University of Afyonkocatepe

Afyonkarahisar, Turkey

University of Afyonkocatepe

Afyonkarahisar, Turkey
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Yazar E.,Selcuk University | Er A.,Selcuk University | Uney K.,Selcuk University | Bulbul A.,University of Afyonkocatepe | And 3 more authors.
Free Radical Research | Year: 2010

The aim of this study was to determine the effects of enrofloxacin (ENR), flunixin meglumine (FM) and dexamethasone (DEX) on antioxidant status and organ damage markers in experimentally-induced endotoxemia. Rats were divided into three groups. To induce endotoxemia, lipopolysaccharide (LPS) was injected into all groups, including the positive control. The two other groups received the following drugs (simultaneously with LPS): ENR FM low-dose DEX and ENR FM high-dose DEX. After the treatments, blood samples were collected at 0, 1, 2, 4, 6, 8, 12, 24 and 48 h. Oxidative stress parameters were determined by ELISA, while serum organ damage markers were measured by autoanalyser. LSP increased (p < 0.05) malondialdehyde, 13,14-dihydro-15-keto-prostaglandin F2α and nitric oxide, while LPS reduced vitamin C. These changes were especially inhibited (p < 0.05) by ENR FM high-dose DEX. LPS increased organ damages markers. Cardiac and hepatic damage was not completely inhibited by any treatment, whereas renal damage was inhibited by two treatments. This study suggested that ENR FM high-dose DEX is most effective in the LPS-caused oxidative stress and organ damages. © 2010 Informa UK Ltd.


Bulbul T.,University of Afyonkocatepe | Ulutas E.,University of Afyonkocatepe | Evcimen M.,University of Afyonkocatepe
Ankara Universitesi Veteriner Fakultesi Dergisi | Year: 2015

The aim of the present research was to determine the effects of arginine and lysine supplementation in laying quail diets on performance and egg quality characteristics. A total of 420 Japanese quails (280 females and 140 males; Coturnix coturnix japonica) aged 10 weeks old were divided into seven equal groups, each consisting of 60 quails. The control group was fed a basal diet without the addition of arginine or lysine (with an arginine:lysine ratio at the required level). Experimental groups were fed the basal diet supplemented with: 0.1% arginine; 0.2% arginine; 0.1% lysine; 0.2% lysine; 0.1% arginine + 0.1% lysine; or 0.2% arginine + 0.2% lysine. Feed intake decreased in the 0.1% lysine, 0.2% lysine, and 0.1% arginine + 0.1% lysine groups compared with the control and arginine groups (P<0.01). At the end of the experiment, body weight increased for females in all experimental groups (P<0.05); eggshell thickness decreased in the 0.2% arginine group (P<0.01); and the albumen index increased in the 0.2% arginine + 0.2% lysine group compared with the 0.1% arginine, 0.2% lysine, and 0.1% arginine + 0.1% lysine groups (P<0.05). There were no differences between the experimental groups in terms of egg production, egg weight, feed conversion ratio, shape index, Haugh unit, yolk index, albumen index and yolk color index. In conclusion, lysine supplementation in the quail diets did not appear to have any significant negative effect; excessive arginine supplementation might impair the quality of the eggshell; and combined arginine and lysine supplementation did not improve performance. © 2015,Chartered Inst. of Building Services Engineers. All rights reserved.


Oznurlu Y.,Selcuk University | Celik I.,Selcuk University | Sur E.,Selcuk University | Ozaydin T.,Selcuk University | And 2 more authors.
Avian Pathology | Year: 2012

Detrimental effects of aflatoxin B1 (AFB1) on the embryonic development of broiler tibia and its proximal growth plate were determined by means of histological, histometric and immunohistochemical methods. For this, 420 fertile eggs from parent stocks of Ross 308 broiler chickens were divided into five groups according to the proposed treatment: a control untreated group, a group injected with 30% ethanol and three further groups to be injected with 5, 15 or 40 ng AFB1. The eggs were injected into the air space prior to incubation. Five eggs from each group were opened at 9, 11, 13, 17, 19 and 21 days of incubation and tibial tissue samples were removed, dissected of muscle and connective tissues, and processed by means of routine histological techniques. The cell proliferation rate of the epiphyseal growth plate cells was determined by immunohistochemical assay of proliferating cell nuclear antigen (PCNA) expression. The results showed that both proliferative and hypertrophic zones narrowed significantly (P<0.05), when compared with the controls, in all of the AFB1-treated groups whereas the transitional zone thickened, especially in the group given 40 ng AFB1 group. The PCNA positivity indices of 15 and 40 ng AFB1-treated groups were significantly higher (P<0.05) on days 11, 13, 17, 19 and 21 of incubation. It was concluded that in ovo-administered AFB1 adversely affected embryonic development of the tibial growth plate, and that affected hatched broilers might also be more susceptible to skeletal disorders during growth. © 2012 Copyright Houghton Trust Ltd.


Er A.,Selcuk University | Ulutas E.,University of Afyonkocatepe | Altan F.,Dicle University | Cetin G.,Mehmet Akif Ersoy University | And 3 more authors.
African Journal of Biotechnology | Year: 2011

The aim of this study was to determine the effect of tulathromycin on serum oxidative status and coagulation factors in rabbits. Tulathromycin was administered to eight rabbits, and blood samples were obtained 0, 1, 5, 10 and 15 days after treatment. Indicators of serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol and β-carotene) and coagulation values (antithrombin III, fibrinogen) were measured after tulathromycin treatment. In addition, routine serum biochemical values (creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high density lipoprotein, amylase, total protein, albumin, glucose and calcium), haemacell counts (white and red blood cells) and arterial blood gas parameters (packed cell volume, hemoglobin, pH, partial pressure of carbon dioxide, partial pressure of oxygen, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, sodium and potassium) were also determined. Tulathromycin increased (P < 0.05) the levels of malondialdehyde, nitric oxide and superoxide dismutase activity, and decreased (P < 0.05) the level of antithrombin III. In conclusion, tulathromycin may cause oxidative damage and coagulation disorders during the treatment period. © 2011 Academic Journals.

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