The University of Arkansas is a public, co-educational, land-grant, space-grant, research university located in Fayetteville, in the U.S. state of Arkansas. It is the flagship campus of the University of Arkansas System which comprises six main campuses within the state – the University of Arkansas at Little Rock, the University of Arkansas at Monticello, the University of Arkansas at Pine Bluff, the University of Arkansas at Fort Smith, and the University of Arkansas for Medical science. Over 25,000 students are enrolled in over 188 undergraduate, graduate, and professional programs. It is classified by the Carnegie Foundation as a research university with very high research activity. Founded as Arkansas Industrial University in 1871, its present name was adopted in 1899 and classes were first held on January 22, 1872. It is noted for its strong architecture, agriculture , business, communication disorders, creative writing, history, law, and Middle Eastern studies programs.The University of Arkansas completed its "Campaign for the 21st Century" in 2005, in which the university raised more than $1 billion for the school, used in part to create a new Honors College and significantly increase the university's endowment. Among these gifts were the largest donation given to a business school at the time , and the largest gift given to a public university in America , both given by the Walton Family Charitable Support Foundation.Total enrollment for the fall semester of 2013 was 25,365. The university campus comprises exactly 360 buildings on 512 acres , including Old Main, the first permanent academic building erected, and The Inn at Carnall Hall, which serves as an on-campus hotel and restaurant facility. Academic programs are in excess of 200. The ratio of students to faculty is 19:1. Wikipedia.
University of Arkansas and University of Pittsburgh | Date: 2017-02-09
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome, such as that of E. coli, yeast, Bacillus subtilis or other prokaryotes, insect cells, mammalian cells, etc. The separatome-based protein expression and purification platform quantitatively describes and identifies priority deletions, modifications, or inhibitions of certain gene products to increase chromatographic separation efficiency, defined as an increase in column capacity, column selectivity, or both. Moreover, the separatome-based protein expression and purification platform provides a computerized knowledge tool that, given separatome data and a target recombinant peptide, polypeptide, or protein, intuitively suggests strategies leading to efficient product purification. The separatome-based protein expression and purification platform is an efficient bioseparation system that intertwines host cell expression systems and chromatography.
University of Arkansas | Date: 2017-03-30
A method of synthesizing a doped carbon composite includes preparing a solution having a carbon source material and a heteroatom containing additive, evaporating the solution to yield a plurality of powders, and subjecting the plurality of powders to a heat treatment for a duration of time effective to produce the doped carbon composite.
University of Arkansas | Date: 2017-04-14
A nanocomposite for detection and treatment of a target of interest including tumor cells or pathogens includes at least one nanostructure, each nanostructure having a core and a shell surrounding the core; a reporter assembled on the shell of each nanostructure; and a layer of a treating agent and a targeting agent conjugated to the reporter. In use, the nanocomposite targets to the target of interest according to the targeting agent and releases the treating agent and the nanostructure therein for therapeutic treatment of the target of interest, and the target of interest transmits at least one signature responsive to the reporter for detection of the target of interest.
University of Arkansas | Date: 2017-02-08
The present disclosure describes disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided, examples include 4,5-diaryl-1,2,3-triazoles, 4-aryl-5-heteroaryl-1,2,3-triazoles. These compounds are synthesized by treating diaryl or aryl-heteroaryl substituted olefins with azides in the presence of a proton donor or acceptor. The inhibition of tubulin polymerization using these 1,2,3-triazoles is also described.
University of Arkansas | Date: 2017-03-15
The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the selective killing of senescent cells delays aging and treats age-related disorders.
University of Arkansas, The Kitasato Institute, Montefiore Medical Center and Kagawa University | Date: 2017-01-17
Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
University of Arkansas and Texas A&M University | Date: 2017-03-06
Vaccine, vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
University of Arkansas | Date: 2017-05-17
Compositions including chitosan covalently linked to a cytokine or growth factor are provided herein. The compositions can be used to produce pharmaceutical compositions and can be used in methods of treating a variety of diseases or disorders. The compositions are especially suitable for localized delivery and may allow for intratumoral delivery and treatment of cancers or stimulation of an immune response to a co-administered antigen.
University of Arkansas and Texas A&M University | Date: 2017-04-12
Adjuvant compositions, vaccines, constructs for preparing the adjuvant compositions and vaccines and methods of using the adjuvant compositions and vaccines to enhance immune responses in subjects are provided herein. In particular, a rapid antibody response to the vaccine including both IgG (in the circulation) and slgA (mucosal secretory IgA) is elicited. The adjuvants and vaccines may be used for sub-cutaneous or mucosal administration enabling low cost, effective vaccination of subjects. A method of epitope mapping to rapidly identify antigenic epitopes is also provided.
University of Arkansas | Date: 2017-04-26
The present disclosure provides genetically modified animals and cells comprising a polynucleotide encoding human profilin1. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising a polynucleotide encoding human profilin1.