The University of Arizona is a public research university located in Tucson, Arizona, United States. UA was the first university in the state of Arizona, founded in 1885 . The university includes the University of Arizona College of Medicine, which operates a medical center in Tucson, and a separate 4-year M.D. college in downtown Phoenix. As of the 2012-2013 calendar year, total enrollment was 40,223 students. The University of Arizona is governed by the Arizona Board of Regents. The mission of the University of Arizona is, "To discover, educate, serve, and inspire." Arizona is one of the elected members of the Association of American Universities and is the only representative from the state of Arizona to this group.Known as the Arizona Wildcats , the athletic teams are members of the Pacific-12 Conference in the NCAA. UA athletes have won national titles in several sports, most notably men's basketball, baseball, and softball. The official colors of the university and its athletic teams are Cardinal Red and Navy Blue. Wikipedia.
University of Arizona | Date: 2015-02-25
Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
Whitehead Institute For Biomedical Research and University of Arizona | Date: 2016-06-07
The present invention provides a novel class of withanolides that have been isolated from W. somnifera under aeroponic conditions or produced semi-synthetically from withanolide natural products. The invention also provides pharmaceutical compositions thereof and methods for using the same in proliferative diseases, neurodegenerative diseases, autoimmune, and inflammatory diseases.
University of Arizona | Date: 2015-03-12
Described are crop-related materials and methods for metabolic engineering. Certain aspects of the invention include applications in food production, carbon sequestration, and biofuel production. Described are methods of enhancing plant traits for increased production of sugar, starch, cellulose, and oil. Described methods include altering cytosolic asparagine to promote production of non-nitrogenous plant compounds.
University of Arizona | Date: 2015-02-18
Disclosed herein are methods of identifying infections, such as methods of identifying bacterial infections which utilize whole metagenome sequence analysis to sequence the entire wound microbiome of clinical samples. The disclosed methods use fast k-mer based sequence analysis, predictive modeling, and Bayesian network analysis, to analyze bacterial metagenomic sequence compositions in conjunction with clinical factors to stratify communities of bacteria into healing versus non-healing clusters. The methods of identifying infections can include performing molecular analysis of a patient wound sample, preparing the data obtained from the molecular analysis, diagnosing the wound sample and/or prognosing the wound sample. The disclosed methods can also be used to identify protein function as well as novel biomarkers.
University of Arizona | Date: 2016-08-29
Optical switch based on a micro-minor device such as a DMD configured to simultaneously switch light from N inputs to M outputs with switching times of about 10 microseconds, where N and M are generally greater than one. The minors of the device are oriented according to a pattern calculated based on a Fourier Transform of spatial distribution of M outputs such as to form, in diffraction of light incident on the device, and diffraction light pattern that in the output plane is substantially congruent with the spatial distribution of M outputs. The device can be configured as a modulator of amplitude and/or a modulator of phase of incident light wavefront.
University of Arizona | Date: 2016-04-07
The present invention relates generally to a head-mounted projection display, and more particularly, but not exclusively to a polarized head-mounted projection display including a light engine and a compact, high-performance projection lens for use with reflective microdisplays.
University of Arizona and University of Naples Federico II | Date: 2017-04-12
The invention relates to compounds of the formula (VIII) wherein the moieties R1, R2, R3, R4, and R5 are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.
University of Arizona, H. Lee Moffitt Cancer Center and Research Institute | Date: 2017-03-15
Disclosed is CT or MR contrast agent which comprises a base or carrier scaffold formed of a polyhydroxol compound having a linker to which a Gd-DOTA is covalently bonded. Also disclosed is a method of screening a patient for colon cancer using a CT or MR contrast, which method comprises administering to a patient undergoing screening a compound as above described.
Matzke M.A.,Academia Sinica, Taiwan |
Mosher R.A.,University of Arizona
Nature Reviews Genetics | Year: 2014
RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. RdDM requires a specialized transcriptional machinery that comprises two plant-specific RNA polymerases-Pol IV and Pol V-and a growing number of accessory proteins, the functions of which in the RdDM mechanism are only partially understood. Recent work has revealed variations in the canonical RdDM pathway and identified factors that recruit Pol IV and Pol V to specific target sequences. RdDM, which transcriptionally represses a subset of transposons and genes, is implicated in pathogen defence, stress responses and reproduction, as well as in interallelic and intercellular communication. © 2014 Macmillan Publishers Limited. All rights reserved.
Smith N.,University of Arizona
Annual Review of Astronomy and Astrophysics | Year: 2014
Our understanding of massive star evolution is in flux due to recent upheavals in our view of mass loss and observations of a high binary fraction among O-type stars. Mass-loss rates for standard metallicity-dependent winds of hot stars are lower by a factor of 2-3 compared with rates adopted in modern stellar evolution codes, due to the influence of clumping on observed diagnostics. Weaker hot star winds shift the burden of H-envelope removal to the winds, pulsations, and eruptions of evolved supergiants, as well as binary mass transfer. Studies of stripped-envelope supernovae, in particular, require binary mass transfer. Dramatic examples of eruptive mass loss are seen in Type IIn supernovae, which have massive shells ejected just a few years earlier. These eruptions are a prelude to core collapse, and may signify severe instabilities in the latest nuclear burning phases. We encounter the predicament that the most important modes of mass loss are also the most uncertain, undermining the predictive power of single-star evolution models. Moreover, the influence of winds and rotation has been evaluated by testing single-star models against observed statistics that, it turns out, are heavily influenced by binary evolution. Altogether, this may alter our view about the most basic outcomes of massive-star mass loss are Wolf-Rayet stars and Type Ibc supernovae the products of winds, or are they mostly the result of binary evolution and eruptive mass loss? This is not fully settled, but mounting evidence points toward the latter. This paradigm shift impacts other areas of astronomy, because it changes predictions for ionizing radiation and wind feedback from stellar populations, it may alter conclusions about star-formation rates and initial mass functions, it affects the origin of compact stellar remnants, and it influences how we use supernovae as probes of stellar evolution across cosmic time. Copyright © 2014 by Annual Reviews.