Aberdeen, United Kingdom
Aberdeen, United Kingdom

The University of Aberdeen is a public research university in the city of Aberdeen, Scotland. It is an ancient university founded in 1495 when William Elphinstone, Bishop of Aberdeen, petitioned Pope Alexander VI on behalf of James IV, King of Scots to create King's College. This makes it Scotland's third-oldest university and fifth-oldest in the English-speaking world. The university as it is today was formed in 1860 by a merger between King's College and Marischal College, a second university founded in 1593 in Aberdeen city centre as a Protestant alternative to King's College. Today, the University of Aberdeen is consistently ranked among the top 150 universities in the world and is one of two universities in Aberdeen, the other being The Robert Gordon University.The university's iconic buildings act as symbols of the City of Aberdeen, particularly Marischal College in the city centre and the spire of King's College in Old Aberdeen. There are two campuses; the main King's College campus is at Old Aberdeen approximately two miles north of the city centre, around the original site of King's College, although most campus buildings were constructed in the 20th century during a period of expansion. The university's Foresterhill campus is located next to Aberdeen Royal Infirmary and houses the School of Medicine and Dentistry and School of Medical science.The University has approximately 13,500 students from undergraduate to doctoral level, including many international students. In addition, the university's Centre for Lifelong Learning acts as an extension college, offering higher education courses to the local community even for those without the usual qualifications for admission to degree-level study. A full range of disciplines are offered and in 2012 the university offered over 650 undergraduate degree programmes.Five Nobel Prize winners are associated with the University. Other academics and graduates of the University include many distinguished figures, including: physicist James Clerk Maxwell; Thomas Reid, the founder of the Scottish School of Common Sense and an important figure in the Scottish Enlightenment; philosopher Robert Adamson; educationalist and philosopher Alexander Bain; and theologian William Robinson Clark. Wikipedia.


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Patent
University of Aberdeen and Lothian Health Board | Date: 2015-05-14

The present invention relates to methods of producing pancreatic endocrine cells and uses of the cells obtained using the methods. The method utilises inhibitors or combinations of factors to provide increased quantities of endocrine material, for example for transplantation purposes.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: LCE-05-2015 | Award Amount: 51.69M | Year: 2016

In order to unlock the full potential of Europes offshore resources, network infrastructure is urgently required, linking off-shore wind parks and on-shore grids in different countries. HVDC technology is envisaged but the deployment of meshed HVDC offshore grids is currently hindered by the high cost of converter technology, lack of experience with protection systems and fault clearance components and immature international regulations and financial instruments. PROMOTioN will overcome these barriers by development and demonstration of three key technologies, a regulatory and financial framework and an offshore grid deployment plan for 2020 and beyond. A first key technology is presented by Diode Rectifier offshore converter. This concept is ground breaking as it challenges the need for complex, bulky and expensive converters, reducing significantly investment and maintenance cost and increasing availability. A fully rated compact diode rectifier converter will be connected to an existing wind farm. The second key technology is an HVDC grid protection system which will be developed and demonstrated utilising multi-vendor methods within the full scale Multi-Terminal Test Environment. The multi-vendor approach will allow DC grid protection to become a plug-and-play solution. The third technology pathway will first time demonstrate performance of existing HVDC circuit breaker prototypes to provide confidence and demonstrate technology readiness of this crucial network component. The additional pathway will develop the international regulatory and financial framework, essential for funding, deployment and operation of meshed offshore HVDC grids. With 35 partners PROMOTioN is ambitious in its scope and advances crucial HVDC grid technologies from medium to high TRL. Consortium includes all major HVDC and wind turbine manufacturers, TSOs linked to the North Sea, offshore wind developers, leading academia and consulting companies.


Grant
Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.97M | Year: 2017

PROTECTED aims to develop expertise and protective capabilities against Endocrine Disruptors (EDs). EDs and their mixtures are a modern day health concern leading to failing ecological systems, poor agricultural production and health effects such as obesity, cancer and infertility. While analytical methods have advanced enormously, focus has been mainly on synthetic chemicals, overlooking emerging EDs and real-life multiple substance exposure. A new generation of creative, entrepreneurial and innovative early-stage researchers equipped with skills to assess and understand the real-life risk of complex mixtures of EDs and trained to convert resulting knowledge and ideas into accessible tools and services for the long-term control of potential ED risk is urgently needed. The PROTECTED Innovative Training Network [ITN] proposes a holistic approach by providing 15 individual, personalised research projects with exposure to scientific, innovative and entrepreneurial training mobility across the ITN. The intersectorial network is comprised of 12 training sites at academia, research centres, a bioassay technology SME, a QSAR technology SME, water provider, and animal feed supplier. Together they cover multiple disciplines including analytical science of food, feed, and environment, epidemiology, risk assessment, social science and toxicology. This combined expertise enables a highly focused program for developing novel tools and concepts and training for the detection, analysis and improved risk assessment of EDs, especially mixture effects. Methodology will include emerging technologies; multiplexed analysis, mixture modelling, mechanistic and exposure studies, explants and cell or whole organism bioassays. The project will provide a unique and high level of training for a new generation of specialists with transferable skills and enhanced career perspectives. These specialists will ultimately aid the efficient development of future control strategies for improved health.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: MG-5.5a-2015 | Award Amount: 17.68M | Year: 2016

Port Cities can be seen as multidimensional laboratories where challenges connected with urban mobility are more complex due to the dual system of gravity centre: the city, the port, not to mention their shared hinterland.These peculiarities are at once a challenge and an opportunity, as they provide scope for planning, researching and implementing integrated mobility solutions in distinctively complex urban contexts. Civitas PORTIS designs, demonstrates and evaluates integrated sets of sustainable mobility measures in 5 major port cities located on the North Sea (Aberdeen and Antwerp), the Mediterranean Sea (Trieste), the Black Sea (Constanta), and Baltic Sea (Klaipeda). The project also involves a major international follower port city on the East China Sea (Ningbo). Thanks to the Civitas Initiative, the partner cities expect to prove that more efficient and sustainable mobility is conducive to the establishment of vital and multi-modal hubs for urban, regional, national and International movements of passengers and goods. To do this, they establish integrated living laboratories clustering local measures according to four major aspects of sustainable urban mobility: 1. Governance: to increase port-city collaborative planning and participation, leading to enhanced forms of SUMPs. 2. People: to foster less car-dependent mobility styles, leading to modal shift in favour of collective and more active transport. 3. Transport system: to strengthen the efficiency of road traffic management to/from the port and through the city, and foster the use of clean vehicles. 4. Goods: to enhance logistics and freight transport, improving the efficiency and coordination of city, port and regional freight movements. Working with port cities, Civitas PORTIS will generate a strong and twofold replication potential: 1) specifically to other port cities, and 2) more generally to cities presenting major transport nodes and attractors for the benefit of the whole CIVITAS Initiative.


Brown G.D.,University of Aberdeen
Annual Review of Immunology | Year: 2011

Fungal diseases have emerged as significant causes of morbidity and mortality, particularly in immune-compromised individuals, prompting greater interest in understanding the mechanisms of host resistance to these pathogens. Consequently, the past few decades have seen a tremendous increase in our knowledge of the innate and adaptive components underlying the protective (and nonprotective) mechanisms of antifungal immunity. What has emerged from these studies is that phagocytic cells are essential for protection and that defects in these cells compromise the host's ability to resist fungal infection. This review covers the functions of phagocytes in innate antifungal immunity, along with selected examples of the strategies that are used by fungal pathogens to subvert these defenses. © 2011 by Annual Reviews. All rights reserved.


Prosser J.I.,University of Aberdeen
Nature Reviews Microbiology | Year: 2015

Technological advances are enabling the sequencing of environmental DNA and RNA at increasing depth and with decreasing costs. Metagenomic and transcriptomic analysis of soil microbial communities and the assembly of 'population genomes' from soil DNA are therefore now feasible. Although the value of such 'omic' approaches is limited by the associated technical and bioinformatic difficulties, even if these obstacles were eliminated and 'perfect' metagenomes and metatranscriptomes were available, important conceptual challenges remain. This Opinion article considers these conceptual challenges in the context of the current use of omics in soil microbiology, but the main arguments presented are also relevant to the application of omics to marine, freshwater, gut or other environments. © 2015 Macmillan Publishers Limited. All rights reserved.


Pennington H.,University of Aberdeen
The Lancet | Year: 2010

Escherichia coli O157 is an uncommon but serious cause of gastroenteritis. This bacterium is noteworthy because a few, but significant, number of infected people develop the haemolytic uraemic syndrome, which is the most frequent cause of acute renal failure in children in the Americas and Europe. Many infections of E coli O157 could be prevented by the more effective application of evidence-based methods, which is especially important because once an infection has been established, no therapeutic interventions are available to lessen the risk of the development of the haemolytic uraemic syndrome. This Review takes into account the evolution and geographical distibution of E coli O157 (and its close pathogenic relatives); the many and varied routes of transmission from its major natural hosts, ruminant farm animals; and other aspects of its epidemiology, its virulence factors, the diagnosis and management of infection and their complications, the repercussions of infection including costs, and prevention. © 2010 Elsevier Ltd.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 864.00K | Year: 2017

Increased longevity with a high quality of life is desirable not only for personal life-satisfaction but also for reducing healthcare costs and for increasing the socioeconomic contributions of individuals in countries with ageing population demographics. Lifelong lifestyle has an important impact on health status in older age and adequate nutrition plays a key role in maintaining cellular functions within normal limits. Microelements such as zinc (Zn) and copper (Cu) are essential for life and are involved in the normal functioning of thousands of proteins. The dysregulation of these metals leads to perturbed homeostasis, disease and diminished quality of life. In this study, the molecular mechanisms by which ageing affects Zn and Cu absorption and excretion will be determined, and the consequent impact on metal flux and transport kinetics will be expressed by mathematical modelling. The project output will include a predictive model for the impact of ageing on Zn and Cu homeostasis, informing intervention with dietary advice or supplementation to improve longevity. The consortium combines intersectoral and interdisciplinary expertise from 3 EU and 2 partner countries with established links and clear potential for knowledge exchange and transfer of skills. The consortium objectives are: 1. To determine the impact of dietary Zn and Cu on the microbiota and also age-related changes in the microbiota composition on the absorption of Zn and Cu. 2. To understand the influence of senescence on the regulation of Zn and Cu flux into and out of key cells controlling their homeostasis (gut mucosal cells, pancreatic acinar cells and hepatocytes) and its impact on the expression of related genes such as transporters. 3. To determine how senescence affects the transporter proteins, channels and chaperones involved in regulating Zn and Cu trafficking through the key absorptive and excretory cells affecting body metal homeostasis.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-11-2015 | Award Amount: 6.60M | Year: 2016

Many diseases are inadequately diagnosed, or not diagnosed early enough by current imaging methods. Examples of unmet clinical needs arise in thromboembolic disease, osteoarthritis, cancer, sarcopenia, and many more areas. Our solution, Fast Field-Cycling (FFC) MRI, can measure quantitative information that is invisible to standard MRI. FFC scanners switch magnetic field while scanning the patient, obtaining new diagnostic information. FFC-MRI has been demonstrated by us, but many challenges must be solved before clinical adoption. Objectives: Understand the mechanisms determining FFC signals in tissues; Create technology to measure and correct for environmental magnetic fields, enabling FFC at ultra-low fields; Investigate contrast agents for FFC, to increase sensitivity and to allow molecular imaging; Improve FFC technology, in order to extend its range of clinical applications; Test FFC-MRI on tissue samples and on patients. Achieved by: Developing the theory of relaxation in tissue at ultra-low fields, leading to models and biomarkers; Developing magnetometers for FFC-MRI, and environmental-field correction; Creating and in vitro testing of new FFC contrast agents; studying existing clinical agents for FFC-MRI sensitivity; Improving technology to monitor and stabilise magnetic fields in FFC; improving magnet power supply stability; investigating better radiofrequency coils and acquisition pulse sequences; Testing FFC methods on tissue samples from surgery and tissue banks; proof-of-principle scans on patients. FFC-MRI is a paradigm-shifting technology which will generate new, quantitative disease biomarkers, directly informing and improving clinical diagnosis, treatment decisions and treatment monitoring. Its lower cost contributes to healthcare sustainability. The proposal consolidates the EU lead in FFC technology and uses new concepts from world-leading teams to deliver solutions based on innovations in theory, modelling, physics, chemistry and engineering.

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