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Hohenberg G.,University of Applied Sciences, Hamm | Reiss G.,Witten/Herdecke University | Ostermann T.,Witten/Herdecke University
HEALTHINF 2016 - 9th International Conference on Health Informatics, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016

Teaching and understanding the principles of physiology is one of the most important and complex fields in medical education. This article describes the development of a digital learning platform for hearing physiology with computer experiments demonstrating the perceptual masking properties of the human ear. The basis for the development of this platform were two different hearing models: the sequential electronic model of the inner ear described by David in 1972 and the parallel Gammatone model by Patterson from 1988. The platform was evaluated from 44 undergraduate students of audiology. On a Likert Scale from 1= absolutely agree to 5=do not agree at all, students found the learning platform helpful for understanding "audiological physics" (2.10 ±0.67). After working on the learning module, the physiological hearing processes also became more evident to the students (2.24 ±0.69). They also were able to use the learning platform independently without relevant technical problems (1.93 ±0.80). As a conclusion, the usage of such interactive digital platforms might also lead to more efficient learning pathways which interconnect knowledge acquisition, skill development and life experience at the same time. Copyright © 2016 by SCITEPRESS - Science and Technology Publications, Lda. All rights reserved. Source

Maass J.S.,Carl Zeiss GmbH | Sandfuchs O.,University of Applied Sciences, Hamm | Gatto A.,Carl Zeiss GmbH | Thomae D.,Jena University of Applied Sciences | Brunner R.,Jena University of Applied Sciences
Proceedings of SPIE - The International Society for Optical Engineering

In this contribution we simulate theoretically the resulting 3D Talbot-carpets of different initial close-packed 2D mask structures. Especially, we investigate the transition from regular periodic to quasi-periodic tessellations. For the pure periodic mask structure a hexagonally tessellation was selected. The calculated field distribution adjacent to the mask still shows a lateral six-fold symmetry but also a rather complex characteristics in the propagation direction. In particular, the appearance and the repetition of self-imaging planes deviate significantly from the classical Talbot-effect. For the quasi-periodic tessellation a Penrose tapestry based on rhombus pairs was chosen. A pronounced lateral fivefold symmetry becomes visible in the field distribution. In the propagation direction dominant planes with increased intensity are observed clearly, but, instead of a simple periodicity, a complex behavior becomes obvious. The numerical algorithm used in our simulations is based on a modified angular spectrum method, in which Bluestein's fast Fourier (FFT) algorithm is applied. This approach allows to decouple the sampling points in the real space and in the spatial frequency domain so that both parameter can be chosen independently. The introduced fast and flexible algorithm requires a minimized number of numerical steps and a minimal computation time, but still offers high accuracy. © 2012 SPIE. Source

Schemionek M.,University of Munster | Elling C.,University of Munster | Steidl U.,Yeshiva University | Baumer N.,University of Munster | And 14 more authors.

In a previously developed inducible transgenic mouse model of chronic myeloid leukemia, we now demonstrate that the disease is transplantable using BCRABL+ Lin-Sca-1+c-kit+ (LSK) cells. Interestingly, the phenotype is more severe when unfractionated bone marrow cells are transplanted, yet neither progenitor cells (Lin -Sca-1-c-kit+), nor mature granulocytes (CD11b+Gr-1+), nor potential stem cell niche cells (CD45-Ter119-) are able to transmit the disease or alter the phenotype. The phenotype is largely independent of BCR-ABL priming before transplantation. However, prolonged BCR-ABL expression abrogates the potential of LSK cells to induce full-blown disease in secondary recipients and increases the fraction of multipotent progenitor cells at the expense of long-term hematopoietic stem cells (LT-HSCs) in the bone marrow. BCR-ABL alters the expression of genes involved in proliferation, survival, and hematopoietic development, probably contributing to the reduced LT-HSC frequency within BCR-ABL+ LSK cells. Reversion of BCR-ABL, or treatment with imatinib, eradicates mature cells, whereas leukemic stem cells persist, giving rise to relapsed chronic myeloid leukemia on reinduction of BCR-ABL, or imatinib withdrawal. Our results suggest that BCRABL induces differentiation of LT-HSCs and decreases their self-renewal capacity. © 2010 by The American Society of Hematology. Source

University of Applied Sciences, Hamm | Entity website

Nach dem Abitur und der Ausbildung als Facharbeiter Maschinenbau in der Geburtsstadt Leipzig hat Prof. Dr ...

University of Applied Sciences, Hamm | Entity website

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