The University of Alberta is a public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford, the first premier of Alberta, and Henry Marshall Tory, its first president. Its enabling legislation is the Post-secondary Learning Act.The university comprises four campuses in Edmonton, the Augustana Campus in Camrose, and a staff centre in downtown Calgary. The original north campus consists of 150 buildings covering 50 city blocks on the south rim of the North Saskatchewan River valley, directly across from downtown Edmonton. More than 39,000 students from across Canada and 150 other countries participate in nearly 400 programs in 18 faculties.The University of Alberta is a major economic driver in Alberta. The university’s impact on the Alberta economy is an estimated $12.3 billion annually, or five per cent of the province’s gross domestic product. With more than 15,000 employees, the university is Alberta's fourth-largest employer.The university has been recognized by the Academic Ranking of World Universities, the QS World University Rankings and the Times Higher Education World University Rankings as one of the top five universities in Canada and one of the top 100 universities worldwide.According to the 2014 QS World University Rankings the top Faculty Area at the University of Alberta is Arts and Humanities , and the top-ranked Subject is English Language and Literature .The University of Alberta has graduated more than 260,000 alumni, including Governor General Roland Michener, Prime Minister Joe Clark, Chief Justice of Canada Beverley McLachlin, Alberta premiers Peter Lougheed, Dave Hancock and Jim Prentice, Edmonton Mayor Don Iveson and Nobel laureate Richard E. Taylor.The university is a member of the Alberta Rural Development Network, the Association for the Advancement of Sustainability in Higher Education and the Sustainability Tracking, Assessment & Rating System. Wikipedia.
University of Alberta | Date: 2016-09-06
A method of converting lipids to useful olefins includes reacting a mixture of lipids and a reactant olefin with microwave irradiation in the presence of ruthenium metathesis catalysts. The lipids may be unsaturated triacylglycerols or alkyl esters of fatty acids. The lipids may be sourced from renewable sources such as vegetable oil, waste cooking oil, or waste animal products.
University of Alberta | Date: 2015-04-17
The invention includes method, pharmaceutical compositions and uses thereof for treating patients with Papillary Thyroid Carcinoma (PTC) using a Platelet Derived Growth Factor Receptor Alpha (PDGFRA) inhibitor. The PDGFRA inhibitor is preferably an antibody specific to PDGFRA and causes an increase in the sensitivity level of PTC cells to radioiodine treatment. Moreover, the antibody can be used in combination with other PDGFRA inhibitors such as tyrosine kinase inhibitors and RNA interference molecules.
Massachusetts Institute of Technology and University of Alberta | Date: 2016-11-23
The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
University of Alberta | Date: 2016-09-21
A combined hydrothermal and activation process that uses hemp bast fiber as the precursor to achieve graphene-like carbon nanosheets, a carbon nanosheet including carbonized crystalline cellulose, a carbon nanosheet formed by carbonizing crystalline cellulose, a capacitative structure includes interconnected carbon nanosheets of carbonized crystalline cellulose, a method of forming a nanosheet including carbonizing crystalline cellulose to create carbonized crystalline cellulose. The interconnected two-dimensional carbon nanosheets also contain very high levels of mesoporosity.
University of Alberta | Date: 2014-11-07
A thermal emitter is provided, including a periodic structure operating as a metamaterial on an optically thick substrate; the periodic structure thermally emitting at high temperatures in a specified narrow wavelength of a predetermined resonance, the metamaterial including a composite medium of natural materials. The emitter may be part of a thermophotovoltaic device. The thermal emitter may include a plurality of layered films, wherein the distance between each adjacent film is substantially less than the wavelength.
University of Alberta | Date: 2016-09-12
The invention provides a binding-induced DNA nanomachine that can be activated by proteins and nucleic acids. This new type of nanomachine hamesses specific target binding to trigger assembly of separate DNA components that are otherwise unable to spontaneously assemble. Three-dimensional DNA tracks of high density are constructed on gold nanoparticles functionalized with hundreds of single-stranded oligonucleotides and tens of an affinity ligand. A DNA swing arm, free in solution, can be linked to a second affinity ligand. Binding of a target molecule to the two ligands brings the swing arm to AuNP and initiates autonomous, stepwise movement of the swing arm around the AuNP surface. The movement of the swing arm generates hundreds of oligonucleotides in response to a single binding event. The new nanomachines have several unique and advantageous features over DNA nanomachines that rely on DNA self-assembly.
University of Alberta | Date: 2016-09-19
An underwater camera system includes a projector operable to project a pattern of electromagnetic radiation toward a target object. The electromagnetic radiation includes at least three different wavelengths. A sensor directed toward the target object receives reflected electromagnetic radiation from the target object and stores corresponding image data received from the sensor. One or more processors process the image data to compute a refractive normal according to a wavelength dispersion represented by differences in the image data, and to compute an interface distance corresponding to a distance from a center point of the sensor to a first refractive interface nearest the sensor according to the refractive normal. The processors generate a 3D representation of the target object by back projecting each pixel of the image data at the first, second, and third wavelengths in order to determine an object point location according to the refractive normal and interface distance.
Frolov V.P.,University of Alberta
Physical Review Letters | Year: 2015
We study a spherical gravitational collapse of a small mass in higher-derivative and ghost-free theories of gravity. By boosting a solution of linearized equations for a static point mass in such theories we obtain in the Penrose limit the gravitational field of an ultrarelativistic particle. Taking a superposition of such solutions we construct a metric of a collapsing null shell in the linearized higher-derivative and ghost-free gravity. The latter allows one to find the gravitational field of a thick null shell. By analyzing these solutions we demonstrate that in a wide class of the higher dimensional theories of gravity as well as for the ghost-free gravity there exists a mass gap for mini-black-hole production. We also found conditions when the curvature invariants remain finite at r=0 for the collapse of the thick null shell. © 2015 American Physical Society.
Ylijoki K.E.O.,University of Alberta |
Stryker J.M.,University of Alberta
Chemical Reviews | Year: 2013
Kojic acid-type cycloaddition reactions yield products similar to those obtained via the perezone-type pathways, with the only difference being a bridging oxygen atom rather than a bridging carbonyl. Mechanistically, these reactions involve the formation of an oxidopyrylium ylid as the reactive intermediate, rather than a pentadienyl cation. Domingo and co-workers have performed density functional theory (DFT) mechanistic investigations of this process and determined that the energetically preferred mechanism does indeed proceed via a discrete intramolecular group transfer, followed by a rate-limiting concerted cycloaddition step. The energy difference between the two diastereomeric cycloaddition transition states is ca. 10 kcal/mol due to constraints imposed by the tether, supporting the high diastereoselectivity observed in these reactions.
Houghton M.,University of Alberta
Immunological Reviews | Year: 2011
Summary: Encouraging efficacy data have been obtained in the hepatitis C virus (HCV) chimpanzee model using prophylactic vaccines comprising adjuvanted recombinant envelope gpE1/gpE2 glycoproteins or prime/boost immunization regimens using defective adenoviruses and plasmid DNA expressing non-structural genes. While usually not resulting in sterilizing immunity after experimental challenge, the progression to chronic, persistent infection (which is responsible for HCV-associated pathogenicity in human) is inhibited. These and other vaccine candidates are in clinical development for both prophylactic as well as possible therapeutic applications. Given that other vaccines tested in the chimpanzee model may be possibly increasing the rate of chronicity, it is very important that this model continues to be available and used prior to initiation of clinical development. Several vaccine monotherapy trials in chronically infected HCV patients are resulting in small declines in viral load, suggesting that in future, combining vaccination with antiviral drug treatment may be beneficial. © 2010 John Wiley & Sons A/S.