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Sun Y.-F.,University of AlbertaAlberta | Li J.-H.,Xiamen University | Li J.-H.,Changji University | Wang M.-N.,University of AlbertaAlberta | And 4 more authors.
Journal of Materials Chemistry A | Year: 2015

For the first time, an iron doped lanthanum strontium chromite with A-site deficiency (A-LSCFe) was fabricated and utilized as an effective bi-functional catalyst for the growth of multi-wall carbon nanotubes (MWCNTs) and solid oxide fuel cells (SOFCs). The introduction of A-site deficiency significantly facilitates the in situ exsolution of nano-iron particles on which considerable amounts of MWCNTs are grown. The material was also used as the anode catalyst for SOFCs and proved to be a very effective anode catalyst in comparison with the stoichiometric material (sto-LSCFe). The exsolved nano-iron particles on A-LSCFe provide many more active sites for the oxidation reaction of fuel, leading to sharp enhancement of the electrochemical performance of the cell. It is also discovered that the growth of MWCNTs with high electron conductivity leads to a further improvement of the electricity output. This journal is © The Royal Society of Chemistry. Source

Prasad M.,Mercer University | Kaur J.,Mercer University | Pawlak K.J.,Mercer University | Bose M.,University of Florida | And 3 more authors.
Journal of Biological Chemistry | Year: 2015

Steroid hormones are essential for carbohydrate metabolism, stress management, and reproduction and are synthesized from cholesterol in mitochondria of adrenal glands and gonads/ovaries. In acute stress or hormonal stimulation, steroidogenic acute regulatory protein (StAR) transports substrate cholesterol into the mitochondria for steroidogenesis by an unknown mechanism. Here, we report for the first time that StAR interacts with voltage-dependent anion channel 2 (VDAC2) at the mitochondria-associated endoplasmic reticulum membrane (MAM) prior to its translocation to the mitochondrial matrix. In the MAM, StAR interacts with mitochondrial proteins Tom22 and VDAC2. However, Tom22 knockdown by siRNA had no effect on pregnenolone synthesis. In the absence of VDAC2, StAR was expressed but not processed into the mitochondria as a mature 30-kDa protein. VDAC2 interacted with StAR via its C-terminal 20 amino acids and N-terminal amino acids 221-229, regulating the mitochondrial processing of StAR into the mature protein. In the absence of VDAC2, StAR could not enter the mitochondria or interact with MAM-associated proteins, and therefore steroidogenesis was inhibited. Furthermore, theNterminus was not essential for StAR activity, and the N-terminal deletion mutant continued to interact with VDAC2. The endoplasmic reticulum-targeting prolactin signal sequence did not affect StAR association with the MAM and thus its mitochondrial targeting. Therefore, VDAC2 controls StAR processing and activity, and MAM is thus a central location for initiating mitochondrial steroidogenesis. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Source

Zarekani M.,University of AlbertaAlberta | Panna M.,University of AlbertaAlberta | Bouferguene A.,University of Alberta | Al-Hussein M.,University of AlbertaAlberta
ICCREM 2015 - Environment and the Sustainable Building - Proceedings of the 2015 International Conference on Construction and Real Estate Management | Year: 2015

Quality of life (QOL) has been an ongoing subject of discussion in the field of urban planning and development in recent decades. Measuring QOL of residents through fundamental neighborhood metrics provides information on the living conditions of citizens and helps to promote sustainable social development. This study investigates the effect of neighborhood design on the QOL of residents. The metrics used to measure the QOL include availability and accessibility to goods and services. For the this paper, Edmonton, Canada, as an example of a growing city that brings challenges for urban planners in terms of sustainable development, is chosen for the case study. The methodology underlying this contribution relies on a comparative study of four neighborhoods located in four different parts of Edmonton having similar densities. The results of this study provide further insight into land development patterns and can assist decision makers involved in urban development. © 2015 ASCE. Source

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