University Of Barcelone

Barcelona, Spain

University Of Barcelone

Barcelona, Spain
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Cano A.,University of Valencia | Silvan J.M.,University of Seville | Estevez A.,Hospital Universitario Of Valme | Baro F.,University of Barcelone | And 5 more authors.
Maturitas | Year: 2014

Denosumab is a new drug developed for the treatment of osteoporosis. Moreover, increasing evidences link denosumab with benefits in cancer, an area of interest for those in charge of the postmenopausal health. Denosumab has shown efficacy in the control of bone loss associated with hypogonadic states created by chemotherapy in breast and other cancers. Moreover, some studies reveal efficacy in reducing the progression of metastases. A panel of experts from the Spanish Menopause Society has met to develop usage recommendations based on the best available evidence. © 2014 Elsevier Ireland Ltd.


Claros P.,Clinica Claros | Claros A.,Clinica Claros | Sarr M.,Fann University Hospital Center | Cardesa A.,University Of Barcelone
Revue de Laryngologie Otologie Rhinologie | Year: 2014

Rare complication of radical surgery (Caldwell Luc procedure) of the maxillary sinus, maxillary cyst can occurred several years after. We describe the case of a patient 56 years old, who came to our consultation for repeated pain in the right maxillary region with moderate facial asymmetry. In her history we noted a previous sinus surgery (Caldwell Luc) more than 10 years before. The imaging showed an expansive process filled with proteinic tissue of the posterior wall of the maxillary. With the history of the former surgery, we suspected the existence of a mucocele. She underwent an endonasal surgery and the pathological examination of the specimen revealed an intra osseous cyst lined with ciliated respiratory type mucosa post surgery of the maxillary sinus. The diagnosis of a maxillary cyst complicating a Caldwell Luc was established based on the results obtained with the clinico-radiological and pathological results.


Kherchouche D.,University of Batna | Kalla M.,University of Batna | Gutierrez E.,University Of Barcelone | Briki A.,Conservation des Fore ts de la Wilaya de Batna Algerie | Hamchi A.,Parc National du Belezma
Science et Changements Planetaires - Secheresse | Year: 2013

The dieback of Atlas cedar forests observed in the last decade in the Aurès and Belezma mountains has been linked by the majority of researchers and planners to the drought as a principal factor. In 1880 and 1979, high levels of mortality were reported after severe droughts. Our main objective is to reconstruct dry years based on the relationship between the tree-ring growth index and precipitation to determine whether these high levels of mortality were preceded by drought events. The threshold of 80% of observed precipitation for the calibration period 1931-2009 was used to identify drought events for the period 1845-2009. The longest period of drought was two years, and it was observed twice: 1877-1878 and 2001-2002. The driest year was 1978. Although these three events of drought preceded the three episodes of dieback observed in the cedar forest of Belezma, the drought may be considered as a determinant factor but not unique to the cedar forest dieback. Other factors acting in conjunction with or after the drought could worsen the situation and cause tree mortality.


Ayari C.,Institute Pasteur Of Tunis | Ayari C.,University of Carthage | Ben Othman S.,Institute Pasteur Of Tunis | Chemkhi J.,Institute Pasteur Of Tunis | And 4 more authors.
Infection, Genetics and Evolution | Year: 2016

In recent years there has been growing interest in Sergentomyia species. Their role in the spread of mammalian leishmaniasis appears repeatedly in the literature and the possibility of its implication in Leishmania transmission to humans remains controversial. Sergentomyia (Sintonius) clydei is one of several cryptic species sharing therefore common morphologic criteria with others species of the subgenera Sintonius. Little is known about this specie in Tunisia.We sampled and identified different specimens including four specimens of S. clydei collected from Sidi Bouzid and Kairouan areas (center of Tunisia) using morphological tools. Male Sergentomyia clydei and Sergentomyia christophersi are known to share several morphological characters and can be mistaken for. Consequently we took advantage of 5 male S. christophersi available in our collection (Tataouin, South of Tunisia). In our study morphological tools were completed by molecular study of cytochrome b gene to identify S. clydei.For the detection of Leishmania spp. that might infect our specimens, Leishmania DNA was analyzed by amplification of kinetoplast minicircle DNA using real-time PCR and nested-PCR. Obtained result was confirmed by restriction analysis of the amplified ribosomal internal transcribed spacer 1 (ITS1).We provide in our study, the first molecular identification of S. clydei, in Tunisia. Our Neighbor Joining tree based on mitochondrial cytochrome b gene shows two different clusters. The first includes the Tunisians S. clydei and other specimens from Africa, Middle East and the Arabic peninsula, and the second cluster containing the specimens from Seychelle.Unexpectedly, we also demonstrate the infection of one anthropophilic female S. clydei by Leishmania major DNA. This finding shows that more attention should be paid when identifying parasites by molecular tools within sandfly vector. © 2015 Elsevier B.V.


Jannick N.,University Of Barcelone | Vazquez J.H.,University Of Barcelone | Rodenas A.B.,University Of Barcelone
Staps | Year: 2010

Our theoretical reflection goes in the sense of explaining the benefits of the dance and his potential as regards the Special Education and particularly targeted on Adapted Physical Education. Dance is analyzed from a multidisciplinary methodology that it is focused in a physical, psychological, cognitive and social dimensions and applying his different elements to intellectually disabled children. We work to create new research lines with the aim to establish the merits of the dance and its importance in educational programmes.


Via-Sosa M.A.,Unidad University | Lopes N.,University of Barcelone | March M.,Unidad University
BMC Family Practice | Year: 2013

Background: Drug dosing errors are common in renal-impaired patients. Appropriate dosing adjustment and drug selection is important to ensure patients' safety and to avoid adverse drug effects and poor outcomes. There are few studies on this issue in community pharmacies. The aims of this study were, firstly, to determine the prevalence of dosing inadequacy as a consequence of renal impairment in patients over 65 taking 3 or more drug products who were being attended in community pharmacies and, secondly, to evaluate the effectiveness of the community pharmacist's intervention in improving dosing inadequacy in these patients when compared with usual care. Methods. The study was carried out in 40 Spanish community pharmacies. The study had two phases: the first, with an observational, multicentre, cross sectional design, served to determine the dosing inadequacy, the drug-related problems per patient and to obtain the control group. The second phase, with a controlled study with historical control group, was the intervention phase. When dosing adjustments were needed, the pharmacists made recommendations to the physicians. A comparison was made between the control and the intervention group regarding the prevalence of drug dosing inadequacy and the mean number of drug-related problems per patient. Results: The mean of the prevalence of drug dosing inadequacy was 17.5% [95% CI 14.6-21.5] in phase 1 and 15.5% [95% CI 14.5-16.6] in phase 2. The mean number of drug-related problems per patient was 0.7 [95% CI 0.5-0.8] in phase 1 and 0.50 [95% CI 0.4-0.6] in phase 2. The difference in the prevalence of dosing inadequacy between the control and intervention group before the pharmacists' intervention was 0.73% [95% CI (-6.0) - 7.5] and after the pharmacists' intervention it was 13.5% [95% CI 8.0 - 19.5] (p < 0.001) while the difference in the mean of drug-related problems per patient before the pharmacists' intervention was 0.05 [95% CI(-0.2) - 0.3] and following the intervention it was 0.5 [95% CI 0.3 - 0.7] (p < 0.001). Conclusion: A drug dosing adjustment service for elderly patients with renal impairment in community pharmacies can increase the proportion of adequate drug dosing, and improve the drug-related problems per patient. Collaborative practice with physicians can improve these results. © 2013 Via-Sosa et al.; licensee BioMed Central Ltd.


Soler L.I.,University of Barcelone | Boix A.,University of Barcelone | Lauroba J.,University of Barcelone | Colom H.,University of Barcelone | Domenech J.,University of Barcelone
Drug Development and Industrial Pharmacy | Year: 2012

Alprazolam, a benzodiazepine widely used for the treatment of psychiatric disorders, has been aimed to be formulated in a transdermal delivery system (TDS) prototype. A series of TDS prototypes dosed in all cases at 0.35 mg·cm-2 of alprazolam were prepared as a monolithic drug in adhesive matrix using acrylic pressure-sensitive adhesives (PSA) of acrylate vinyl acetate (Duro-tack®). The effects of several permeation enhancers as azone, transcutol, propylene glycol, dodecyl alcohol, decyl alcohol, diethanolamine, N-methyl pyrrolidone and lauric acid were studied. Prototypes have been characterized based on adhesion parameters (peel adhesion and shear adhesion), in vitro human skin permeation and in vitro drug release according to European Pharmacopoeia for the selected prototype. Best results show that a combination of permeation enhancers from different chemical groups is able to provide almost a 33 fold increase in the transdermal alprazolam flux of an aqueous saturated dispersion (from 0.054±0.019 to 1.76±0.21 μg h.cm-2). Based on these in vitro flux data, a predictive simulation of the achievable plasmatic levels was performed assuming a constant systemic infusion of drug. In summary, it is possible to obtain a prototype of a TDS of alprazolam with adequate adhesive properties (peel adhesion and shear adhesion) and able to predict sustained therapeutic plasmatic levels. © 2012 Informa Healthcare USA, Inc.


Abid-Ayadi I.,University Of Barcelone | Abid-Ayadi I.,Institute Superieur Of Biologie Appliquee Of Medenine Isbam | Guix S.,University Of Barcelone | Pinto R.M.,University Of Barcelone | Bosch A.,University Of Barcelone
Pathologie Biologie | Year: 2011

Aims: Unlike group A, a few studies have interested other groups of the rotavirus, especially in Tunisia. The role of rotavirus C (RVC) infection is underestimated because of its sporadic nature. The aim of our study was to develop rapid diagnostic procedures of RVC by using an internal positive control of reverse transcription PCR (RT-PCR). Methods: The internal positive control (386pb) was designed from the recombinant baculovirus BacVP6C containing the full length cDNA of the Cowden strain gene 5 (1353pb). A fragment of 596pb was amplified by PCR using the BacVP6C DNA ds as template. Then, a central part of 210pb was deleted and the remaining fragment (386pb) was cloned into pGEM-3Zf+ plasmid between SP6 and T7 RNA polymerase promoters. Results: The obtained recombinant plasmid " pIAM1" was then used for the generation of the internal positive control by in vitro transcription. The sensibility of the RT-PCR was about 3.66×105 molecules of RNA/μl. Conclusion: The use of a shorter positive control, as compared to the wild type, allows increased specificity of the RT-PCR reaction, and could be used for efficient diagnostic and surveillance of RVC-caused diseases. © 2009 Elsevier Masson SAS.


PubMed | University Of Barcelone, University of Carthage and Institute Pasteur Of Tunis
Type: | Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases | Year: 2016

In recent years there has been growing interest in Sergentomyia species. Their role in the spread of mammalian leishmaniasis appears repeatedly in the literature and the possibility of its implication in Leishmania transmission to humans remains controversial. Sergentomyia (Sintonius) clydei is one of several cryptic species sharing therefore common morphologic criteria with others species of the subgenera Sintonius. Little is known about this specie in Tunisia. We sampled and identified different specimens including four specimens of S. clydei collected from Sidi Bouzid and Kairouan areas (center of Tunisia) using morphological tools. Male Sergentomyia clydei and Sergentomyia christophersi are known to share several morphological characters and can be mistaken for. Consequently we took advantage of 5 male S. christophersi available in our collection (Tataouin, South of Tunisia). In our study morphological tools were completed by molecular study of cytochrome b gene to identify S. clydei. For the detection of Leishmania spp. that might infect our specimens, Leishmania DNA was analyzed by amplification of kinetoplast minicircle DNA using real-time PCR and nested-PCR. Obtained result was confirmed by restriction analysis of the amplified ribosomal internal transcribed spacer 1 (ITS1). We provide in our study, the first molecular identification of S. clydei, in Tunisia. Our Neighbor Joining tree based on mitochondrial cytochrome b gene shows two different clusters. The first includes the Tunisians S. clydei and other specimens from Africa, Middle East and the Arabic peninsula, and the second cluster containing the specimens from Seychelle. Unexpectedly, we also demonstrate the infection of one anthropophilic female S. clydei by Leishmania major DNA. This finding shows that more attention should be paid when identifying parasites by molecular tools within sandfly vector.


PubMed | University Of Barcelone
Type: Journal Article | Journal: Pathologie-biologie | Year: 2011

Unlike group A, a few studies have interested other groups of the rotavirus, especially in Tunisia. The role of rotavirus C (RVC) infection is underestimated because of its sporadic nature. The aim of our study was to develop rapid diagnostic procedures of RVC by using an internal positive control of reverse transcription PCR (RT-PCR).The internal positive control (386pb) was designed from the recombinant baculovirus BacVP6C containing the full length cDNA of the Cowden strain gene 5 (1353pb). A fragment of 596pb was amplified by PCR using the BacVP6C DNA ds as template. Then, a central part of 210pb was deleted and the remaining fragment (386pb) was cloned into pGEM-3Zf(+) plasmid between SP6 and T7 RNA polymerase promoters.The obtained recombinant plasmid pIAM1 was then used for the generation of the internal positive control by in vitro transcription. The sensibility of the RT-PCR was about 3.6610(5) molecules of RNA/l.The use of a shorter positive control, as compared to the wild type, allows increased specificity of the RT-PCR reaction, and could be used for efficient diagnostic and surveillance of RVC-caused diseases.

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