Bath, United Kingdom
Bath, United Kingdom

The University of Bath is a campus university located in Bath, United Kingdom. It received its Royal Charter in 1966. According to 2013 National Student Survey the University of Bath was ranked 1st for student satisfaction out of more than 150 UK higher education institutions. In The Times and The Sunday Times Good University Guide 2014 the University was awarded the title of "Best Campus University in Britain". Bath was awarded the title of ‘University of the Year 2011/12’. In the 2008 Research Assessment Exercise two thirds of Bath's individual subject submissions are ranked in the top ten nationally, including over a third in the top five.The university is a member of the Association of Commonwealth Universities, the Association of MBAs, the European Quality Improvement System, the European University Association, Universities UK and GW4, a grouping which brings together the South West and Wales’ four leading, research-intensive universities . Until 30 October 2012, it was also a member of the 1994 Group. Wikipedia.


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The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R^(1), R^(2), R^(3), R^(4), R^(5), and X are as defined in the specification.


A method of detecting peroxynitrite in a sample is described comprising the steps of: (a) providing a complex of a saccharide with an aryl boronate compound of formula (I): Fp-L^(1)-Z-L^(2)-ArB(OH)_(2 )(I) wherein: Fp comprises a fluorophore; L^(1 )and L^(2 )are linker groups; Z is a fluorescence switch; and Ar is optionally substituted aryl; (b) contacting said aryl boronate-saccharide complex with said sample, whereby peroxynitrite in said sample cleaves said aryl boronate-saccharide complex to produce a compound of formula (II): F-L^(1)-Z-L^(2)-ArOH (II); and (c) detecting a decrease in a fluorescence intensity of said fluorophore resulting from said cleavage reaction in step (b). Peroxynitrite reacts quantitatively, rapidly, and selectively in step (b) of the reaction, whereby medical conditions associated with elevated peroxynitrite can be diagnosed. Also provided are compounds of formula (I) for use in the methods.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.39M | Year: 2017

TREASURE will provide specialist training in the strategic and emerging area of European GNSS. Collectively, GNSS (Global Navigation Satellite Systems) includes systems such as the US Global Positioning System (GPS) and the Russian GLONASS, as well as the new, under development systems like Chinas Beidou and most importantly Europes Galileo. Galileo is what we call the European GNSS (EGNSS) and is to be fully operational around 2020, therefore the pressing need to invest on research and training right now. This is especially so because GPS has clearly been the frontrunner of all these systems and has dominated the market for two decades now. EGNSS (Galileo) is aimed at changing this market unbalance and is the main focus of this proposal, which concentrates on its use in support of applications demanding high accuracy positioning and navigation. TREASUREs cohort of 13 young researchers will be given gap-bridging innovative training through an exceptional and unique network of industrial, research and academic beneficiaries, with the aim to form a group of outstanding researchers who would not be able to acquire the equivalent set of skills by training at any individual European institution alone. World-class expertise on EGNSS exists in Europe, however multi-disciplinary research skills need expanding to maximise the enormous potential that there is for promotion and exploitation of this technology. TREASURE addresses that need and responds to the much desired involvement of end-users and businesses, by bringing together four top Universities, one research Institute and four leading European companies, with extensive track record and experience in a wide breadth of disciplines to provide the necessary coordinated research training that will enable the ultimate real time high accuracy EGNSS solution.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: GV-03-2016 | Award Amount: 11.69M | Year: 2016

Mild Hybrid cOst effective solution for a fast Market penetratiON. THOMSON (Mild Hybrid cOst effective solutions for a fast Market penetration) project aims to the development of cost effective solutions, based on 48V architectures, answering the need in reducing the environmental impact of the transportation sector through a clever combination of advanced engines technologies, electrification and wider use of alternative/renewable fuels. The project addresses very precise and consistent objectives to support a quick transition towards high efficient, cleaner and affordable electrified powertrains focusing on the 48V architectures, intended as key element to increase fuel economy and reduce environmental impact and to support a quick penetration on the market of the hybrid powertrains. Approaches developed in the THOMSON project will demonstrate how the right combination of advanced engine downsizing/turbocharging technologies, coupled with a 48V motor-generator system, can provide the most cost effective solution for a rapid electrification through conventional vehicles. The project will provide an exhaustive evaluation of this concept through the development of two different 48V architectures (one integrating the e-machine on the front engine belt drive, the other between the engine and the transmission) on two different engine families: on one side a mid-size 1.6 litre Diesel engine and, on the other one, a small downsized Spark Ignited CNG engine equipped with a Direct Injection system. This twin approach will allow to demonstrate how 48V architecture interacts with Diesel technologies (especially with regard to noxious pollutant reduction) and, on the other side, with Spark Ignited CNG ones, emphasizing the CO2 reduction already achieved through the use of a low carbon fuel such as CNG. Moreover, for both engine families, 48V architecture represent an important enabler to introduce electrically driven auxiliaries and sub-systems leading to a global better man


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-01-2016-2017 | Award Amount: 10.01M | Year: 2017

Europe has become a global leader in optical-near infrared astronomy through excellence in space and ground-based experimental and theoretical research. While the major infrastructures are delivered through major national and multi-national agencies (ESO, ESA) their continuing scientific competitiveness requires a strong community of scientists and technologists distributed across Europes nations. OPTICON has a proven record supporting European astrophysical excellence through development of new technologies, through training of new people, through delivering open access to the best infrastructures, and through strategic planning for future requirements in technology, innovative research methodologies, and trans-national coordination. Europes scientific excellence depends on continuing effort developing and supporting the distributed expertise across Europe - this is essential to develop and implement new technologies and ensure instrumentation and infrastructures remain cutting edge. Excellence depends on continuing effort to strengthen and broaden the community, through networking initiatives to include and then consolidate European communities with more limited science expertise. Excellence builds on training actions to qualify scientists from European communities which lack national access to state of the art research infrastructures to compete successfully for use of the best available facilities. Excellence depends on access programmes which enable all European scientists to access the best infrastructures needs-blind, purely on competitive merit. Global competitiveness and the future of the community require early planning of long-term sustainability, awareness of potentially disruptive technologies, and new approaches to the use of national-scale infrastructures under remote or robotic control. OPTICON will continue to promote this excellence, global competitiveness and long-term strategic planning.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETPROACT-01-2016 | Award Amount: 4.94M | Year: 2017

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients life and increase quality of life.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 4.00M | Year: 2017

Lightning is an extremely energetic electric discharge process in our atmosphere. It significantly affects the concentration of greenhouse gases and it threatens electrical and electronic devices, in particular, when placed on elevated structures like wind turbines or aircraft, and when these structures are built with modern composite materials with inherently low electric conductivity. In addition, even our fundamental understanding of atmospheric electricity is far from complete. New discharge processes in the atmosphere above thunderstorms have been discovered, the so-called Transient Luminous Events (TLEs) in the stratosphere and mesosphere, and Terrestrial Gamma-ray Flashes (TGFs) that emit particle beams of antimatter. These phenomena demand thorough investigations, in geophysics and in the related fields of plasma and high-voltage technology where similar discharges appear. These challenges are approached within the SAINT project with a multidisciplinary and inter-sectorial training platform for 15 ESRs. The platform brings together satellite and ground observations with modelling and lab experiments. It couples scientific studies to applications relevant to industries developing satellite data products, plasma discharge technologies, lightning detection systems and lightning protection devices. With SAINT, we take advantage of the extraordinary opportunity presented by three simultaneous space missions with dedicated instruments to study lightning discharges, TLEs and TGFs, to integrate the unique space data with dedicated novel ground observations, model developments and lab experiments. SAINT will train the next generation of young, innovative scientists to shape the future of research and technology in Europe.


Islam M.S.,University of Bath | Fisher C.A.J.,Japan Fine Ceramics Center
Chemical Society Reviews | Year: 2014

Energy storage technologies are critical in addressing the global challenge of clean sustainable energy. Major advances in rechargeable batteries for portable electronics, electric vehicles and large-scale grid storage will depend on the discovery and exploitation of new high performance materials, which requires a greater fundamental understanding of their properties on the atomic and nanoscopic scales. This review describes some of the exciting progress being made in this area through use of computer simulation techniques, focusing primarily on positive electrode (cathode) materials for lithium-ion batteries, but also including a timely overview of the growing area of new cathode materials for sodium-ion batteries. In general, two main types of technique have been employed, namely electronic structure methods based on density functional theory, and atomistic potentials-based methods. A major theme of much computational work has been the significant synergy with experimental studies. The scope of contemporary work is highlighted by studies of a broad range of topical materials encompassing layered, spinel and polyanionic framework compounds such as LiCoO2, LiMn2O4 and LiFePO4 respectively. Fundamental features important to cathode performance are examined, including voltage trends, ion diffusion paths and dimensionalities, intrinsic defect chemistry, and surface properties of nanostructures. © 2014 The Royal Society of Chemistry.


Skryabin D.V.,University of Bath | Gorbach A.V.,University of Bath
Reviews of Modern Physics | Year: 2010

A traditional view on solitons in optical fibers as robust particlelike structures suited for information transmission has been significantly altered and broadened over the past decade when solitons have been found to play the major role in generation of octave broad supercontinuum spectra in photonic crystal and other types of optical fibers. This remarkable spectral broadening is achieved through complex processes of dispersive radiation being scattered from, emitted, and transformed by solitons. Thus solitons have emerged as the major players in nonlinear frequency conversion in optical fibers. Unexpected analogies of these processes have been found with dynamics of ultracold atoms and ocean waves. This Colloquium focuses on recent understanding and new insights into physics of soliton-radiation interaction and supercontinuum generation. © 2010 The American Physical Society.


Ward M.D.,University of Sheffield | Raithby P.R.,University of Bath
Chemical Society Reviews | Year: 2013

Many naturally occurring systems show us how multi-component supramolecular assemblies can generate useful functional behaviour. In this article the problems and limitations associated with achieving such behaviour in artificial multi-component assemblies is discussed, together with two examples of functions in artificial supramolecular assemblies based on (i) host-guest chemistry in cavities of cages, and (ii) light-harvesting in multi-chromophore arrays. Important challenges for the future are summarised. © 2013 The Royal Society of Chemistry.

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