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Amsterdam, Netherlands

The University of Amsterdam or UvA is a public university located in Amsterdam, Netherlands. Established in 1632 by municipal authorities and later renamed for the city of Amsterdam, the University of Amsterdam is the third-oldest university in the Netherlands. It is one of the largest research universities in Europe with 29,783 students, 4,629 staff, and an endowment of €613.5 million. It is the largest university in the Netherlands by enrollment and has the second-largest university endowment in the country. The main campus is located in central Amsterdam, with a few faculties located in adjacent boroughs. The university is organised into seven faculties: Humanities, Social and Behavioural science, Economics and Business, Science, Law, Medicine, and Dentistry. The University of Amsterdam has produced six Nobel Laureates and five prime ministers of the Netherlands. In 2013, it was ranked 58th in the world, 17th in Europe, and 1st in the Netherlands by the QS World University Rankings. The university placed in the top 50 worldwide in seven fields in the 2011 QS World University Rankings in the fields of Linguistics, Sociology, Philosophy, Geography, Science, Economics & Econometrics, and Accountancy & Finance.The University of Amsterdam is a member of the League of European Research Universities , the Institutional Network of the Universities from the Capitals of Europe , European University Association , and Universitas 21. Wikipedia.


Watts A.L.,University of Amsterdam
Annual Review of Astronomy and Astrophysics | Year: 2012

Burst oscillations, a phenomenon observed in a significant fraction of Type I (thermonuclear) X-ray bursts, involve the development of highly asymmetric brightness patches in the burning surface layers of accreting neutron stars. Intrinsically interesting as nuclear phenomena, they are also important as probes of dense matter physics and the strong gravity, high magnetic field environment of the neutron star surface. Burst oscillation frequency is also used to measure stellar spin, and doubles the sample of rapidly rotating (above 10 Hz) accreting neutron stars with known spins. Although the mechanism remains mysterious, burst oscillation models must take into account thermonuclear flame spread, nuclear processes, rapid rotation, and the dynamical role of the magnetic field. This review provides a comprehensive summary of the observational properties of burst oscillations, an assessment of the status of the theoretical models that are being developed to explain them, and an overview of how they can be used to constrain neutron star properties such as spin, mass, and radius. Copyright © 2012 by Annual Reviews.


Van Der Vlugt J.I.,University of Amsterdam
Chemical Society Reviews | Year: 2010

Recent developments toward selective N-H cleavage and the use of ammonia as a substrate in homogeneous catalysis are discussed in this critical review (134 references). © The Royal Society of Chemistry 2010.


Artis D.,Cornell University | Spits H.,University of Amsterdam
Nature | Year: 2015

The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation and tissue repair. Innate lymphoid cells are the most recently identified constituents of the innate immune system and have been the focus of intense investigation over the past five years. We summarize the studies that formally identified innate lymphoid cells and highlight their emerging roles in controlling tissue homeostasis in the context of infection, chronic inflammation, metabolic disease and cancer. © 2015 Macmillan Publishers Limited. All rights reserved.


Rader D.J.,University of Pennsylvania | Hovingh G.K.,University of Amsterdam
The Lancet | Year: 2014

The cholesterol contained within HDL is inversely associated with risk of coronary heart disease and is a key component of predicting cardiovascular risk. However, despite its properties consistent with atheroprotection, the causal relation between HDL and atherosclerosis is uncertain. Human genetics and failed clinical trials have created scepticism about the HDL hypothesis. Nevertheless, drugs that raise HDL-C concentrations, cholesteryl ester transfer protein inhibitors, are in late-stage clinical development, and other approaches that promote HDL function, including reverse cholesterol transport, are in early-stage clinical development. The final chapters regarding the effect of HDL-targeted therapeutic interventions on coronary heart disease events remain to be written. © 2014 Elsevier Ltd.


Barclay A.N.,University of Oxford | Van Den Berg T.K.,University of Amsterdam
Annual Review of Immunology | Year: 2014

CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIRPα by CD47 provides a downregulatory signal that inhibits host cell phagocytosis, and CD47 therefore functions as a "don't-eat-me" signal. Here, we discuss recent structural analysis of CD47-SIRPα interactions and implications of this for the function and evolution of SIRPα and paired receptors in general. Furthermore, we review the proposed roles of CD47-SIRPα interactions in phagocytosis, (auto)immunity, and host defense, as well as its potential significance as a therapeutic target in cancer and inflammation and for improving graft survival in xenotransplantation. © 2014 by Annual Reviews. All rights reserved.

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