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Bonnet F.,Rennes University Hospital Center | Velayoudom Cephise F.-L.,University Hospital of Pointe a Pitre | Gautier A.,Rennes University Hospital Center | Dubois S.,University of Angers | And 6 more authors.
Clinical Endocrinology | Year: 2013

Background SHBG and liver enzymes levels are both associated with the risk of type 2 diabetes. However, the relationship between SHBG with liver enzymes and intrahepatic fat content remain poorly understood. Objective To investigate whether SHBG is correlated with glucose and lipids levels and whether this association depends on fatty liver content, liver enzymes or sex hormone concentrations. Design and Patients We studied 233 dysmetabolic men with measures of plasma SHBG, total testosterone, 17β-oestradiol, glucose, adiponectin, liver enzymes and hepatokines. Intrahepatic liver fat and visceral fat contents were measured by magnetic resonance imaging in 108 of these individuals. Results After adjustment for age, SHBG concentration was inversely correlated with fasting glucose (βstandardized= -0·21, P = 0·0007), HbA1c (βstandardized= -0·27, P < 0·0001), triglycerides (βstandardized= -0·19, P = 0·003) and positively correlated with HDL-Cholesterol (βstandardized= 0·14, P = 0·03). These correlations persisted after adjustment for either total testosterone or 17β-oestradiol levels. SHBG was not related to either fetuin A or FGF 21 concentrations. The inverse association of SHBG with HbA1c and glycaemia was not altered after adjusting for liver markers but was no longer significant after adjustment for hepatic fat content. Conclusion The significant association between SHBG and fasting glycaemia, HbA1c and lipid levels in dysmetabolic men was not related to either sex hormones or markers of liver function, but was dependent on intrahepatic fat. This suggests that intrahepatic fat, but not alterations in liver function markers, may be involved in the association between SHBG and glucose and lipid metabolism. © 2012 John Wiley & Sons Ltd.

Ilies A.,University of Oradea | Dehoorne O.,University of Antilles and Guyane | Ilies D.C.,University of Oradea
Carpathian Journal of Earth and Environmental Sciences | Year: 2012

The external border of the EU and NATO is overlapping the state border between Romania and Ukraine, for a length of 440.1 km in a dominating mountain range of the Carpathians Mountains. By applying specific methods and tools we have identified in quantitative, qualitative and functionalsystemic terms, the factors that determine and the items that compose the functioning mechanisms of the Romanian and Ukrainian border contiguous areas. There were considered: the geographical location; the natural morpho-structural aspects; the morphological support profile of the state border; the legislative and administrative framework; the routes and communication networks; the historical, social and cultural elements etc. Based on the results obtained, new strategies can be generated for transforming these areas into a cross-border territorial system with high degree of functionality. Such a system has an important role in the process of social and economic integration and elimination of the traditional functions of the political frontier generating juxtaposed territorial systems.

Cadelis G.,Universitary Hospital of Pointe a Pitre | Tourres R.,Universitary Hospital of Pointe a Pitre | Molinie J.,University of Antilles and Guyane
PLoS ONE | Year: 2014

Background: The prevalence of asthma in children is a significant phenomenon in the Caribbean. Among the etiologic factors aggravating asthma in children, environmental pollution is one of the main causes. In Guadeloupe, pollution is primarily transported by Saharan dust including inhalable particles. Methods: This study assesses, over one year (2011), the short-term effects of pollutants referred to as PM10 (PM10: particulate matter <10 μm) and PM2.5-10 (PM2.5-10: particulate matter >2.5 mm and <10 μm) contained in Saharan dust, on the visits of children aged between 5 and 15 years for asthma in the health emergency department of the main medical facility of the archipelago of Guadeloupe. A time-stratified case-crossover model was applied and the data were analysed by a conditional logistic regression for all of the children but also for sub-groups corresponding to different age classes and genders. Results: The visits for asthma concerned 836 children including 514 boys and 322 girls. The Saharan dust has affected 15% of the days of the study (337 days) and involved an increase in the average daily concentrations of PM10 (49.7 μg/m3 vs. 19.2 μg/m3) and PM 2.5-10 (36.2 μg/m3 vs. 10.3 μg/m3) compared to days without dust. The excess risk percentages (IR%) for visits related to asthma in children aged between 5 and 15 years on days with dust compared to days without dust were, for PM10, ((IR %: 9.1% (CI95%, 7.1%-11.1%) versus 1.1%(CI95%, 25.9%-4.6%)) and for PM2.5-10 (IR%: 4.5%(CI95%, 2.5%-6.5%) versus 1.6% (CI95%, 21.1%-3.4%). There was no statistical difference in the IR% for periods with Saharan dust among different age group of children and between boys and girls for PM10 and PM2.5-10. Conclusion: The PM 10 and PM2.5-10 pollutants contained in the Saharan dust increased the risk of visiting the health emergency department for children with asthma in Guadeloupe during the study period. © 2014 Cadelis et al.

Ncibi M.C.,Lappeenranta University of Technology | Ranguin R.,University of Antilles and Guyane | Pintor M.J.,University of Antilles and Guyane | Jeanne-Rose V.,University of Antilles and Guyane | And 2 more authors.
Journal of Analytical and Applied Pyrolysis | Year: 2014

In the present work, the preparation of several chemically activated carbons (CACs) from marine Posidonia oceanica fibrous biomass was performed using various activating agents. The chemical activation was carried out using phosphoric acid (H3PO4), potassium hydroxide (KOH), zinc chloride (ZnCl2) and hydrogen peroxide (H2O2). The effects of those impregnating agents were investigated for all produced CACs via several chemical and structural analyses. The results showed that H3PO4 seems to induce the deepest impact on the P. oceanica fibres by providing the lowest conversion yield (16.9%). Besides, the pore analysis showed that two types of porosity were developed: (i) CACs characterized by an inner structure combining significant fraction of both mesopores and micropores (i.e. CAC-H3PO4, CAC-KOH and CAC-ZnCl2) and (ii) CAC-H2O2 with a large mesoporous structure and a small fraction of microporosity. Dealing with the RAMAN and XPS analysis, it was showed that the main carbon fraction is structurally organized (i.e. graphite), especially for the CAC-ZnCl2 sample. As for the isotherm and kinetic investigation, the experimental and modelling results revealed that CAC-H3PO4 was the best performing activated carbon by removing the highest methylene blue dye amount (137 mg/g) in the shortest time (1.3 h to reach the half reaction point). © 2014 Elsevier B.V.

Krika F.,Jijel University | Azzouz N.,Jijel University | Ncibi M.C.,University of Antilles and Guyane
International Journal of Environmental Science and Technology | Year: 2015

Posidonia oceanica (L.), a marine biomass, has been used as an effective and efficient biosorbent for the removal of Cd(II) from aqueous media. The physico-chemical properties of biosorbent were investigated by elemental analysis, BET surface area, FT-IR, SEM and EDX methods before and after adsorption. Batch adsorption experiments were carried out to investigate the effects of solution pH, dosage of biosorbent, contact time and temperature. The biosorbent exhibited the maximum uptake of 58.82 mg/g under the optimal adsorption condition. Kinetics experiments indicated that the pseudo-second-order model displayed the best correlation with adsorption kinetics data. Besides, experimental data could be better described by the Langmuir isotherm model. Desorption experiments were carried out to explore the feasibility of regenerating the biosorbent. The regeneration efficiency was 96.03 % using desorption agent of 0.2 M HCl. The thermodynamic parameters (ΔH0, ΔS0 and ΔG0) of the cadmium ion uptake onto P.O indicated that the process is endothermic and proceeds spontaneously. The findings of the present study indicate that P.O can be successfully used for separation of Cd(II) from aqueous solutions. The results suggested that the adsorbent is promising for use as an effective and economical adsorbent for Cd(II) ions removal. © 2014, Islamic Azad University (IAU).

Foucan L.,University of Antilles and Guyane | Ducros J.,Ricou Hospital | Merault H.,Ricou Hospital | Merault H.,CEA DAM Ile-de-France | Merault H.,University Hospital
Journal of Nephrology | Year: 2012

Background: Vitamin D (vitD) insufficiency is common in end-stage renal disease. Seasonal and ethnic differences in vitD status have been reported previously. We hypothesized that vitD status in Afro-Caribbean patients on hemodialysis (HD) living in a country with a constant sunny climate would be better than that in African-American HD patients living in countries with a winter season. Method: A cross-sectional study was conducted in152 Afro-Caribbean HD patients in a dialysis center located in Guadeloupe. We evaluated the prevalence of vitD insufficiency, defined as serum 25-hydroxyvitamin D (25(OH)D) levels below 30 ng/mL, compared with those results previously reported in African-American HD patients (88%). Results: Prevalence of vitD insufficiency was 60% and thus lower than that in the African-American patients considered as the reference population (p<0.001). In our diabetic patients, this prevalence was 72.4%. Globally, 9.2% of patients had 25(OH)D below 15 ng/ mL. Alfacalcidol therapy was prescribed in 29%. Mean 25(OH)D levels were higher in treated than in untreated patients (32 vs. 27 ng/mL; p=0.009). Patients with vitD insufficiency had dyslipidemia and diabetes more frequently. No significant differences were found between patients with and without vitD insufficiency for serum calcium, phosphorus and parathyroid hormone (PTH). In untreated patients, no significant correlation was found between 25(OH)D and PTH levels. Conclusion: Prevalence of vitD insufficiency in Afro- Caribbean HD patients was lower than that previously reported in African Americans undergoing HD in the United States. This finding may be due to the constantly sunny weather with a high intensity of UVB radiation in Guadeloupe. © 2012 Società Italiana di Nefrologia.

Krika F.,Jijel University | Azzouz N.,Jijel University | Ncibi M.C.,University of Antilles and Guyane
Desalination and Water Treatment | Year: 2013

In this study, biosorption of cadmium (II) from saline solutions by Posidonia oceanica (L.), a marine biomass, was studied as a function of pH, initial cadmium (II) and NaCl concentrations in a batch system. The sorbent exhibited the maximal cadmium (II) uptake at pH 6 in the absence and in the presence of increasing concentration of NaCl. Equilibrium uptake increased with the cadmium (II) concentration up to 250 mg/L and diminished considerably in the presence of increasing concentrations of salt up to 50 g/L. At 100 mg/L, initial cadmium (II) concentration, P. oceanica biosorbed 15.69 mg/g of cadmium (II) without salt medium. When NaCl concentration was raised to 50 g/L, this value dropped to 6.87 mg/g of cadmium (II) at the same conditions resulting in 56.21% decrease in biosorption capacity. The equilibrium sorption data were analysed by using Freundlich, Langmuir and Redlich-peterson models. Langmuir was the most suitable adsorption model for describing the biosorption equilibrium data of cadmium (II) both individually and in salt-containing medium. Pseudo-second-order kinetic model also fitted well to both systems, viz. cadmium (II) and cadmium (II) + NaCl. Isotherm constants varied due to the level of salt were expressed as a function of initial NaCl concentration. © 2013 Copyright Balaban Desalination Publications.

Krika F.,Jijel University | Azzouz N.,Jijel University | Ncibi M.C.,University of Antilles and Guyane
International Journal of Environmental Research | Year: 2012

The biosorption of hexavelent chromium from saline solutions by Posidonia oceanica, a marine biomass, was studied as a function of pH, initial chromium (VI) and salt (NaCl) concentrations in batch system. The sorbent exhibited the maximal chromium (VI) uptake at pH 2 regardless of the presence of increasing salt concentration. Equilibrium uptake increased with chromium (VI) concentration up to 250 mg/ l and decreased slightly in the presence of increasing salt concentrations of salt up to 50 g/l. The biomass adsorbed 14.48 mg of metal per gram of biomass at 100 mg/l initial chromium concentration in the absence of salt. When 50 g/l salt concentration was added to the solution, the value diminished to 11.49 mg/g under the same conditions (i.e. a 20.6% decrease in the biosorption capacity). The equilibrium sorption data were analyzed using Freundlich, Langmuir and Redlich-Peterson models. The Langmuir equation was the most suitable adsorption model for describing the biosorption equilibrium data of chromium (VI) both in salt free and loaded media. The pseudo-second-order type kinetic model depicted the biosorption kinetics accurately at all chromium concentrations in absence and presence of increasing concentrations of salt.

El Jamal M.M.,Lebanese University | Ncibi M.C.,University of Antilles and Guyane
Acta Chimica Slovenica | Year: 2012

Adsorptive removal capacities of renewable and highly available Chaetophora elegans algae have been investigated in this study. To assess the use of this soft water algae to remove organic pollutants from aqueous solution, Methylene blue (MB) dye was used as a model molecule. The effect of dye concentrations, pH, adsorbent mass, temperature, and particle size have been evaluated. The algal biomass showed quite interesting adsorption capacity under optimized operating conditions (333 mg of dye per gram of biomass at 30 °C). Pseudo-first and pseudo-second order kinetic models were applied to the adsorption dynamic data. Pseudo second order model was well in line with the experimental data, therefore suggesting a probable chemically-based adsorption process. Several isotherm models were investigated to monitor the adsorption behavior. The Langmuir-Freundlich isotherm model fitted the experimental data best. The adsorption thermodynamic parameters ΔG°, ΔH° and ΔS° were calculated. The maximum uptake is independent of temperature. From the values of the thermodynamic parameters, we concluded that the adsorption is exothermic, more ordered and spontaneous.

PubMed | University of Antilles and Guyane
Type: | Journal: BMC endocrine disorders | Year: 2013

Our aim was to assess the associations between vitamin D (vitD) status, metabolic profile and polymorphisms in genes involved in the transport (Group-Component: GC) and the hydroxylation (NAD synthetase 1: NADSYN1) of 25 hydroxyvitamin D (25(OH)D) in non-diabetic individuals.We conducted a cross-sectional study with 323 individuals recruited from the Health Center of Guadeloupe, France. The rs2282679 T>G and rs2298849 T>C in GC and rs12785878 G>T in NADSYN1 were genotyped.Mean age was 46(range 18-86) years. 57% of participants had vitD insufficiency, 8% had vitD deficiency, 61% were overweight and 58% had dyslipidemia. A higher frequency of overweight was noted in women carrying rs2298849T allele v CC carriers (71% v 50%; P=0.035). The rs2282679G allele was associated with increased risks of vitD deficiency and vitD insufficiency (OR =3.53, P=0.008, OR=2.34, P=0.02 respectively). The rs2298849 TT genotype was associated with vitD deficiency and overweight (OR =3.4, P=0.004 and OR=1.76, P=0.04 respectively) and the rs12785878 GG genotype with vitD insufficiency and dyslipidemia (OR=1.80, P=0.01 and OR=1.72, P=0.03 respectively). Based on the number of risk alleles for rs2282679 and rs12785878 combined, a genotype score of 3 (vs. 0-1) was associated with a 5.5 ng/mL average reduction in serum 25(OH)D levels (P=0.001).The GC and NADSYN1 genes are associated with the vitamin D status and might contribute to dyslipidemia and overweight independently of 25(OH)D levels.

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