Tucson, AZ, United States
Tucson, AZ, United States

The University of Arizona is a public research university located in Tucson, Arizona, United States. UA was the first university in the state of Arizona, founded in 1885 . The university includes the University of Arizona College of Medicine, which operates a medical center in Tucson, and a separate 4-year M.D. college in downtown Phoenix. As of the 2012-2013 calendar year, total enrollment was 40,223 students. The University of Arizona is governed by the Arizona Board of Regents. The mission of the University of Arizona is, "To discover, educate, serve, and inspire." Arizona is one of the elected members of the Association of American Universities and is the only representative from the state of Arizona to this group.Known as the Arizona Wildcats , the athletic teams are members of the Pacific-12 Conference in the NCAA. UA athletes have won national titles in several sports, most notably men's basketball, baseball, and softball. The official colors of the university and its athletic teams are Cardinal Red and Navy Blue. Wikipedia.


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Patent
Whitehead Institute For Biomedical Research and University of Arizona | Date: 2016-06-07

The present invention provides a novel class of withanolides that have been isolated from W. somnifera under aeroponic conditions or produced semi-synthetically from withanolide natural products. The invention also provides pharmaceutical compositions thereof and methods for using the same in proliferative diseases, neurodegenerative diseases, autoimmune, and inflammatory diseases.


Patent
University of Arizona | Date: 2017-01-25

Disclosed herein are isolated polypeptides capable of preventing collapsin response mediator protein 2 (CRMP2)-small ubiquitin-like modifier (SUMO)ylation mediated trafficking of voltage gated sodium channel 1.7 (Navl.7) function. In some examples, the disclosed peptides comprise three to twenty amino acids and include the amino acid sequence KMD. Also disclosed are methods of decreasing nociception including administering an effective amount of one or more disclosed peptides to a subject in need thereof, such as a subject experiencing chronic pain.


Patent
University of Arizona and University of Naples Federico II | Date: 2017-04-12

The invention relates to compounds of the formula (VIII) wherein the moieties R1, R2, R3, R4, and R5 are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.


Patent
University of Arizona, H. Lee Moffitt Cancer Center and Research Institute | Date: 2017-03-15

Disclosed is CT or MR contrast agent which comprises a base or carrier scaffold formed of a polyhydroxol compound having a linker to which a Gd-DOTA is covalently bonded. Also disclosed is a method of screening a patient for colon cancer using a CT or MR contrast, which method comprises administering to a patient undergoing screening a compound as above described.


The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.


Patent
University of Arizona and University of Connecticut | Date: 2017-01-11

A wearable 3D augmented reality display and method, which may include 3D integral imaging optics.


Patent
University of Arizona and University of Connecticut | Date: 2017-01-11

A wearable 3D augmented reality display and method, which may include 3D integral imaging optics.


Patent
Omnigen Research LLC and University of Arizona | Date: 2017-01-04

Disclosed herein is a method for promoting reduction of heat stress in animals, as well as a composition for use in the disclosed method. The composition comprises a glucan, silica, mineral clay, mannan, and optionally an endoglucanohydrolase, and may be administered to an animal that is susceptible to or suffers from heat stress.


Patent
University of Arizona and Columbia University | Date: 2017-07-19

An optical communication system includes a plurality of optical system nodes, a plurality of optical space switches and a plurality of optical fibers. The plurality of optical system nodes each includes at least one reconfigurable optical add/drop multiplexer (ROADM). The optical system nodes each have at least one client side port and at least one line side port. Each optical space switch is operatively coupled to the line side port of one of the plurality of optical system nodes. Each of the optical fibers couples one of the optical space switches to another of the optical space switches.


Smith N.,University of Arizona
Annual Review of Astronomy and Astrophysics | Year: 2014

Our understanding of massive star evolution is in flux due to recent upheavals in our view of mass loss and observations of a high binary fraction among O-type stars. Mass-loss rates for standard metallicity-dependent winds of hot stars are lower by a factor of 2-3 compared with rates adopted in modern stellar evolution codes, due to the influence of clumping on observed diagnostics. Weaker hot star winds shift the burden of H-envelope removal to the winds, pulsations, and eruptions of evolved supergiants, as well as binary mass transfer. Studies of stripped-envelope supernovae, in particular, require binary mass transfer. Dramatic examples of eruptive mass loss are seen in Type IIn supernovae, which have massive shells ejected just a few years earlier. These eruptions are a prelude to core collapse, and may signify severe instabilities in the latest nuclear burning phases. We encounter the predicament that the most important modes of mass loss are also the most uncertain, undermining the predictive power of single-star evolution models. Moreover, the influence of winds and rotation has been evaluated by testing single-star models against observed statistics that, it turns out, are heavily influenced by binary evolution. Altogether, this may alter our view about the most basic outcomes of massive-star mass loss are Wolf-Rayet stars and Type Ibc supernovae the products of winds, or are they mostly the result of binary evolution and eruptive mass loss? This is not fully settled, but mounting evidence points toward the latter. This paradigm shift impacts other areas of astronomy, because it changes predictions for ionizing radiation and wind feedback from stellar populations, it may alter conclusions about star-formation rates and initial mass functions, it affects the origin of compact stellar remnants, and it influences how we use supernovae as probes of stellar evolution across cosmic time. Copyright © 2014 by Annual Reviews.

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