The Autonomous University of Barcelona also known as UAB is a public university mostly located in Cerdanyola del Vallès, near the city of Barcelona in Catalonia, Spain.As of 2012, it consists of 57 departments in the experimental, life, social and human science, spread among 13 faculties/schools. All these centers together award a total of 85 qualifications in the form of first degrees, diplomas, and engineering degrees. Moreover, almost 80 doctoral programs, and more than 80 other postgraduate programs are offered. UAB has more than 40,000 students and more than 3,600 academic and research staff. The UAB is a pioneering institution in terms of fostering research. There are many research institutes in the campus, as well as other research centers, technical support services and service-providing laboratories. Vila Universitària is the residential complex of the Universitat Autònoma de Barcelona, located on its campus, which has 812 apartments with a total housing capacity for 2193 persons and very good train and bus connections, only 25 minutes away from the centre of Barcelona.The UAB is considered to be the best University in Spain by the 2012 QS World University Rankings, which ranked the university 176th overall in the world. Its subject rankings were: 144th in Life science & Biomedicine, 92th in Arts & Humanities, 106th in Natural science, 95th in Social science and 203rd in Engineering & IT. Wikipedia.
Beyer K.,Autonomous University of Barcelona
Molecular neurobiology | Year: 2013
Lewy body diseases include Parkinson disease and dementia with Lewy bodies and are characterized by the widespread distribution of Lewy bodies in virtually every brain area. The main component of Lewy bodies is alpha-synuclein (AS). Accumulating evidence suggests that AS oligomerization and aggregation are strongly associated with the pathogenesis of Lewy body diseases. AS is a small soluble protein with aggregation-prone properties under certain conditions. These properties are enhanced by posttranslational modifications such as phosphorylation, ubiquitination, nitration, and truncation. Accordingly, Lewy bodies contain abundant phosphorylated, nitrated, and monoubiquitinated AS. However, alternative splicing of the AS gene is also known to modify AS aggregation propensities. Splicing gives rise to four related forms of the protein, the main transcript and those that lack exon 4, exon 6, or both. Since AS structure and properties have been extensively studied, it is possible to predict the consequences of the splicing out of the two aforesaid exons. The present review discusses the latest insights on the mechanisms of AS posttranslational modifications and intends to depict their role in the pathogenesis of Lewy body diseases. The implications of deregulated alternative splicing are examined as well, and a hypothesis for the development of the pure form of dementia with Lewy bodies is proposed.
Fullana M.A.,Autonomous University of Barcelona
Molecular Psychiatry | Year: 2015
Classical Pavlovian fear conditioning remains the most widely employed experimental model of fear and anxiety, and continues to inform contemporary pathophysiological accounts of clinical anxiety disorders. Despite its widespread application in human and animal studies, the neurobiological basis of fear conditioning remains only partially understood. Here we provide a comprehensive meta-analysis of human fear-conditioning studies carried out with functional magnetic resonance imaging (fMRI), yielding a pooled sample of 677 participants from 27 independent studies. As a distinguishing feature of this meta-analysis, original statistical brain maps were obtained from the authors of 13 of these studies. Our primary analyses demonstrate that human fear conditioning is associated with a consistent and robust pattern of neural activation across a hypothesized genuine network of brain regions resembling existing anatomical descriptions of the ‘central autonomic–interoceptive network’. This finding is discussed with a particular emphasis on the neural substrates of conscious fear processing. Our associated meta-analysis of functional deactivations—a scarcely addressed dynamic in fMRI fear-conditioning studies—also suggests the existence of a coordinated brain response potentially underlying the ‘safety signal’ (that is, non-threat) processing. We attempt to provide an integrated summary on these findings with the view that they may inform ongoing studies of fear-conditioning processes both in healthy and clinical populations, as investigated with neuroimaging and other experimental approaches.Molecular Psychiatry advance online publication, 30 June 2015; doi:10.1038/mp.2015.88. © 2015 Macmillan Publishers Limited
Servant G.,Autonomous University of Barcelona
Physical Review Letters | Year: 2014
We show that strong CP violation from the QCD axion can be responsible for the matter antimatter asymmetry of the Universe in the context of cold electroweak baryogenesis if the electroweak phase transition is delayed below the GeV scale. This can occur naturally if the Higgs couples to a O(100)GeV dilaton, as expected in some models where the Higgs is a pseudo-Nambu-Goldstone boson of a new strongly interacting sector at the TeV scale. The existence of such a second scalar resonance with a mass and properties similar to the Higgs boson will soon be tested at the LHC. In this context, the QCD axion would not only solve the strong CP problem, but also the matter antimatter asymmetry and dark matter. © 2014 American Physical Society.
Rurali R.,Autonomous University of Barcelona |
Rurali R.,CSIC - Institute of Materials Science
Reviews of Modern Physics | Year: 2010
In this Colloquium the theory of silicon nanowires is reviewed. Nanowires with diameters below 10 nm are the focus, where quantum effects become important and the properties diverge significantly from those of bulk silicon. These wires can be treated within electronic structure simulation methods and will be among the most important functional blocks of future nanoelectronic devices. First, the structural properties of silicon nanowires are reviewed, emphasizing the close connection between the growth orientation, the cross section, and the bounding facets. Second, the electronic structure of pristine and doped nanowires is discussed, which holds the ultimate key for their applicability in novel electronic devices. Finally, transport properties are reviewed where some important limitations in the performances of nanowire-based devices can lay. Many unique properties of these systems are at the same time defying challenges and opportunities for technological advances. © 2010 The American Physical Society.
Matias J.,Autonomous University of Barcelona
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012
It has been argued recently that transverse asymmetries that are expected to be shielded from the presence of the S-wave Kπ pairs originating from the decay of a scalar K0* meson, are indeed affected by this pollution due to the impossibility to extract cleanly the normalization for these observables. In this short article we show how using folded distributions, which is nowadays the preferred method to obtain the information from the 4-body decay mode B→K *(→Kπ)l +l -, one can easily bypass this problem and extract the clean observables P 1,2,3 and also P4,5,6′ in a way completely free from this pollution including all lepton mass corrections. We also show that in case one insists in using uniangular distributions to extract these observables, it is possible to reduce this pollution to just lepton mass suppressed terms. On the contrary, the S i observables, that are by definition normalized by the full differential decay distribution, will indeed suffer from this pollution via their normalization. Finally, we also present a procedure to minimize the error associated to neglecting lepton mass corrections in the distribution defining a massless-improved limit. © 2012 American Physical Society.