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Ayari C.,Institute Pasteur Of Tunis | Ayari C.,University of Carthage | Ben Othman S.,Institute Pasteur Of Tunis | Chemkhi J.,Institute Pasteur Of Tunis | And 4 more authors.
Infection, Genetics and Evolution | Year: 2016

In recent years there has been growing interest in Sergentomyia species. Their role in the spread of mammalian leishmaniasis appears repeatedly in the literature and the possibility of its implication in Leishmania transmission to humans remains controversial. Sergentomyia (Sintonius) clydei is one of several cryptic species sharing therefore common morphologic criteria with others species of the subgenera Sintonius. Little is known about this specie in Tunisia.We sampled and identified different specimens including four specimens of S. clydei collected from Sidi Bouzid and Kairouan areas (center of Tunisia) using morphological tools. Male Sergentomyia clydei and Sergentomyia christophersi are known to share several morphological characters and can be mistaken for. Consequently we took advantage of 5 male S. christophersi available in our collection (Tataouin, South of Tunisia). In our study morphological tools were completed by molecular study of cytochrome b gene to identify S. clydei.For the detection of Leishmania spp. that might infect our specimens, Leishmania DNA was analyzed by amplification of kinetoplast minicircle DNA using real-time PCR and nested-PCR. Obtained result was confirmed by restriction analysis of the amplified ribosomal internal transcribed spacer 1 (ITS1).We provide in our study, the first molecular identification of S. clydei, in Tunisia. Our Neighbor Joining tree based on mitochondrial cytochrome b gene shows two different clusters. The first includes the Tunisians S. clydei and other specimens from Africa, Middle East and the Arabic peninsula, and the second cluster containing the specimens from Seychelle.Unexpectedly, we also demonstrate the infection of one anthropophilic female S. clydei by Leishmania major DNA. This finding shows that more attention should be paid when identifying parasites by molecular tools within sandfly vector. © 2015 Elsevier B.V. Source


Via-Sosa M.A.,Unidad University | Lopes N.,University Of Barcelone | March M.,Unidad University
BMC Family Practice | Year: 2013

Background: Drug dosing errors are common in renal-impaired patients. Appropriate dosing adjustment and drug selection is important to ensure patients' safety and to avoid adverse drug effects and poor outcomes. There are few studies on this issue in community pharmacies. The aims of this study were, firstly, to determine the prevalence of dosing inadequacy as a consequence of renal impairment in patients over 65 taking 3 or more drug products who were being attended in community pharmacies and, secondly, to evaluate the effectiveness of the community pharmacist's intervention in improving dosing inadequacy in these patients when compared with usual care. Methods. The study was carried out in 40 Spanish community pharmacies. The study had two phases: the first, with an observational, multicentre, cross sectional design, served to determine the dosing inadequacy, the drug-related problems per patient and to obtain the control group. The second phase, with a controlled study with historical control group, was the intervention phase. When dosing adjustments were needed, the pharmacists made recommendations to the physicians. A comparison was made between the control and the intervention group regarding the prevalence of drug dosing inadequacy and the mean number of drug-related problems per patient. Results: The mean of the prevalence of drug dosing inadequacy was 17.5% [95% CI 14.6-21.5] in phase 1 and 15.5% [95% CI 14.5-16.6] in phase 2. The mean number of drug-related problems per patient was 0.7 [95% CI 0.5-0.8] in phase 1 and 0.50 [95% CI 0.4-0.6] in phase 2. The difference in the prevalence of dosing inadequacy between the control and intervention group before the pharmacists' intervention was 0.73% [95% CI (-6.0) - 7.5] and after the pharmacists' intervention it was 13.5% [95% CI 8.0 - 19.5] (p < 0.001) while the difference in the mean of drug-related problems per patient before the pharmacists' intervention was 0.05 [95% CI(-0.2) - 0.3] and following the intervention it was 0.5 [95% CI 0.3 - 0.7] (p < 0.001). Conclusion: A drug dosing adjustment service for elderly patients with renal impairment in community pharmacies can increase the proportion of adequate drug dosing, and improve the drug-related problems per patient. Collaborative practice with physicians can improve these results. © 2013 Via-Sosa et al.; licensee BioMed Central Ltd. Source


Cano A.,University of Valencia | Silvan J.M.,University of Seville | Estevez A.,Hospital Universitario Of Valme | Baro F.,University Of Barcelone | And 5 more authors.
Maturitas | Year: 2014

Denosumab is a new drug developed for the treatment of osteoporosis. Moreover, increasing evidences link denosumab with benefits in cancer, an area of interest for those in charge of the postmenopausal health. Denosumab has shown efficacy in the control of bone loss associated with hypogonadic states created by chemotherapy in breast and other cancers. Moreover, some studies reveal efficacy in reducing the progression of metastases. A panel of experts from the Spanish Menopause Society has met to develop usage recommendations based on the best available evidence. © 2014 Elsevier Ireland Ltd. Source


Claros P.,Clinica Claros | Claros A.,Clinica Claros | Sarr M.,Fann University Hospital Center | Cardesa A.,University Of Barcelone
Revue de Laryngologie Otologie Rhinologie | Year: 2014

Rare complication of radical surgery (Caldwell Luc procedure) of the maxillary sinus, maxillary cyst can occurred several years after. We describe the case of a patient 56 years old, who came to our consultation for repeated pain in the right maxillary region with moderate facial asymmetry. In her history we noted a previous sinus surgery (Caldwell Luc) more than 10 years before. The imaging showed an expansive process filled with proteinic tissue of the posterior wall of the maxillary. With the history of the former surgery, we suspected the existence of a mucocele. She underwent an endonasal surgery and the pathological examination of the specimen revealed an intra osseous cyst lined with ciliated respiratory type mucosa post surgery of the maxillary sinus. The diagnosis of a maxillary cyst complicating a Caldwell Luc was established based on the results obtained with the clinico-radiological and pathological results. Source


Llasat M.C.,University Of Barcelone | Zaragoza A.,University Of Barcelone | Cabot J.,Clabsa | Aznar B.,Clabsa
Houille Blanche | Year: 2010

Low flows and droughts are a hydro-climatic feature in Spain. The last drought that has affected Spain has last four years in Catalonia from 2004 to the spring of 2008. The aim of this contribution is to show its evolution and the potential use of seasonal forecasting to improve the water management in Catalonia. Due to the fact that the principal rivers in the Internal Basins of Catalonia born in Pyrenees and Pre-Pyrenees region the analysis of the precipitation is focused on this region. Monthly precipitation series representatives of the three basins of study have been obtained from 127 raingauges for the period 1940-2008. These series have been used to calibrate the hydrological model and to validate the seasonal forecasting. All seasonal predictions from internet sites have been analysed and one have been selected ECM4 and later validated for the region of study with 127 raingauges for the period 1998-2008. Then a seasonal prediction index has been created as a linear combination of climatic data and the ECM4 prediction that has been validated too. This information has implemented into a hydrological model and it has been applied to the last drought considering the real water demands of population. It has been found a considerable advance in the forecasting of water volume into reservoirs that can be applied in the future. The advantage of this methodology is that it only requires seasonal forecasting free through internet. This work has been developed into SOSTAQUA project. © Société Hydrotechnique de France, 2010. Source

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