Bath, United Kingdom

University of Bath

www.bath.ac.uk
Bath, United Kingdom

The University of Bath is a campus university located in Bath, United Kingdom. It received its Royal Charter in 1966. According to 2013 National Student Survey the University of Bath was ranked 1st for student satisfaction out of more than 150 UK higher education institutions. In The Times and The Sunday Times Good University Guide 2014 the University was awarded the title of "Best Campus University in Britain". Bath was awarded the title of ‘University of the Year 2011/12’. In the 2008 Research Assessment Exercise two thirds of Bath's individual subject submissions are ranked in the top ten nationally, including over a third in the top five.The university is a member of the Association of Commonwealth Universities, the Association of MBAs, the European Quality Improvement System, the European University Association, Universities UK and GW4, a grouping which brings together the South West and Wales’ four leading, research-intensive universities . Until 30 October 2012, it was also a member of the 1994 Group. Wikipedia.


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The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R^(1), R^(2), R^(3), R^(4), R^(5), and X are as defined in the specification.


A method of detecting peroxynitrite in a sample is described comprising the steps of: (a) providing a complex of a saccharide with an aryl boronate compound of formula (I): Fp-L^(1)-Z-L^(2)-ArB(OH)_(2 )(I) wherein: Fp comprises a fluorophore; L^(1 )and L^(2 )are linker groups; Z is a fluorescence switch; and Ar is optionally substituted aryl; (b) contacting said aryl boronate-saccharide complex with said sample, whereby peroxynitrite in said sample cleaves said aryl boronate-saccharide complex to produce a compound of formula (II): F-L^(1)-Z-L^(2)-ArOH (II); and (c) detecting a decrease in a fluorescence intensity of said fluorophore resulting from said cleavage reaction in step (b). Peroxynitrite reacts quantitatively, rapidly, and selectively in step (b) of the reaction, whereby medical conditions associated with elevated peroxynitrite can be diagnosed. Also provided are compounds of formula (I) for use in the methods.


Patent
University of Bath | Date: 2016-10-23

A process for the production of particles comprises the steps of formation of a solution of a desired substance in a suitable solvent; ii) generation of an aerosol from the solution of said substance; iii) collection of the aerosol droplets in a vessel containing a non-solvent of said substance; and iv) the application of ultrasound to the droplets dispersed in the non-solvent to effect crystallisation of said substance. The particles produced find application in for example pharmaceutical and agrochemical formulations, especially in inhalation formulations.


Patent
University of Bath | Date: 2015-02-02

A method of measuring -methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon-carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.


Patent
University of Bath | Date: 2015-06-12

A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions, optionally comprising further pharmaceutical agents; and related methods.


Patent
University of Bath | Date: 2017-04-19

A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions, optionally comprising further pharmaceutical agents;and related methods.


A method of detecting peroxynitrite in a sample is described comprising the steps of: (a) providing a complex of a saccharide with an aryl boronate compound of formula (I): Fp - L1 - Z - L2 - Ar - B(OH)2 (I) wherein: Fp comprises a fluorophore; L1 and L2 are linker groups; Z is a fluorescence switch; and Ar is optionally substituted aryl; (b) contacting said aryl boronate- saccharide complex with said sample, whereby peroxynitrite in said sample cleaves said aryl boronate- saccharide complex to produce a compound of formula (II): F - L1 - Z - L2 - Ar - OH (II); and (c) detecting a decrease in a fluorescence intensity of said fluorophore resulting from said cleavage reaction in step (b). Peroxynitrite reacts quantitatively, rapidly, and selectively in step (b) of the reaction, whereby medical conditions associated with elevated peroxynitrite can be diagnosed. Also provided are compounds of formula (I) for use in the methods.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-01-2016-2017 | Award Amount: 10.01M | Year: 2017

Europe has become a global leader in optical-near infrared astronomy through excellence in space and ground-based experimental and theoretical research. While the major infrastructures are delivered through major national and multi-national agencies (ESO, ESA) their continuing scientific competitiveness requires a strong community of scientists and technologists distributed across Europes nations. OPTICON has a proven record supporting European astrophysical excellence through development of new technologies, through training of new people, through delivering open access to the best infrastructures, and through strategic planning for future requirements in technology, innovative research methodologies, and trans-national coordination. Europes scientific excellence depends on continuing effort developing and supporting the distributed expertise across Europe - this is essential to develop and implement new technologies and ensure instrumentation and infrastructures remain cutting edge. Excellence depends on continuing effort to strengthen and broaden the community, through networking initiatives to include and then consolidate European communities with more limited science expertise. Excellence builds on training actions to qualify scientists from European communities which lack national access to state of the art research infrastructures to compete successfully for use of the best available facilities. Excellence depends on access programmes which enable all European scientists to access the best infrastructures needs-blind, purely on competitive merit. Global competitiveness and the future of the community require early planning of long-term sustainability, awareness of potentially disruptive technologies, and new approaches to the use of national-scale infrastructures under remote or robotic control. OPTICON will continue to promote this excellence, global competitiveness and long-term strategic planning.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETPROACT-01-2016 | Award Amount: 4.94M | Year: 2017

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients life and increase quality of life.


Islam M.S.,University of Bath | Fisher C.A.J.,Japan Fine Ceramics Center
Chemical Society Reviews | Year: 2014

Energy storage technologies are critical in addressing the global challenge of clean sustainable energy. Major advances in rechargeable batteries for portable electronics, electric vehicles and large-scale grid storage will depend on the discovery and exploitation of new high performance materials, which requires a greater fundamental understanding of their properties on the atomic and nanoscopic scales. This review describes some of the exciting progress being made in this area through use of computer simulation techniques, focusing primarily on positive electrode (cathode) materials for lithium-ion batteries, but also including a timely overview of the growing area of new cathode materials for sodium-ion batteries. In general, two main types of technique have been employed, namely electronic structure methods based on density functional theory, and atomistic potentials-based methods. A major theme of much computational work has been the significant synergy with experimental studies. The scope of contemporary work is highlighted by studies of a broad range of topical materials encompassing layered, spinel and polyanionic framework compounds such as LiCoO2, LiMn2O4 and LiFePO4 respectively. Fundamental features important to cathode performance are examined, including voltage trends, ion diffusion paths and dimensionalities, intrinsic defect chemistry, and surface properties of nanostructures. © 2014 The Royal Society of Chemistry.

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