The University of Bari Aldo Moro is a higher education institution in Bari, Apulia, in southern Italy.The University of Bari was founded in 1925. It is a state-supported university which is divided into 12 faculties. Each faculty has its own set of departments that focus on the arts science, mathematics, social science, literature, medicine, law, and education.The university offers various courses for undergraduate, graduate and post-graduate students. Aside from teaching, the university is also focused on scientific research at the doctorate level. The University of Bari research centres are highly-interactive, having connections among different departments, universities, and other research centres.The University of Bari is one of the most prestigious universities in Southern Italy and it is one of the largest universities in Italy, with a student population of around 60,000.The University has been recently entitled to one of its most famous student, the statesman Aldo Moro. Moro taught for several years Criminal Law at the University of Bari.The University has been awarded the following ranking positions:ranked 305 by Performance Ranking of Scientific Papers for World Universities ranked 401-500 by Academic Ranking of World Universities - Shanghai Jiao Tong University ranked 350-400 by Times Higher Education Supplement Ranking of World Universities ranked 508 by QS World University Rankings ranked 186 by the Leiden Ranking The University is one of the 20 Italian higher education institutions in the ARWU list of the top 500 universities in the world for 2012. Moreover, it has been ranked between 151st and 200th in the world for Physics by Academic Ranking of World Universities - Shanghai Jiao Tong University . Wikipedia.
University of Bari and University of Pisa | Date: 2017-08-02
Object of the present invention is the use of selective agonists of beta-adrenergic type 3 receptors (BAR3) in the treatment of nephrogenic diabetes insipidus (NDI), in particular of X-linked nephrogenic diabetes insipidus (X-NDI).
University of Bari and Marche Polytechnic University | Date: 2016-04-14
Object of the present invention is the use of Irisin for the treatment and/or prevention of osteoporosis. In particular, the present invention refers to the use of recombinant irisin for the treatment and/or prevention of osteoporosis.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.20M | Year: 2017
FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of non-alcoholic fatty liver disease (NAFLD). Its progression to nonalcoholic steatohepatitis (NASH) is a leading risk factor for development of Type 2 diabetes, cirrhosis, and hepatocellular carcinoma. FOIE GRAS is first in supporting a cohesive and synergistic intersection of complementary and interdisciplinary training skills from academic and non-academic partners. FOIE GRAS combines strong scientific expertise with integrated and complementary training in translational research, clinical practice, technology commercialization, and public outreach, the combination of which in targeting NAFLD is lacking in the EU. Industrial partners CETICS, Mediagnost and Seahorse Biosciences provide experience on technology commercialization alongside scientific contributions while the affiliated patient organization will contribute with important training in societal awareness topics. ESRs training will utilize network-wide workshops and secondments to foster translation of basic research to clinical applications and SME creation. This diverse yet integrated skill set enhances the employment prospects of the trained researchers in both academic and non-academic sectors. Researchers will be endowed with excellent basic scientific knowledge and timely technology transfer know-how for developing novel therapeutic approaches for reversing the burden of NAFLD, thereby advancing both health and economic well-being of European citizens and approaching NAFLD research in the EU from its counterparts in the US and Asia.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-03a-2014 | Award Amount: 6.92M | Year: 2015
This proposal SFS-03a-2014-aligned focuses to minimize the risk of introduction/impact of emerging pests threatening EU agriculture and forestry. The targets are: 1) Xylella fastidiosa and its vectors in olive, grapevine, citrus, stone fruit, ornamentals and landscape trees of high socio-economic importance; 2) Ca. Liberibacter solanacearum and its vectors affecting a number of strategic crops such as potato, tomato and carrot; and 3) Hymenoscyphus pseudoalbidus (anomorph. Chalara fraxinea) and Phytophtora spp. seriously affecting broadleaf and conifer species in forest ecosystems. Targeted pests, their vectors and the host response will be explored using innovative approaches (NGS, transcriptomic). Diseases surveillance and epidemiology given by current methods will integrate improved survey protocols and remote sensing. Innovative IPM will include studies of microbiome to develop sustainable solutions in line with the EU plant health legislation. New knowledge gained with POnTE will result in an outcome-based pest prevention and management work plan to: a) implement area-wide pest risk assessments; b) prevent the entry and develop surveillance and early detection tools (diagnostic kits, lab-on-chip, new biomarkers); c) mitigate the spread and reduce the socio-economic impact; d) IPM based on disease resistance, disease-free seeds, cultural practices and physical environmentally-friendly treatments; e) support knowledge-based decision-making policies at EU level. The proposal fosters and promotes a multi-actor approach and transnational research collaborations among 25 Partners at the forefront of research in plant protection, agro-engineering and economics. It involves key industries/SMEs that develop diagnostic kits and services, agrochemical and seed companies, stakeholder groups. End-users will participate in the development of the project and immediately implement the practical solutions derived from the outcomes to solve these serious emerging diseases.
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 454.50K | Year: 2017
Non-Alcoholic Fatty Liver Disease (NAFLD), including its more pathologic consequence, non-alcoholic steatohepatitis (NASH), is believed to be the most common chronic liver disease worldwide, affecting between 6 to 37% of the population. NAFLD is a so called silent killer, as clinical symptoms only surface at late stages of the disease, when it is no longer treatable: untreated, NAFLD/NASH can lead to cirrhosis and hepatocellular carcinoma, culminating in liver failure. Currently the best method of diagnosing and staging the disease is liver biopsy, a costly, invasive and somewhat risky procedure, not to mention unfit for routine assessment. Besides, no therapeutic consensus exists for NAFLD/NASH treatment. mtFOIE GRAS (Foie Gras being French for fat liver) proposes to address the pressing need for non-invasive, accurate, rapid assessment of NAFLD/NASH stages, before and after intervention, through the development of biomarkers and innovative tools to follow mitochondrial (mt) dysfunction, a central mediator of fatty liver disease pathogenesis. This promising R&D strategy will also bring new knowledge about the disease mechanisms and improved understanding of the pathogenic process and disease drivers. To that end, mtFOIE GRAS envisages a training-through-work plan that brings together an intersectoral, multidisciplinary team of researchers and technicians experts in their fields, from basic to translational research, clinical practice, technology commercialization and public advocacy. Together with several PhD students, the team will share expertises and work synergistically along the value creation chain to address the unmet medical need of more informative NAFLD assessment. In the process, mtFOIE GRAS will endow the involved staff with excellent scientific knowledge and transferable skills while building and strengthening intersectoral cooperation among partners, thus contributing to EU RD&I excellence.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-09-2016 | Award Amount: 7.06M | Year: 2016
XF-ACTORS aims to establish a multidisciplinary research program to answer the urgent need to improve prevention, early detection and control of Xylella fastidiosa (Xf). Recently, Xf was introduced into Italy, where it is causing severe damage to olive crops, and in France, where so far it is limited to ornamental plants and some landscape trees. The overall goal of the research program is to assess Xf potential to spread throughout EU territory, while maximizing its impact through a multifactor approach, based on a seamless integration amongst the 29 partners involved. Proposed actions will be complementary to those carried out under the Project POnTE - 635646, thus ensuring an unbroken continuity with currently ongoing efforts. Specific objectives have been outlined following a step-by-step route, from preventing its introduction into pest-free areas to the establishment of successful eradication strategies in infected zones. Preventive measures against Xf will be strengthened by implementing EU certification programs and developing a plan for establishing a EU Clean Plant Network. EU policy makers will be supported through the development of pest risk assessment tools, focused on current outbreaks and forecasting potentially threatened regions. Surveillance will be properly implemented, supporting the development of early detection tools for field use, remote sensing technology and predictive modelling. Critical information on the pathogen biology, epidemiological traits and hosts under threat, will be gathered with the guidance of the American research groups with long-established research. At the same time, the insect-bacteria interactions will be determined, for developing strategic control measures. The final overall objective is a comprehensive integrated management strategy for diseases associated with Xf, applicable both IPM and organic farming systems, to prevent Xf spread, control its economic, environmental/social impact, when an outbreak would occur.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-23-2016 | Award Amount: 10.00M | Year: 2016
The GEMex project is a complementary effort of a European consortium with a corresponding consortium from Mexico, who submitted an equivalent proposal for cooperation. The joint effort is based on three pillars: 1 Resource assessment at two unconventional geothermal sites, for EGS development at Acoculco and for a super-hot resource near Los Humeros. This part will focus on understanding the tectonic evolution, the fracture distribution and hydrogeology of the respective region, and on predicting in-situ stresses and temperatures at depth. 2 Reservoir characterization using techniques and approaches developed at conventional geothermal sites, including novel geophysical and geological methods to be tested and refined for their application at the two project sites: passive seismic data will be used to apply ambient noise correlation methods, and to study anisotropy by coupling surface and volume waves; newly collected electromagnetic data will be used for joint inversion with the seismic data. For the interpretation of these data, high-pressure/ high-temperature laboratory experiments will be performed to derive the parameters determined on rock samples from Mexico or equivalent materials. 3 Concepts for Site Development: all existing and newly collected information will be applied to define drill paths, to recommend a design for well completion including suitable material selection, and to investigate optimum stimulation and operation procedures for safe and economic exploitation with control of undesired side effects. These steps will include appropriate measures and recommendations for public acceptance and outreach as well as for the monitoring and control of environmental impact. The consortium was formed from the EERA joint programme of geothermal energy in regular and long-time communication with the partners from Mexico. That way a close interaction of the two consortia is guaranteed and will continue beyond the duration of the project.
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 1.58M | Year: 2016
Technological advances in remote sensing have increased the availability of satellite images with different spatiotemporal and spectral characteristics.There is difficulty for retrieving the most appropriate data for each users needs.One key challenge is to connect the quantitative information of the EO images with the qualitative (high-level user queries) and be able to mine these connections in big archives.An inherent question arises; how to retrieve EO images based on user semantically aware questions.Content based EO image retrieval techniques have been introduced for bridging the gap between low-level image features and high-level queries.The main constraint of the existing approaches is the generalization of the problem.The formulated ontologies are not focused on the constraints of EO images.The main objective of SEO-DWARF is to realize the content-based search of EO images on an application specific basis.The marine application domain and data from Sentinels 1,2,3, ENVISAT will be used.Queries such as Calculate the rate of increasing chlorophyll in the NATURA area will be answered by the SEO-DWARF, helping users to retrieve the appropriate EO images for their specific needs or alert them when a specific phenomenon occurs.The research contains the:a) ontology formalization for the specific research topics,b) determination of the semantic queries for the application domains,c) algorithm development for extracting metadata from the EO images,d) design of an architecture of the platform to perform the semantic image retrieval and storage and management of the extracted metadata.All four aspects will be integrated in an innovative and user-friendly web based platform enabling the users to retrieve images for marine applications or register for a semantic alert.A strong and experienced research team, of 4 academic and 5 industrial partners, coming from Greece(3), Italy(2), Germany(1), France(1), Cyprus(1) and Switzerland(1) constitute the projects consortium.
Palmieri F.,University of Bari
Molecular Aspects of Medicine | Year: 2013
SLC25 is a large family of nuclear-encoded transporters embedded in the inner mitochondrial membrane and in a few cases other organelle membranes. The members of this superfamily are widespread in eukaryotes and involved in numerous metabolic pathways and cell functions. They can be easily recognized by their striking sequence features, i.e.; a tripartite structure, six transmembrane α-helices and a 3-fold repeated signature motifs. SLC25 members vary greatly in the nature and size of their transported substrates, modes of transport (i.e.; uniport, symport or antiport) and driving forces, although the molecular mechanism of substrate translocation may be basically the same. Based on substrate specificity, 24 subfamilies, well conserved throughout evolution, have been functionally characterized mainly by transport assays upon heterologous gene expression, purification and reconstitution into liposomes. Several other SLC25 family members remain to be characterized. In recent years mutations in the SLC25 genes have been shown to be responsible for 11 diseases, highlighting the important role of SLC25 in metabolism. © 2012 Elsevier Ltd. All rights reserved.
Farinola G.M.,University of Bari |
Ragni R.,University of Bari
Chemical Society Reviews | Year: 2011
White organic light emitting diodes (WOLEDs) are promising devices for application in low energy consumption lighting since they combine the potentialities of high efficiency and inexpensive production with the appealing features of large surfaces emitting good quality white light. However, lifetime, performances and costs still have to be optimized to make WOLEDs commercially competitive as alternative lighting sources. Development of efficient and stable emitters plays a key role in the progress of WOLED technology. This tutorial review discusses the main approaches to obtain white electroluminescence with organic and organometallic emitters. Representative examples of each method are reported highlighting the most significant achievements together with open issues and challenges to be faced by future research. © 2011 The Royal Society of Chemistry.