment and packaging technologies. These control measures will be exploited in collaboration with SMEs and industrial partners. Baseline studies on the hazards, intervention technologies and best practices in the fresh produce chain will provide input for both microbial and chemical risk assessment to elaborate support to risk-based sampling plans, evaluate the risks of newly identified threats as affected by the global trade system and anticipated climate change. The project output will craft a discussion forum for stakeholders in the global food chain reflecting on issues of acceptable risk, sustainability of fresh produce production and long term strategy of international food trade, while making no compromise in food safety for European consumers and in respectation of food sovereignty. Risk communication to increase awareness of trade partners production systems and the uneven consumer behaviour will provide key conditions for prioritisation of risk management strategies.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST.2011.5.2-3. | Award Amount: 3.96M | Year: 2011

In response to the calls demand for cost effective modernization of the inland fleet for freight transport, MoVe IT! develops a suite of options for the modernisation of inland ships that meet the challenges of over-aging of the fleet, climate change and stronger environmental objectives and provides decision support regarding the application of these options. In this suite of options, knowledge gained from newbuildings, technology transfer from other transport modes, improvement of energy efficiency & ecological performance, transition to the post-fossil-fuel-era and adaptation to new ADN rules are prominent. One of the main focal points of MoVe IT! is the modernisation of the ships drive and power system in a way that is matched to the conditions it will face throughout its life. This will result in significantly better performance compared to the ships old systems that are designed to fulfil a single design condition. First, the conditions the ship will encounter are established through full-scale measurements. Using the operational profiles resulting from these measurements, the ships power systems and hydrodynamics are reviewed and optimal, integrated solutions are developed that minimize investments and ecological impact while maximizing efficiency. Research topics include new power system configurations, alternative fuels, retrofitting techniques for existing engines, improved hull and propulsors and assistance to the captain for efficient sailing. Further crucial modernization measures are to increase the vessels main dimensions to achieve economical and ecological scale advantages and upgrade of old tankers to meet new ADN requirements. MoVe IT! also invests heavily in assessing the economic viability of solutions as well as their contribution to environmental improvements. Subsequently, modernisation support for ship owners, policy support and (full scale) demonstrators will contribute to lowering the acceptance threshold for modernisation.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2013.3.7.1 | Award Amount: 5.16M | Year: 2013

The main aim of this project is to support the sustainable delivery of non-food biomass feedstock at local, regional and pan European level through developing strategies, and roadmaps that will be informed by a computerized and easy to use toolset (and respective databases) with update harmonized datasets at local, regional, national and pan European level for EU27, western Balkans, Turkey and Ukraine. It will do so by comparing and making use of the most recent relevant information from recent and ongoing EU projects by a set of carefully selected validation case studies and in concise collaboration with key stakeholders from policy, industry and markets.The project fits under the overall umbrella of the Europe 2020 strategy for the building of a bioeconomy, as well as the targets for deployment of renewable energies and reduction of greenhouse gas emissions.The project will build up a concise knowledge base both for the sustainable supply and logistics of nonfood biomass (quantities, costs, technological pathway options for 2020 and beyond), for the development of technology and market strategies to support the development of a resource efficient Bioeconomy for Europe. This includes industrial processes (i.e. bio-based industries) for manufacturing biomass-derived goods/products as well as energy conversion, both for large scale and small scale units.The research work will be organized in three individual but strongly interrelated Themes: Theme 1 will focus on methodological approaches, data collection and estimation of sustainable biomass potentials, resource efficient pathways and optimal logistical supply routes as well as will develop the computerized toolset. Theme 2 will make use of the findings of Theme 1 and develop a Vision, Strategies and an R&D roadmap for the sustainable delivery of non-food biomass feedstock at local, regional and pan European level. Theme 3 will validate the findings from Themes 1 and 2 and ensure the project outreach

Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: GEANT-CABLE-2015 | Award Amount: 12.45M | Year: 2016

The BELLA-S1 proposal aims to provide for the long-term interconnectivity needs of the European and Latin American research and education networks, and answers the call for transatlantic connectivity to Latin America in the H2020 Work Programme 2014-15. The objective will be to strengthen connectivity to Latin America ensuring very high capacity, cost benefits and the shortest possible route, whilst stimulating diversity over the transatlantic segment. The objective will be met in two phases: phase one will procure an indefeasible right of use for a portion of the spectrum of a direct submarine telecommunications cable between Europe and Latin America; phase two will deploy one or more wavelengths, as required, on the spectrum procured to interconnect the GANT and RedCLARA networks, and provide for the intercontinental connectivity needs of the European and Latin American research and education communities.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-20-2015 | Award Amount: 6.91M | Year: 2016

Strength2Food is a 5-year, 6.9 million project to improve the effectiveness of EU food quality schemes (FQS), public sector food procurement (PSFP) and to stimulate Short Food Supply Chains (SFSC) through research, innovation and demonstration activities. Our 30-partner consortium representing 11 EU and 4 non-EU countries combines leading academic, communication, SME and stakeholder organisations to ensure a multi-actor approach. It will undertake case study-based quantitative research to measure economic, environmental and social impacts of FQS, PSFP and SFSC. The impact of PSFP policies on balanced nutrition in schools will also be assessed. Primary research will be complemented by advanced econometric analysis of existing datasets to determine impacts of FQS and SFSC participation on farm performance and survival, as well as understand price transmission and trade patterns. Consumer knowledge, confidence in, valuation and use of FQS labels and products will be assessed via cross-national survey, ethnographic and virtual supermarket-based research. Lessons from the research will be applied and verified in 6 pilot initiatives, focusing on less-developed and transition regions. These initiatives bring together academic and non-academic stakeholder partners in action research. The six pilot actions are: a school meals initiative to improve the nutritional outcomes and economic benefits for local agri-food producers; in-store trials (undertaken with a grocery retailer) to upscale sales of local produce; a scheme to stimulate a sustainable SFSC that adds value to the fishing community; and pilot actions to expand regional food labelling; increase sales of FQS products in non-traditional markers; and improve returns to local producers at food fairs and farmers markets (via a smartphone app). Project impact will be maximised through a knowledge exchange platform, hybrid forums, school educational resources, a Massive Open Online Course and practitioner recommendations.

Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: GEANT | Award Amount: 44.18M | Year: 2015

The overall objective is to provide a stable environment for the implementation of GANT as the European Communications Commons for the European Research Area, which will provide the best possible digital infrastructure to ensure that Europe remains in the forefront of research. GANTs extensive and long-standing contacts with large data disciplines such as biology, radioastronomy and high-energy physics help shape the evolution of the networking facilities required. This is complemented by partner contacts with research domains that are new users of high-performance networks and services, such as: digital preservation, real-time art and humanities. The vision is to position the GANT partnership optimally to achieve the strategic objectives of the FPA while ensuring the continuity and improvement of the services successfully offered under the GN3plus FP7 project. The extensive experience of the GANT partnership in providing high-quality and innovative services has been applied to the preparation phase of this proposal. The following GN4-1 work package objectives deserve to be highlighted: Maintain and enhance the production service and achieve cost reductions without negative effects on network service levels. Coordinate with the other European e-infrastructure efforts both individually and in the framework of the increased coordination effort. Prepare a new round of Open Call projects to start immediately after the end of the GN4-1 project. Expand the footprint and the depth of services offered to roaming users with enhanced trust and identity services through Federation as a Service and with group and attribute management added to eduGAIN. Develop online real-time services to improve the ease and function of videconferencing, open learning support and general multimedia use. Review the existing service catalogue using the Product Lifecycle Management process to assess the cost/benefits of each carefully to define the future service strategy.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: KBBE.2013.2.3-02 | Award Amount: 4.41M | Year: 2013

In the European Union, Small and Medium Enterprises (SMEs) of the food sector are increasingly under pressure due to developing open markets, increasing demand of standardized and price competitive food products by the consumers, rising importance of large retailers and challenges in obeying governmental regulations. This raises the risk of losing many traditional foods as well as traditional processing techniques which are applied by SMEs using regional raw materials and often have a role in the cultural identity of regions. In urban centers in Europe, groups of consumers are increasingly demanding traditional, local and/or organic food productions as food poisoning cases and the dispute on GMO undermined public confidence on industrial food producing systems. To reach these markets, SMEs of traditional foods must extend their skills in modern as well as competitive marketing and production techniques to comply with existing European regulations and to promote the aspects of their products related to nutrition and health. To support these traditional SMEs, a knowledge transfer network shall be established with the focus on different food product sectors: Grains, fishes, fruits, vegetables and mushrooms. These food sectors are traditional, healthy foodstuffs which are essential for a balanced nutrition. To support traditional SMEs in these food sectors, a European network will interlink researchers, knowledge transfer organizations and associations of SMEs on European, national and region levels. The network will act as a mediator of information about innovations in production and marketing of traditional food, will foster entrepreneurship in the sector of traditional food producers and researchers as well as will develop strategic research and innovation agendas for the traditional food sectors to be competitive on future markets.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2009-IRSES | Award Amount: 52.20K | Year: 2010

RECOSET aims to stimulate the creation of a network among research centres that are committed to studying cooperative and social enterprises in EU/AC and TC. The societal interest in cooperative and social enterprises stems from their capacity to sustain the welfare of individuals and families, to fight social inequalities, and to enhance social cohesion and solidarity behaviours through the production of a wide spectrum of general interest services (ranging from health, social and cultural services to the work integration of disadvantaged workers), heavily affecting the welfare and political systems. Despite the growing number of individual researchers and research centres involved in studies concerning this theme, a general consolidated literature on the matter is still lacking. The lack of uniformity, coupled with a poor understanding of cooperative and social enterprises roles in contemporary societies and economies, prevents the enhancement of awareness of policy makers and practitioners on the potential of cooperative and social enterprises and thus jeopardizes the sectors development. Against the background of overcoming the lack of a common theoretical framework and empirical methodologies in this field, RECOSET promotes the exchange of researchers (both early-stage and experienced). Furthermore, given the goal of establishing a lasting cooperation among the beneficiaries ,the exchange of one staff member from EURICSE specialised in networking activities is promoted. As for Third Country, the main goal is to give researchers the opportunity to benefit from the theoretical and empirical knowledge that has been accumulated so far by the EU/AC research centres involved. Researchers from EU/AC countries will be offered the opportunity to broaden the geographical reach of the studies so far accomplished, by focusing on countries where research on cooperative and social enterprises is still rather scarce.

Agency: European Commission | Branch: FP7 | Program: | Phase: | Award Amount: 3.21M | Year: 2008

eInfrastructure in Europe has reached a mature state where the GEANT network forms a backbone on top of which a distributed computing infrastructure - the Grid - provides processing and storage services for eScience research. The South-East European eInfrastructure initiatives are committed to ensuring equal participation of the less-resourced countries of the region in European trends. SEEREN initiative has established a regional network and its GEANT connection and the SEE-GRID initiative the regional Grid. Hereby proposed SEE-GRID-SCI will leverage the SEE eInfrastructure to enable new scientific collaborations among SEE user communities. SEE-GRID-SCI will stimulate widespread integrated eInfrastructure uptake by new cross-border user groups extending over the region, fostering collaboration and providing advanced capabilities to more researchers, with an emphasis on strategic groups in seismology, meteorology and environmental protection. The initiative thus aims to have a catalytic and structuring effect on a variety of user communities that currently do not directly benefit from the available eInfrastructures. In parallel, it will enlarge the regional eInfrastructure to cater for demands of the communities: a number of new Grid clusters and countries will be added, engaging a wider range of players and expanding the provider pool. Finally, SEE-GRID-SCI will help mature and stabilise the National Grid Initiatives in the region, allowing them to join the new era of longer-term sustainable Grid infrastructure in Europe. In this context, SEE-GRID-SCI will aim to attract political and financial support for materializing the eInfrastructure vision. In longer term, SEE-GRID-SCI aspires to contribute to the stabilisation and development of South-East Europe, by easing the digital divide and stimulating eInfrastructure development and adoption by new user communities, thus enabling collaborative high-quality research across a spectrum of scientific fields.

Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: INFRA-2013-1.2.1 | Award Amount: 85.21M | Year: 2013

This proposal details activities that will ensure the continued enhancement and ongoing operation of the leading-edge GANT network, supporting a range of network and added-value services, targeted at users across the GANT service area.\nIn the area of multi-domain network service operation, GN3plus plans to deliver fast, efficient provisioning of advanced services, develop operational support across management domains, and improve security to ensure service integrity and protect network resources. These initiatives will be complemented by the development of application services in a federated environment such as mobile and wireless roaming supported by safe and secure Authentication and Authorisation Infrastructure.\nNetworking Activities will provide management and support for all GN3plus activities through communication, promotion, international liaison and business development. Emphasis will be placed on supporting and encouraging service take-up among users by working closely with NRENs. GANT will increase digital inclusion through closer collaboration between NRENs, exchange of staff and specialist expertise, as well as by seeking synergies between public administrations and the GN3plus partners using their vast, shared knowledge base.\nJoint Research Activities will be targeted at providing critical analyses of future network and application technologies, with a view to future deployment of emerging technologies within and outside the GANT community.\nThe governance model aims to increase effectiveness and user influence. The GN3plus Partners Assembly will deal with overall policy and an Executive Board will oversee its implementation. An International User Advisory Committee and External Advisory Committee will ensure users views and senior industry and service provider expertise are channelled directly to the Assembly. Specialised Advisory Boards will ensure highly efficient decision making, and that the voice of the stakeholder community is heard.

Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: GEANT-2016 | Award Amount: 95.90M | Year: 2016

GN4-2 is the proposed project for the second Specific Grant Agreement under the 68-month Framework Partnership Agreement (FPA) established between the GANT Consortium and the European Commission in April 2015.This second phase of implementing the FPA will raise European research to the next level by promoting scientific excellence, access and re-use of research data. It will also drive European-wide cost efficiencies in scientific infrastructure by promoting interoperability with other e-infrastructures on an unprecedented scale. The FPA objective for the GANT Partnership is to contribute to effective European research by making Europe the best-connected region in the world. GANT must offer European researchers the network, communications facilities and application access that ensure the digital continuum necessary to conduct world-class research in collaboration with their peers, regardless of geographical location. GANT will maintain the operational excellence of the established GANT services, while achieving economies on the costs of the backbone network. The reliable, secure and state-of-the-art network services offered to researchers and other network users across Europe will remain exceptional. Massive data-transfer capacities required by extreme-scale instruments and by the penetration of big data in many areas of science will be prototyped with due consideration to the specific security and deployment challenges. Trust and identity is also prioritised with the introduction of a scalable operational model and with user requirements addressed in close concertation with the AARC and proposed AARC2 projects. GN4-2 developments are also guided by the vision of a future where a set of coherent and integrated European e-infrastructure services will offer convenient, seamless access for end-users through a common service catalogue, and facilitating the adoption of services offered by new e-infrastructure developments, such as the European Open Science Cloud.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-2-2014 | Award Amount: 13.13M | Year: 2015

OpenAIRE2020 represents a pivotal phase in the long-term effort to implement and strengthen the impact of the Open Access (OA) policies of the European Commission (EC), building on the achievements of the OpenAIRE projects. OpenAIRE2020 will expand and leverage its focus from (1) the agents and resources of scholarly communication to workflows and processes, (2) from publications to data, software, and other research outputs, and the links between them, and (3) strengthen the relationship of European OA infrastructures with other regions of the world, in particular Latin America and the U.S. Through these efforts OpenAIRE2020 will truly support and accelerate Open Science and Scholarship, of which Open Access is of fundamental importance. OpenAIRE2020 continues and extends OpenAIREs scholarly communication infrastructure to manage and monitor the outcomes of EC-funded research. It combines its substantial networking capacities and technical capabilities to deliver a robust infrastructure offering support for the Open Access policies in Horizon 2020, via a range of pan-European outreach activities and a suite of services for key stakeholders. It provides researcher support and services for the Open Data Pilot and investigates its legal ramifications. The project offers to national funders the ability to implement OpenAIRE services to monitor research output, whilst new impact measures for research are investigated. OpenAIRE2020 engages with innovative publishing and data initiatives via studies and pilots. By liaising with global infrastructures, it ensures international interoperability of repositories and their valuable OA contents. To ensure sustainability and long-term health for the overall OpenAIRE infrastructure, the proposed OpenAIRE2020 project will establish itself as a legal entity, which will manage the production-level responsibilities securing 24/7 reliability and continuity to all relevant user groups, data providers and other stakeholders.

Vujkovic M.,University of Belgrade | Stojkovic I.,University of Belgrade | Cvjeticanin N.,University of Belgrade | Mentus S.,University of Belgrade | Mentus S.,Serbian Academy of Science and Arts
Electrochimica Acta | Year: 2013

The LiFePO4/C composite containing 13.4 wt.% of carbon was synthesized by combustion of a metal salt-(glycine + malonic acid) gel, followed by an isothermal heat-treatment of combustion product at 750 °C in reducing atmosphere. By a brief test in 1 M LiClO4-propylene carbonate solution at a rate of C/10, the discharge capacity was proven to be equal to the theoretical one. In aqueous LiNO3 solution equilibrated with air, at a rate C/3, initial discharge capacity of 106 mAh g-1 was measured, being among the highest ones observed for various Li-ion intercalation materials in aqueous solutions. In addition, significant prolongation of cycle life was achieved, illustrated by the fact that upon 120 charging/discharging cycles at various rates, the capacity remained as high as 80% of initial value. The chemical diffusion coefficient of lithium in this composite was measured by cyclic voltammetry. The obtained values were compared to the existing literature data, and the reasons of high scatter of reported values were considered. © 2013 Elsevier Ltd.

Papic Z.,University Paris - Sud | Papic Z.,French National Center for Scientific Research | Papic Z.,University of Belgrade | Goerbig M.O.,University Paris - Sud | Regnault N.,French National Center for Scientific Research
Physical Review Letters | Year: 2010

We study, with the help of exact-diagonalization calculations, a four-component trial wave function that may be relevant for the recently observed graphene fractional quantum Hall state at a filling factor νG=1/3. Although it is adiabatically connected to a 1/3 Laughlin state in the upper spin branch, with SU(2) valley-isospin ferromagnetic ordering and a completely filled lower spin branch, it reveals physical properties beyond such a state that is the natural ground state for a large Zeeman effect. Most saliently, it possesses at experimentally relevant values of the Zeeman gap low-energy spin-flip excitations that may be unveiled in inelastic light-scattering experiments. © 2010 The American Physical Society.

The inhibition behaviour of the TRITON-X-405 mixed with KBr or C 4H 12NI in 2.0M H 2SO 4 on the ferritic SS was studied using potentiodynamic and EIS measurements. The electrochemical data showed that mixtures used in this study adsorbed on the SS's surface, in agreement with the Flory-Huggins adsorption isotherm. Polarization and EIS measurements indicated that KBr or C 4H 12NI had a significant synergistic effect with TRITON-X-405 in 2.0M H 2SO 4. This effect was more pronounced when adding C 4H 12NI, and at concentrations above the CMC of the used mixtures, which had been determined via corrosion-kinetic parameters. The inhibitive mechanism is proposed. © 2012 Elsevier Ltd.

Davidovic T.,Serbian Academy of Science and Arts | Ramljak D.,Temple University | Selmic M.,University of Belgrade | Teodorovic D.,University of Belgrade
Computers and Operations Research | Year: 2011

Bee colony optimization (BCO) is a relatively new meta-heuristic designed to deal with hard combinatorial optimization problems. It is biologically inspired method that explores collective intelligence applied by the honey bees during nectar collecting process. In this paper we apply BCO to the p-center problem in the case of symmetric distance matrix. On the contrary to the constructive variant of the BCO algorithm used in recent literature, we propose variant of BCO based on the improvement concept (BCOi). The BCOi has not been significantly used in the relevant BCO literature so far. In this paper it is proved that BCOi can be a very useful concept for solving difficult combinatorial problems. The numerical experiments performed on well-known benchmark problems show that the BCOi is competitive with other methods and it can generate high-quality solutions within negligible CPU times. © 2010 Elsevier Ltd. All rights reserved.

Popovic D.B.,University of Belgrade | Popovic D.B.,Serbian Academy of Science and Arts
Journal of Electromyography and Kinesiology | Year: 2014

This review discusses the advancements that are needed to enhance the effects of electrical stimulation for restoring or assisting movement in humans with an injury/disease of the central nervous system. A complex model of the effects of electrical stimulation of peripheral systems is presented. The model indicates that both the motor and sensory systems are activated by electrical stimulation. We propose that a hierarchical hybrid controller may be suitable for functional electrical stimulation (FES) because this type of controller acts as a structural mimetic of its biological counterpart. Specific attention is given to the neural systems at the periphery with respect to the required electrodes and stimulators. Furthermore, we note that FES with surface electrodes is preferred for the therapy, although there is a definite advantage associated with implantable technology for life-long use. The last section of the review discusses the potential need to combine FES and robotic systems to provide assistance in some cases. © 2014 Elsevier Ltd.

Fleischmann R.M.,University of Texas Southwestern Medical Center | Damjanov N.S.,University of Belgrade | Kivitz A.J.,Altoona Center for Clinical Research | Legedza A.,Vertex Pharmaceuticals | And 2 more authors.
Arthritis and Rheumatology | Year: 2015

Objective. To assess the efficacy and safety of oral decernotinib (VX-509; Vertex Pharmaceuticals) monotherapy in a 12-week, randomized, double-blind, placebo-controlled, dose-ranging study of patients with rheumatoid arthritis (RA). Methods. Two hundred four adults with active RA who had been unsuccessfully treated with ≥1 disease-modifying antirheumatic drug were administered placebo tablets or decernotinib twice a day at dosages of 25 mg, 50 mg, 100 mg, or 150 mg. Primary measures of efficacy at week 12 were the response rate according to the American College of Rheumatology 20% improvement criteria (ACR20) and mean change from baseline in the Disease Activity Score in 28 joints using the C-reactive protein level (DAS28-CRP). Results. At week 12, the ACR20 response rates were 39.0%, 61.0%, 65.0%, and 65.9% in the 25-mg, 50-mg, 100-mg, and 150-mg groups, respectively, and were significantly higher in the 50-mg group (P = 0.007) and the 100-mg and 150-mg groups (P = 0.002) as compared to the response rates in the placebo group (29.3%). The mean change from baseline in DAS28-CRP was greater in the 50-mg, 100-mg, and 150-mg groups as compared to the placebo group (P < 0.001). Decernotinib treatment resulted in higher ACR50 and ACR70 response rates, more patients with DAS28-CRP scores <2.6, and improvements in the Health Assessment Questionnaire disability index as compared to placebo. The most common adverse events in any decernotinib group were nausea (6.1%), headache (4.3%), an increase in levels of alanine aminotransferase (4.3%), and hypercholesterolemia (3.7%). In the groups receiving decernotinib, there was an increased risk of infections and increased liver transaminase levels. Conclusion. Decernotinib was efficacious in improving clinical signs and symptoms of RA at week 12 at dosages of 50-150 mg twice a day. Infections and increases in liver transaminase and lipid levels were noted as potential safety signals. Copyright © 2015 by the American College of Rheumatology.

Vucicevic J.,University of Belgrade | Goerbig M.O.,University Paris - Sud | Milovanovic M.V.,University of Belgrade
Physical Review B - Condensed Matter and Materials Physics | Year: 2012

We introduce a microscopic model on the honeycomb bilayer, which in the small-momentum limit captures the usual (quadratic dispersion in the kinetic term) description of bilayer graphene. In the limit of strong interlayer hopping it reduces to an effective honeycomb monolayer model with also third-neighbor hopping. We study interaction effects in this effective model, focusing on possible superconducting instabilities. We find dx2-y2 superconductivity in the strong-coupling limit of an effective tJ-model-like description that gradually transforms into d+id time-reversal symmetry-breaking superconductivity at weak couplings. In this limit the small-momentum order-parameter expansion is (kx+ik y)2 [or (kx-ik y)2] in both valleys of the effective low-energy description. The relevance of our model and investigation for the physics of bilayer graphene is also discussed. © 2012 American Physical Society.

Vucicevic J.,University of Belgrade | Tanaskovic D.,University of Belgrade | Rozenberg M.J.,University Paris - Sud | Rozenberg M.J.,University of Buenos Aires | Dobrosavljevic V.,Florida State University
Physical Review Letters | Year: 2015

Bad-metal (BM) behavior featuring linear temperature dependence of the resistivity extending to well above the Mott-Ioffe-Regel (MIR) limit is often viewed as one of the key unresolved signatures of strong correlation. Here we associate the BM behavior with the Mott quantum criticality by examining a fully frustrated Hubbard model where all long-range magnetic orders are suppressed, and the Mott problem can be rigorously solved through dynamical mean-field theory. We show that for the doped Mott insulator regime, the coexistence dome and the associated first-order Mott metal-insulator transition are confined to extremely low temperatures, while clear signatures of Mott quantum criticality emerge across much of the phase diagram. Remarkable scaling behavior is identified for the entire family of resistivity curves, with a quantum critical region covering the entire BM regime, providing not only insight, but also quantitative understanding around the MIR limit, in agreement with the available experiments. © 2015 American Physical Society.

Papic Z.,University of Belgrade | Papic Z.,University Paris - Sud | Papic Z.,French National Center for Scientific Research | Bernevig B.A.,Princeton University | Regnault N.,French National Center for Scientific Research
Physical Review Letters | Year: 2011

Entanglement in topological phases of matter has so far been investigated through the perspective of their ground-state wave functions. In contrast, we demonstrate that the excitations of fractional quantum Hall (FQH) systems also contain information to identify the system's topological order. Entanglement spectrum of the FQH quasihole (QH) excitations is shown to differentiate between the conformal field theory (CFT) sectors, based on the relative position of the QH with respect to the entanglement cut. For Read-Rezayi model states, as well as Coulomb interaction eigenstates, the counting of the QH entanglement levels in the thermodynamic limit matches exactly the CFT counting, and sector changes occur as non-Abelian quasiholes successively cross the entanglement cut. © 2011 American Physical Society.

Cvetkovic S.,REPUBLIC RESOURCES | Kalucrossed D Signerovic Radoicic T.,University of Belgrade | Vukadinovic B.,University of Belgrade | Kijevcanin M.,University of Belgrade
Renewable and Sustainable Energy Reviews | Year: 2014

Biogas is a sustainable and renewable energy source that can provide green energy, a better environment and new jobs. The aim of this paper is to present potentials for biogas production in the Republic of Serbia from different sources (agricultural crops directly provided for energy, livestock residues, municipal solid waste, slaughterhouse waste and wastewater from milk processing industry) and to analyze the current situation in this sector in Serbia. The barriers that limit the wider production of biogas are considered. Results have shown that there is a great potential for biogas production in Serbia. The yearly potentials were calculated as follows: biogas production potential from agricultural crops directly cultivated for energy is 0.85 Mega tons of oil equivalent (Mtoe); potential from livestock residues amounts to 94.13 ktoe; potential from municipal solid waste (MSW) is 49.72 ktoe; potential from slaughterhouse waste is 9.94 ktoe and potential from milk processing industry is 3.21 ktoe. The analysis of incentives, barriers and status of biogas technologies presented in this paper represents a contribution for the further improvement and analysis of the biogas sector in the Republic of Serbia. © 2013 Elsevier Ltd.

Vujkovic M.,University of Belgrade | Mentus S.,University of Belgrade | Mentus S.,Serbian Academy of Science and Arts
Journal of Power Sources | Year: 2014

By potentiodynamic polarization in saturated aqueous NaNO3 solution, the composite LiFePO4/C was transformed completely to NaFePO4/C composite. The voltammograms of sodiated olivine were successfully recorded at the rate for two order of magnitude higher than reported for the same material in organic electrolyte. A high storage capacity amounting to 118 mAh g-1 at a scan rate of 10 mV s-1 was measured. The diffusion coefficients have been calculated via cyclic voltammetry and faster diffusion of sodium in comparison to lithium was found. This finding was confirmed also with the impedance measurements. The presence of dissolved oxygen in the electrolyte did not disturb the electrochemical behaviour of this composite material. © 2013 Elsevier B.V. All rights reserved.

Durr H.-B.,University of Stuttgart | Stankovic M.S.,University of Belgrade | Ebenbauer C.,University of Stuttgart | Johansson K.H.,KTH Royal Institute of Technology
Automatica | Year: 2013

Extremum seeking feedback is a powerful method to steer a dynamical system to an extremum of a partially or completely unknown map. It often requires advanced system-theoretic tools to understand the qualitative behavior of extremum seeking systems. In this paper, a novel interpretation of extremum seeking is introduced. We show that the trajectories of an extremum seeking system can be approximated by the trajectories of a system which involves certain Lie brackets of the vector fields of the extremum seeking system. It turns out that the Lie bracket system directly reveals the optimizing behavior of the extremum seeking system. Furthermore, we establish a theoretical foundation and prove that uniform asymptotic stability of the Lie bracket system implies practical uniform asymptotic stability of the corresponding extremum seeking system. We use the established results in order to prove local and semi-global practical uniform asymptotic stability of the extrema of a certain map for multi-agent extremum seeking systems. © 2013 Elsevier Ltd. All rights reserved.

Lazic V.,ENEA | Laserna J.J.,University of Malaga | Jovicevic S.,University of Belgrade
Spectrochimica Acta - Part B Atomic Spectroscopy | Year: 2013

Influence of time delay between two laser pulses on the LIBS (laser induced breakdown spectroscopy) signal inside liquids was investigated and the results are compared with data from literature. Plasma was produced by laser ablation (LA) of aluminum inside water and its emission after the second laser pulse was characterized by spectrally and time resolved detection. Light propagation through the vapor bubble formed by the first laser pulse was studied by measurements of beam scattering and transmission. Optical absorption by the evolving bubble is not significant, but its growth is accompanied by lowering of its refraction index nb with respect to surrounding liquid; this effect increases defocusing both of the incident beam and of the out-coming plasma radiation. Collection efficiency of the secondary plasma emission rapidly degrades with the cavity growth, but close to its full expansion the LIBS signal partially recovers through Snell's reflections at the liquid-vapor interface, which produce a bright spot close to the bubble center. Such a light redistribution allows detecting of the emission from external plasma volume, otherwise deflected out of the collection system. Except for strong line transitions from the main sample constituents, self-absorbed inside the high-pressure cavity, we observed the highest LIBS signal when sending the second pulse well before the bubble is fully expanded. Transitions of the pressure wave through the focal volume, formed by the first laser pulse and reflected from the cell's walls and sample back-plane, enhances the LIBS signal importantly. The measured lifetime of the secondary plasma rapidly decreases with the bubble expansion. Here, we also discuss the optimization of the optical collection system and some analytical aspects of double-pulse (DP) LIBS inside liquids. © 2013 Elsevier B.V.

Lazic V.,ENEA | Laserna J.J.,University of Malaga | Jovicevic S.,University of Belgrade
Spectrochimica Acta - Part B Atomic Spectroscopy | Year: 2013

Plasma and vapor bubble formation and evolution after a nanosecond laser pulse delivered to aluminum targets inside water were studied by fast photography. This technique was also applied to monitor the plasma produced by a second laser pulse and for different interpulse delays. The bubble growth was evident only after 3 μs from the first laser pulse and the bubble shape changed during expansion and collapse cycles. The evolution and propagation of the initial shockwave and its reflections both from the back sample surface and cell walls were detected by Schlieren photography. The primary plasma develops in two phases: violent particle expulsion and ionization during the first μs, followed by slow plasma growth from the ablation crater into the evolving vapor bubble. The shape of the secondary plasma strongly depends on the inner bubble pressure whereas the particle expulsion into the expanded bubble is much less evident. Both the primary and secondary plasma have similar duration of about 30 μs. Detection efficiency of the secondary plasma is much reduced by light refraction at the curved bubble-water interface, which behaves as a negative lens; this leads to an apparent reduction of the plasma dimensions. Defocusing power of the bubble lens increases with its expansion due to the lowering of the vapor's refraction index with respect to that of the surrounding liquid (Lazic et al., 2012 [1]). Smell's reflections of secondary plasma radiation at the expanded bubble wall redistribute the detected intensity on a wavelength-dependent way and allow gathering of the emission also from the external plasma layer that otherwise, would not enter into the optical system. © 2013 Elsevier B.V.

Santibanez J.F.S.,University of Belgrade | Quintanilla M.,Autonomous University of Madrid | Bernabeu C.,CSIC - Biological Research Center
Clinical Science | Year: 2011

The TGF-β (transforming growth factor-β) system signals via protein kinase receptors and Smad mediators to regulate a plethora of biological processes, including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-β signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-β signal transduction has allowed a better understanding of the disease pathogenicity as well as the identification of several molecular targets with great potential in therapeutic interventions. © The Authors Journal compilation. © 2011 Biochemical Society.

Stankovic S.S.,University of Belgrade | Stankovic M.S.,KTH Royal Institute of Technology | Stipanovic D.M.,University of Illinois at Urbana - Champaign
IEEE Transactions on Automatic Control | Year: 2011

In this paper, an algorithm for decentralized multi-agent estimation of parameters in linear discrete-time regression models is proposed in the form of a combination of local stochastic approximation algorithms and a global consensus strategy. An analysis of the asymptotic properties of the proposed algorithm is presented, taking into account both the multi-agent network structure and the probabilities of getting local measurements and implementing exchange of inter-agent messages. In the case of non-vanishing gains in the stochastic approximation algorithms, an asymptotic estimation error covariance matrix bound is defined as the solution of a Lyapunov-like matrix equation. In the case of asymptotically vanishing gains, the mean-square convergence is proved and the rate of convergence estimated. In the discussion, the problem of additive communication noise is treated in a methodologically consistent way. It is also demonstrated how the consensus scheme in the algorithm can contribute to the overall reduction of measurement noise influence. Some simulation results illustrate the obtained theoretical results. © 2006 IEEE.

Pavlovic M.Z.,University of Belgrade | Urosevic D.,University of Belgrade | Urosevic D.,Isaac Newton Institute of Chile | Vukotic B.,Astronomical Observatory | And 2 more authors.
Astrophysical Journal, Supplement Series | Year: 2013

In this paper, we present new empirical radio surface-brightness-to- diameter (Σ-D) relations for supernova remnants (SNRs) in our Galaxy. We also present new theoretical derivations of the Σ-D relation based on equipartition or on a constant ratio between cosmic rays and magnetic field energy. A new calibration sample of 60 Galactic SNRs with independently determined distances is created. Instead of (standard) vertical regression, used in previous papers, different fitting procedures are applied to the calibration sample in the log Σ-log D plane. Non-standard regressions are used to satisfy the requirement that values of parameters obtained from the fitting of Σ-D and D-Σ relations should be invariant within estimated uncertainties. We impose symmetry between Σ-D and D-Σ due to the existence of large scatter in both D and Σ. Using four fitting methods that treat Σ and D symmetrically, different Σ-D slopes β are obtained for the calibration sample. Monte Carlo simulations verify that the slopes of the empirical Σ-D relation should be determined by using orthogonal regression because of its good performance in data sets with severe scatter. The slope derived here (β = 4.8) is significantly steeper than those derived in previous studies. This new slope is closer to the updated theoretically predicted surface-brightness-diameter slope in the radio range of the Sedov phase. We also analyze the empirical Σ-D relations for SNRs in a dense environment of molecular clouds and for SNRs evolving in the lower-density interstellar medium. Applying new empirical relations to estimate distances of Galactic SNRs results in a dramatically changed distance scale. © 2013. The American Astronomical Society. All rights reserved..

Vujkovic M.,University of Belgrade | Mitric M.,Vinča Institute of Nuclear Sciences | Mentus S.,University of Belgrade | Mentus S.,Serbian Academy of Science and Arts
Journal of Power Sources | Year: 2015

(Graph Presented). The nanodispersed NaTi2(PO4)3/C composite containing 20-25 wt.% of in-situ formed carbon, was synthesized by gel combustion procedure followed by a heat treatment at 650, 700 and 750 C. The samples calcined at 700 and 750 C displayed crystalline nasicon structure. They were subjected to the investigation of intercalation/deintercalation kinetics in aqueous NaNO3 and LiNO3 solutions, using cyclic voltammetry and galvanostatic charging/discharging measurements. As regards to the effect of electrolyte composition, the reactions were evidenced to be roughly twice faster in sodium nitrate than in lithium nitrate solution. Among the samples treated at 700 and 750 C, better performance was evidenced for the sample treated at lower temperature. Coulombic capacity in NaNO3 solution at charging rate 1C amounted to ∼70 mAh g-1 and ∼55 mAh g-1 for the sample calcined at 700 and 750 C, respectively, and displayed surprisingly slight dependence on charging rate up to even 100C. © 2015 Elsevier B.V. All rights reserved.

Davies A.,University of Southampton | Merli F.,Hematology Unit | Mihaljevic B.,University of Belgrade | Siritanaratkul N.,Siriraj Hospital | And 7 more authors.
The Lancet Oncology | Year: 2014

Background: Intravenous rituximab is a mainstay of treatment for follicular lymphoma. A subcutaneous formulation that achieves equivalent rituximab serum concentrations might improve convenience and save health-care resources without sacrificing clinical activity. We aimed to assess pharmacokinetic non-inferiority of 3 week cycles of fixed-dose subcutaneous rituximab versus standard intravenous rituximab. Methods: In our two-stage, randomised, open-label, phase 3 trial, we enrolled patients with previously untreated grade 1-3a, CD20-positive follicular lymphoma at 67 centres in 23 countries. In stage 1, we randomly allocated patients 1:1 with the Pocock and Simon algorithm to intravenous rituximab (375 mg/m2) or fixed-dose subcutaneous rituximab (1400 mg), stratified by induction chemotherapy regimen (cyclophosphamide, doxorubicin, vincristine, prednisone or cyclophosphamide, vincristine, prednisone), Follicular Lymphoma International Prognostic Index score, and region. After randomisation, patients received one induction dose of intravenous rituximab in cycle 1 and then allocated treatment for cycles 2-8. Patients with a complete or partial response following induction therapy continued intravenous or subcutaneous rituximab as maintenance every 8 weeks. The primary endpoint was the ratio of observed rituximab serum trough concentrations (Ctrough) between groups at cycle 7 (before cycle 8 dosing) of induction treatment in a per-protocol population. Patients were analysed as treated for safety endpoints. Stage 2 follow-up is ongoing and is fully accrued. This study is registered with, number NCT01200758. Findings: Between Feb 4, 2010, and Oct 21, 2011, we enrolled 127 patients. Pharmacokinetic data were available for 48 (75%) of 64 patients randomly allocated intravenous rituximab and 54 (86%) of 63 patients randomly allocated subcutaneous rituximab. Geometric mean Ctrough was 83·13 μg/mL in the intravenous group and 134·58 μg/mL in the subcutaneous group (ratio 1·62, 90% CI 1·36-1·94), showing non-inferiority of subcutaneous rituximab. 57 (88%) of 65 patients in the intravenous rituximab safety population had adverse events (30 [46%] grade ≥3), as did 57 (92%) of 62 patients in the subcutaneous rituximab safety population (29 [47%] grade ≥3). The most common grade 3 or worse adverse event in both groups was neutropenia (14 [22%] patients in the intravenous group and 16 [26%] patients in the subcutaneous group). Adverse events related to administration were mostly grade 1-2 and occurred in 21 (32%) patients in the intravenous group and 31 (50%) patients in the subcutaneous group. Interpretation: Stage 1 data show that the pharmacokinetic profile of subcutaneous rituximab was non-inferior to intravenous rituximab and was not associated with new safety concerns. Stage 2 will provide data for efficacy and safety of the subcutaneous administration. Funding: F Hoffmann-La Roche. © 2014 Elsevier Ltd.

Nina A.,University of Belgrade | Cadez V.M.,Astronomical Observatory
Geophysical Research Letters | Year: 2013

We present a new method to study harmonic waves in the low ionosphere (60-90 km) by detecting their effects on reflection of very low frequency (VLF) radio waves. Our procedure is based on amplitude analysis of reflected VLF radio waves recorded in real time, which yields an insight into the dynamics of the ionosphere at heights where VLF radio waves are being reflected. The method was applied to perturbations induced by the solar terminator motions at sunrises and sunsets. The obtained results show that typical perturbation frequencies found to exist in higher regions of the atmosphere are also present in the lower ionosphere, which indicates a global nature of the considered oscillations. In our model atmosphere, they turn out to be the acoustic and gravity waves with comparatively short and long periods, respectively. © 2013. American Geophysical Union. All Rights Reserved.

Novakovic B.,University of Belgrade | Cellino A.,National institute for astrophysics | Knezevic Z.,Astronomical Observatory
Icarus | Year: 2011

We present a new classification of families identified among the population of high-inclination asteroids. We computed synthetic proper elements for a sample of 18,560 numbered and multi-opposition objects having sine of proper inclination greater than 0.295. We considered three zones at different heliocentric distances (inner, intermediate and outer region) and used the standard approach based on the Hierarchical Clustering Method (HCM) to identify families in each zone. In doing so, we used slightly different approach with respect to previously published methodologies, to achieve a more reliable and robust classification. We also used available SDSS color data to improve membership and identify likely family interlopers. We found a total of 38 families, as well as a significant number of clumps and clusters deserving further investigation. © 2011 Elsevier Inc.

Milic Zitnik I.,Astronomical Observatory | Novakovic B.,University of Belgrade
Astrophysical Journal Letters | Year: 2016

Here, we report our findings about the effect of 11 two-body mean-motion resonances (MMRs) with Jupiter, on the mobility of an asteroid's semimajor axis caused by the Yarkovsky effect. This study is accomplished using numerical integrations of test particles. The obtained results reveal that MMRs could either speed up or slow down the drift in the semimajor axis. Moreover, this allows us to determine the distribution that represents the best data obtained for time delays dtr caused by the resonances on the mobility of an asteroid. We also found a certain functional relationship that describes dependence of the average time lead/lag on the strength of the resonance SR and the semimajor axis drift speed da/dt. As the Yarkovsky effect scales as , an important consequence of this relationship is that average time lead/lag is directly proportional to the diameter D of an asteroid. © 2016. The American Astronomical Society. All rights reserved.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EE-12-2014 | Award Amount: 958.75K | Year: 2015

HERON aims at facilitating policy makers of multi-level governance in EU, to develop and monitor energy efficiency policies in building and transport sectors, through forward-looking socio-economic research in seven EU and one candidate countries. The objectives are: i. the impact of socio-economic and institutional factors on implementing energy efficiency policies and measures, ii. the development of energy-efficient pathways to the horizon 2030 and beyond taking into account the socio-economic drivers and the updated energy efficiency measures, iii. the contribution to improving energy modeling by incorporating social, educational and cultural factors so as to reflect the end-user behavior, iv. the establishment of communication channels between researchers, decision makers of different governance levels and social and market stakeholders. These objectives will be achieved through: (1) Mapping of energy efficiency policy instruments, available technologies and social, economic, cultural and educational barriers in transport and buildings, (2) Assessment of the evidenced barriers and the main driving factors, in order to define their weight/importance for the implementation of energy efficiency policies, (3) Determination of linkages between the factors and the energy efficiency, (4) Forward-looking scenario analysis, focusing on macro- and micro-economic impacts of energy efficiency policy options, (5) Policy recommendations through multi-criteria evaluation and feedback mechanisms with policy makers and market stakeholders from EU (member states, Covenant of Mayors) and neighboring countries (Business Council of BSEC). HERON will develop an innovative decision support tool to incorporate non-economic and non-market elements, such as social, educational and cultural, into scenario analysis.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: PEOPLE | Award Amount: 218.35K | Year: 2008

This project aims at streamlining and institutionalization of existing efforts in development of infrastructure for encouraging and facilitating the mobility of researchers in Serbia Serbian mobility network. The proposal results from the experience that the proposal coordinator gained by taking part in the FP6 SSA project WEB-MOB Development of researchers mobility policy guidelines for the region of Western Balkans, in the period of 2005-2007. Main project objectives are: a) to establish structured network of service and information providers, enabling practical assistance to researchers in all issues related to their experience of mobility; b) to develop organizational framework, comprised of organizational structure, communication strategies, data requirements and procedures for providing of best performance in information and services delivery; and c) to promote ERA-MORE values through the awareness campaign, including promotional events, dissemination of printed material with valuable information and delivery of information and services through the national researchers mobility portal, linked to pan-European Mobility Portal. The fulfillment of the above objectives, in accordance with European standards and values, will be ensured by a four-level organizational structure of the network, consisting of the steering, coordination, operational and beneficiary (contact points) layer. As such, Serbian mobility network will provide a backbone for involvement and concentration of all relevant actors policy stakeholders, industry, public and private university representatives and researchers community. The network is guided by the steering committee, providing high-level support, coordinated by the bridgehead organization and operated by four regional mobility centers, with geographical coverage of universities and one specific mobility center for private universities and faculties as well as other research organizations.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.2-05 | Award Amount: 12.09M | Year: 2013

The objective of BIOCOMES is to develop 11 new biological control agents (BCAs) for key markets in European agriculture and forestry. BCAs were identified through market analysis by six manufactures of biological control products. BCAs will primarily be for use in open field crops of vegetables (3), of which 2 are also for use in protected crops, arable crops (3), fruit crops (3), and three different types of forests (2). Primary targeted pests are: gypsy moth (Lymantria dispar), pine weevil (Hylobius abietis), tomato pinworm (Tuta absoluta), white flies, aphids of fruit tree crops and Mamestra brassicae. Primary targeted pathogens are: damping-off diseases in forest nurseries, soilborne pathogens of oilseed rape and cereals, brown rot (Monilinia spp.) of stone fruit, and powdery mildew of cereals (Blumeria graminis). The economic sustainability during the entire development process will be assessed by the responsible industrial partners. The environmental sustainability will be quantified for each BCA by means of the Sustainable Process Index method. The entire developmental process for each of the 11 BCA products is guided by a consultancy partner specialized and leading in (bio) pesticide registration including risk assessments for European (bio) pesticide industries. In vitro production of entomopathogenic viruses as new innovative technique like will be developed aimed at a breakthrough in economic production. Downstream-technology and shelf life for entomopathogenic nematodes will be improved. BIOCOMES will communicate project results with all stakeholders with special attention to European IPM networks throughout the whole project duration. BIOCOMES combines the expertise of 10 industrial SME partners, 3 larger industrial partners and 14 research partners with 38% of the requested EU contribution supporting SMEs. All 11 BCA solutions will be novel IPM tools and new alternatives to replace major pesticide applications in European agriculture and forestry.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-19-2014 | Award Amount: 4.86M | Year: 2015

A good functioning of the European food system is key to deliver food and nutrition security for all Europeans. However, that system faces many economic, environmental and social challenges as well as opportunities following socio-economic and technological developments, that are not equally distributed throughout the EU. Future policymaking aiming at healthy and resilient systems needs to take into account this differentiation and diversity of approaches, which necessitate foresight activities that take into account both the development of important driving forces as well as the social and spatial diversity. Primary productionthat is agriculture, fisheries and aquacultureforms the foundation of the food system. Its structure and performance is influenced by various conditions shaped by both the public and the private sector. As economic agents, primary producers aim at generating a sufficient amount of income, but their financial conditions are highly dependent on public and private actors, such as government regulators (including the EUs agricultural and fisheries policies), the financial sector, suppliers, the food industry, retailers, etc. In other words, the web of policy requirements as well as input and output market imperfections greatly shape farmers and fishermens livelihoods. Knowledge on the conditions of primary producers and the driving forces influencing these conditions exists, but in a fragmented way: not all primary producers and regions are covered, not all driving forces have been investigated, cross-linkages between them have been insufficiently analysed, future opportunities are not well integrated, etc. The purpose of SUFISA is to identify sustainable practices and policies in the agricultural, fish and food sectors that support the sustainability of primary producers in a context of multi-dimensionsal policy requirements, market uncertainties and globalisation.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-5.3-2014 | Award Amount: 2.90M | Year: 2015

This project will explore the potential of walking and cycling tracking services to promote walking and cycling mobility. We will focus on established walking and cycling promotion measures and thoroughly assess the potential of ICT based tracking services to overcome barriers to implementation and finding new factors driving the effectiveness of those measures. Through specific research, the related ICT challenges like scheme dynamics, privacy, trust, low-cost, interoperability and flexibility will be tackled for each type of measure. The measures to target will be established measures to promote walking and cycling travel to workplace, shopping, school and leisure promotion measures. We will investigate both the ability that tracking tools may have to address traditional challenges of these measures and their potential to bring new features in the fields of awareness raising, financial/tax incentives, infrastructure planning and service concepts. A common, flexible and open access tool will be developed to provide an ICT input and output platform that addresses the related ICT challenges. Over this platform it will be easy for anyone to build products based on tracking services tailored to the requirements of the specific measures. This project will develop and test a representative set of such products in real measures underway. These test cases will at the same time validate and provide additional inputs for the projects research issues and trigger the widespread of tracking services to support walking and cycling measures in Europe. Users, policy makers and walking and cycling practitioners and final users will be deeply involved in all stages of the project.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: MSCA-NIGHT-2014 | Award Amount: 181.68K | Year: 2014

The FLIRT proposes a project that is based on the idea that falling in love with science is just as exciting as falling in love with a real person, and shows how a passionate crush can develop into real love. Massive awareness campaign will include continuous coverage and media sponsorship of tens of media outlets, visits to schools, and a development complex interactive RN Community Hub. The RN activities will address to different target groups the most important being youth aged 13 to 19. It will offer a wide range of indoor and outdoor activities, lasting from early afternoon until midnight, for different age groups, and a variety of personal tastes and interests. All of the activities will, however, evolve around the central point of the event and that is Love. The project team will undertake a comprehensive impact assessment, aimed at measuring the baseline data indicating the public recognition of research and researchers in Serbia, and the popularity of scientific careers, and then measuring any changes that might occur over the course of the project.

Agency: European Commission | Branch: H2020 | Program: SESAR-RIA | Phase: Sesar-11-2015 | Award Amount: 783.84K | Year: 2016

The APACHE project proposes a new framework to assess European ATM performance based on simulation, optimization and performance assessment tools that will be able to capture complex interdependencies between KPAs at different modelling scales (micro, meso and macro). In this context, the purpose of APACHE is threefold: - to evolve the Performance Scheme towards new methodologies and metrics capable of capturing with proportional detail the performance drivers of ATM to foster a progressive and performance-driven introduction of new operational and technical ATM concepts in line with SESAR; - to make an (initial) impact assessment of long-term ATM concepts with the new APACHE Performance Scheme, to measure the impact on ATM KPAs under different assumptions in line with the SESAR ConOps 2020\; and - to analyse the interdependencies between the different KPAs at the Pareto-frontier of the ATM performance, by finding the theoretical optimal limits for each KPA and assessing how the promotion of one KPA may actually reduce the performance of the other KPAs An initial performance assessment of new concepts of operations will be required, covering the new concepts t: free-routing in 2D (2DFR) and in 3D (3DFR) for airline operators; dynamic airspace configuration (DAC) for air navigation service providers (ANSPs); and dynamic demand and capacity balance (dDCB) for the Network Manager (NM). All these concepts will be analysed at EU-wide and/or functional airspace block (FAB) level combined under different scenarios and case studies. The optimization tools will be used to model the ATM performance drivers underpinning each of the the stakeholders business models, in particular regarding the optimization of processes for aircraft trajectory planning, sectorization planning and network safety planning. Assessment tools will be used to measure the level of KPA performances in the simulations. Tools will be provided by partners and initial versions are already available.

Agency: European Commission | Branch: H2020 | Program: SESAR-RIA | Phase: Sesar-05-2015 | Award Amount: 534.16K | Year: 2016

COCTA project proposes coordinated economic measures aiming to pre-emptively reconcile air traffic demand and airspace capacity, by acting on both sides of the inequality. In performing demand-capacity balancing COCTA primarily aims to reduce the cost arising from lack of coordination in the ATM system, stemming both from divorced planning horizons of ANSPs and aircraft operators (AOs), and from an inadequate pricing of navigation services. ANSPs plan their capacities weeks and months in advance, with only very limited and costly possibilities to adjust those on a short notice. On the other side, AOs attach great value to flight planning flexibility and tend to file their route choice decisions only hours before the time of departure. The mismatch between the predictability for ANSPs and flexibility for AOs results in substantial and costly capacity buffers built into ANSP planning decisions. COCTA recognizes this as a major issue and designs mechanisms acting on both sides, to incentivize more cost-efficient outcomes. To make this possible, COCTA envisages a new role for the network manager (NM), supported by re-designed regulatory setting. On capacity side, the NM purchases airspace capacities in line with expected network demand, employing a network-centred, demand driven approach, as opposed to the current, piecemeal and supply-driven practice, which is tailored against local (ANSP) traffic peaks. As a consequence, excessive provision of airspace capacity is to be reduced, with associated cost savings. On the demand side, the NM performs trajectory pricing, offering route menus to AOs, including novel, flexible products, aiming at an appropriate balance between cost-efficiency, delays, environmental impact and equity, without compromising safety. COCTA mechanisms and choice-based mathematical models thus work in a re-designed ATM value chain and optimize multi-criteria objectives, fully complying with multi-dimensional SES policy goals.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: SST.2010.1.3-1. | Award Amount: 2.98M | Year: 2011

The objective of the project is to upgrade and further develop the current TRANSTOOLS model, here referred to as TT2, to a new and improved European transport demand and network model (TT3). The project will improve the methodological basis of TRANSTOOLS, improve and validate its data foundation, deal with known deficiencies of the existing model, make the software faster and more efficient, and focus on the user needs, model documentation and model validation. The model will be updated to the 2010 base year based upon ETISplus data. The level of detail with regard to the rail, maritime and air transport modules will be increased. The aim here is to better analyse issues of cost, capacity and externalities of transport. The impact assessment model will be improved. Cross cutting activities will focus on methodological improvements of the model, updating and validating the data, re-estimating and re-calibrating the model, and performing an overall validation of the entire framework. Special focus will be on making the model more efficient with regard to calculation time, yet without compromising on the scientific validity with regard to causal relationships and described transport behaviour. The TT3 will deliver a validated, well documented and user friendly model that will provide policy makers with a tool for assessing and developing better transport policies. TT3 will continue the tool-box approach from prior versions of the model, which ensures that it can address the needs of many different types of user, for example analyses of EU-wise transport policies, analyses of TEN-projects and links to interregional and national project appraisals. The final model of TT3 will be IPR free and more open than the present model. The consortium ensures links back to TT1, TT2, a number of other relevant Framework projects, and ensures a strong University research base including several of the leading European Universities. This guarantees a clolink to recent research.

Stankovic A.,Serbian Academy of Science and Arts | Dimitrijevic S.,University of Belgrade | Uskokovic D.,Serbian Academy of Science and Arts
Colloids and Surfaces B: Biointerfaces | Year: 2013

Metal oxide nanoparticles represent a new class of important materials that are increasingly being developed for use in research and health-related applications. Although the antibacterial activity and efficiency of bulk zinc oxide were investigated in vitro, the knowledge about the antibacterial activity of ZnO nanoparticles remains deficient. In this study, we have synthesized ZnO particles of different sizes and morphologies with the assistance of different types of surface stabilizing agents - polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and poly (α,γ, l-glutamic acid) (PGA) - through a low-temperature hydrothermal procedure. The characterization of the prepared powders was preformed using X-ray diffraction (XRD) method and field emission scanning electron microscopy (FE SEM), as well as Malvern's Mastersizer instrument for particle size distribution. The specific surface area (SSA) of the ZnO powders was measured by standard Brunauer-Emmett-Teller (BET) technique. The antibacterial behavior of the synthesized ZnO particles was tested against gram-negative and gram-positive bacterial cultures, namely Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively. We compared the results of the antibacterial properties of the synthesized ZnO samples with those of the commercial ZnO powder. According to the obtained results, the highest microbial cell reduction rate was recorded for the synthesized ZnO powder consisting of nanospherical particles. In all of the examined samples, ZnO particles demonstrated a significant bacteriostatic activity. © 2012 Elsevier B.V.

Radivojevic G.,University of Belgrade | Gajovic V.,Dunav Insurance Company
Journal of Risk Research | Year: 2014

Supply chain management is a discipline dealing with organization, coordination, and optimization of relations within supply chains. Complexity and dynamics of supply chains are not always proportional to their reliability, and supply chain risk management becomes a very important tool in minimizing risk and uncertainties caused by, or impacting on, logistics-related activities or resources in the supply chain. Because risk modeling presents a very important segment of risk management, the paper includes a description of the main characteristics of supply chains and a model for risk assessment based on the Analytic Hierarchy Process (AHP) and Fuzzy Analytic Hierarchy Process (FAHP) methods. The main intention of the research presented here is to propose approaches based on application of the AHP and FAHP methods which are used as a tool for ranking supply chain risk categories, determining its share in total risk, and as a method for the supply chain risk assessment. The proposed approach is based on the experience and the knowledge of experts from insurance companies which are professionally engaged in the process of risk assessment, and possibility of its application is tested on a numerical example. © 2013 © 2013 Taylor & Francis.

Nedic O.,University of Belgrade | Rattan S.I.S.,University of Aarhus | Grune T.,Friedrich - Schiller University of Jena | Trougakos I.P.,National and Kapodistrian University of Athens
Free Radical Research | Year: 2013

Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the Maillard chemical process of non-enzymatic glycation of free amino groups of proteins, lipids and nucleic acids. This chemical modification of biomolecules is triggered by endogeneous hyperglycaemic or oxidative stress-related processes. Additionally, AGEs can derive from exogenous, mostly diet-related, sources. Considering that AGE accumulation in tissues correlates with ageing and is a hallmark in several age-related diseases it is not surprising that the role of AGEs in ageing and pathology has become increasingly evident. The receptor for AGEs (RAGE) is a single transmembrane protein being expressed in a wide variety of human cells. RAGE binds a broad repertoire of extracellular ligands and mediates responses to stress conditions by activating multiple signal transduction pathways being mostly responsible for acute and/or chronic inflammation. RAGE activation has been implicated in ageing as well as in a number of age-related diseases, including atherosclerosis, neurodegeneration, arthritis, stoke, diabetes and cancer. Here we present a synopsis of findings that relate to AGEs-reported implication in cell signalling pathways and ageing, as well as in pathology. Potential implications and opportunities for translational research and the development of new therapies are also discussed. © 2013 Informa UK, Ltd.

Milovanovic M.V.,University of Belgrade | Ciric M.D.,University of Belgrade | Juricic V.,KTH Royal Institute of Technology
Physical Review B - Condensed Matter and Materials Physics | Year: 2016

Recently, a Dirac (particle-hole symmetric) description of composite fermions in the half-filled Landau level (LL) was proposed [D. T. Son, Phys. Rev. X 5, 031027 (2015)2160-330810.1103/PhysRevX.5.031027], and we study its possible consequences on BCS (Cooper) pairing of composite fermions (CFS). One of the main consequences is the existence of anisotropic states in single-layer and bilayer systems, which was previously suggested in Jeong and Park [J. S. Jeong and K. Park, Phys. Rev. B 91, 195119 (2015)PRBMDO1098-012110.1103/PhysRevB.91.195119]. We argue that in the half-filled LL in the single-layer case the gapped states may sustain anisotropy, because isotropic pairings may coexist with anisotropic ones. Furthermore, anisotropic pairings with the addition of a particle-hole symmetry-breaking mass term may evolve into rotationally symmetric states, i.e., Pfaffian states of Halperin-Lee-Read (HLR) ordinary CFS. On the basis of the Dirac formalism, we argue that in the quantum Hall bilayer at total filling factor 1, with decreasing distance between the layers, weak pairing of p-wave paired CFS is gradually transformed from Dirac to ordinary, HLR-like, with a concomitant decrease in the CF number. Global characterization of low-energy spectra based on the Dirac CFS agrees well with previous calculations performed by exact diagonalization on a torus. Finally, we discuss features of the Dirac formalism when applied in this context. © 2016 American Physical Society.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: INFRA-2008-3.0.1 | Award Amount: 1.88M | Year: 2009

The South-East European eInfrastructure initiatives aim to ensure equal participation of the region in European networking and Grid computing trends. SEEREN initiative has established regional network and SEE-GRID the regional Grid. SEE-LIGHT project is currently establishing dark-fibre backbone in the region, and SEE-GRID-SCI empowering strategic regional user communities in common use of the eInfrastructure. Close collaboration of National Research & Education Networks and National Grid Initiatives in the region was crucial in materialising this vision. The above initiatives have also raised awareness of national ministries for the necessity of local programmes and financial support for eInfrastructures: a number of ministries have contributed to local network funding and regional interconnections, as well as national Grid programmes. SEERA-EI will capitalise on this momentum and link national-level programme managers and provide an open forum for information exchange, in order to enable coordination of national programmes in eInfrastructures, and to set the framework for a common regional agenda. The project will gather and exchange information regarding current programmes and carry out a state-of-the-art analysis; produce set of best practices and guidelines for national eInfrastructure programmes; and identify areas for joint regional activities, ranging from short-term soft actions, mid-term policy-level actions, to preparatory activities for long-term actions. SEERA-EI will reduce fragmentation of national programmes, create a harmonised approach to national-level initiatives in eInfrastructures, ensure local commitment, and pave the way towards common regional vision, strategy and sustainable cooperation which will give the region a common voice on European and international stage and strengthen the ERA as a whole, enabling collaborative high-quality research across a spectrum of scientific fields.

News Article | November 11, 2016

NEW YORK, NY, November 11, 2016-- Magda Campbell, MD, has been included in Marquis Who's Who. As in all Marquis Who's Who biographical volumes, individuals profiled are selected on the basis of current reference value. Factors such as position, noteworthy accomplishments, visibility, and prominence in a field are all taken into account during the selection process.Dr. Campbell began her medical career upon receiving an MD from the University of Belgrade in Yugoslavia. Several years after immigrating to the United States in 1957, she joined New York University School of Medicine as a Teaching Assistant in Psychiatry. Between 1963 and 1995, Dr. Campbell rose to the rank of Professor of Psychiatry and Professor Emeritus of Psychiatry. During this time, she also served as the Director of the Division of Children and Adolescent Psychiatry between 1987 and 1991, and Director of Training and Education between 1990 and 1991. For 21 years, Dr. Campbell was also the recipient of grants from the National Institute of Mental Health. She is a diplomate in Psychiatry and Child Psychiatry of the American Board of Psychiatry and Neurology.Since entering the field of child psychiatry, Dr. Campbell was a teacher and researcher. She has contributed more than 225 articles to professional journals and books. She was the co-author of "Child and Adolescent Psychopharmacology," published in 1985, and "Clinical Evaluation of Psychotropic Drugs for Psychiatric Disorders," published in 1993. She retired in 1995. Dr. Campbell remains Emeritus Fellow of the American College of Neuropsychopharmacology, Life Fellow of the American Academy of Child Adolescent Psychiatry and of the American Psychiatric Association.Throughout the course of her career, Dr. Campbell has been continually recognized for her commitment to medicine and mental health. She has been published in a wide variety of honors publications, including Who's Who in America, Who's Who of American Women, Who's Who in Medicine and Healthcare, Who's Who in Science and Engineering, Who's Who in the East and Who's Who in the World. Most recently, Dr. Campbell received the First Virginia Q. Anthony Outstanding Woman Leader Award from the American Academy of Child and Adolescent Psychiatry in 2013. In addition to her professional achievements, Dr. Campbell takes great pride in her family, including her children, Maria and John, as well as her grandchildren, John Jr., James and Catherine.About Marquis Who's Who :Since 1899, when A. N. Marquis printed the First Edition of Who's Who in America , Marquis Who's Who has chronicled the lives of the most accomplished individuals and innovators from every significant field of endeavor, including politics, business, medicine, law, education, art, religion and entertainment. Today, Who's Who in America remains an essential biographical source for thousands of researchers, journalists, librarians and executive search firms around the world. Marquis now publishes many Who's Who titles, including Who's Who in America , Who's Who in the World , Who's Who in American Law , Who's Who in Medicine and Healthcare , Who's Who in Science and Engineering , and Who's Who in Asia . Marquis publications may be visited at the official Marquis Who's Who website at

News Article | December 7, 2016

OAK BROOK, Ill. - People with Parkinson's disease and cognitive impairment have disruptions in their brain networks that can be seen on a type of MRI, according to a study appearing online in the journal Radiology. Parkinson's disease (PD) is a progressive disorder of the central nervous system characterized by tremors or trembling and stiffness in the limbs, impaired balance and coordination. It affects about 10 million people worldwide. As PD progresses, many patients develop mild cognitive impairment (MCI), a decline in cognitive abilities, including thinking, memory and language. MCI can be identified in approximately 25 percent of newly diagnosed PD patients, and patients with MCI progress to dementia more frequently than those with normal cognitive performance. For the new study, lead investigator Massimo Filippi, M.D., from the Neuroimaging Research Unit at San Raffaele Scientific Institute in Milan, Italy, coauthors Federica Agosta, M.D., Ph.D., and Sebastiano Galantucci, M.D., and other colleagues used an MRI technique called diffusion tractography to look for differences in the neural networks of PD patients with and without MCI. Increasingly, the human brain is understood as an integrated network, or connectome, that has both a structural and functional component. By applying an analytical tool called graph analysis to the imaging results, researchers can measure the relationships among highly connected and complex data like the network of connections in the human brain. "Cognitive impairment in PD is one of the major non-motor complications of the disease, as well as one of the major concerns of patients and caregivers at the time of diagnosis," Dr. Agosta said. "Study of the changes related to cognitive impairment in PD is imperative in order to be able to answer patients' questions and finally be able to predict the future development of this condition." The study group was made up of 170 PD patients, including 54 with MCI and 116 without, and 41 healthy controls. Analysis of imaging results showed that only PD patients with MCI had significant alterations at the brain network level. Measurements of the movement and diffusion of water in the brain, an indicator of the condition of the brain's signal-carrying white matter, differentiated PD patients with MCI from healthy controls and non-MCI PD patients with a good accuracy. Researchers said the results show that cognitive impairment in PD is likely the consequence of a disruption of complex structural brain networks rather than degeneration of individual white matter bundles. The results may offer markers to differentiate PD patients with and without cognitive deficits, according to Dr. Agosta. "If confirmed and replicated by other studies, these results would suggest the use of MRI in PD to support the clinicians in monitoring the disease and predicting the occurrence of cognitive complications," she said. The researchers have obtained resting state functional MRI data from the patients and plan to study the functional connectome alterations associated with cognitive impairment in PD and how structural and functional abnormalities are interrelated. The study is part of an international collaboration between the San Raffaele Scientific Institute and the Clinic of Neurology at the University of Belgrade in Belgrade, Serbia, led by Vladimir Kostic, M.D. "Structural Brain Connectome and Cognitive Impairment in Parkinson's Disease." Collaborating with Drs. Filippi, Agosta and Galantucci were Elka Stefanova, M.D., Silvia Basaia, M.Sc., Martijn P. van den Heuvel, Ph.D., Tanja Stojkovi?, M.D., Elisa Canu, Ph.D., Iva Stankovi?, M.D., Vladana Spica, M.D., Massimiliano Copetti, Ph.D., Delia Gagliardi, M.D., and Vladimir S. Kostic, M.D. Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc. (http://radiology. ) RSNA is an association of more than 54,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (

Redzic D.V.,University of Belgrade
Serbian Astronomical Journal | Year: 2014

We made an attempt to remedy recent confusing treatments of some basic relativistic concepts and results. Following the argument presented in an earlier paper (Redžić 2008b), we discussed the misconceptions that are recurrent points in the literature devoted to teaching relativity such as: there is no change in the object in Special Relativity, illusory character of relativistic length contraction, stresses and strains induced by Lorentz contraction, and related issues. We gave several examples of the traps of everyday language that lurk in Special Relativity. To remove a possible conceptual and terminological muddle, we made a distinction between the relativistic length reduction and relativistic FitzGerald-Lorentz contraction, corresponding to a passive and an active aspect of length contraction, respectively; we pointed out that both aspects have fundamental dynamical contents. As an illustration of our considerations, we discussed briefly the Dewan-Beran-Bell spaceship paradox and the 'pole in a barn' paradox.

Bondzulic B.P.,University of Belgrade | Petrovic V.S.,University of Manchester
Signal Processing | Year: 2014

Objective quality metrics predict perceived quality of image signals computationally and can: (i) benchmark and monitor compression and processing algorithms and (ii) optimise their performance for a given application (content, bandwidth, packet loss.). Structural similarity, represented by the well known SSIM index is a framework for objective assessment of image quality well known for its relative simplicity and robustness. Despite its practical appeal, SSIM's performance level, measured as agreement with subjective quality scores, lags more complex state-of-the-art metrics. We present a new look into structural similarity that uses an additive model and a spatial pooling approach that decouples individual structural comparisons and utilises the quality driven aggregation paradigm. We apply this new approach to both baseline intensity SSIM and gradient SSIM (GSSIM) frameworks and show, through extensive evaluation on four publicly available subjective datasets that it provides considerably more ordered (linear) relationship between objective and subjective quality for a variety of input conditions. We demonstrate that newly formulated structural similarity metrics using this approach are capable of equal or even better performance than more complex state-of-the-art objective metrics in the process lending support to the theory that humans base their opinion on the worst sections of the observed signal. © 2013 Elsevier B.V.

Milinkovic Z.B.,University of Belgrade
Acta chirurgica Iugoslavica | Year: 2010

The goals of surgery for spinal deformity are to correct or improve the deformity to get a stable, balanced and fused spine. The long-term success of any procedure for scoliosis depends on a solid arthrodesis. Getting fusion of the instrumented segment with the aid of copious autogenous iliac graft has been the most important goal of treatment. However, harvesting copious graft from teenage iliac bone has its limitation in the quantity of graft, surgical time, and other complications of graft sites. Bone substitute is a promising concept, but there is not ideal bone substitute with all the characteristics of an autogenous bone graft. Several alternative graft materials like tricalcium phosphate, hydroxyapatite, and demineralized bone matrix have osteoinductive properties. Bone morphogenic protein has osteoconductive properties. The limitations with bone substitutes are osteoinduction and osteoconduction properties, sterilization, chances of transmitting infective disease and cost. We consider that the introduction of segmental spinal instrumentation which enables strong and firm correction and fixation of the scoliotic deformity has enabled getting fusion with less graft. We can obtain that quantity of graft after laminae and spinous process decortication. This retrospective study has been done in our hospital from January 2002 to December 2004. A total of 188 patients underwent posterior corrections for adolescent idiopathic scoliosis using segmental fixation by Moss-Miami. No autogenous iliac crest graft was taken or graft substitutes. After meticulous decortication and destruction of facet joints, we used local graft taken from spinous process and laminae. All patients had minimum thirty months follow-up. We have excellent results. Out of these 188 patients, 177 patients have fused spine, no implant failure, no pain, no infection and no loss of correction. Eleven (5.8%) patients underwent re-operation; four among them because of infection, three for symptomatic implants and four due to pseudarthrosis. We consider that the use of local harvesting graft is enough for getting good spondylodesis.

Nikolic B.,University of Belgrade | Sazdovic B.,University of Belgrade
Journal of High Energy Physics | Year: 2010

In the present paper we investigate noncommutativity of D9 and D5-brane world-volumes embedded in space-time of type IIB superstring theory. Boundary conditions, which preserve half of the initial supersymmetry, are treated as canonical constraints. Solving the constraints we obtain original coordinates in terms of the effective coordinates and momenta. Presence of momenta induces noncommutativity of string endpoints. We show that noncommutativity relations are connected by N = 1 supersymmetry transformations and noncommutativity parameters are components of N = 1 supermultiplet. © 2010 SISSA, Trieste, Italy.

Pantic I.,University of Belgrade | Pantic S.,University of Belgrade
Molecular Imaging and Biology | Year: 2012

Purpose: In this article, we present the results indicating that spleen germinal center (GC) texture entropy determined by gray-level co-occurrence matrix (GLCM) method is related to humoral immune response. Procedures: Spleen tissue was obtained from eight outbred male short-haired guinea pigs previously immunized by sheep red blood cells (SRBC). A total of 312 images from 39 germinal centers (156 GC light zone images and 156 GC dark zone images) were acquired and analyzed by GLCM method. Angular second moment, contrast, correlation, entropy, and inverse difference moment were calculated for each image. Humoral immune response to SRBC was measured using T cell-dependent antibody response (TDAR) assay. Results: Statistically highly significant negative correlation was detected between light zone entropy and the number of TDAR plaque-forming cells (rs=-0.86, pG0.01). The entropy decreased as the plaque-forming cells increased and vice versa. A statistically significant negative correlation was also detected between dark zone entropy values and the number of plaque-forming cells (rs=-0.69, pG0.05). Conclusions: Germinal center texture entropy may be a powerful indicator of humoral immune response. This study is one of the first to point out the potential scientific value of GLCM image texture analysis in lymphoid tissue cytoarchitecture evaluation. Lymphoid tissue texture analysis could become an important and affordable addition to the conventional immunophysiology techniques. © World Molecular Imaging Society, 2011.

This study was intended to investigate, through resonance frequency analysis (RFA), the stability of implants placed in an early loading protocol via the osteotome sinus floor elevation technique in the posterior maxilla. All implants featured a sandblasted/acid-etched active surface. An early loading protocol was considered for patients in whom implants with a sandblasted, large-grit/acid-etched active surface (SLActive) were placed in the posterior maxilla by the osteotome sinus floor elevation technique. Implant stability, which was measured by RFA at surgery and at weekly intervals for the following 6 weeks, was used as the most significant inclusion criterion. At the end of the stability observation period, only implants with a stability quotient of 65 or higher were loaded. Implants were followed for 2 years. Twenty-seven patients received 42 implants, 40 of which were subjected to an early loading protocol 6 weeks after placement. Two years after loading, all 40 implants were surviving, without clinically or radiographically detectible complications. An early loading protocol can be used for SLActive implants placed in the posterior maxilla via the osteotome sinus floor elevation technique if their stability is confirmed by RFA.

Berec V.,University of Belgrade | Berec V.,Vinča Institute of Nuclear Sciences
PLoS ONE | Year: 2012

Selective coherence control and electrically mediated exchange coupling of single electron spin between triplet and singlet states using numerically derived optimal control of proton pulses is demonstrated. We obtained spatial confinement below size of the Bohr radius for proton spin chain FWHM. Precise manipulation of individual spins and polarization of electron spin states are analyzed via proton induced emission and controlled population of energy shells in pure 29Si nanocrystal. Entangled quantum states of channeled proton trajectories are mapped in transverse and angular phase space of 29Si <100> axial channel alignment in order to avoid transversal excitations. Proton density and proton energy as impact parameter functions are characterized in single particle density matrix via discretization of diagonal and nearest off-diagonal elements. We combined high field and low densities (1 MeV/92 nm) to create inseparable quantum state by superimposing the hyperpolarizationed proton spin chain with electron spin of 29Si. Quantum discretization of density of states (DOS) was performed by the Monte Carlo simulation method using numerical solutions of proton equations of motion. Distribution of gaussian coherent states is obtained by continuous modulation of individual spin phase and amplitude. Obtained results allow precise engineering and faithful mapping of spin states. This would provide the effective quantum key distribution (QKD) and transmission of quantum information over remote distances between quantum memory centers for scalable quantum communication network. Furthermore, obtained results give insights in application of channeled protons subatomic microscopy as a complete versatile scanning-probe system capable of both quantum engineering of charged particle states and characterization of quantum states below diffraction limit linear and in-depth resolution. PACS numbers: 03.65.Ud, 03.67.Bg, 61.85.+p, 67.30.hj. © 2012 Vesna Berec.

Jankovic B.,University of Belgrade
Transactions of Nonferrous Metals Society of China (English Edition) | Year: 2015

Isothermal decomposition process of chemically transforming indium tin oxide (ITO) powders into indium (III) hydroxide powders was investigated. Two types of powders were analyzed, i.e., non-activated and mechanically activated. It has been found that in the case of activated sample, shorter induction periods appear, which permits growth of smaller crystals, while in the case of non-activated sample, long induction periods appear, characterized by the growth of larger crystals. DAEM approach has shown that decomposition processes of non-activated and mechanically activated samples can be described by contracting volume model with a linear combination of two different density distribution functions of apparent activation energies (Ea), and with first-order model, with a single symmetrical density distribution function of Ea, respectively. It was established that specific characteristics of particles not only affect the mechanism of decomposition processes, but also have the significant impact on thermodynamic properties. © 2015 The Nonferrous Metals Society of China.

Ajdzanovic V.Z.,University of Belgrade
General physiology and biophysics | Year: 2012

Advanced age is often accompanied by glucocorticoid excess which contributes to the pathogenesis of the metabolic syndrome associated with some hemodynamic disorders. Impaired central regulation of stress hormones secretion and increased glucocorticoids/adrenal androgens ratio trigger hyperglycemia, elevated blood lipids and visceral fat accumulation, associated with hypertension and increased blood viscosity, all of which represent cardiovascular morbidity factors in this age. Finding the adequate therapeutic solutions is set as an imperative in the treatment of listed symptoms. Biologically active soy isoflavones, exhibiting estrogen- and membrane-receptor agonistic/antagonistic activity, and antioxidative and tyrosine kinase/steroidogenic enzyme inhibiting effects, appear as alternative therapeutics for various ageing-related diseases. It has been shown that soy isoflavones reduce some of the listed risk factors, while affecting the hemodynamic group of cardiovascular parameters directly, as well as indirectly via endocrine perturbations. Soy isoflavones may reverse the glucocorticoids/adrenal androgens ratio, lower serum cholesterol, slow the development of atherosclerotic plaque formation, inhibit platelet aggregation, increase cardiac contractility, but they may have diverse effects on blood viscosity and may increase triglyceride levels. Herein, we present the projection of soy isoflavones-based therapy of glucocorticoid excess and disturbed hemodynamics in advanced age, concluding that although promising, it requires the impartial approach and certain precautions.

Jovanovic R.,University of Belgrade | Tosic V.,University of Belgrade | Cangalovic M.,University of Belgrade | Stanojevic M.,University of Belgrade
Transportation Research Part A: Policy and Practice | Year: 2014

Excess of air traffic demand over available capacity in certain segments of the European airspace network typically results in substantial delays imposed on airspace users, despite a possible parallel existence of underutilised adjacent network segments. Recent EU legislation lays down a performance scheme for air navigation services (ANS) and network functions, in an attempt to improve overall efficiency of the ANS, across the areas of safety, environment, capacity and cost-efficiency. It sets a framework for a possible introduction of incentive schemes which would drive the behaviour of involved stakeholders towards meeting the established performance objectives. In such a context, this paper examines an economic concept to incentivise a more efficient use of available network capacities. We put forward a method and develop a model for an anticipatory, time-dependent modulation of ANS charges, aiming to alleviate the demand-capacity imbalance on an airspace network, at minimal cost to airspace users. The proposed method is conceptualised as a bi-level optimisation problem, reconciling the perspectives of network manager and individual network users. The results of a medium-scale real-life case study indicate that an imposition of a revenue-neutral matrix of tolls and rebates on a congested airspace network may yield a fairly equitable route assignment, which seems capacity-wise more efficient than current administrative demand management practices. © 2014 Elsevier Ltd.

Dojnov B.,University of Belgrade | Vujcic Z.,University of Belgrade
Analytical Biochemistry | Year: 2012

Detection of α-amylase and glucoamylase in crude fermentation extracts using a single native electrophoresis gel and zymogram is described in this article. Proteins were printed on substrate gel and simultaneously onto a membrane in a three-sandwich gel. α-Amylase was detected on the substrate gel with copolymerized β-limit dextrins and iodine reagent. Glucoamylases were detected on the membrane using a coupled assay for glucose detection. Both amylases were detected in native gel using starch and iodine reagent. The described technique can be a helpful tool for monitoring and control of fermentation processes because fungal amylase producers almost always synthesize both amylases. © 2011 Elsevier Inc. All rights reserved.

Buric M.,University of Belgrade | Wohlgenannt M.,Vienna University of Technology
Journal of High Energy Physics | Year: 2010

We analyze properties of a family of finite-matrix spaces obtained by a truncation of the Heisenberg algebra and we show that it has a three-dimensional, noncommutative and curved geometry. Further, we demonstrate that the Heisenberg algebra can be described as a two-dimensional hyperplane embedded in this space. As a consequence of the given construction we show that the Grosse-Wulkenhaar (renormalizable) action can be interpreted as the action for the scalar field on a curved background space. We discuss the generalization to four dimensions. © 2010 SISSA.

Petrovic Mihajlovic M.B.,University of Belgrade | Antonijevic M.M.,University of Belgrade
International Journal of Electrochemical Science | Year: 2015

This review is a result of the literature survey concerning the possibility of copper corrosion prevention. Focus is on the efficiency obtained using various organic compounds as corrosion inhibitors in numerous conditions. Several groups of compounds are found to be particularly important such as: azoles, purine and derivatives and amino acids. On the other hand plant extracts and natural products also have prominent positions in these studies. There are some new methods of inhibitor application and new investigating techniques as well as the novel research approaches developed recently. © 2015 The Authors.

Knezevic-Jugovic Z.D.,University of Belgrade
Methods in molecular biology (Clifton, N.J.) | Year: 2011

A selection of the best combination of adequate immobilization support and efficient immobilization method is still a key requirement for successful application of immobilized enzymes on the industrial level. Eupergit) supports exhibit good mechanical and chemical properties and allow establishment of satisfactory hydrodynamic regime in enzyme reactors. This is a good recommendation for their wide application in enzyme immobilization after finding the most favorable immobilization method. Methods for enzyme immobilization that have been previously reported as efficient, considering the obtained activity of immobilized enzyme are presented: direct binding to polymers via their epoxy groups, binding to polymers via a spacer made from ethylene diamine/glutaraldehyde, and coupling the periodate-oxidized sugar moieties of the enzymes to the polymer beads.

Hatami T.,University of Kurdistan | Glisic S.B.,University of Belgrade | Orlovic A.M.,University of Belgrade
Journal of Supercritical Fluids | Year: 2012

Modelling and optimization of the extraction of St. John's Wort using supercritical fluid is the subject of this study. Applying conservation of mass, two partial differential equations were written for solute concentration in both solvent and solid phase. The equilibrium constant of St. John's Wort extract between solid and solvent phase was determined using genetic algorithm optimization technique. The differential equations were solved using numerical techniques simultaneously and were compared with experimental data. The results showed a good agreement between model results and experimental data. Simulation and optimization according to genetic algorithm have shown that 313 K and 20 MPa were the optimum temperature and pressure for supercritical carbon dioxide extraction of St. John's Wort. © 2011 Elsevier B.V. All rights reserved.

Kuntic V.,University of Belgrade | Filipovic I.,Serbian Institute for Oncology and Radiology of Serbia | Vujic Z.,University of Belgrade
Molecules | Year: 2011

Two flavonoids, rutin and hesperidin, were investigated in vitro for anticoagulant activity through coagulation tests: activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT). Only an ethanolic solution of rutin at the concentration of 830 μM prolonged aPTT, while TT and PT were unaffected. In order to evaluate whether the prolongation of aPTT was due to the decrease of coagulation factors, the experiment with deficient plasma was performed, showing the effects on factors VIII and IX. Since pharmacological activity of flavonoids is believed to increase when they are coordinated with metal ions, complexes of these flavonoids with Al(III) and Cu(II) ions were also tested. The results showed that complexes significantly prolonged aPTT and had no effects on PT and TT. Assay with deficient plasma (plasma having the investigated factor at less then 1%) revealed that complexes could bind to the coagulation factors, what may lead to a non-specific inhibition and aPTT prolongation. An effort was made to correlate stability of complexes with their anticoagulant properties. © 2011.

Djordjevic M.,University of Belgrade | Blagojevic B.,University of Belgrade
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

Understanding properties of QCD matter created in ultra-relativistic heavy-ion collisions is a major goal of RHIC and LHC experiments. An excellent tool to study these properties is high-momentum hadron suppression of light and heavy flavor observables. Utilizing this tool requires accurate suppression predictions for different experiments, probes and experimental conditions, and their unbiased comparison with experimental data. With this goal, we here extend our dynamical energy loss formalism towards generating predictions for non-central collisions; the formalism takes into account both radiative and collisional energy loss, dynamical (as opposed to static) scattering centers, finite magnetic mass, running coupling and uses no free parameters in comparison with experimental data. Specifically, we here generate predictions for all available centrality ranges, for both LHC and RHIC experiments, and for four different probes (charged hadrons, neutral pions, D mesons and non-prompt J/ψ). We obtain good agreement with all available non-central data, and also generate predictions for suppression measurements that will soon become available. Finally, we discuss implications of the obtained good agreement with experimental data with different medium models that are currently considered. © 2014 The Authors.

The force exerted by a slowly moving current-carrying loop on a stationary or co-moving charge is derived within two distinct frameworks: Maxwell's electrodynamics classically interpreted (operating in the Galilean space and time) and relativistic electrodynamics (operating in Minkowski space-time). A comparison between the 'classical Maxwellian' and relativistic solutions is presented, offering some intriguing insights that have been neglected in earlier discussions of the issue. © 2014 IOP Publishing Ltd.

Djordjevic M.,University of Belgrade
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

Jet suppression of light and heavy flavor observables is considered to be an excellent tool to study the properties of QCD matter created in ultra-relativistic heavy ion collisions. We calculate the suppression patterns of light hadrons, D mesons, non-photonic single electrons and non-prompt J/ψ in Pb + Pb collisions at the LHC. We use a theoretical formalism that takes into account finite size dynamical QCD medium with finite magnetic mass effects and running coupling, which is integrated into a numerical procedure that uses no free parameters in model testing. We obtain a good agreement with the experimental results across different experiments/particle species. Our results show that the developed theoretical formalism can robustly explain suppression data in ultra relativistic heavy ion collisions, which strongly suggests that pQCD in Quark-Gluon Plasma is able to provide a reasonable description of the underlying jet physics at LHC. © 2014 The Authors.

Isic G.,University of Belgrade | Gajic R.,University of Belgrade
Journal of the Optical Society of America B: Optical Physics | Year: 2014

The lifetime and propagation length of gap surface plasmon polaritons in nanoscopically thin metal-cladded planar dielectric slots are investigated theoretically. It is shown that both can, in principle, be accurately estimated from the width of peaks in angle-resolved spectroscopic data, such as that obtained by the attenuated total reflection experiment. The propagation length is shown to be given by the product of lifetime and group velocity. Their dependence on geometric parameters is investigated and simple long-wavelength limit expressions are derived. Based on these, it is possible to make quick estimates of the lifetime and propagation length for a given structure. © 2014 Optical Society of America.

Sestak J.,University of West Bohemia | Holba P.,University of West Bohemia | Zivkovic Z.,University of Belgrade
Journal of Mining and Metallurgy, Section B: Metallurgy | Year: 2014

The famous Kissinger's kinetic evaluation method (Anal. Chem. 1957) is examined with respect to the feasible impact of the individual quantities and assumptions involved, namely the model of reaction mechanism, f(α) (with the iso-and nonisothermal degrees of conversion, λ and l) the rate constant, k(T) (and associated activation energy, E), heating/cooling rate, β (supplementing additional thermodynamic term for the melt undercooling, δT) and above all, the association of the characteristic temperature, Tm , with the DTA peak apex. It is shown that the Kissingeŕs equation, in contrary to the results of Vold (Anal. Chem. 1949), is omitting the term of heat inertia arising from the true balance of heat fluxes. The absence of this term skews the evaluated values of activation energies.

Milicev D.,University of Belgrade | Mijailovic Z.,University of Belgrade
IEEE Transactions on Software Engineering | Year: 2013

We present a novel approach to modeling and implementing user interfaces (UI) of large business applications. The approach is based on the concept of capsule, a profiled structured class from UML which models a simple UI component or a coherent UI fragment of logically and functionally coupled components or other fragments with a clear interface. Consequently, the same modeling concept of capsule with internal structure can be reapplied recursively at successively lower levels of detail within a model, starting from high architectural modeling levels down to the lowest levels of modeling simple UI components. The interface of capsules is defined in terms of pins, while the functional coupling of capsules is specified declaratively by simply wiring their pins. Pins and wires transport messages between capsules, ensuring strict encapsulation. The approach includes a method for formal coupling of capsules' behavior with the underlying object space that provides proper impedance matching between the UI and the business logic while preserving clear separation of concerns between them. We also briefly describe an implementation of a framework that supports the proposed method, including a rich library of ready-to-use capsules, and report on our experience in applying the approach in large-scale industrial systems. © 1976-2012 IEEE.

Vrankovic J.,University of Belgrade | Slavic M.,University of Belgrade
Ecological Indicators | Year: 2015

PCBs are potential genotoxicants and inductors of increased levels of ROS and oxidative stress in both humans and wildlife. In this study, biotransformation parameters and antioxidant (AO) enzymes were analyzed in the Asian clam, Corbicula fluminea, with respect to the presence of dioxin-like PCBs (dl-PCBs) in the environment. For this purpose, clams were collected from three localities with different environmental conditions. Sediments from each locality and clam tissues were analyzed for the presence of dl-PCBs. Biological responses included changes in the expression of fish CYP1A immunoreactive protein, changes in the activities of AO enzymes, SOD, CAT, GR and GPx, and the phase II biotransformation enzyme GST. Clams from the locality with the highest ΣWHO-TEQ values for sediment dl-PCBs had the highest ΣWHO-TEQ values for tissue dl-PCBs and the highest level of fish CYP1A immunoreactive protein expression. The correlations found between the concentrations of dl-PCBs and AO and GST activities revealed both concentration-dependent inhibitory and stimulatory effects. The activities of GPx, GR and GST were very sensitive to environmental xenobiotics, including dl-PCBs. The obtained results indicate that the activities of these enzymes were fine-tuned to provide optimized antioxidant responses. We also observed seasonal changes in GST and AO enzyme activities in Asian clam. The highest levels of activity were observed in spring as compared to summer or autumn. CDA, which was performed in order to classify the different clam populations, revealed a coordinated rearrangement of the clams' metabolic components that were probably aimed at compensating for environmental fluctuations. The presented data reveal the sensitivity of C. fluminea to the presence of dl-PCBs in the environment and support the use of this clam as a sentinel species for biomonitoring studies. © 2014 Elsevier Ltd.

Obradovic M.D.,University of Belgrade | Gojkovic S.L.,University of Belgrade
Electrochimica Acta | Year: 2013

The oxidation of HCOOH has been investigated on thin Pd layers ranging from 1 to 17 ML equivalents electrodeposited on polycrystalline Au substrate (Pd@Au). The results are compared to those on Pd black. Potentiodynamic polarization curves suggest that on both types of catalyst HCOOH oxidizes through dehydrogenation path. The high current densities achieved on 4-17 ML Pd@Au surpass more than three times the activity of Pd black. Chronoamperometric test reveals that the Pd@Au electrodes lose their activity faster than Pd black. In the stripping experiment performed after the chronoamperometry CO ads is detected on all the surfaces. On the 4 ML Pd@Au, which exhibits the highest deactivation rate, the COads coverage is the largest. After the chronoamperometric test repeated in the CO2 saturated supporting electrolyte, the anodic stripping shows that CO ads is present on all the electrodes, again with the highest coverage on 4 ML Pd@Au. It is concluded that deactivation of Pd surfaces is caused by the COads formed in the electrochemical reduction of CO2, which is the product of HCOOH oxidation. Electronic modification of Pd by Au substrate causes stronger interactions of Pd with HCOOH and CO, which increases HCOOH oxidation rate, but also accelerates the poisoning by COads. © 2012 Elsevier Ltd. All rights reserved.

Vukmirovic N.,Lawrence Berkeley National Laboratory | Vukmirovic N.,University of Belgrade | Wang L.-W.,Lawrence Berkeley National Laboratory
Journal of Physical Chemistry B | Year: 2011

We present large-scale calculations of electronic structure of strongly disordered conjugated polymers. The calculations have been performed using the density functional theory based charge patching method for the construction of single-particle Hamiltonian and the overlapping fragments method for the efficient diagonalization of that Hamiltonian. We find that the hole states are localized due to the fluctuations of the electrostatic potential and not by the breaks in the conjugation of the polymer chain. The tail of the density of hole states exhibits an exponentially decaying behavior. The main features of the electronic structure of the system can be described by an one-dimensional nearest neighbor tight-binding model with a correlated Gaussian distribution of on-site energies and constant off-site coupling elements. © 2011 American Chemical Society.

Dragovic G.,University of Belgrade
Asian Pacific Journal of Tropical Biomedicine | Year: 2013

Pancreatitis is a well-described complication of human immunodeficiency virus (HIV) itself and its combination antiretroviral therapy. Historically, this has been predominantly associated with the usage of nucleoside reverse transcriptase inhibitors such as didanosine and stavudine, but only rarely with the usage of protease inhibitors via the induction of hypertriglyceridemia. Pancreatitis rates in HIV/AIDS population may have been exceedingly high because of the comorbid conditions prevalent in HIV/AIDS patients (e.g. ethanol use and biliary disease), and the use of non-combination antiretroviral therapy medications such as pentamidine, corticosteroids, ketoconazole, sulphonamides, metronidazole, isoniazid and opportunistic infections (e.g. cytomegalovirus, cryptosporidiosis, mycobacterial disease). In resource limited settings, where didanosine and stavudine are widely available in cheaper generic fixed dose combinations it is likely that their usage will remain in the first line HIV treatment in common. In such settings management or estimation of a patient's risk of pancreatitis still remains an issue of concern. © 2013 Asian Pacific Tropical Biomedical Magazine.

Djordjevic M.,University of Belgrade
Physical Review Letters | Year: 2014

Both charged hadrons and D mesons are considered to be excellent probes of QCD matter created in ultrarelativistic heavy ion collisions. Surprisingly, recent experimental observations at LHC show the same jet suppression for these two probes, which - contrary to pQCD expectations - may suggest similar energy losses for light quarks and gluons in the QCD medium. We here use our recently developed energy loss formalism in a finite-size dynamical QCD medium to analyze this phenomenon that we denote as the "heavy flavor puzzle at LHC." We show that this puzzle is a consequence of an unusual combination of the suppression and fragmentation patterns and, in fact, does not require invoking the same energy loss for light partons. Furthermore, we show that this combination leads to a simple relationship between the suppressions of charged hadrons and D mesons and the corresponding bare quark suppressions. Consequently, a coincidental matching of jet suppression and fragmentation allows considerably simplifying the interpretation of the corresponding experimental data. © 2014 American Physical Society.

Grujic M.M.,University of Belgrade | Grujic M.M.,University of Antwerp | Tadic M.Z.,University of Belgrade | Peeters F.M.,University of Antwerp
Physical Review Letters | Year: 2014

The interplay of massive electrons with spin-orbit coupling in bulk graphene results in a spin-valley dependent gap. Thus, a barrier with such properties can act as a filter, transmitting only opposite spins from opposite valleys. In this Letter we show that a strain induced pseudomagnetic field in such a barrier will enforce opposite cyclotron trajectories for the filtered valleys, leading to their spatial separation. Since spin is coupled to the valley in the filtered states, this also leads to spin separation, demonstrating a spin-valley filtering effect. The filtering behavior is found to be controllable by electrical gating as well as by strain. © 2014 American Physical Society.

The as-cast microstructure of Fe–Cr–C–V white irons consists of M7C3 and vanadium rich M6C5 carbides in austenitic matrix. Vanadium changed the microstructure parameters of phase present in the structure of these alloys, including volume fraction, size and morphology. The degree of martensitic transformation is also dependent on the content of vanadium in the alloy. The volume fraction of the carbide phase, carbide size and distribution has an important influence on the wear resistance of Fe–Cr–C–V white irons under low-stress abrasion conditions. However, the dynamic fracture toughness of Fe–Cr– –C–V irons is mainly determined by the properties of the matrix. The austenite is more effective in this respect than martensite. Since the austenite in these alloys contained very fine M23C6 carbide particles, higher fracture toughness was attributed to a strengthening of the austenite during fracture. Besides, the secondary carbides which precipitate in the matrix regions also influence the abrasion behavior. By increasing the matrix strength through a dispersion hardening effect, the fine secondary carbides can increase the mechanical support of the carbides. Deformation and appropriate strain hardening have occurred in the retained austenite of Fe–Cr–C–V alloys under repeated impact loading. The particles of precipitated M23C6 secondary carbides disturb dislocations movement and contribute to increase the effects of strain hardening in Fe–Cr–C–V white irons. © 2014, Association of Chemists and Chemical Engineers of Serbia. All rights reserved.

Masovic S.,University of Belgrade | Hajdin R.,University of Belgrade
Structure and Infrastructure Engineering | Year: 2014

In order to improve bridge management practice for public roads in Serbia, a deterioration model for bridge elements was developed using condition data collected over the last 20 years. The distribution of condition data over condition states allows the estimation of reasonably reliable deterioration models even for advanced deterioration. Based on the literature review, discrete-time Markov chains were chosen for this purpose. Estimating the transition probabilities of discrete Markov chains is straightforward when the time between condition records on bridge elements closely matches the chosen time interval for the Markov chain, which is not the case with condition data in Serbia. To overcome this problem, an expectation maximisation (EM) algorithm has been applied to estimate the transition probabilities. It is shown here that the EM algorithm is a sound and robust method, which can yield a reasonable deterioration model even if limited data are available. In addition, the EM is used to determine the overall bridge deterioration using existing agency rules to derive bridge rating from element condition states. © 2013 © 2013 Taylor & Francis.

Suvakov M.,University of Belgrade | Dmitrasinovic V.,University of Belgrade
Physical Review Letters | Year: 2013

We present the results of a numerical search for periodic orbits of three equal masses moving in a plane under the influence of Newtonian gravity, with zero angular momentum. A topological method is used to classify periodic three-body orbits into families, which fall into four classes, with all three previously known families belonging to one class. The classes are defined by the orbits' geometric and algebraic symmetries. In each class we present a few orbits' initial conditions, 15 in all; 13 of these correspond to distinct orbits. © 2013 American Physical Society.

Blazencic J.,University of Belgrade
Botanica Serbica | Year: 2014

The study provides insights into stoneworts of Serbia (1851-2013). For each taxon, the synonym(s), distribution, threat factors and the IUCN threat category is given. In Serbia, 23 species are present of ca. 400 known worldwide. © 2014 Institute of Botany and Botanical Garden Jevremovac, Belgrade.

Stojadinovic S.,University of Belgrade | Vasilic R.,University of Belgrade | Peric M.,University of Belgrade
RSC Advances | Year: 2014

A review of results of molecular spectroscopic investigations during plasma electrolytic oxidation of valve metals is presented. Particular attention is paid to three spectral systems, B1Σ+ → X 1Σ+ of MgO, and B2Σ+ → X2Σ+, and C2Π-X 2Σ+ of AlO. It was shown that a reliable assignment of the observed spectral features can only be carried out by critical comparison with the data obtained from high-resolution spectroscopy, and by using the results of quantum mechanical structure calculations. Assuming the existence of partial local thermal equilibrium, we used our spectroscopic results to determine the plasma temperature. Although limited in quality, the obtained spectra are very rich, they cover large wavelength regions, and are used to obtain information about physical and chemical processes that take place in the course of plasma electrolytic oxidation of light metals and their alloys. © the Partner Organisations 2014.

Gieseler J.,ICFO - Institute of Photonic Sciences | Spasenovic M.,ICFO - Institute of Photonic Sciences | Spasenovic M.,University of Belgrade | Novotny L.,ETH Zurich | And 2 more authors.
Physical Review Letters | Year: 2014

We study the dynamics of a laser-trapped nanoparticle in high vacuum. Using parametric coupling to an external excitation source, the linewidth of the nanoparticle's oscillation can be reduced by three orders of magnitude. We show that the oscillation of the nanoparticle and the excitation source are synchronized, exhibiting a well-defined phase relationship. Furthermore, the external source can be used to controllably drive the nanoparticle into the nonlinear regime, thereby generating strong coupling between the different translational modes of the nanoparticle. Our work contributes to the understanding of the nonlinear dynamics of levitated nanoparticles in high vacuum and paves the way for studies of pattern formation, chaos, and stochastic resonance. © 2014 American Physical Society.

Vasilic M.,University of Belgrade
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

I examine the idea that our world is a branelike object of negligible influence on the bulk spacetime. No particular action functional is specified. Instead, the probe brane dynamics is derived from the universally valid stress-energy conservation equations. As an example, I study the case of a three-sphere in the five-dimensional Minkowski spacetime. The resulting four-universe turns out to depend on the equation of state of the brane constituent matter but differs from that of general relativity. One observes that, for every general relativistic universe, there exists a brane universe of equal geometry but a slightly different equation of state. As for the stability of brane universes, I find that no equation of state leads to a stable solution. However, the situation changes if the bulk spacetime has a Euclidean signature. In this case, a class of stable cosmological solutions is obtained. The brane vibrations are guided by the covariant Klein-Gordon equation with an effective metric of the Minkowski signature. It is this effective metric that local observers actually detect. As a consequence, the detected Universe is of bouncing type, with an accelerating expanding phase. © 2013 American Physical Society.

Spasojevic D.,University of Belgrade | Janicevic S.,University of Belgrade | Knezevic M.,University of Belgrade
Physical Review Letters | Year: 2011

We give numerical evidence that the two-dimensional nonequilibrium zero-temperature random field Ising model exhibits critical behavior. Our findings are based on the results of scaling analysis and collapsing of data, obtained in extensive simulations of systems with sizes sufficiently large to clearly display the critical behavior. © 2011 American Physical Society.

Hrenovic J.,University of Zagreb | Milenkovic J.,University of Belgrade | Ivankovic T.,University of Zagreb | Rajic N.,University of Belgrade
Journal of Hazardous Materials | Year: 2012

The antibacterial activity of natural zeolitized tuffs containing 2.60wt.% Cu 2+, 1.47 Zn 2+ or 0.52 Ni 2+ were tested. Antibacterial activities of the zeolites against Escherichia coli and Staphylococcus aureus were tested after 1h and 24h of exposure to 1g of the zeolite in 100mL of three different media, namely Luria Bertani, synthetic wastewater and secondary effluent wastewater. The antibacterial activities of the zeolites in Luria Bertani medium were significantly lower than those in the other media and negatively correlated with the chemical oxygen demand of the media. The Ni-loaded zeolite showed high leaching of Ni 2+ (3.44-9.13wt.% of the Ni 2+ loaded) and weak antibacterial activity in the effluent water. Since Cu-loaded zeolite did not leach Cu 2+ and the leaching of Zn 2+ from Zn-loaded zeolite was low (1.07-1.61wt.% of the Zn 2+ loaded), the strong antibacterial activity classified the Cu- and Zn-loaded zeolite as promising antibacterial materials for disinfection of secondary effluent water. © 2011 Elsevier B.V..

Miljkovic D.,University of Belgrade | Spasojevic I.,University of Belgrade
Antioxidants and Redox Signaling | Year: 2013

The pathophysiology of multiple sclerosis (MS) involves several components: redox, inflammatory/autoimmune, vascular, and neurodegenerative. All of them are supported by the intertwined lines of evidence, and none of them should be written off. However, the exact mechanisms of MS initiation, its development, and progression are still elusive, despite the impressive pace by which the data on MS are accumulating. In this review, we will try to integrate the current facts and concepts, focusing on the role of redox changes and various reactive species in MS. Knowing the schedule of initial changes in pathogenic factors and the key turning points, as well as understanding the redox processes involved in MS pathogenesis is the way to enable MS prevention, early treatment, and the development of therapies that target specific pathophysiological components of the heterogeneous mechanisms of MS, which could alleviate the symptoms and hopefully stop MS. Pertinent to this, we will outline (i) redox processes involved in MS initiation; (ii) the role of reactive species in inflammation; (iii) prooxidative changes responsible for neurodegeneration; and (iv) the potential of antioxidative therapy. Antioxid. Redox Signal. 19, 2286-2334. © Copyright 2013, Mary Ann Liebert, Inc. 2013.

Stojkovic-Filipovic J.,University of Belgrade | Kittler H.,Medical University of Vienna
JDDG - Journal of the German Society of Dermatology | Year: 2014

Amelanotic melanoma is a subtype of cutaneous melanoma without pigment. The clinical diagnosis is challenging because it may mimic benign or malignant melanocytic and non-melanocytic neoplasms and inflammatory skin diseases. In synchrony with the improvement of the diagnosis of pigmented lesions, dermatoscopy may assist the clinician in the diagnosis of non-pigmented skin neoplasms in general and of amelanotic melanoma in particular. We have searched the literature to extract the most relevant dermatoscopic clues to diagnose amelanotic and hypomelanotic melanomas by dermatoscopy. In addition we present eight consecutive cases and discuss their clinical and dermatoscopic characteristics in the light of published data. © 2014 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Nikolic N.D.,University of Belgrade | Maksimovic V.M.,Vinča Institute of Nuclear Sciences | Brankovic G.,University of Belgrade
RSC Advances | Year: 2013

Electrodeposition of lead from a concentrated nitrate solution was examined by scanning electron microscopy (SEM) and by X-ray diffraction (XRD) analysis of the obtained powder particles. Single crystals of the (111) preferred orientation were formed at a low overpotential by ohmic controlled electrodeposition. Irregular crystals, needle-like and fern-like dendrites, predominantly of the (111) preferred orientation, were formed at high overpotentials (the diffusion control of the electrodeposition). The ratio of Pb crystallites oriented in the (200), (220), (311) and (331) planes increased with increasing electrodeposition overpotential. The correlation between the morphologies and crystallographic structures of the lead deposits was discussed by the consideration of general characteristics of growth layers in electrodeposition processes. © The Royal Society of Chemistry 2013.

Sljukic B.,University of Lisbon | Milikic J.,University of Belgrade | Santos D.M.F.,University of Lisbon | Sequeira C.A.C.,University of Lisbon
Electrochimica Acta | Year: 2013

Electrochemical oxidation of sodium borohydride (NaBH4) at carbon-supported platinum (Pt/C) and carbon-supported bimetallic platinum alloys (Pt0.75M0.25/C, with M = Ni or Co) is studied in alkaline media using cyclic voltammetry and linear scan voltammetry with rotating disc electrode. Main kinetic parameters (e.g., charge transfer coefficients, number of electrons exchanged, standard heterogeneous rate constants and activation energies) for NaBH4 oxidation on these electrocatalysts are determined. Results indicate the highest catalytic activity of Pt 0.75Ni0.25/C alloy electrocatalyst, followed by Pt 0.75Co0.25/C, while the lowest activity is observed for Pt/C electrocatalyst. The influence of electrolyte composition and temperature on NaBH4electrooxidation at the three materials is also explored. The good performance of these bimetallic alloys makes them a lower cost alternative to single Pt as electrocatalysts for the direct borohydride fuel cell anode. © 2013 Elsevier Ltd. All rights reserved.

Ninkovic P.,University of Belgrade
IEEE International Symposium on Industrial Electronics | Year: 2014

This paper presents a novel method for calculation of magnitude and frequency of single-phase voltage sources in hard real-time applications. It is developed for supervision of renewable power sources, both for converter and grid side. The method is based on Discrete Fourier Transform (DFT) of input signal, but it avoids the DFT errors due to off-nominal frequency operation. Steady-state error and second-harmonic oscillations in output signal are decreased within acceptable levels for all frequencies of interest. Accuracy of 20mHz for frequency and 0,2% for magnitude without harmonic content in input signal is obtained. The method described is applied on ARM7TDMI microcontroller platform and verified by experiments. © 2014 IEEE.

Terletska H.,Florida State University | Vucicevic J.,University of Belgrade | Tanaskovic D.,University of Belgrade | Dobrosavljevic V.,Florida State University
Physical Review Letters | Year: 2011

We perform a systematic study of incoherent transport in the high temperature crossover region of the half filled one-band Hubbard model. We demonstrate that the family of resistivity curves displays characteristic quantum critical scaling of the form ρ(T,δU)=ρc(T)f(T/ T0(δU)), with T0(δU)∼|δU|zν, and ρc(T)∼T. The corresponding β function displays a "strong coupling" form β∼ln(ρc/ρ), reflecting the peculiar mirror symmetry of the scaling curves. This behavior, which is surprisingly similar to some experimental findings, indicates that Mott quantum criticality may be acting as the fundamental mechanism behind the unusual transport phenomena in many systems near the metal-insulator transition. © 2011 American Physical Society.

Maric N.P.,University of Belgrade | Svrakic D.M.,University of Washington
Psychiatria Danubina | Year: 2012

Schizophrenia (SZ) is a highly heritable disorder, with about 80% of the variance attributable to genetic factors. There is accumulating evidence that both common genetic variants with small effects and rare genetic lesions with large effects determine risk of SZ. As recently shown, thousands of common single nucleotide polymorphisms (SNPs), each with small effect, cumulatively could explain about 30% of the underlying genetic risk of SZ. On the other hand, rare and large copy number variants (CNVs) with high but incomplete penetrance, variable in different individual, could explain about additional 30% of SZ cases. Although these rare CNVs frequently develop de novo, it is not clear whether they affect risk independently or via interaction with a polygenic liability in the background. Finally, the role of environmental risk factors has been well established in SZ. Environmental factors are rarely sufficient to cause SZ independently, but act in parallel or in synergy with the underlying genetic liability. Epigenetic misregulation of the genome and direct CNS injury are probably the main mechanism to mediate prenatal environmental effects (e.g., viruses, ethanol, or nutritional deficiency) whereas postnatal risk factors (e.g., stress, urbanicity, cannabis use) may also affect risk via usebased potentiation of vulnerable CNS pathways implicated in SZ. In this review, we outline a general theoretical background of epigenetic mechanisms involved in GxE interactions, and then discuss epigenetic and neurodevelopmental features of SZ based on available information from genetics, epigenetics, epidemiology, neuroscience, and clinical research. We argue that epigenetic model of SZ provides a framework to integrate a variety of diverse empirical data into a powerful etiopathogenetic synthesis. The promising future of this model is the possibility to develop truly specific prevention and treatment strategies for SZ. © Medicinska naklada.

Aschieri P.,University of Piemonte Orientale | Castellani L.,University of Piemonte Orientale | Dimitrijevic M.,University of Belgrade
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We develop a general strategy to express noncommutative actions in terms of commutative ones by using a recently developed geometric generalization of the Seiberg-Witten map between noncommutative and commutative fields. We apply this general scheme to the noncommutative vierbein gravity action and provide a Seiberg-Witten differential equation for the action itself as well as a recursive solution at all orders in the noncommutativity parameter θ. We thus express the action at order θn+2 in terms of noncommutative fields of order at most θn+1 and, iterating the procedure, in terms of noncommutative fields of order at most θn. This in particular provides the explicit expression of the action at order θ2 in terms of the usual commutative spin connection and vierbein fields. The result is an extended gravity action on commutative spacetime that is manifestly invariant under local Lorentz rotations and general coordinate transformations. © 2013 American Physical Society.

Radetic M.,University of Belgrade
Journal of Photochemistry and Photobiology C: Photochemistry Reviews | Year: 2013

Extraordinary photocatalytic activity, non-toxicity, high availability, biocompatibility, and low price make TiO2 nanoparticles particularly attractive for manufacturing of different high value-added products. During the past several years, many efforts have been made to immobilize TiO2 nanoparticles onto textile materials with an aim to produce goods with multifunctional properties such as UV protective, self-cleaning and antibacterial. The processing of textile materials with TiO2 nanoparticles is relatively simple, but insufficient binding efficiency between certain fibers and TiO2 nanoparticles imposes a problem concerning the stability and durability of nanocomposite systems during their exploitation. Therefore, recent studies were more oriented toward chemical and physico-chemical modification of fiber surfaces that may enhance the binding efficiency of TiO2 nanoparticles. This article looks at some latest advances in finishing of different textile materials with TiO2 nanoparticles. © 2013 Elsevier B.V.

Radetic M.,University of Belgrade
Journal of Materials Science | Year: 2013

Nanoparticles gained much scientific attention in the past decade due to their specific surface chemistry and properties which are significantly different from that of the corresponding bulk materials. Silver nanoparticles were the most extensively studied and they can be already found in a wide range of commercially available products. This article reviews the latest developments in finishing of textile materials with differently synthesized silver nanoparticles. Although antimicrobial activity of functionalized textile materials was primarily discussed, the possibilities to apply silver nanoparticles as a colorant or antistatic agent were also evaluated. In addition, the effect of chemical and physico-chemical activation of fibers before loading of silver nanoparticles on their binding efficiency was considered. Taking into account the importance of environmental impact of novel technologies, potential environmental risks emerging from silver release during washing of textile materials have been also discussed. © 2012 Springer Science+Business Media, LLC.

Simic V.,University of Belgrade
Metalurgia International | Year: 2013

As various resources are rapidly being depleted, efficient automobile shredder residue (ASR) processing is considered as one of the most important methods to promote sustainable development. In this review paper, we presented a holistic view of the ASR problem by covering a wide range of peer-reviewed journal papers. The purpose of this review paper is to give an extensive content analysis overview of the literature published in the period 2003-2012. In addition, the major classification scheme and a distribution list of journal papers published in the considered period are created to identify the primary publication outlets. Finally, on the basis of the performed review, several important recommendations for the future research are given and briefly discussed.

Konjevic N.,University of Belgrade | Ivkovic M.,University of Belgrade | Jovicevic S.,University of Belgrade
Spectrochimica Acta - Part B Atomic Spectroscopy | Year: 2010

An overview of spectroscopic diagnostics techniques for low temperature plasmas is presented with an emphasis to electron number density-Ne measurement. Stark broadening of non-hydrogenic atom and positive ion spectral lines is given. The attention is drawn to experimental techniques used for line intensity and line profile measurement. Self-absorption test, importance of Abel inversion, deconvolution of experimental line profiles and measurement of line asymmetry are treated in some detail in order to improve Ne measurements. Finally the sources of theoretical and experimental Stark broadening data are reviewed and some details discussed. © 2010 Elsevier Ltd. All rights reserved.

Golovatch S.I.,RAS A.N. Severtsov Institute of Ecology and Evolution | Makarov S.E.,University of Belgrade
Arthropoda Selecta | Year: 2011

Two new species of the Mediterranean genus Anamastigona are being described: A. ter-raesanctae sp.n. from Israel, and A. mauriesi sp.n. from Abkhazia, Caucasus. At present, both of these species are the easternmost representatives of this genus, while the one from Israel is simultaneously the first and south-easternmost member of the order Chordeumatida in the diplopod fauna of the entire Near East. The new species from Abkhazia is the first record of Anamastigona in the Caucasus, one of the long acknowledged centres of an-throleucosomatid generic and species differentiation globally. The following new synonymy is formalized: Ana-mastigona aspromontis (Strasser, 1970) = A. meridio-nalis Silvestri, 1898, syn.n., and Anamastigona halophi-la (Verhoeff, 1940) = A. bilselii (Verhoeff, 1940), syn.n. (the valid names in the right). © arthropoda selecta, 2011.

Majkic-Singh N.,University of Belgrade | Sumarac Z.,University of Belgrade
Journal of Medical Biochemistry | Year: 2012

Quality indicators are tools that allow the quantification of quality in each of the segments of health care in comparison with selected criteria. They can be defined as an objective measure used to assess the critical health care segments such as, for instance, patient safety, effectiveness, impartiality, timeliness, efficiency, etc. In laboratory medicine it is possible to develop quality indicators or the measure of feasibility for any stage of the total testing process. The total process or cycle of investigation has traditionally been separated into three phases, the pre-analytical, analytical and post-analytical phase. Some authors also include a »pre-pre« and a »post-post« analytical phase, in a manner that allows to separate them from the activities of sample collection and transportation (pre-analytical phase) and reporting (post-analytical phase). In the year 2008 the IFCC formed within its Education and Management Division (EMD) a task force called Laboratory Errors and Patient Safety (WG-LEPS) with the aim of promoting the investigation of errors in laboratory data, collecting data and developing a strategy to improve patient safety. This task force came up with the Model of Quality Indicators (MQI) for the total testing process (TTP) including the pre-, intra- and post-analytical phases of work. The pre-analytical phase includes a set of procedures that are difficult to define because they take place at different locations and at different times. Errors that occur at this stage often become obvious later in the analytical and post-analytical phases. For these reasons the identification of quality indicators is necessary in order to avoid potential errors in all the steps of the pre-analytical phase.

Baranac-Stojanovic M.,University of Belgrade
RSC Advances | Year: 2014

Nuclear magnetic resonance (NMR) spectroscopy is an important technique for structure determination. Within it, anisotropic effects of different functional groups and ring systems, depicted as familiar "anisotropy cones", are broadly used to deduce the stereochemistry, for chemical shift assignments and to explain shielding or deshielding of nuclei spatially close, or directly attached to the corresponding functional group, or ring. Progress in computational methods has enabled the quantification of anisotropic effects, an insight into their origin and to the source of (de)shielding of proximal nucleus. Some widely accepted traditional explanations, presented in NMR spectroscopy textbooks, have been questioned. The purpose of this review is to collect and discuss the research, mainly based on theoretical calculations, that provided new insight into the anisotropic effects, their origin and factors responsible for (de)shielding of proximal protons. © 2014 The Royal Society of Chemistry.

Dragisic V.T.,University of Belgrade
Procedia Engineering | Year: 2015

Additionally to the electrical properties of silicon solar wafers and cells, the mechanical properties (especially strength) must also need to be scrutinized investigated. This paper describes several aspects regarding silicon wafer crystal structure, saw-damage removal and surface roughness parameters in relation to mechanical strength. The results may be used to increase production yields, which ultimately leads to reduced cell costs. © 2015 Published by Elsevier Ltd.

Jankovic B.,University of Belgrade
Journal of Thermal Analysis and Calorimetry | Year: 2016

The on-line dynamic pyrolysis kinetics of swine manure solid samples was investigated in this paper. It has been found that the model which includes combined Friedman's isoconversional and multi-distributed reactivity approaches can best describe the pyrolysis process. Pyrolysis kinetics of swine manure samples proceeds through two major pyrolysis zones, where in first zone exists the kinetically complex reactions related to decompositions of hemicelluloses and fat/proteins, as well as decomposition reactions related to degradation of cellulose and lignin structures. Second zone includes the reactions attached to follow-up devolatilization and carbonization processes. It was found that identified high reaction orders represent the measure of complexity and multiplicity of the mechanism. It has been found that the change in reaction order (n) values is the result of reactions that are taking place due to the instability of products, or the secondary reactions, change in apparent activation energy, and effect of varying of the pre-exponential factor values. © 2015 Akadémiai Kiadó, Budapest, Hungary.

Cica Z.,University of Belgrade
Electronics Letters | Year: 2016

It has been shown that input queued (IQ) switches have throughput limitations when loaded with multicast traffi c. However, if circulation of packets is allowed, the IQ switches can be non-blocking for any admissible multicast traffi c scenario using only a speedup of two. The non-blocking frame based algorithm for schedulin g the multicast traffi c is proposed. © 2016 The Institution of Engineering and Technology.

In pathophysiological conditions related to oxidative stress, the application of selected antioxidants could have beneficial effects on human health. Electron paramagnetic resonance (EPR) spectroscopy is a technique that provides unique insight into the redox biochemistry, due to its ability to: (i) distinguish and quantify different reactive species, such as hydroxyl radical, superoxide, carbon centered radicals, hydrogen atom, nitric oxide, ascorbyl radical, melanin, and others; (ii) evaluate the antioxidative capacity of various compounds, extracts and foods; (iii) provide information on other important parameters of biological systems. A combination of EPR spectroscopy and traditional biochemical methods represents an efficient tool in the studies of disease mechanisms and antioxidative therapy prospects, providing a more complete view into the redox processes in the human organism.

Aleksendric D.,University of Belgrade
Wear | Year: 2010

Wear of brake friction materials depends on many factors such as temperature, applied load, sliding velocity, properties of mating materials, and durability of the transfer layer. Prediction of friction materials wear versus their formulation and manufacturing conditions in synergy with brakes operating conditions can be considered as a crucial issue for further friction materials development. In this paper, the artificial neural network abilities have been used for predicting wear of the friction materials versus influence of all relevant factors. The neural model of friction materials wear has been developed taking into account: (i) complete formulation of the friction material (18 ingredients), (ii) the most important manufacturing conditions of the friction material (5 parameters), (iii) applied load and sliding velocity of the friction material both represented by work done by brake application, and (iv) brake interface temperature. © 2009 Elsevier B.V. All rights reserved.

Blachnio A.,Catholic University of Lublin | Przepiorka A.,Catholic University of Lublin | Pantic I.,University of Belgrade
European Psychiatry | Year: 2015

Facebook has become a very popular social networking platform today, particularly among adolescents and young adults, profoundly changing the way they communicate and interact. However, some reports have indicated that excessive Facebook use might have detrimental effects on mental health and be associated with certain psychological problems. Because previous findings on the relationship between Facebook addiction and depression were not unambiguous, further investigation was required. The main objective of our study was to examine the potential associations between Internet use, depression, and Facebook intrusion. A total of 672 Facebook users took part in the cross-sectional study. The Facebook Intrusion Questionnaire and the Center for Epidemiologic Studies Depression Scale were used. For collecting the data, the snowball sampling procedure was used. We showed that depression can be a predictor of Facebook intrusion. Our results provides additional evidence that daily Internet use time in minutes, gender, and age are also predictors of Facebook intrusion: that Facebook intrusion can be predicted by being male, young age, and an extensive number of minutes spent online. On the basis of this study, it is possible to conclude that there are certain demographic - variables, such as age, gender, or time spent online - that may help in outlining the profile of a user who may be in danger of becoming addicted to Facebook. This piece of knowledge may serve for prevention purposes. © 2015 Elsevier Masson SAS.

Nikolic B.,University of Belgrade
Journal of Physics Condensed Matter | Year: 2010

In this work Raman excitation profiles of metallic carbon nanotubes have been calculated and thoroughly analyzed. Suppression and vanishing of the high-energy resonance is completely confirmed by our calculations. The presented results clearly show that the suppression, and finally the absence, of the resonance is caused by electron-phonon interaction and interference effects. Electron-phonon coupling for low-energy resonance is significantly larger than for high-energy resonance. Furthermore, the transition energies of those two transitions are close enough to make interference effects important. The type of interference is determined by the sign of the electron-phonon interaction matrix elements. Constructive interference makes the low-energy resonance more intensive and destructive interference destroys the high-energy resonance for most of the metallic tubes. © 2010 IOP Publishing Ltd.

Miljkovic D.,University of Belgrade
Archives of Biological Sciences | Year: 2012

I. pumila natural populations usually occur in two different habitat types: dune and forest. These I. pumila habitats differ in many abiotic environmental factors, but mostly in available light intensity and quality. The effects of different light intensity on the developmental stability of I. pumila floral traits were analyzed on clones taken from two different natural light habitat types that were raised in contrasting light treatments in experimental garden conditions (common garden experiment). As an indicator of developmental stability, we used two fluctuating asymmetry indices (FA1 and FA8a) of three bilateral symmetric traits of I. pumila flower (FW-fall width, SW-standard width and STW- style branch width). In addition, statistically significant treatment x population interaction was observed for style width. According to the presented results, the observed FA patterns of particular traits did not reflect the whole organism buffering capacity under the given environmental conditions.

Urosevic A.,University of Belgrade | Ljubisavljevic K.,University of Belgrade | Ivanovic A.,University of Belgrade
Journal of Evolutionary Biology | Year: 2013

We explored the ontogenetic dynamics of the morphological and allometric disparity in the cranium shapes of twelve lacertid lizard species. The analysed species (Darevskia praticola, Dinarolacerta mosorensis, Iberolacerta horvathi, Lacerta agilis, L. trilineata, L. viridis, Podarcis erhardii, P. melisellensis, P. muralis, P. sicula, P. taurica and Zootoca vivipara) can be classified into different ecomorphs: terrestrial lizards that inhabit vegetated habitats (habitats with lush or sparse vegetation), saxicolous and shrub-climbing lizards. We observed that there was an overall increase in the morphological disparity (MD) during the ontogeny of the lacertid lizards. The ventral cranium, which is involved in the mechanics of jaw movement and feeding, showed higher levels of MD, an ontogenetic shift in the morphospace planes and more variable allometric patterns than more conserved dorsal crania. With respect to ecology, the allometric trajectories of the shrub-climbing species tended to cluster together, whereas the allometric trajectories of the saxicolous species were highly dispersed. Our results indicate that the ontogenetic patterns of morphological and allometric disparity in the lacertid lizards are modified by ecology and functional constraints and that the identical mechanisms that lead to intraspecific morphological variation also produce morphological divergence at higher taxonomic levels. © 2012 European Society For Evolutionary Biology.

Sekara T.B.,University of Belgrade | Matausek M.R.,University of Belgrade
Journal of Process Control | Year: 2010

The Ziegler-Nichols process dynamics characterization is based on the estimation of the ultimate gain ku and ultimate frequency ωu. The angle φ of the tangent to the Nyquist curve at the frequency ωu is introduced, as an additional parameter in the frequency domain. The essential dynamic characteristics of the process can be captured by using the tangent rule, proposed here as an extension of the Ziegler-Nichols approach. The validity of the tangent rule is confirmed by using the PID controller optimization on a test batch consisting of stable, integrating and unstable processes, including dead-time. Parameters ku, ωu and φ can be determined from the sustained oscillations, using the phase-locked loop identifier module. © 2009 Elsevier Ltd. All rights reserved.

Pyrolysis process of coffee paper cup samples was investigated in a flow stream of nitrogen at different heating rates (10, 20, 30 and 40 °C min -1), using thermo-analytical techniques. It was found that second pyrolysis stage can be described by Šesták-Berggren (SB) autocatalytic model, with mechanism function f(α) = α 0.011(1 - α)1.459. Based on analysis of SB kinetic exponents (designated by M and N), it was found that second pyrolysis stage is mainly controlled by chemical process, involving reactions with reaction-order (n) higher than unity. Applying specific statistical analysis, in order to obtain precise distribution of reactivity, the discrete (binomial) distribution has shown that there are two important areas of current distribution for corresponding energy outcomes, within the apparent activation energy as random variable. The first "concentration" area of energy outcomes corresponds to start of chain end depolymerization reaction forming levoglucosan at high enough temperature region, while second "concentration" area of energy outcomes includes occurrence of macro-radicals in liquid phase propagate with radical addition on unsaturated C-C bonds, with cross-linking and formation of small chemical species. It was found that further elevating of temperature (above 340 °C), will leads to fact that rate of tar-forming reactions increases and formation of char decreases. © 2014 Elsevier Ltd. All rights reserved.

Matausek M.R.,University of Belgrade | Ribic A.I.,Institute Mihajlo Pupin
Journal of Process Control | Year: 2012

The Modified Smith Predictor (MSP) is designed, and in the literature classified, as a Dead-Time Compensator for integrating processes. In the present paper it is shown that the MSP is a PID controller in series with a second-order filter, defined by the dead-time and an adjustable parameter. Optimization of the regulatory performance of this controller is performed under constraints on the robustness and sensitivity to measurement noise. Excellent performance/robustness tradeoff is obtained for stable, integrating and unstable processes, including dead-time, as confirmed by simulations and by experimental result obtained on a laboratory thermal process. © 2011 Elsevier Ltd. All Rights Reserved.

Pajic-Lijakovic I.,University of Belgrade
Critical Reviews in Biotechnology | Year: 2015

Various modeling approaches have been applied to describe the rearrangement of immobilized cell clusters within the extracellular matrix. The cell rearrangement has been related with the micro-environmental restrictions to cell growth. Herein, an attempt is made to discuss and connect various modeling approaches on various time scales which have been proposed in the literature in order to shed further light to this complex phenomenon which induces microenvironmental restrictions to cell growth. The rearrangement is driven by internal stress generated within the cluster. The internal stress represents a consequence of the matrix rheological response to cell expansion. The rearrangement includes the interplay between the processes of: (1) single and collective cell migrations, (2) cell deformation and orientation, (3) decrease of cell-to-cell separation distances and (4) cell growth. It has been considered on two time scales: a short time scale (i.e. the rearrangement time) and a long time scale (i.e. the growing time). The results indicate that short and long times cell rearrangement induces energy dissipation. The dissipation provokes biological responses of cells which cause the resistance effects to cell growth. Deeper insight in the anomalous nature of the energy dissipation would be useful for understanding the biological mechanisms which causes the resistance effects to cell growth. © 2015 Informa Healthcare USA, Inc.

Elezovic I.,University of Belgrade
Srpski arhiv za celokupno lekarstvo | Year: 2010

Acquired inhibitors against coagulation factor VIII (FVIII), also termed acquired haemophilia A, neutralize its procoagulant function and result in severe or often life-threatening bleeding. The antibodies arise in individuals with no prior history of clinical bleeding. Acquired haemophilia occurs rarely with the incidence of approximately 1 to 4 per million/year, with severe bleeds in up to 90% of affected patients, and high mortality between 8-22%. About 50% of diagnosed patients were previously healthy, while the remaining cases may be associated with postpartum period, autoimmune diseases, malignancy, infections, or medications. Most patients have spontaneous haemorrhages into the skin, muscles or soft tissues, and mucous membranes, or after trauma and surgery, whereas haemarthroses are uncommon. The diagnosis of acquired haemophilia A based on the prolongation of activated partial thromboplastin time which does not normalize after the addition of normal plasma, reduced FVIII, with evidence of FVIII inhibitor measured by the Bethesda assay (Nijmegen modification). The treatment of acute bleeding episodes and the long-term eradication of the autoantibodies in acquired haemophilia are the main therapeutic strategy. Two options are currently available for acute bleeding control: the use rFVIIa or FEIBA in patients with higher inhibitor titer (> 5 BU), or to raise the level of FVIII by administration of DDAVP or concentrates of FVIII in patients with low level of inhibitors (< 5 BU). Treatment with FEIBA (50-100 IU/ kg every 8-12 hours) has shown good haemostatic response in 76-89% of the bleeding episodes. Patients treated with rFVIIa (90 microg/kg every 2-6 hours) have achieved good response in 95-100% as a first-line, and 75-80% as a salvage therapy. Patients with low inhibitor titer and lower response can be treated with concentrate of FVIII in the recommended dose of 40 IU/kg plus 20 IU/kg for each BU of inhibitor. The treatment of non-life-threatening haemorrhages with desmopressin (DDAVP 0.3 microg/kg) may increase both FVIII and vWF. Sometimes inhibitors disappear spontaneously, but long-term management is necessary for eradication of inhibitors by immunosuppression (prednisone 1 mg/kg 3 weeks alone or in combination cyclophosphamide 2 mg/kg), immunomodulation, intravenous immunoglobulin (HD IgG 2 g/kg 2 or 5 d), physical removal of antibodies (plasmapheresis or immunoadsorption), or various combinations. Recently, a therapy with rituximab, an anti-CD20 monoclonal antibody, has shown to be effective in acquired haemophilia.

Todorovic M.S.,University of Belgrade | Todorovic M.S.,Kyung Hee University | Kim J.T.,Kyung Hee University
Energy and Buildings | Year: 2012

Further advance of the healthy building's energy efficiency and sustainability is inextricably linked to the building's envelopes/facades physics study, particularly fundamentals of the dynamic control of sunlight and optimal control of solar heat gains. Based on the improved understanding of mechanism which physically control specific materials intensity, e.g. absorption, reflection and transmission of solar radiation, are to be improved strategies to dynamically control separation of the daylight admittance from the solar heat gains. Relevant dynamic control mathematical models and algorithms, as well as infrastructure/hardware and software integrated performance prediction and validation are to be further developed. This paper reviews the most recent research and development results, the current state of the science and art, as well as some of the ongoing R&D at the edge of new breakthroughs of the healthy buildings daylighting dynamic control's performance prediction and validation. Finally defined is a challenging future research goal - tuning control of buildings glazing's transmittance dependence on the solar radiation wavelength to optimize daylighting and building's energy efficiency. © 2011 Elsevier B.V. All rights reserved.

Ristic L.B.,University of Belgrade | Jeftenic B.I.,University of Belgrade
IEEE Transactions on Industrial Electronics | Year: 2012

The paper presents a control strategy for the system of belt conveyors (BCs) with adjustable speed drives based on the principle of optimum energy consumption. Fuzzy logic controller is used in the algorithm for generating the reference speed. The proposed control structure is developed and tested on the detailed mathematical model of the drive system with the rubber belt. The presented algorithm is implemented on the new variable speed BC system with remote control on an open-pit mine. The measurements were performed to verify the proposed concept during the eight months of exploitation. Results of the measurements are presented in the paper. © 2012 IEEE.

Ivanovic A.,University of Belgrade | Kalezic M.L.,University of Belgrade
Zoomorphology | Year: 2012

In this study, we applied geometric morphometrics to explore variations in the level and pattern of sexual size dimorphism (SSD) and sexual shape dimorphism (SShD) of the ventral cranium in three different Modern Eurasian newt taxa (Ichthyosaura alpestris, Triturus species group and Lissotriton vulgaris). The ventral cranium is the part of the skull that is more directly related to foraging and feeding. Our results indicate that the level and pattern of sexual dimorphism in the ventral cranium differ among Modern Eurasian newt taxa. Regarding sexual dimorphism in skull size, Ichthyosaura alpestris and Triturus species show female-biased patterns (females are larger than males), whereas Lissotriton vulgaris appears to be non-dimorphic in skull size. In I. alpestris and Triturus species, SShD is mostly absent, whereas in L. vulgaris, SShD is more pronounced. A high level of variation between populations in both SSD and SShD indicates that local conditions may have a profound effect on the magnitude and direction of sexual dimorphism. The significant sexual differences in ventral cranium size and shape indicate possible subtle intersexual differences in ecological demands due to diet specialisation, in spite of similar general ecological settings. © 2011 Springer-Verlag.

Radinovic D.,University of Belgrade | Curic M.,University of Belgrade
Theoretical and Applied Climatology | Year: 2012

Many areas of society are susceptible to the effects of extreme temperatures. Without an adequate definition of what constitutes heat and cold waves, it is impossible to assess either their changes in the past or their possible consequences for the future. The Intergovernmental Panel on Climate Change recommended criteria for heat wave duration indexes based on two arbitrarily defined constants. The principal weakness of this approach is that it does not yield comparable results for different geographical locations. This paper remedies the current lack of a meteorologically based definition of heat and cold waves and offers a preliminary test of its performance. Having previously shown that maximum daily temperature values follow normal frequency distribution, we derive statistical thresholds (e.g., below and above normal) from that distribution. These thresholds are thus climate specific and their change can be compared across geographical locations. These criteria are then tested on the homogeneous time series of maximum daily temperature observed for the period 1961-2008 with respect to three different geographical locations. The results obtained show an increase in the frequency of heat waves for the period 1991-2008 in comparison with the normal climatological period 1961-1990. © 2011 Springer-Verlag.

Rasuo B.,University of Belgrade
Transactions of the Japan Society for Aeronautical and Space Sciences | Year: 2012

The establishment of exact two-dimensional flow conditions in wind tunnels is a very difficult problem. This has been evident for wind tunnels of all types and scales. In this paper, the principal factors that influence the accuracy of two-dimensional wind tunnel test results are analyzed. The influences of the Reynolds number, Mach number and wall interference with reference to solid and flow blockage (blockage of wake) as well as the influence of side-wall boundary layer control are analyzed. Interesting results are brought to light regarding the Reynolds number effects of the test model versus the Reynolds number effects of the facility in subsonic and transonic flow. © 2012 The Japan Society for Aeronautical and Space Sciences.

Jankovic S.,University of Belgrade
The European journal of esthetic dentistry : official journal of the European Academy of Esthetic Dentistry | Year: 2010

The main objective of this study was to evaluate the clinical effectiveness of platelet-rich fibrin membrane used in combination with a coronally advanced flap (CAF) and to compare it with the use of an enamel matrix derivative (EMD) in combination with a coronally advanced flap in gingival recession treatment. 20 split-mouth cases of maxillary anterior teeth or bicuspids presenting with Miller Class I or II gingival recession were treated with a CAF combined with a platelet-rich fibrin membrane (PRF group) or with EMD (EMD group) placed under a CAF. The following parameters were measured at baseline and at 12 months post treatment: gingival recession (GR), apicocoronal width of the keratinized tissue (WKT), and probing depth (PD). Complete rot coverage in the PRF group was 65% (13 out of 20 recessions) and 60% in the EMD group (12 out of 20 recessions). GR was 4.10 ± 1.05 mm in the PRF group and 3.90 ± 1.00 mm in the EMD group at baseline, and 1.05 ± 0.45 mm in the PRF group and 1.15 ± 0.65 mm in the EMD group at 12 months. The difference observed between the tow groups at 12 months was statistically significant. Average root coverage was 70.5% in the EMD group and 72.1% in the PRF group. WKT was 1.30 ± 0.56 mm in the EMD group and 1.45 ± 0.86 mm in the PRF group at baseline, and 1.90 ± 0.81 mm in the EMD group and 1.62 ± 0.28 mm in the PRF group at 12 months. The difference observed between the two groups at 12 months was not statistically significant. Twelve-month changes in PD were not significantly different between the two groups. The pain intensity was statistically different between the two groups. The pain intensity was statistically different between groups for the first 5 days, favoring the PRF group. The present study did not succeed in demonstrating any clinical advantage of the use of PRF compared to EMD in the coverage of gingival recession with the CAF procedure. The EMD group showed a higher success rate in increasing WKT than did the PRF group.

Zhong W.-P.,Shunde Polytechnic | Belic M.R.,Texas A&M University at Qatar | Belic M.R.,University of Belgrade | Huang T.,Texas A&M University at Qatar
Nonlinear Dynamics | Year: 2012

Two-dimensional parity-time (PT) symmetric potentials are introduced, which allow the existence of spatial solitons in the model of the strongly nonlocal nonlinear Schrödinger equation. Two-dimensional accessible solitons are found in the form of solutions separating the radial amplitude, given in terms of Laguerre polynomials, a phase function involving quadratic, linear, and constant phase shifts, and a specific azimuthal modulation function. Shape-preserving solitons are constructed from Laguerre-Gaussian functions containing the self-similar variable and an exponential form of the azimuthal modulation, containing sine and cosine functions, when a suitable PT-symmetric potential is chosen. Interesting soliton profiles and the corresponding PT-symmetric potentials are displayed for different values of the parameters. © Springer Science+Business Media B.V. 2012.

Panic N.,Catholic University | Panic N.,University of Belgrade | Larghi A.,University of Belgrade
Gastrointestinal Endoscopy Clinics of North America | Year: 2014

Although endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the method of choice to obtain samples to reach definitive diagnosis of lesions of the gastrointestinal tract and of adjacent organs, it cannot fully characterize certain neoplasms. The lack of cytology expertise has hindered the dissemination of EUS, limiting its widespread use. The obtainment of a tissue specimen through EUS fine-needle biopsy (EUS-FNB) may overcome the limitations of EUS-FNA. EUS-FNB is expected to move the practice of EUS from cytology to histology, expanding the use of EUS and facilitating targeted therapies and monitoring of treatment response in a more biologically driven manner. © 2014 Elsevier Inc.

Krstic J.,University of Belgrade | Santibanez J.F.,University of Belgrade
The Scientific World Journal | Year: 2014

Transforming growth factor-beta (TGF-β) is a pleiotropic factor with several different roles in health and disease. In tumorigenesis, it may act as a protumorigenic factor and have a profound impact on the regulation of the immune system response. Matrix metalloproteinases (MMPs) are a family that comprises more than 25 members, which have recently been proposed as important regulators acting in tumor stroma by regulating the response of noncellular and cellular microenvironment. Tumor stroma consists of several types of resident cells and infiltrating cells derived from bone marrow, which together play crucial roles in the promotion of tumor growth and metastasis. In cancer cells, TGF-β regulates MMPs expression, while MMPs, produced by either cancer cells or residents' stroma cells, activate latent TGF-β in the extracellular matrix, together facilitating the enhancement of tumor progression. In this review we will focus on the compartment of myeloid stroma cells, such as tumor-associated macrophages, neutrophils, and dendritic and mast cells, which are potently regulated by TGF-β and produce large amounts of MMPs. Their interplay and mutual implications in the generation of pro-tumorigenic cancer microenvironment will be analyzed. © 2014 Jelena Krstic and Juan F. Santibanez.

Ognjanovic M.,University of Belgrade | Benur M.,University of Belgrade
Meccanica | Year: 2011

In the future progress of technical systems it is impossible to avoid the power transmission (PT) components. Mechatronical technical systems will include the innovated PT components with high-level quality indicators. The article proposes the application of the new approaches to those components design in order to challenge innovation and inventions. The main objective is to define the design parameters in terms of reliability, vibration and noise as design constraints in the stage of the Embodiment design of PT components. Robust design is provided by using the axiomatic method in this way. Reliability as the design constraint of PT components is defined and modeled in a specific way suitable for this purpose and application. Also, the model of gear vibrations and gear units noise generation is presented in a new way suitable for applying as the design constraint. Those design constraints provide design parameters definition in an efficient way, with high-level service quality indicators. The presented models are based on a great volume of experimental data about service conditions probability, gear and bearing failure probability, gear units vibration and modal behavior etc. Theoretical knowledge and models are insufficient yet to provide the necessary data. The article contains presentation of testing methods and data processing oriented to provide data necessary for the application in the suggested approach to PT components design. © 2010 Springer Science+Business Media B.V.

Tasic M.S.,University of Belgrade | Kolundzija B.M.,University of Belgrade
IEEE Transactions on Antennas and Propagation | Year: 2011

A new iterative procedure is presented that enables method of moment (MoM) solution of scattered field from electrically large and complex perfectly conducting bodies using significantly reduced number of unknown coefficients. In each iteration the body is excited by a plane wave and by the currents, which are obtained as an approximate solution in the previous iteration. The physical optics (PO) and modified PO techniques are used to determine the PO and the correctional PO currents, which are expressed in terms of original MoM basis functions and grouped into macro-basis functions (MBFs). Weighting coefficients of all MBFs are determined from the condition that mean square value of residuum of original MoM matrix equation is minimized. The iterative procedure finishes when the residuum decreases below the maximum allowed value. The accuracy and efficiency of the proposed method are illustrated on two examples: cube scatterer and airplane scatterer. Since the construction of MBFs by PO and modified PO techniques ensures fast convergence to the original MoM solution, the method is named PO driven MoM. © 2011 IEEE.

In this work, Apis mellifera carnica and A. m. macedonica honey bees from Serbia, Bosnia and Herzegovina and Republic of Macedonia were analysed using molecular techniques in order to improve our knowledge about biogeography of A. mellifera on the Balkan peninsula. This is the first time that the indigenous honey bees from Bosnia and Herzegovina and Republic of Macedonia have been analyzed using a molecular approach. Sampling was carried out from 560 stationary apiaries where bees were kept in traditional hives (woven skeps). The COI-COII regions of 1680 samples were PCR-amplified and sequenced. To reveal the haplotype of studied bees, the obtained sequences were aligned with published sequence data of haplotypes that belong to A. mellifera C phylogenetic lineage. The C2D mtDNA haplotype was found in all honey bees sampled from Serbia, Bosnia and Herzegovina and Republic of Macedonia. These results show that A. m. carnica and A. m. macedonica share the same C2D mtDNA haplotype. COI gene segments of 1680 samples were PCR-amplified and digested with restriction enzymes NcoI and StyI in order to discriminate A. m. macedonica from A. m. carnica. Amplified fragment patterns produced by both restriction enzymes matched with diagnostic pattern characteristic for A. m. macedonica in case of samples from east, south and south-west parts of Serbia, and Republic of Macedonia, fragments of samples from northern part of Serbia and Bosnia and Herzegovina did not include NcoI and StyI restriction sites. These results indicate that honey bees from east, south and south-west parts of Serbia, and Republic of Macedonia belong to the A. m. macedonica, and honey bees from northern part of Serbia and Bosnia and Herzegovina belong to another subspecies, probably to the A. m. carnica. Therefore A. m. macedonica has much wider area of distribution than it was previously considered.

Nikolic B.,University of Belgrade | Sazdovic B.,University of Belgrade
Nuclear Physics B | Year: 2010

We consider type IIB superstring theory with embedded D5-brane and choose boundary conditions which preserve half of the initial supersymmetry. In the canonical approach that we use, boundary conditions are treated as canonical constraints. The effective theory, obtained from the initial one on the solution of boundary conditions, has the form of the type I superstring theory with embedded D5-brane. We obtain the expressions for D5-brane background fields of type I theory in terms of the D5-brane background fields of type IIB theory. We show that beside known Ω even fields, they contain squares of Ω odd ones, where Ω is world-sheet parity transformation, Ω:σ→-σ. We relate result of this paper and the results of Nikolić and Sazdović (2008) [1] using T-dualities along four directions orthogonal to D5-brane. © 2010 Elsevier B.V.

Pantic I.,University of Belgrade
Reviews on Advanced Materials Science | Year: 2010

Despite intensive research efforts, cancer remains one of the leading causes of death in the world. Many new methods and techniques have been developed in order to improve diagnosis and treatment, often promising in the beginning, but with limited results during the course of their application. This concise review focuses on novel approaches in development and production of magnetic nanoparticals, as well as their application in today's cancer diagnosis and treatment. © 2010 Advanced Study Center Co. Ltd.

Kojic S.,University of Belgrade
Journal of Medical Biochemistry | Year: 2010

The MARP (muscle ankyrin repeat protein) family comprises three structurally similar proteins: CARP/Ankrd1, Ankrd2/Arpp and DARP/Ankrd23. They share four conserved copies of 33-residue ankyrin repeats and contain a nuclear localization signal, allowing the sorting of MARPs to the nucleus. They are found both in the nucleus and in the cytoplasm of skeletal and cardiac muscle cells, suggesting that MARPs shuttle within the cell enabling them to play a role in signal transduction in striated muscle. Expression of MARPs is altered under different pathological conditions. In skeletal muscle, CARP/Ankrd1 and Ankrd2/Arpp are up-regulated in muscle in patients suffering from Duchene muscular dystrophy, congenital myopathy and spinal muscular atrophy. Mutations in Ankrd1 gene (coding CARP/Ankrd1) were identified in dilated and hypertrophic cardiomyopathies. Altered expression of MARPs is also observed in rhabdomyosarcoma, renal oncocytoma and ovarian cancer. In order to functionally characterize MARP family members CARP/Ankrd1 and Ankrd2/Arpp, we have found that both proteins interact with the tumor suppressor p53 both in vivo and in vitro and that p53 up-regulates their expression. Our results implicate the potential role of MARPs in molecular mechanisms relevant to tumor response and progression.

Miljkovic Z.,University of Belgrade | Mitic M.,University of Belgrade | Lazarevic M.,University of Belgrade | Babic B.,University of Belgrade
Expert Systems with Applications | Year: 2013

It is known that most of the key problems in visual servo control of robots are related to the performance analysis of the system considering measurement and modeling errors. In this paper, the development and performance evaluation of a novel intelligent visual servo controller for a robot manipulator using neural network Reinforcement Learning is presented. By implementing machine learning techniques into the vision based control scheme, the robot is enabled to improve its performance online and to adapt to the changing conditions in the environment. Two different temporal difference algorithms (Q-learning and SARSA) coupled with neural networks are developed and tested through different visual control scenarios. A database of representative learning samples is employed so as to speed up the convergence of the neural network and real-time learning of robot behavior. Moreover, the visual servoing task is divided into two steps in order to ensure the visibility of the features: in the first step centering behavior of the robot is conducted using neural network Reinforcement Learning controller, while the second step involves switching control between the traditional Image Based Visual Servoing and the neural network Reinforcement Learning for enabling approaching behavior of the manipulator. The correction in robot motion is achieved with the definition of the areas of interest for the image features independently in both control steps. Various simulations are developed in order to present the robustness of the developed system regarding calibration error, modeling error, and image noise. In addition, a comparison with the traditional Image Based Visual Servoing is presented. Real world experiments on a robot manipulator with the low cost vision system demonstrate the effectiveness of the proposed approach. © 2012 Elsevier Ltd. All rights reserved.

Batalovic V.,University of Belgrade
Journal of Tribology | Year: 2010

Erosion wear is a process that accompanies the facility for hydraulic transportation of solids. Since the pump is one of the vital parts of this facility, the working life of the pump is conditioned by the amount of wear. The working life can be realized only if the parameters chosen, for the pump elements, slurry, and transport conditions, will provide economic transport with minimal wear. Testing is the most reliable method for acquiring valid data. The two issues that need to be solved while planning the testing process are the choice of valid similarity criteria (test-industrial facility) and data selection. After the theoretical analyses, technically acceptable similarity criteria are obtained. A group of data needs to be defined through the experiment. © 2010 by ASME.

Net fluxes of Ca2+ and H+ ions were measured non-invasively close to the surface of Phycomyces blakesleeanus sporangiophores stage I using ion-selective vibrating microelectrodes. The measurements were performed on a wild type (Wt) and a gravitropic mutant A909 kept in either vertical or tilted orientation. Microelectrodes were positioned 4 μm from the surface of sporangiophore, and ion fluxes were recorded from the apical (0-20 μm) and subapical (50-100 μm) regions. The magnitude and direction of ionic fluxes measured were dependent on the distance from the tip along the growing zone of sporangiophore. Vertically oriented sporangiophores displayed characteristic tip-to-base ion fluxes patterns. Ca2+ and H+ fluxes recorded from apical region of Wt sporangiophores were inward-directed, while ion fluxes from subapical locations occurred in both directions. In contrast to Wt, mutant A909 showed opposite (outward) direction of Ca2+ fluxes and reduced H+ influxes in the apical region. Following gravistimulation, the magnitude and direction of ionic fluxes were altered. Wt sporangiophore exhibited oppositely directed fluxes on the lower (influx) and the upper (efflux) sides of the cell, while mutant A909 did not show such patterns. A variable elongation growth in vertical position and reduced growth rate upon gravistimulation were observed in both strains. The data show that tip-growing sporangiophores exhibit a tip-to-base ion flux pattern which changes characteristically upon gravistimulation in Wt in contrast to the mutant A909 with a strongly reduced gravitropic response. © 2012 Springer-Verlag.

Franovic I.,University of Belgrade | Miljkovic V.,University of Belgrade
European Physical Journal B | Year: 2010

The widely represented network motif, constituting an inhibitory pair of bursting neurons, is modeled by chaotic Rulkov maps, coupled chemically via symmetrical synapses. By means of phase plane analysis, that involves analytically obtaining the curves guiding the motion of the phase point, we show how the neuron dynamics can be explained in terms of switches between the noninteracting and interacting map. The developed approach provides an insight into the observed time series, highlighting the mechanisms behind the regimes of collective dynamics, including those concerning the emergent phenomena of partial and common oscillation death, hyperpolarization of membrane potential and the prolonged quiescence. The interdependence between the chaotic neuron series takes the form of intermittent synchronization, where the entrainment of membrane potential variables occurs within the sequences of finite duration. The contribution from the overlap of certain block sequences embedding emergent phenomena gives rise to the sudden increase of the parameter characterizing synchronization. We find its onset to follow a power law, that holds with respect to the coupling strength and the stimulation current. It is established how different types of synaptic threshold behavior, controlled by the gain parameter, influence the values of the scaling exponents. © 2010 EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg.

Jovanovic M.M.,University of Belgrade
Polish Journal of Environmental Studies | Year: 2016

Focusing on the implementation of increasingly strict energy and emission standards, the effect of the rapid increase in the use of motor vehicles on the degree of air pollution and energy consumption is completely neglected. All recent technological improvements and changes in the transport sector: sub stitution of fuels, increased use of diesel vehicles, direct gasoline injection, supercharging, electric vehicles, hybrid vehicles, etc., cannot offset massive growth in traffic, combined with significantly heavier, more powerful, more luxurious and thus more fuel-consuming vehicles. Hence, in this paper we focused on the carbon emissions and energy consumption of urban transport in Belgrade from an international perspective. Although the level of automobile CO2 emissions in Belgrade is still very low at 228 CO2 kg/per capita, due to the low volume of automobile passenger kilometres (1,502 pkm), the fact must not be overlooked that automobile mobility is of major importance to the total level of energy consumption in urban transport, and this can change surprisingly quickly. Only if Belgrade adopts transport and spatial development strategies similar to those applied by wealthy Asian metropolises at a similar stage of development is there high probability that its total urban transport CO2 emissions will stop at a reasonable level of around 700-800 kg CO2/per capita. Belgrade can prevent a dramatic increase in CO2 emissions and energy consumption (and mitigate the negative local environmental effects of traffic congestion, traffic accidents, and air pollution), only if it: 1. Implements a more decisive strategy to limit private vehicle use while its level of car passenger km (PKT) is still relatively low. 2. Does not try to solve its transport problems only by trying to build urban road infrastructure (bridges and ring roads). 3. Concentrates on more CO2 and energy-efficient urban transport systems, while at the same time …. 4. Developing urban rail systems (metro or LRT) with exclusive tracks that are immune to traffic congestion on urban streets. © 2016, HARD Publishing Company. All rights reserved.

Simic V.,University of Belgrade | Dimitrijevic B.,University of Belgrade
Expert Systems with Applications | Year: 2013

End-of-life vehicles (ELVs) represent one of the most important waste flows in Japan and 3.58 million was processed only in fiscal year 2008. In an attempt to reduce waste originating from ELVs, the Japanese Government introduced the ELV Recycling Law in 2002. Automobile shredder residue (ASR) recycling is essential to achieving the goals of the ELV Recycling Law and represents a major concern for the Japanese vehicle recycling industry. This paper proposes the tactical ASR recycling planning model, which can be used to assist Japanese vehicle recyclers to improve their profitability and ASR recycling efficiency. A numerical study is conducted in order to illustrate the potentials and applicability of the proposed modelling approach, and to gain insights into the performances of the Japanese vehicle recycling system and into the influence of the ELV Recycling Law. Sensitivity analyses demonstrate and validate the approach and its potentials. ELV Recycling Law influence is found to be crucial for the decision making on ASR recycling, as the 20% increase in valid recycling quota will cause approximately 50% decrease in the quantity of disposed ASR. We show that the stringent ASR recycling quota is easily attainable and present many interesting insights. © 2013 Elsevier Ltd. All rights reserved.

Andrejic M.,University of Belgrade | Bojovic N.,University of Belgrade | Kilibarda M.,University of Belgrade
Expert Systems with Applications | Year: 2013

The efficiency of distribution systems is largely affected by the performances of distribution centres. The main objective of this paper is to develop and propose a DEA model for distribution centres efficiency measuring that can help managers in decision making and improving the efficiency. Due to numerous indicators that describe DCs operating, the main problem is indicators selection. In order to improve discriminatory power of classical DEA models PCA-DEA approach is used. This paper analysis the efficiency of distribution centres of one trading company in Serbia. Proposed models integrate operational, quality, energy, utilisation and equipment warehouse and transport indicators. Several hypotheses are tested in this paper. The results showed that small distribution centres are more efficient than large. © 2012 Elsevier Ltd. All rights reserved.

Vucetic M.,University of Belgrade | Hudec M.,INFOSTAT Institute of Informatics and Statistics | Vujosevic M.,University of Belgrade
Expert Systems with Applications | Year: 2013

In this paper, we present a new method for computing fuzzy functional dependencies between attributes in fuzzy relational database systems. The method is based on the use of fuzzy implications. A literature analysis has shown that there is no algorithm that would enable the identification of attribute relationships in fuzzy relational schemas. This fact was the motive for development a new methodology in the analysis of fuzzy functional dependencies over a given set of attributes. Solving this, not so new problem, is not only research challenge having theoretical importance, but it also has practical significance. Possible applications of the proposed methodology include GIS, data mining, information retrieval, reducing data redundancy in fuzzy relations through implementation of logical database model, estimation of missing values etc. © 2012 Elsevier B.V. All rights reserved.

One of the main negative consequences of uncontrolled export of used vehicles from the European Union to developing countries is resource shortage for major players of European vehicle recycling systems. The resource scarcity puts serious pressure on vehicle recycling managers. An effective end-of-life vehicles (ELVs) allocation management is considered vital for mitigating the effect of the growing export of used vehicles. This paper proposes an interval-parameter two-stage stochastic full-infinite programming model for end-of-life vehicles allocation management under multiple uncertainties. A case study is conducted in order to demonstrate the potentials and applicability of the proposed model. Influences of parameter uncertainty on model solutions are thoroughly investigated. The developed model can efficiently handle uncertainties expressed as functional intervals, probability distributions and conventional crisp intervals. It is able to reduce risk of ELV management system failure due to the possible constraints violation. The formulated model can take into account connections of modeling parameters and their impact factors, thus reflecting external uncertainties of ELV management systems. It can provide a flexible ELV allocation management schemes adjustable with the variations in prices of secondary metals and end-of-life vehicles. The proposed model is able to reflect trade-off between conflicting waste management system revenues and the associated penalties for violating ELV allocation targets, thus providing a valuable insight for decision makers. © 2016 Elsevier B.V.

Batalovic V.,University of Belgrade
Journal of Tribology | Year: 2010

Erosion wear is a serious problem that constantly accompanies the operation of the system for hydraulic transportation of solid materials. The consequences are the loss of material (steel), loss of work element's working capacity, great operational expenses, etc. The choice of new materials for working elements, improvements in construction, and optimization of the slurry flow are all various ways of softening the consequences of erosion wear that reflects on the working life of the hydraulic transportation pump's elements. Data, which would be used for acquiring the above mentioned goals, are mainly acquired through testing in laboratory or semi industrial conditions. It has been proved that numerous influential and time effected values, complex and long term research, etc., make this job an expensive one, and the results are often solely applicable to specific operating conditions. To resolve this problem, the author suggests a combined approach: shorthand experimental researches and mathematical modeling of erosion wear. The suggested model, used for defining the mass loss of the working element affected by solid particles in the slurry, offers the possibility of introducing a greater number of influential values, some of which have a coincidental character. Through the realization of this model, wear intensity data is acquired, which are practically noncoincidental values with a great degree of reliability, and which greatly coincide with the results acquired through measurements conducted on the test facility. Copyright © 2010 by ASME.

Drajic D.B.,University of Belgrade
2015 12th International Conference on Telecommunications in Modern Satellite, Cable and Broadcasting Services, TELSIKS 2015 | Year: 2015

In this lecture the sketch of the academic career of Michal Pupin will be presented. After finishing his studies at Columbia University, he went to Cambridge and at the end made his Ph.D. in Berlin (mentor was Helmholz). He returned to USA and was professor at Columbia University until the retainment. He founded the first genuine Physics Laboratory in USA. His scientific results will be shortly described. His patents will be commented, as well as some important discoveries (especially pupinization). At the end its pedagogical and organizational work will be presented. © 2015 IEEE.

Majkic-Singh N.,University of Belgrade
Journal of Medical Biochemistry | Year: 2011

The term biomarker in medicine most often stands for a protein measured in the circulation (blood) whose concentration indicates a normal or a pathological response of the organism, as well as a pharmacological response to the applied therapy. From a wider perspective, a biomarker is any indicator that is used as an index of the intensity of a disease or other physiological state in the organism. This means that biomarkers have a very important role in medical research and practice providing insight into the mechanism and course of a disease. Since a large number of biomarkers exist today that are used for different purposes, they have been classified into: 1) antecedent biomarkers, indicating risk of disease occurrence, 2) screening biomarkers, used to determine a subclinical form of disease, 3) diagnostic biomarkers, revealing an existing disease, 4) staging biomarkers, that define the stage and severity of a disease, and 5) prognostic biomarkers, that confirm the course of disease, including treatment response. Regardless of their role, their clinical significance depends on their sensitivity, specificity, predictive value, and also precision, reliability, reproducibility, and the possibility of easy and wide application. For a biomarker to become successful, it must undergo the process of validation, depending on the level of use. It is very important for every suggested biomarker, according to its purpose or its nature, to possess certain characteristics and to meet the strict requirements related to sensitivity, accuracy and precision, in order for the proper outcome to be produced in the estimation of the state for which it is intended. Finally, the development of guidelines for biomarker application is very important, based on well defined and properly conducted assessments of biomarker determination, providing the means by which research is translated into practice and allowing evidence based on facts to promote the clinical application of new biomarkers.

Ostojic B.D.,University of Belgrade | Dordevic D.S.,University of Belgrade
Chemosphere | Year: 2012

There is little information on trimethylnaphthalenes (TMNs) which are constituents of diesel fuel and bitumen emissions. In this study, a theoretical investigation of the electronic properties of all trimethylnaphthalene (TMN) isomers and their relation to biodegradation are presented. Equilibrium geometries, ionization potentials (IPs), electron affinities (EAs), dipole moments and electronic dipole polarizabilities of TMN isomers calculated by ab initio and Density Functional Theory (DFT) methods are reported. Polarizability and dipole moment computations have been performed in gas and in water solution using the polarizable continuum model (PCM). The results obtained show that the IP value varies little along the series of isomers while averaged static dipole polarizabilities (〈 α〉) increase on passing from α,α,α-TMN to β,β,β-TMN isomers. This indicates that the binding affinity between TMNs and active site of bacterial enzymes is mainly determined by dispersive and inductive effects. Therefore, the computed polarizability values of TMNs can be used as predictors of the rates of biodegradation of TMNs. © 2012 Elsevier Ltd.