Arhus, Denmark
Arhus, Denmark

Aarhus University is a public university located in Aarhus, Denmark. Founded in 1928, it is Denmark's second oldest university and the largest, with a total of 43,600 enrolled students as of 1 January 2012, after a merger with Aarhus School of Engineering. In most prestigious ranking lists of the world´s best universities, Aarhus University is placed in the top 100. The university belongs to the Coimbra Group of European universities.Denmark's first professor of sociology was a member of the faculty of Aarhus University , and in 1997 Professor Jens Christian Skou received the Nobel Prize in Chemistry for his discovery of the sodium-potassium pump. In 2010 Dale T. Mortensen, a Niels Bohr Visiting Professor at Aarhus University, received the Nobel Prize in Economic science together with his colleagues Peter Diamond and Christopher Pissarides. Wikipedia.

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Fejerskov B.,University of Aarhus | Zelikin A.N.,University of Aarhus
PLoS ONE | Year: 2012

In this report, we detail Substrate Mediated Enzyme Prodrug Therapy (SMEPT) as a novel approach in drug delivery which relies on enzyme-functionalized cell culture substrates to achieve a localized conversion of benign prodrug(s) into active therapeutics with subsequent delivery to adhering cells or adjacent tissues. For proof-of-concept SMEPT, we use surface adhered micro-structured physical hydrogels based on poly(vinyl alcohol), β-glucuronidase enzyme and glucuronide prodrugs. We demonstrate enzymatic activity mediated by the assembled hydrogel samples and illustrate arms of control over rate of release of model fluorescent cargo. SMEPT was not impaired by adhering cells and afforded facile time - and dose - dependent uptake of the in situ generated fluorescent cargo by hepatic cells, HepG2. With the use of a glucuronide derivative of an anticancer drug, SN-38, SMEPT afforded a decrease in cell viability to a level similar to that achieved using parent drug. Finally, dose response was achieved using SMEPT and administration of judiciously chosen concentration of SN-38 glucuronide prodrug thus revealing external control over drug delivery using drug eluting surface. We believe that this highly adaptable concept will find use in diverse biomedical applications, specifically surface mediated drug delivery and tissue engineering. © 2012 Fejerskov, Zelikin.

University of Aarhus | Date: 2016-12-02

The present invention provides mutant cereal plants and mature grain thereof, characterised by enhanced levels of the enzyme phytase in the grain, and methods for inducing, detecting and selecting the mutant cereal plants. The invention further relates to animal feed comprising said grain having enhanced amounts of phytase.

University of Southern Denmark and University of Aarhus | Date: 2017-04-12

The present invention relates to glycosylated YghJ polypeptides from or derived from enterotoxigenic Escherichia coli (ETEC) that are immunogenic. In particular, the present invention relates to compositions or vaccines comprising the polypeptides and their application in immunization, vaccination, treatment and diagnosis of ETEC.

Arabkoohsar A.,University of Aarhus | Andresen G.B.,University of Aarhus
Energy | Year: 2017

A major portion of the electricity demand in Denmark is provided by wind farms. As wind power fluctuates sharply, there may be either surplus power or electricity deficit relative to the local demand. Thus, storing the surplus electricity and reclaiming it in demand times can increase the power plant incomes and reliability. On the other hand, as Denmark is one of the countries in which energy consumers are supplied by district heating, the demand for efficient and reliable heat production systems is also high. In this work, a novel and efficient energy storage system capable of providing both heat and electricity is designed and analyzed. This system is a smart combination of a thermal energy storage system and a gas turbine cycle without any combustion chamber. In order to have an optimal configuration, the system is designed based on thermodynamics criteria and net economic revenue. It is shown that the designed system may present an overall energy efficiency of about 90% and an electricity efficiency of approximately 35%. The economic assessment indicates that this innovative high temperature heat and power storage system, even taking into account conservative electricity and heat prices, is very profitable. © 2017 Elsevier Ltd

Arabkoohsar A.,University of Aarhus | Andresen G.B.,University of Aarhus
Energy | Year: 2017

A novel energy storage system that produces both electricity and heat at high efficiencies and takes advantage of a high temperature hot rock cavern thermal energy storage was recently introduced and designed. This study aims at evaluating the performance of the system in terms of energy and exergy efficiencies under realistic operational conditions where the storage supports a number of wind turbines over a long period. The potential value creation of the energy storage system in the local electricity and heat markets is also assessed. The Western part of Denmark with its high number of wind turbine plants and flexible electricity and heat markets have been chosen for the case study of this work. Having both forecasted and realized wind power generation as well as energy prices for the recent years, the system is designed with rigor and a smart bid strategy for the power plant equipped with the energy storage unit for day-ahead and intra-day markets is determined. The results show that the system is able to compensate the fluctuations of wind power plants, and present high annual overall energy and electricity efficiencies of 80.2% and 31.4% and exergy efficiency of 56.1%. © 2017 Elsevier Ltd

Sogaard T.F.,University of Aarhus
Drugs: Education, Prevention and Policy | Year: 2017

In early club studies, nightlife domains are often depicted as scenes where class and ethno-racial boundaries are dissolved into post-modern cultural formations. This article adds to a growing body of research challenging this characterisation, by exploring how the policing of nightlife accessibility contributes to the (re)production of ethnic divisions and inequalities in nocturnal consumer spaces. Based on ethnographic research in Denmark, the article explores the key governmental rationalities informing bouncers’ exclusion of visible ethnic minority men. The article argues that bouncers’ ethnic governance is a multi-dimensional process which can be analysed using different analytical approaches. While the first part uses the concept of “vernacular risk perception” to highlight how bouncers’ ethnic governance is driven by loss-reductive logics, combined with prejudiced thinking, the second part uses an interactional perspective to illustrate how bouncers’ ethnic governance is also the product of situated power struggles between bouncers and minority youth. Third, I use a performative perspective to demonstrate how the exclusion of minority men is also driven by intra-group processes and implicated in bouncers’ dramatised in-group construction of masculine identities. In conclusion, I discuss how a focus on bouncers’ ethnic governance and regulation of access can contribute to the study of (nightlife) youth culture. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Andersen J.P.,University of Aarhus
Journal of Informetrics | Year: 2017

The recently proposed Euclidean index offers a novel approach to measure the citation impact of academic authors, in particular as an alternative to the h-index. We test if the index provides new, robust information, not covered by existing bibliometric indicators, discuss the measurement scale and the degree of distinction between analytical units the index offers. We find that the Euclidean index does not outperform existing indicators on these topics and that the main application of the index would be solely for ranking, which is not seen as a recommended practice. © 2017 Elsevier Ltd

Sorensen M.M.,University of Aarhus
Discrete Optimization | Year: 2017

A path-block cycle is a graph that consists of several cycles that all intersect in a common subset of nodes. The associated path-block-cycle inequalities are valid, and sometimes facet-defining, inequalities for polytopes in connection with graph partitioning problems and corresponding multicut problems. Special cases of the inequalities were introduced by De Souza and Laurent (1995) and shown to be facet-defining for the equicut polytope. Generalizations of these inequalities were shown by Ferreira et al. (1996) to be valid for node-capacitated graph partitioning polytopes on general graphs.This paper considers the special case of the inequalities, where all cycles intersect in two nodes, and establishes conditions under which these inequalities induce facets of node-capacitated multicut polytopes and bisection cut polytopes. These polytopes are associated with simple versions of the node-capacitated graph partitioning and bisection problems, where all node weights are assumed to be 1. © 2017 Elsevier B.V.

Periole X.,Zernike Institute for Advanced Materials | Periole X.,University of Aarhus
Chemical Reviews | Year: 2017

G protein-coupled receptors (GPCRs) are central to many fundamental cellular signaling pathways. They transduce signals from the outside to the inside of cells in physiological processes ranging from vision to immune response. It is extremely challenging to look at them individually using conventional experimental techniques. Recently, a pseudo atomistic molecular model has emerged as a valuable tool to access information on GPCRs, more specifically on their interactions with their environment in their native cell membrane and the consequences on their supramolecular organization. This approach uses the Martini coarse grain (CG) model to describe the receptors, lipids, and solvent in molecular dynamics (MD) simulations and in enough detail to allow conserving the chemical specificity of the different molecules. The elimination of unnecessary degrees of freedom has opened up large-scale simulations of the lipidmediated supramolecular organization of GPCRs. Here, after introducing the Martini CGMD method, we review these studies carried out on various members of the GPCR family, including rhodopsin (visual receptor), opioid receptors, adrenergic receptors, adenosine receptors, dopamine receptor, and sphingosine 1-phosphate receptor. These studies have brought to light an interesting set of novel biophysical principles. The insights range from revealing localized and heterogeneous deformations of the membrane bilayer at the surface of the protein, specific interactions of lipid molecules with individual GPCRs, to the effect of the membrane matrix on global GPCR self-assembly. The review ends with an overview of the lessons learned from the use of the CGMD method, the biophysical-chemical findings on lipid-protein interplay. © 2016 American Chemical Society.

Herendeen P.S.,Chicago Botanic Garden | Friis E.M.,Swedish Museum of Natural History | Pedersen K.R.,University of Aarhus | Crane P.R.,Oak Spring Garden Foundation
Nature Plants | Year: 2017

Angiosperms (flowering plants) are the most diverse of all major lineages of land plants and the dominant autotrophs in most terrestrial ecosystems. Their evolutionary and ecological appearance is therefore of considerable interest and has significant implications for understanding patterns of diversification in other lineages, including insects and other animals. More than half a century ago, influential reviews showed that while angiosperms are richly represented in sediments of Late Cretaceous and younger ages, there are no reliable records of angiosperms from pre-Cretaceous rocks. The extensive new macrofossil, mesofossil, and microfossil data that have accumulated since have confirmed and reinforced this pattern. Recently, however, molecular dating methods have raised the possibility that angiosperms may have existed much earlier, and there have been scattered reports of putative angiosperms from Triassic and Jurassic rocks. Critical assessment of these reports shows that, so far, none provide unequivocal evidence of pre-Cretaceous angiosperms. Angiosperms may ultimately be recognized from Jurassic or earlier rocks, but credible palaeobotanical evidence will require unambiguous documentation of the diagnostic structural features that separate angiosperms from other groups of extant and extinct seed plants. © 2017 Macmillan Publishers Limited, part of Springer Nature.

Andersson K.E.,Wake forest University | Andersson K.E.,University of Aarhus
International Neurourology Journal | Year: 2017

The clinical success of mirabegron as the first ß3-adrenoceptor (AR) agonist for treatment of the overactive bladder (OAB) syndrome, has resulted in substantial interest in its site and mechanism of action. Even if the adrenergic innervation of the bladder and urethra has been well studied, the location(s) of B3-ARs in different structures within the bladder wall and urethra, and the mode(s) of action of B3-AR stimulation have still not been established. The recent demonstration of B3-ARs on cholinergic nerve terminals with no immunoreactivity in urothelium or detrusor smooth muscle, is not in agreement with previous morphological studies, and functional data strongly suggest that B3-ARs can be found these structures. However, recent studies suggest that the B3-ARs on detrusor smooth muscle may not be the functionally most relevant. The assumption that B3-AR activation during bladder filling inhibits acetylcholine release from parasympathetic neurons by a prejunctional mechanism and that this decreases bladder micromotions that generate afferent activity, is an attractive hypothesis. It does not exclude that other mechanisms may be contributing, and supports combined approaches to reduce afferent activity for treatment of the OAB syndrome.

Riisager K.,University of Aarhus
Few-Body Systems | Year: 2017

Beta decay is a well tested probe of nuclear structure for near-stable nuclei. This contribution focusses on specific changes in beta decay processes that may occur in halo nuclei. Certain decay branches appear to proceed mainly directly to continuum states. As an example the beta-delayed proton emission from 11Be is discussed in detail. © 2017, Springer-Verlag Wien.

Brix H.,University of Aarhus
Water (Switzerland) | Year: 2017

Sludge Treatment Reed Beds (STRBs) are widely used in Northern Europe to dewater and mineralize surplus sludge from activated sludge systems used to treat urban domestic sewage. STRBs are low-technology, energy-efficient, and do not require addition of chemicals. They dewater and stabilize the sludge and produce a final product that can be safely used as a fertilizer for agricultural crops. Long-term sludge reduction takes place in the reed beds due to dewatering and mineralization of the organic matter in the sludge. Although, in theory, a simple technique relying largely on natural processes, experience has shown that it is very important to understand and respect the basic design and operation requirements of STRBs. This paper describes the basic design and operation requirements of STRBs, with special focus on pivotal requirements to respect in order to secure proper functioning. Also, the paper summarizes performance experience concerning final dry matter content, degree of mineralization, emission of greenhouse gases, and degradation of micro-pollutants in STRBs. There are still a number of outstanding issues that are not fully understood, particularly in relation to the importance of the sludge quality for the dewatering in an STRB. Therefore, extreme care should be taken when attempting to extrapolate the use of STRBs to applications and regions outside of their 'normal' and documented area of application. © 2017 by the authors.

Adoptive transfer of genetically engineered human cells secreting bispecific T-cell engagers has shown encouraging therapeutic effects in preclinical models of cancer. However, reducing the toxicity and improving the effectiveness of this emerging immunotherapeutic strategy will be critical to its successful application. We have demonstrated that for gene-based bispecific antibody strategies, two-chain diabodies have a better safety profile than single-chain tandem scFvs (single-chain variable fragments), because their reduced tendency to form aggregates reduces the risk of inducing antigen-independent T-cell activation. Here, we demonstrate that the incorporation of a 2A self-processing peptide derived from foot-and-mouth disease virus conveying co-translational cleavage into a two-chain anti-CD3 × anti-CEA diabody gene enables near-equimolar expression of diabody chains 1 and 2, and thus increases the final amount of assembled diabody. This was found to maximize diabody-mediated T-cell activation and cytotoxicity against carcinoembryonic antigen-positive tumor cells.Gene Therapy advance online publication, 26 January 2017; doi:10.1038/gt.2017.3. © 2017 The Author(s)

Jonsson L.,University of Aarhus
Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering, LNICST | Year: 2017

With the current emphasis on innovation and research in higher education, this paper proposes design-based research as base for a teaching approach to enhance the learning environment of university college students. The paper depicts how students, professors, professional educationalists, and people with learning disabilities worked together to develop five new visual and digital methods for interviewing in special education. Thereby not only enhancing the students’ competences, knowledge and proficiency in innovation and research, but also proposing a new teaching paradigm for university colleges and providing new tools for communication in special education. © ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering 2017.

Daugaard I.,University of Aarhus | Hansen T.B.,University of Aarhus
Trends in Genetics | Year: 2017

Numerous sophisticated high-throughput sequencing technologies have been developed over the past decade, and these have enabled the discovery of a diverse catalog of small non-coding (nc)RNA molecules that function as regulatory entities by associating with Argonaute (Ago) proteins. MicroRNAs (miRNAs) are currently the best-described class of post-transcriptional regulators that follow a specific biogenesis pathway characterized by Drosha/DGCR8 and Dicer processing. However, more exotic miRNA-like species that bypass particular steps of the canonical miRNA biogenesis pathway continue to emerge, with one of the most recent additions being the agotrons, which escape both Drosha/DGCR8- and Dicer-processing. We review here the current knowledge and most recent discoveries relating to alternative functions and biogenesis strategies for Ago-associated RNAs in mammals. miRNAs are a class of small (∼22 nt) ncRNAs that arise through a series of enzymatic maturation steps mediated by Drosha/DGCR8 in the nucleus and Dicer in the cytoplasm. Mature miRNAs associate with Ago proteins, thereby generating active regulatory complexes that function as post-transcriptional regulators of gene expression.Several miRNA-like species that follow alternative biogenesis pathways have been shown to associate with Ago proteins in a functional manner.The agotrons constitute the most recently discovered class of Ago-associated RNAs that employ a novel biogenesis strategy independent of both Drosha/DGCR8 and Dicer processing. Similarly to conventional miRNAs, agotrons have been shown to be capable of functioning as post-transcriptional regulators of gene expression, but their full potential and biological relevance have yet to be determined. © 2017 Elsevier Ltd.

Larsen K.G.,University of Aarhus | Williams R.,Stanford University
Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms | Year: 2017

We consider the Online Boolean Matrix-Vector Multiplication (OMV) problem studied by Henzinger et al. [STOC'15]: given an nfin Boolean matrix M, we receive n Boolean vectors v1; : : : ;vn one at a time, and are required to output Mvi (over the Boolean semiring) before seeing the vector vi+1, for all i. Previous known algorithms for this problem are combinatorial, running in O(n3=log2 n) time. Henzinger et al. conjecture there is no O(n3-ϵ ) time algorithm for OMV, for all e > 0; their OMV conjecture is shown to imply strong hardness results for many basic dynamic problems. We give a substantially faster method for computing OMV, running in n3=2W( p logn) randomized time. In fact, after seeing 2w( p logn) vectors, we already achieve n2=2W( p logn) amortized time for matrix-vector multiplication. Our approach gives a way to reduce matrix-vector multiplication to solving a version of the Orthogonal Vectors problem, which in turn reduces to "small" algebraic matrix-matrix multiplication. Applications include faster independent set detection, partial match retrieval, and 2-CNF evaluation. We also show how a modification of our method gives a cell probe data structure for OMV with worst case O(n7=4= p w) time per query vector, where w is the word size. This result rules out an unconditional proof of the OMV conjecture using purely information-theoretic arguments. Copyright © by SIAM.

Lyons J.A.,University of Aarhus | Nissen P.,University of Aarhus
EMBO Journal | Year: 2017

Transient protein interactions are paramount to life where fast and efficient transfer of information and cargo are often integral to pathways and networks. However, complexes formed by transient protein interactions are often times resistant to direct structural characterization due to their inherent, dynamic nature, so our knowledge to date typically derives from biochemical, biophysical and computational methods. In this issue, Shimada and co-authors present the crystal structure of the mammalian cytochrome c oxidase in complex with its electron donor cytochrome c, identifying a new class of protein-protein interaction termed "soft and specific". © 2017 EMBO.

Goncalves N.P.,University of Aarhus
Nature Reviews Neurology | Year: 2017

The prevalence of diabetes worldwide is at pandemic levels, with the number of patients increasing by 5% annually. The most common complication of diabetes is peripheral neuropathy, which has a prevalence as high as 50% and is characterized by damage to neurons, Schwann cells and blood vessels within the nerve. The pathogenic mechanisms of diabetic neuropathy remain poorly understood, impeding the development of targeted therapies to treat nerve degeneration and its most disruptive consequences of sensory loss and neuropathic pain. Involvement of Schwann cells has long been proposed, and new research techniques are beginning to unravel a complex interplay between these cells, axons and microvessels that is compromised during the development of diabetic neuropathy. In this Review, we discuss the evolving concept of Schwannopathy as an integral factor in the pathogenesis of diabetic neuropathy, and how disruption of the interactions between Schwann cells, axons and microvessels contribute to the disease. © 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

Thogersen J.,University of Aarhus
Food Quality and Preference | Year: 2017

This paper investigates how country of residence and food-related lifestyle (FRL) interact in shaping (un)sustainable food consumption patterns. An online survey was carried out in ten European countries (n ≈ 335 in each country), covering the five regions North, South, East, West and Central Europe. Multi-group CFA (AMOS22) was used to test the cross-national validity of the FRL instrument. After deleting a few items, it was found that the factorial structure of all five FRL domains is invariant with respect to factor configuration and factor loadings but not with respect to item intercepts. The segmentation analysis was performed by means of Latent Gold 5.1 and multi-level latent class analysis based on data from all ten countries and using the 23 FRL dimensions as input. A five-segment, three-country class solution was judged to produce the best compromise between fit and parsimony, confirming that cross-country FRL segments can be meaningfully identified, but that the segment structure differs across Europe's regions. The joint effect of country class and FRL on sustainable food-related consumer behaviour was analysed by means of GLM (SPSS22). Both country class and FRL significantly account for variation in meat and organic food consumption and FRL in addition for variation in sustainable food product innovativeness. Further, there is significant interaction between country and FRL for all outcome variables. Hence, the impact of FRL on sustainability choices partly depends on country of residence. © 2016 Elsevier Ltd

Hagsten L.G.,University of Aarhus
Journal of Civil Engineering and Management | Year: 2017

A physically based method for the determination of equilibrium for structures with inelastic response is described. The method is based on minimisation of the potential energy. For structures with inelastic response, some of the applied energy is converted to non-mechanical energy. This part of the energy is dissipated. According to the conservation of energy the dissipated energy must simultaneously be subtracted the mechanical energy in order to determine the change of the potential energy. Changes of the strains in the structure, from non-static conditions, such as thermal deformations and shrinkage, as well as plastic strains from previous load scenarios, will also change the potential energy. The method is also capable of taken these effects into account. Three examples are included in order to support the physical understanding, and to illustrate the procedure for the application of the method. Information regarding the necessary ductility of the individual parts forming the complete structure is achieved as outcome of the analysis. © 2017 Vilnius Gediminas Technical University (VGTU) Press

Dalsgaard P.,University of Aarhus
Conference on Human Factors in Computing Systems - Proceedings | Year: 2016

Research through Design (RtD), a research approach that employs methods and approaches from design as a mode of inquiry, has gained momentum within HCI. However, the approach is not yet formalised, and there are ongoing debates about fundamental issues, such as how to articulate and evaluate knowledge that springs from RtD, and how this knowledge is comparable to knowledge from other forms of research. I propose that Rheinberger's conceptualisation of experimental systems, originally developed in the domain of the natural sciences, offers insights that can add to the understanding of these issues, and in turn to the development of RtD as a research approach. I examine key characteristics of experimental systems as they pertain to RtD, with a focus on the role of designs and forms of knowledge representation. I furthermore propose that the experimental systems perspective can shed light on similarities and differences between RtD and other research approaches.

Bennedsen M.,University of Aarhus
Energy Economics | Year: 2017

We introduce a new continuous-time mathematical model of electricity spot prices which accounts for the most important stylized facts of these time series: seasonality, spikes, stochastic volatility, and mean reversion. Empirical studies have found a possible fifth stylized fact, roughness, and our approach explicitly incorporates this into the model of the prices. Our setup generalizes the popular Ornstein–Uhlenbeck-based multi-factor framework of Benth et al. (2007) and allows us to perform statistical tests to distinguish between an Ornstein–Uhlenbeck-based model and a rough model. Further, through the multi-factor approach we account for seasonality and spikes before estimating – and making inference on – the degree of roughness. This is novel in the literature and we present simulation evidence showing that these precautions are crucial for accurate estimation. Lastly, we estimate our model on recent data from six European energy exchanges and find statistical evidence of roughness in five out of six markets. As an application of our model, we show how, in these five markets, a rough component improves short term forecasting of the prices. © 2017 Elsevier B.V.

News Article | May 5, 2017

The people of Denmark have not seen a wolf prowling in its wild lands since the last of the species was killed by hunters in 1813, however, scientists have just confirmed sighting of the first wolf pack in the country after 200 years. There have been sightings of male wolves in Denmark since 2012, but there had been no indication that a real pack had formed since there was no evidence of even a single female wolf found in the area — until now. Scientists ran DNA tests on feces samples collected in West Jutland and identified four male wolves and one female in the pack. According to the researchers investigating the new arrivals, the wolf pack traveled all the way from Germany in search of new hunting grounds. "We think these are young wolves rejected by their families who are looking for new hunting grounds," University of Aarhus scientist Peter Sunde said. Some have speculated that unofficial rewilders deliberately released the pack of wolves in Denmark but Guillaume Chapron, a researcher at the Swedish University of Agricultural Sciences, is convinced that the wolves' journey was natural. Among the pack, a pair of wolves were spotted traveling together in Autumn of 2016, leading the researchers to believe that it was only a matter of time before the pair mates. According to experts, wolves only pair up to breed so it is possible that Denmark could welcome its first cubs in late 2017 or in 2018. However, it is still unsure whether the pair will mate in the spring of 2017 since they are still new in West Justland. Experts believe that the pair could postpone mating in favor of establishing their presence in the area first. "If we observe two wolves together in May-June, they are most likely not mating as the female will stay with the cubs in or near the den while the male is foraging on his own," Sunde explained. Not everyone is happy about the return of a once extinct predatory species in the region. "As long as we don't disturb them, they will be fine in these human-dominated landscapes... But the question has to be asked, are people going to accept the wolves? The wolf will need to eat something. When they realise that Danish sheep don't taste too bad that may be a little problematic," Chapron said. Farmers have already raised their concern over the return of wolves in the region, especially after several reported attacks on their sheep in early 2017. In fact, sheep farmers have already demanded government funding to build secure enclosures for their flocks. In order to protect the wolves from hunters and angry farmers, the involved scientists have declined to reveal information with regard to the pack's exact location and the government supports this decision. "The wolf is an animal we're not allowed to hunt so we must protect it," Danish Environmental Protection Agency spokesman Henrik Hagen Olesen said. © 2017 Tech Times, All rights reserved. Do not reproduce without permission.

News Article | May 4, 2017

The predators came from Germany to settle in western Denmark's agricultural region, the least densely populated in the Scandinavian country. Peter Sunde, scientist at the University of Aarhus, told AFP the wolves must have walked more than 500 kilometres (310 miles). "We think these are young wolves rejected by their families who are looking for new hunting grounds," the researcher added. Scientists have established a genetic profile from the faeces of five wolves—four males and one female—but there could be more. Sunde said researchers had suspected since 2012 that wolves had entered Denmark. "Now we have evidence (including) that there's one female," signalling the possibility of giving birth this spring, he said. Proof was also established through the wolves' fingerprints and video surveillance showed their location, which scientists refuse to reveal out of fear that it will attract hunters. "We're following that. The wolf is an animal we're not allowed to hunt so we must protect it," Henrik Hagen Olesen, spokesman at the Danish Environmental Protection Agency, told AFP. Exterminated by hunters, wolves had been completely extinct in Denmark since the beginning of the nineteenth century. In other Nordic countries with a higher wolf population, culling the species, protected by the Bern Convention, is under a fierce debate between inhabitants, farmers, hunters, the government, the European Union and wildlife activists. Explore further: Sweden allows wolf hunt despite outcry

CHICAGO, IL, April 19, 2017 - To examine the latest scientific evidence related to non-caloric sweeteners, focused on stevia, the Global Stevia Institute is hosting a sponsored symposium on Saturday, April 22 from Noon - 3:00 PM at the American Society for Nutrition (ASN) Scientific Sessions, taking place at the annual Experimental Biology conference in Chicago. "The symposium features leading researchers from around the globe who will present the latest scientific evidence related to the health benefits, safety and innovations in low/zero calorie sweeteners, with a focus on the newest natural-origin sweetener, stevia," said symposium chair and Global Stevia Institute director, Dr. Priscilla Samuel. Stevia is plant based, zero calorie, and sustainable sweetening ingredient for foods and beverages. It is a new kind of sweetener because stevia is neither like sugar - as it has no calories - nor an artificial sweetener, as it is a natural plant extract, making it ideal for people who want zero calorie sweetness from a natural source. The symposium is open to all registered attendees of the Experimental Biology conference. Featured speakers and topics include: Keith Ayoob, EdD, RD, FADA of Albert Einstein College of Medicine, Bronx, NY and co-chair of the symposium, provides a historical perspective on the development of stevia as a sweetener. Ursula Wölwer-Rieck, PhD, of the University of Bonn, Germany highlights the naturality of stevia leaf extract and emerging innovations. Berna Magnuson, PhD, of Health Science Consultants, Canada, reviews the metabolic fate and safety of stevia leaf extract. Per Bendix Jeppesen, PhD, University of Aarhus, Denmark delves into stevia's impact on blood glucose, diabetes and overall health. Peter Rogers, PhD, University of Bristol, UK addresses the debate of whether low/no-calorie sweeteners help or hurt appetite and weight management. Ian Rowland, PhD, University of Reading, UK looks at the influence of low/no-calorie sweeteners on gut microbiota and interactions. The symposium concludes with a summary and consumer and stevia market insights by chair and Global Stevia Institute director, Priscilla Samuel, Ph.D. The Global Stevia Institute (GSI) provides science-based information about stevia, a plant-based, zero calorie sustainable sweetener of natural origin. The GSI was founded in June 2010, to advance and share scientific research and provide education on stevia for health professionals, scientists, public affairs leaders, consumers and food and beverage manufacturers internationally. GSI is advised by an international board of leading scientists and health professionals. GSI is supported by PureCircle, Ltd., a global leader in purified stevia leaf extract ingredients. For more information, and to sign up to be part of the Stevia Community, visit http://www. .

Stevia is plant based, zero calorie, and sustainable sweetening ingredient for foods and beverages. It is a new kind of sweetener because stevia is neither like sugar – as it has no calories –  nor an artificial sweetener, as it is a natural plant extract, making it ideal for people who want zero calorie sweetness from a natural source. The symposium is open to all registered attendees of the Experimental Biology conference.  Featured speakers and topics include: Keith Ayoob, EdD, RD, FADA of Albert Einstein College of Medicine, Bronx, NY and co-chair of the symposium, provides a historical perspective on the development of stevia as a sweetener. Ursula Wölwer-Rieck, PhD, of the University of Bonn, Germany highlights the naturality of stevia leaf extract and emerging innovations. Berna Magnuson, PhD, of Health Science Consultants, Canada, reviews the metabolic fate and safety of stevia leaf extract. Per Bendix Jeppesen, PhD, University of Aarhus, Denmark delves into stevia's impact on blood glucose, diabetes and overall health. Peter Rogers, PhD, University of Bristol, UK addresses the debate of whether low/no-calorie sweeteners help or hurt appetite and weight management. Ian Rowland, PhD, University of Reading, UK looks at the influence of low/no-calorie sweeteners on gut microbiota and interactions. The symposium concludes with a summary and consumer and stevia market insights by chair and Global Stevia Institute director, Priscilla Samuel, Ph.D. About the Global Stevia Institute The Global Stevia Institute (GSI) provides science-based information about stevia, a plant-based, zero calorie sustainable sweetener of natural origin. The GSI was founded in June 2010, to advance and share scientific research and provide education on stevia for health professionals, scientists, public affairs leaders, consumers and food and beverage manufacturers internationally. GSI is advised by an international board of leading scientists and health professionals. GSI is supported by PureCircle, Ltd., a global leader in purified stevia leaf extract ingredients. For more information, and to sign up to be part of the Stevia Community, visit To view the original version on PR Newswire, visit:

Bijlsma R.,University of Groningen | Loeschcke V.,University of Aarhus
Evolutionary Applications | Year: 2012

Biodiversity is increasingly subjected to human-induced changes of the environment. To persist, populations continually have to adapt to these often stressful changes including pollution and climate change. Genetic erosion in small populations, owing to fragmentation of natural habitats, is expected to obstruct such adaptive responses: (i) genetic drift will cause a decrease in the level of adaptive genetic variation, thereby limiting evolutionary responses; (ii) inbreeding and the concomitant inbreeding depression will reduce individual fitness and, consequently, the tolerance of populations to environmental stress. Importantly, inbreeding generally increases the sensitivity of a population to stress, thereby increasing the amount of inbreeding depression. As adaptation to stress is most often accompanied by increased mortality (cost of selection), the increase in the 'cost of inbreeding' under stress is expected to severely hamper evolutionary adaptive processes. Inbreeding thus plays a pivotal role in this process and is expected to limit the probability of genetically eroded populations to successfully adapt to stressful environmental conditions. Consequently, the dynamics of small fragmented populations may differ considerably from large nonfragmented populations. The resilience of fragmented populations to changing and deteriorating environments is expected to be greatly decreased. Alleviating inbreeding depression, therefore, is crucial to ensure population persistence. © 2011 Blackwell Publishing Ltd.

Tamiola K.,University of Groningen | Mulder F.A.A.,University of Aarhus
Biochemical Society Transactions | Year: 2012

NMR spectroscopy offers the unique possibility to relate the structural propensities of disordered proteins and loop segments of folded peptides to biological function and aggregation behaviour. Backbone chemical shifts are ideally suited for this task, provided that appropriate reference data are available and idiosyncratic sensitivity of backbone chemical shifts to structural information is treated in a sensible manner. In the present paper, we describe methods to detect structural protein changes from chemical shifts, and present an online tool [ncSPC (neighbour-corrected Structural Propensity Calculator)], which unites aspects of several current approaches. Examples of structural propensity calculations are given for two well-characterized systems, namely the binding of α-synuclein to micelles and light activation of photoactive yellow protein. These examples spotlight the great power of NMR chemical shift analysis for the quantitative assessment of protein disorder at the atomic level, and further our understanding of biologically important problems. ©The Authors Journal compilation ©2012 Biochemical Society.

Georgiadis J.R.,University of Groningen | Kringelbach M.L.,University of Oxford | Kringelbach M.L.,University of Aarhus
Progress in Neurobiology | Year: 2012

Sexual behavior is critical to species survival, yet comparatively little is known about the neural mechanisms in the human brain. Here we systematically review the existing human brain imaging literature on sexual behavior and show that the functional neuroanatomy of sexual behavior is comparable to that involved in processing other rewarding stimuli. Sexual behavior clearly follows the established principles and phases for wanting, liking and satiety involved in the pleasure cycle of other rewards. The studies have uncovered the brain networks involved in sexual wanting or motivation/anticipation, as well as sexual liking or arousal/consummation, while there is very little data on sexual satiety or post-orgasmic refractory period. Human sexual behavior also interacts with other pleasures, most notably social interaction and high arousal states. We discuss the changes in the underlying brain networks supporting sexual behavior in the context of the pleasure cycle, the changes to this cycle over the individual's life-time and the interactions between them. Overall, it is clear from the data that the functional neuroanatomy of sex is very similar to that of other pleasures and that it is unlikely that there is anything special about the brain mechanisms and networks underlying sex. © 2012 Elsevier Ltd.

Helgaker T.,University of Oslo | Coriani S.,University of Trieste | Jorgensen P.,University of Aarhus | Kristensen K.,University of Aarhus | And 2 more authors.
Chemical Reviews | Year: 2012

Developments in computational molecular electronic structure theory are discussed, emphasizing on molecular response theory based on construction of a many-electron wave function. To establish a variation principle for the quasi-energy in the intermediate normalization, the quasi-energy is calculated subject to the constraint that the intermediately normalized state satisfies the projected Schrödinger equation. The equations of motion for the response functions is used to obtain relations between transition-matrix elements. The studies have also found that eigenvalues are not encountered for electronic systems dominated by a single determinant and may always be removed by extending the excitation manifold. In the formulation by Olsen and Jørgensen, response functions are obtained by applying the Ehrenfest theorem to determine the time evolution of an expectation value for the Hartree-Fock and multi-configurational self-consistent field (MCSCF) states.

de Almeida A.M.,Instituto Of Investigacao Cientifica Tropical | Bendixen E.,University of Aarhus
Journal of Proteomics | Year: 2012

The pig (Sus scrofa) is one of the most important animal species used for meat production worldwide, playing a fundamental role in numerous cultures from Southern Europe to the Pacific Islands. Additionally, it is broadly used as an experimental animal for several purposes, from physiological studies to drug testing and surgical training. Proteomics studies have covered both physiological and biomedical application studies of pig to a much greater extent than for any other farm animal. Despite this fact, no review seems to be available on the application of proteomics to production aspects in pig. The aim of this article is to provide a review on such applications of proteomics to the pig species. The article is divided in three parts. The first is dedicated to productive characterization and includes aspects related to reproduction and meat science. The second concerns the management of health and disease in production. Finally, the third part concerns the use of the pig as a model organism in biomedical research. This article is part of a Special Issue entitled: Farm animal proteomics. © 2012 Elsevier B.V.

Poulsen T.G.,University of Aalborg | Bester K.,University of Aarhus
Environmental Science and Technology | Year: 2010

Degradation of 12 common organic micropollutants in sewage sludge representing bactericides, flame retardants, fragrances, vulcanizers, and plasticizers (part of many common products) during thermophilic composting was investigated. Micropollutant concentrations, compost temperature, water content, and organic matter content were measured over 24 days in a full-scale compost windrow made from digested sewage sludge, yard waste, and horse manure. Composting took place indoors, and the windrow was turned several times during the experimental period. Concentrations of all 12 micropollutants decreased during composting, and degradation was statistically significant for 7 of the 12 micropollutants. Metabolites (galaxolidone and methyl-triclosan) were produced from two micropollutants (galaxolide and triclosan) during composting, indicating microbial degradation. Pollutant concentrations early in the experiment were more variable than those experienced for the chemical method development. This was likely due to compost heterogeneity. After the second compost turning, concentrations became more stable as compost became more homogeneous. © 2010 American Chemical Society.

Tutenges S.,University of Aarhus | Sandberg S.,University of Oslo
International Journal of Drug Policy | Year: 2013

Aims: To study the characteristics, contexts and implications of drinking stories among young drinkers. Methods: Ethnographic fieldwork was conducted among Danish youth at a beach resort in Bulgaria. The fieldwork included three months of participant observation and 45 semi-structured interviews with a total of 104 tourists and 11 guides. The participants in the study were aged between 16 and 26 years. Results: The participants often shared drinking stories with each other. The stories they told involved alcohol consumption followed by one or several acts of transgression such as stripping, fighting or vomiting. They generally told the stories with amusement or pride. However, some stories were told in a critical tone and focused on negative experiences. The data suggest that for many participants, part of their reason for engaging in heavy drinking and drunken transgressions was that they wanted to build a repertoire of personal drinking stories. Their drinking behaviour was subtly motivated, inspired and guided by the drinking stories that they heard from others, as well as by the drinking stories that they themselves wanted to create. Conclusion: There is an intimate interactional relationship between drinking behaviour and drinking stories. Drinking behaviours can generate stories, but the stories, in turn, influence behaviours and attitudes related to alcohol. Drinking stories are therefore key to understanding drinking among youth. © 2013 Elsevier B.V.

Alemany A.,University of Barcelona | Mossa A.,University of Aarhus | Ritort F.,University of Barcelona | Ritort F.,CIBER ISCIII
Nature Physics | Year: 2012

Recent advances in non-equilibrium statistical mechanics and single-molecule technologies have made it possible to use irreversible work measurements to extract free-energy differences associated with the mechanical (un)folding of molecules. To date, free-energy recovery has been focused on native (or equilibrium) molecular states, but free-energy measurements of kinetic states have remained unexplored. Kinetic states are metastable, finite-lifetime states that are generated dynamically, and play important roles in diverse physical processes. In biophysics, there are many examples in which these states determine the fate of molecular reactions, including protein binding, enzymatic reactions, as well as the formation of transient intermediate states during molecular-folding processes. Here we demonstrate that it is possible to obtain free energies of kinetic states by applying extended fluctuation relations, using optical tweezers to mechanically unfold and refold deoxyribonucleic acid (DNA) structures exhibiting intermediate and misfolded kinetic states. © 2012 Macmillan Publishers Limited. All rights reserved.

Overgaard M.,University of Aalborg | Overgaard M.,University of Aarhus | Sandberg K.,University of Aarhus
Philosophical Transactions of the Royal Society B: Biological Sciences | Year: 2012

In experimental investigations of consciousness, participants are asked to reflect upon their own experiences by issuing reports about them in different ways. For this reason, a participant needs some access to the content of her own conscious experience in order to report. In such experiments, the reports typically consist of some variety of ratings of confidence or direct descriptions of one's own experiences. Whereas different methods of reporting are typically used interchangeably, recent experiments indicate that different results are obtained with different kinds of reporting. We argue that there is not only a theoretical, but also an empirical difference between different methods of reporting. We hypothesize that differences in the sensitivity of different scales may reveal that different types of access are used to issue direct reports about experiences and metacognitive reports about the classification process. © 2012 The Royal Society.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.46M | Year: 2010

The world-wide demand for primary plant products to be used for food, feed and fuel is increasing dramatically. The foreseen climate changes are expected to have a negative impact on plant productivity in addition. Future agriculture urgently needs new crop plant varieties with enhanced and sustainable productivity. To meet this challenge, CropLife focuses on leaf lifespan as a major determinant of plant productivity and aims to develop new breeding strategies for prolonging leaf photosynthesis and delaying senescence processes. The network focuses on barley and perennial ryegrass, which are excellent models for research and crop development in Europe. The CropLife primary objectives will be addressed in the four workpackages. These are: the identification of key factors initiating senescence (1), and proteins regulating leaf lifespan (2), the elucidation of molecular mechanisms of senescence-associated protein degradation and nitrogen remobilization (3), and the analysis of lifespan and exploitation of genetic variation in lifespan in order to breed new varieties with increased productivity (4). CropLife provides intersectorial experience by integrating partners from the public and private sectors. The training programme includes state-ofthe-art local training activities and network-wide courses, summer schools and workshops. Young researchers will be trained in a range of cutting edge research skills, as well as in complementary skills that will enhance their career prospects. Further benefits will arise from secondments in partner laboratories and intersectorial visits to associated partners from the private sector. To guarantee training at the most advanced level, outstanding scientists in the field will be integrated as visiting researchers. Workshops and a final network conference will provide a platform for dissemination of the networks achievements which are expected to increase the competitiveness of European plant research and agriculture.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 6.05M | Year: 2010

Astronomical observations are revealing in ever increasing detail how our Universe works. Existing and planned European investment in sophisticated observational platforms approaches many billions of Euros. However, the observations that can be made on these telescopes would be little more than pretty pictures were it not for the efforts of the experimental and theoretical laboratory astrophysics communities in collaboration with their astronomical colleagues in developing models of our Universe firmly grounded here on Earth. These models recognise the importance of chemical processes in the astronomical environment and the young science of Astrochemistry seeks to understand the rich variety of this chemistry in such a way as to make a significant contribution to us truly understanding the evolution of the modern day Universe. The LASSIE (Laboratory Astrochemical Surface Science in Europe) Initial Training Network seeks to address the key issue of the interaction of the astronomical gas phase with the dust that pervades the Universe. The gas-grain interaction, as it is know, has been recognised by astronomers as crucial in promoting chemistry. The LASSIE ITN brings together the leading European players in experimental and computational surface and solid state astrochemistry, astronomers seeking to understand the detailed role of chemical species in our modern Universe, industrial partners engaged in the development of relevant laboratory instrumentation and experts in public engagement. Through this combination LASSIE will develop capacity in astrochemistry in Europe, produce researchers equipped with a range of specialist and generic skills necessary to engage in a wide range knowledge-based careers and to reach out to all aspects of European society to deliver a positive message in relation to the scientific and technical advancement of Europe.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2008.10.1.2;NMP-2008-2.6-1 | Award Amount: 2.75M | Year: 2009

At present there is no solid state hydrogen storage material available fulfilling all requirements for practical use in mobile applications. These are 1. high storage density, 2. temperatures and heats of operation compatible with PEM fuel cells, 3. high hydrogen loading and unloading speeds in the range of a few minutes and 4. low production costs. FlyHy focuses especially on the first three points while using commercially upscalable materials preparation processes. High hydrogen capacity materials like alane or borohydrides as well as so called Reactive Hydride Composites (mixtures of borohydrides with selected other hydrides), nowadays suffering from too high or too low reaction temperatures and heats, shall be modified by substituting halogens for part of the hydrogen or hydrogen containing complexes. The project partners IFE, GKSS and AU have shown that by this approach novel mixed hydrido-halogenide compounds can be prepared. Fluorine substituted Sodium Alanate exhibited drastically increased desorption pressures at the same reaction temperature or lowered reaction temperatures at the same pressure resp. Targets of the FlyHy project are (i) to exploit these findings on materials destabilisation and stabilisation resp. by halogen substitution for alane, borohydrides and Reactive Hydride Composites , in order to achieve a breakthrough in the thermodynamic properties of these materials exhibiting the highest hydrogen capacities known at present, (ii) to obtain an in depth scientific understanding of the sorption properties of the substituted materials by extended structural and thermodynamical characterisation and modelling, for materials optimisation, (iii) determine tank relevant materials properties like e.g. densification behaviour and heat conductivity, and, if applicable, do first tests in a prototype tank.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.97M | Year: 2013

COMIQ (COld Molecular Ions at the Quantum limit) will investigate how cooling, trapping, and control techniques applied molecular ion can expand the realm of quantum technology, enhance precision meaurements on molecular systems and lead to chemistry at the ultracold quantum limit.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.46M | Year: 2015

BigDataFinance, a Marie Skodowska-Curie Innovative Training Network Training for Big Data in Financial Research and Risk Management, provides doctoral training in sophisticated data-driven risk management and research at the crossroads of Finance and Big Data for 13 researchers. The main objectives are i) to meet an increasing commercial demand for well-trained researchers experienced in both Big Data techniques and Finance and ii) to develop and implement new quantitative and econometric methods for empirical finance and risk management with large and complex datasets. To achieve the objectives, the emphasis is put on exploiting big data techniques to manage and use datasets that are too large and complex to process with conventional methods. Banks and other financial institutions must be able to manage, process, and use massive heterogeneous data sets in a fast and robust manner for successful risk management; nonetheless, financial research and training has been slow to address the data revolution. Compared to the USA, Europe is still at an early stage of adopting Big Data technologies and services. Immediate action is required to seize opportunities to exploit the huge potential of Big Data within the European financial world. This world-class network consists of eight academic participants and six companies, representing banks, asset management companies, and data and solution providers. The proposed research is relevant both academically and practically, because the program is built around real challenges faced both by the academic and private sector partners. To bridge research and practice, all researchers contribute to the private sector via secondments. BigDataFinance provides the European financial community with specialists with state-of-the-art skills in finance and data-analysis to facilitate the adoption of reliable and realistic methods in the industry. This increases the financial strength of banks and other financial institutions in Europe.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: KBBE-2009-2-5-03 | Award Amount: 1.18M | Year: 2009

The core relevance of transparency as a critical success factor and the need for the delivery of appropriate support by research has been emphasized in the Strategic Research Agenda (SRA) of the European Technology Platform Food for Life from where this proposal evolved. It utilizes its links with the European-wide network of more than 30 National Technology Platforms to link up with stakeholders of the food chain including industry, consumers, research, and sector representatives of different European countries. The complexities in reaching transparency are due to complexities in products and processes but also due to the dynamically changing open network organization of the food sector with its multitude of SMEs, its cultural diversity, its differences in expectations, its differences in the ability to serve transparency needs, and its lack of a consistent appropriate institutional infrastructure that could support coordinated initiatives towards higher levels of transparency throughout the food value chain. The project focus is on the analysis, documentation, and dissemination of our present knowledge (including from literature, expert knowledge, and best practice experiences) on transparency solutions and needs, their realization through chain communication schemes and the implementation environment required for the uptake of solutions and their success. The integration of the knowledge into a standardized general framework provides the basis for a GAP analysis that identifies a Strategic Research Agenda for future research that could have a major impact on the establishment of European transparency schemes.

Agency: GTR | Branch: NERC | Program: | Phase: Research Grant | Award Amount: 1.82M | Year: 2015

The impacts of climate change, and warming in particular, on natural ecosystems remain poorly understood, and research to date has focused on individual species (e.g. range shifts of polar bears). Multispecies systems (food webs, ecosystems), however, can possess emergent properties that can only be understood using a system-level perspective. Within a given food web, the microbial world is the engine that drives key ecosystem processes, biogeochemical cycles (e.g. the carbon-cycle) and network properties, but has been hidden from view due to difficulties with identifying which microbes are present and what they are doing. The recent revolution in Next Generation Sequencing has removed this bottleneck and we can now open the microbial black box to characterise the metagenome (who is there?) and metatranscriptome (what are they doing?) of the community for the first time. These advances will allow us to address a key overarching question: should we expect a global response to global warming? There are bodies of theory that suggest this might be the case, including the Metabolic Theory of Ecology and the Everything is Everywhere hypothesis of global microbial biogeography, yet these ideas have yet to be tested rigorously at appropriate scales and in appropriate experimental contexts that allow us to identify patterns and causal relationships in real multispecies systems. We will assess the impacts of warming across multiple levels of biological organisation, from genes to food webs and whole ecosystems, using geothermally warmed freshwaters in 5 high-latitude regions (Svalbard, Iceland, Greenland, Alaska, Kamchatka), where warming is predicted to be especially rapid,. Our study will be the first to characterise the impacts of climate change on multispecies systems at such an unprecedented scale. Surveys of these sentinel systems will be complemented with modelling and experiments conducted in these field sites, as well as in 100s of large-scale mesocosms (artificial streams and ponds) in the field and 1,000s of microcosms of robotically-assembled microbial communities in the laboratory. Our novel genes-to-ecosystems approach will allow us to integrate measures of biodiversity and ecosystem functioning. For instance, we will quantify key functional genes as well as quantifying which genes are switched on (the metatranscriptome) in addition to measuring ecosystem functioning (e.g. processes related to the carbon cycle). We will also measure the impacts of climate change on the complex networks of interacting species we find in nature - what Darwin called the entangled bank - because food webs and other types of networks can produce counterintuitive responses that cannot be predicted from studying species in isolation. One general objective is to assess the scope for biodiversity insurance and resilience of natural systems in the face of climate change. We will combine our intercontinental surveys with natural experiments, bioassays, manipulations and mathematical models to do this. For instance, we will characterise how temperature-mediated losses to biodiversity can compromise key functional attributes of the gene pool and of the ecosystem as a whole. There is an assumption in the academic literature and in policy that freshwater ecosystems are relatively resilient because the apparently huge scope for functional redundancy could allow for compensation for species loss in the face of climate change. However, this has not been quantified empirically in natural systems, and errors in estimating the magnitude of functional redundancy could have substantial environmental and economic repercussions. The research will address a set of key specific questions and hypotheses within our 5 themed Workpackages, of broad significance to both pure and applied ecology, and which also combine to provide a more holistic perspective than has ever been attempted previously.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2011.1.2-02 | Award Amount: 4.16M | Year: 2011

The objective driven goal of this SME targeted project is to improve the currently used compost and biochar treatment systems, towards advanced, efficient and comprehensive bio-waste treatment and nutrient recovery process with zero emission performance. The improved output products are safe, economical, ecological and standardized compost and bio-char combined natural fertilizers and soil amendment agricultural products used by farmers. The added value and energy efficient transformation of urban organic waste, farm organic residues and food industrial by-product streams made by improved carbonization, biotechnological formulation and upgraded composting technologies, with particular attention to the recovery of nutrients, such as phosphorous and nitrogen. The targeted high quality output products aiming to reduce mineral fertilizers and intensive chemicals use in agriculture; enhancing the environmental, ecological and economical sustainability of food crop production; reducing the negative footprint of the cities and overall contributing to climate change mitigation. In this context the improved bio-waste treatment process opens new technical, economical, environmental and social improvement opportunities, while improving the use, effectiveness and safety of the resulting compost and bio-char products in agriculture. The output products developed in a standardized way to meet all industrial, agricultural and environmental norms and stands in European dimension. Proactive and coherently integrated cooperation made between multi level stakeholder in Europe, with result oriented potential benefit to SMEs and farmers for more efficient utilization of the final products by the end-users. The project is providing strong support for policy makers for the revision of relevant policies, while setting up future common bio-waste recycling targets, common quality standard requirements for bio-waste treatment, compost and bio-char quality and trading requirements.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-26-2014 | Award Amount: 4.95M | Year: 2015

Most adults who try to lose weight fail to maintain it. Obesity is a key economic and healthcare challenge for Europe. Effective interventions and commercial programmes for weight loss are widely available, but most people re-gain their lost weight. Currently few comprehensive solutions exist to help Europeans manage weight loss maintenance (WLM). Current research suggests the most promising evidence-based behaviour change techniques for WLM are self-monitoring, goal setting, action control, building self-efficacy and intrinsic motivation. Recent research also suggests that stress management and emotion regulation skills are key enablers of relapse prevention and weight-regain. Information technology offers attractive tools for teaching and supporting these techniques, some of which are currently delivered through resource-intensive face-to-face therapies. ICT-delivery includes networked-wireless tracking technologies, weighing-scales and activity sensors, online tools and smart-phone apps, multi-media resources and internet-based support. A broad choice of tools is most likely to be acceptable to users, who can pick and choose their own preferred technologies. The NoHoW project tests whether ICT-based delivery of the most promising evidence-based behavior change techniques is effective for WLM. We will carry out a large-scale international 3-centre trial of information technology tools that implement the most up-to-date behavioural science research. This trial will establish the effectiveness of these ICT tools in supporting WLM, linked to studies of European consumer needs and behaviour. Impact: The project will directly feed results into development of new products and services from the UKs largest commercial weight-loss provider, Slimming World providing immediate benefit to 500,000\ consumers. Commercialisation of project results will provide much needed WLM services that promote health education and long-term weight management programmes.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2011.3.5-01 | Award Amount: 7.78M | Year: 2011

The project aims at 1 providing baseline data on biodiversity in agro-ecosystems in the EU, 2 translating regional protection goals in measurable assessment endpoints, 3 defining lists of suitable bioindicators for various European regions, 4 improving knowledge on potential long term environmental effects of genetically modified plants (GMPs), 5 testing the efficacy of the EFSA Guidance Document (GD) for the Environmental Risk Assessment (ERA) of GMPs, 6 exploring new strategies for post market monitoring, 7 estimating the compatibility of GMPs with the Integrated Pest Management (IPM) principles implemented in the EU, 8 providing a systematic analysis of economical aspects of GMPs cultivation in the EU, and 9 setting a training and communication plan addressing public concerns about GMPs. The consortium includes 22 partners (Research institutes, Universities, State Agencies and SMEs) located in 15 EU countries and. An ICPC country (Argentina) will contribute in validating the monitoring methodology in areas where GM crops are cultivated on larger scales. A cornerstone is the application of the EFSA ERA GD, which is the basis for the update of the regulatory process of GMPs in the EU. The GD has provided ecologically sound principles for ERA, triggering the need of practically testing them. Partners of the consortium participated to the preparation of GD and 3 of them are senior authors of relevant chapters. The scientific activities will consist of case studies of maize and potato, the two GM crops currently approved for cultivation in the EU, and surveys in non-GM agro-ecosystems. The final outcome will include a network of EU representative sites for pre-market risk assessment and long-term monitoring studies, a set of standardised testing methods and a geographical information system integrating relevant datasets, protocols and tools to help EU decision-makers. To be implemented in 4 years, the project estimated costs are 7779852.15 , requested grant 5997963 .

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.2.3.2-2 | Award Amount: 7.84M | Year: 2013

Extensive clinical and epidemiological data clearly shows that chronic periodontal disease (PD), the most prevalent infectious inflammatory disease of mankind, is strongly linked to systemic inflammatory diseases such as cardiovascular diseases (CVD) , rheumatoid arthritis (RA) , and chronic obstructive pulmonary disease (COPD) . Taking into account that up to 30% of the adult population worldwide suffers from severe periodontitis , the impact of this disease on human health is immense and has been recognized by World Health Organization . Nevertheless, in many EU countries PD is a neglected disease, both by the population in general and health-care personnel. Often this negligence comes to the point that, like a hair-loss, the tooth-loss due to periodontitis is still considered as a normal inevitable event associated with aging. To combat this misconception and conceive novel approaches to prevent and/or treat CVD, RA, and COPD we will explore highly innovative ideas that these non-communicable diseases are at least aggravated, if not initiated, by periodontal infection. Results emanating from our project will: i) elucidate a relationship between the presence of specific periodontal pathogens and severity of systemic diseases; ii) show that extensive periodontal treatment improves clinical parameters of investigated systemic diseases; iii) reveal the impact of eradication of specific periodontal pathogen on the level of inflammatory markers; iv) develop novel, periodontal-pathogen specific bactericidal compounds based on periodontal glutaminyl cyclase (QC), the enzyme essential for these pathogens vitality. This will reduce mortality and ameliorated quality of life of CVD, RA, and COPD patients. All of these will be possible based on the knowledge of mechanisms beyond the causative links between specific pathogen driven periodontal disease and CVD, RA, and COPD revealed by research program outlined in this project.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: WATER-1a-2014 | Award Amount: 3.46M | Year: 2015

iMETland project aims to construct and validate a full-scale application of a eco-friendly device to treat urban wastewater from small communities at zero-energy operation cost. Our concept comes from the integration of Microbial Electrochemical Technologies (MET) with the biofilters used in constructed wetlands. iMETland outperforms classical biofilters from constructed wetlands by using electroactive bacteria in combination with a innovative electroconductive material to achive depuration rates that are 10-fold higher than classical techniques. On top of that, the low biomass yield generated under electrogenic conditions avoids any bed colmatation. Wastewater will be also converted into pathogen-free water suitable for irrigation by using an electro-oxidative methodology. Furthermore, the unique conversion of sewage treatment into electric current by electricity-producing bacteria makes such a process an internal reporter of the biological depuration process. So thus, it can be used as output signal to control the process and can easily inform the operator through ICT tools, converting the depuration in an interactive process between device and a smart-phone in end-users hands. iMETland try to fill the gap that was sharply identified by the programme topic: WATER-1-2014/2015: Bridging the gap: from innovative water solutions to market replication. Our solution has already passed both research and pilot scale and is ready to try a full-scale demonstration to accelerate the market uptake. The multidisciplinary nature of iMETland makes it to fit well with the water and wastewater treatment priority of the EIP-water. Moreover, the coordinator of iMETland consortium is also the Technical Manager of a recent ACTION GROUP at EIP-WATER called MEET-ME4WATER, Meeting Microbial Electrochemistry for Water. This AG focuses on overcoming the barriers to scaling up and demonstrate microbial electrochemical technologies (METs) and bring them faster to the market.

Agency: European Commission | Branch: FP7 | Program: CSA-ERA-Plus | Phase: KBBE.2013.1.4-06 | Award Amount: 9.09M | Year: 2013

Organic agriculture is considered to be one of the important development pathways for improving agricultures relation with the environment while at the same time ensuring food safety and future food security. This role is dependent on continuous research and innovation. CORE Organic Plus will continue, update and consolidate the series of transnational research calls which support a focused and coordinated research and innovation effort covering the most important and pertinent challenges along the organic value chains. Moreover, the effort will - where relevant - combine research and innovation in primary production with development in processing techniques, value adding and market and consumer research. Thematic research areas for a joint call will be selected by the participating national funding bodies and the European Commission and in consultation with national and transnational stakeholders such as TP Organics. The CORE Organic network will be expanded with Romania and Poland, and 22 countries are taking part in the Plus call. One large joint call with 3-4 thematic areas will be launched with co-funding from the Commission. Moreover, within the Plus project, the partners will prepare for the next research programme based on an update of the priorities for research and innovation. The project will assist and advise the on-going and initiated research and innovation projects in their stakeholder involvement and dissemination efforts in order to secure high impact of the research and innovation efforts. The impact of the research and the increased monitoring efforts will be assessed after the end of the projects. Looking to the future, CORE Organic Plus aims to further improve the European Research Area by delivering results that can be used to develop the organic sector throughout Europe and the world.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2007. | Award Amount: 4.20M | Year: 2009

Tropical forests harbour thousands of useful plants which are harvested and used in subsistence economies or traded in local, regional or international markets. The effect on the ecosystem is little known, and the forests resilience is badly understod. Palms are the most useful group of plants in tropical American forests and we will study the effect of extraction and trade of palms on forest in the western Amazon, the Andes and the Pacific lowlands. We will determine the size of the resource by making palm community studies in the different forest formations and determine the number of species and individuals of all palm species. The genetic structure of useful palm species will be studied to determine how much harvesting of the species contributes to genetic erosion of its populations, and whether extraction can be made without harm. We then determine how much palms are used for subsistence purposes by carrying out quantitative, ethnobotanical research in different forest types and then we study trade patterns for palm products from local markets to markets which involve export to other countries and continents. Palm populations are managed in various ways from sustainable ones to destructive harvesting; we will study different ways in which palms are managed and propose sustainable methods to local farmers, local governments, NGOs and other interested parties. Finally we will study national level mechanism that governs extraction, trade and commercialization of palm products, to identify positive and negative policies in relation to resilience of ecosystems and use this to propose sustainable policies to the governments. The results will be diseminated in a variety of ways, depending on need and stake holders, from popular leaflets and videos for farmers, reports for policy makers to scientific publication for the research community. The team behind the proposal represents 10 universities and research institutions in Europe and northwestern South America.

Agency: European Commission | Branch: H2020 | Program: ERA-NET-Cofund | Phase: SC5-15-2015 | Award Amount: 52.36M | Year: 2016

In the last decade a significant number of projects and programmes in different domains of environmental monitoring and Earth observation have generated a substantial amount of data and knowledge on different aspects related to environmental quality and sustainability. Big data generated by in-situ or satellite platforms are being collected and archived with a plethora of systems and instruments making difficult the sharing of data and knowledge to stakeholders and policy makers for supporting key economic and societal sectors. The overarching goal of ERA-PLANET is to strengthen the European Research Area in the domain of Earth Observation in coherence with the European participation to Group on Earth Observation (GEO) and the Copernicus. The expected impact is to strengthen the European leadership within the forthcoming GEO 2015-2025 Work Plan. ERA-PLANET will reinforce the interface with user communities, whose needs the Global Earth Observation System of Systems (GEOSS) intends to address. It will provide more accurate, comprehensive and authoritative information to policy and decision-makers in key societal benefit areas, such as Smart cities and Resilient societies; Resource efficiency and Environmental management; Global changes and Environmental treaties; Polar areas and Natural resources. ERA-PLANET will provide advanced decision support tools and technologies aimed to better monitor our global environment and share the information and knowledge in different domain of Earth Observation.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH.2013.2.1-1 | Award Amount: 5.99M | Year: 2014

Typically, end users or consumers are perceived as adopters of sustainable products and services, developed by companies. Thus, a lot of attention is paid to the (non-) diffusion of sustainable products and services. From this perspective end users are seen as more or less passive recipients of sustainable products and services. We propose to investigate the active roles of end users in shaping sustainable lifestyles and the transition to a green economy in Europe. More specifically, we suggest exploring, explaining and enhancing the role of end users in (co-) innovating novel sustainable products, services, and systems (Sustainable Lifestyles 2.0). Generally, there are two options: First, end users are integrated in the process of sustainability innovations driven by companies (user integration). Second, end users innovative for themselves, and eventually form enterprises to capture value from their sustainability innovations (user innovation and entrepreneurship). We argue that end user integration, innovation and entrepreneurship offer great potentials for smart, sustainable and inclusive growth in the upcoming years, which is largely untapped and unexplored. While acknowledging the value of company-driven sustainability innovations, we want to investigate pathways towards a sustainable society, which is more user-centred and user-driven. We aim to gain a better and broadened understanding of the active roles of end users in sustainability innovation processes with a special emphasis on the four domains food, living, mobility, and energy. These domains are responsible for the highest life cycle environmental impacts related to the final consumption, and put together shape sustainable lifestyles in Europe.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-2.1.1-5 | Award Amount: 15.72M | Year: 2008

The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infrastructure for scientists characterising channel and transport functions in man and pathogenic microorganisms. Our experts in the analyses of all the databases of these membrane proteins and molecular modelling will work with our industrial partners on specific targets chosen for their potential to improve the health of European citizens, increase the competitiveness of European health-related industries and businesses and address global health issues. EDICT will increase knowledge of biological processes and mechanisms involved in normal health and in specific disease situations, and transpose this knowledge into clinical applications. By combining computational and experimental analyses, existing detailed molecular models of channel and transporter proteins, and novel structures derived by our partners, will be analysed to identify the critical regions constituting drug targets. These basic discoveries will be translated via in silico and experimental strategies with our industrial partners into the design of novel drugs that modify activities of the membrane proteins for the benefit of the patients. The range of human proteins covered includes potassium channels, anion and cation transporters, neurotransmitter transporters, cation-transporting ATPases and mitochondrial transporters. Structures of bacterial homologues to the human proteins are exploited to inform the studies of their human counterparts

Agency: GTR | Branch: NERC | Program: | Phase: Research Grant | Award Amount: 510.21K | Year: 2014

The Atlantic Oceans conveyor belt circulation is a fundamental component of the global climate system, transporting heat from low to high latitudes, and thus warming Northern Europe. The strength of this circulation is thought to have varied abruptly in the past, giving rise to rapid climate changes of more than 10 degrees C in a decade during the last glacial period. Changes of this nature today would have a severe impact on society, so we want to know more about the sensitivity of this circulation. In order to do this, we will study intervals of rapid climate and circulation change in the past. To better understand these past circulation changes we will reconstruct the concentration of radiocarbon in surface and deep waters in the North Atlantic Ocean. This is known as a radiocarbon reservoir age, and it is highly sensitive to the rate of ocean circulation. Therefore, by reconstructing reservoir ages, we can tell how quickly the ocean was circulating during intervals of rapid climate change. We also need to know what the reservoir age was in the past if we want to use radiocarbon as a dating tool, to tell the age of geological and archeological objects and events. Radiocarbon can be thought of as a stopwatch for a geological sample. For a marine sample, however, there is already some time on the clock when we press go. This extra time before starting the clock is the reservoir age, and we must know what it is in order to accurately tell geological time. By reconstructing reservoir ages, we will therefore improve understanding of rapid circulation and climate change, and also improve the most important dating tool used in earth and archeological sciences. To reconstruct radiocarbon reservoir ages we need to measure the radiocarbon content of a sample, and also to know its age independently, so we can work out what was already on the clock when the sample formed. To do this we will make radiocarbon measurements on shells taken from sediment cores from the North Atlantic, and pair them with a range of exciting new techniques that can tell their age. Firstly we will look for layers of volcanic ash in the sediment cores, which we can date using their argon content, and match to precisely dated ash layers in ice cores and on Iceland. Secondly we can look at changes in sea surface temperature records, and match these to the same events that are precisely dated in ice cores. Thirdly we will use the concentration of thorium in sediments to tell how much sediment accumulated between these ash and temperature tie points. Fourthly, we will combine all this information using statistical modelling, which will also provide a good measure of the uncertainty in our results. This work will create maps of reservoir ages and how they changed in the North Atlantic over the last 10 to 50 thousand years, with a special focus on times of rapid climate change. To help us link the reservoir ages to different circulation regimes, we will use a climate model that can simulate radiocarbon. We will make this models ocean circulation operate in different ways, and see which circulations best match our data. This will allow us to better understand how ocean circulation changed in the past to cause rapid climate change, and improve confidence in how ocean circulation may operate in the future. Finally, we will package our reservoir age maps into a tool that can be used by earth scientists and archeologists to improve their radiocarbon dating.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.3.5 | Award Amount: 4.18M | Year: 2012

LIPHOS is focused on the development of completely innovative biophotonic diagnosis tools, which are for the first time implemented using cells as constituent material. Here, and unlike existing systems, light remains confined in a waveguide whose core is uniquely composed by cells, giving rise to the Living photonics concept. In this context, cells play a two-fold role: i) they form the biomaterial with higher refractive index than the surrounding media, thus defining the waveguide; ii) they are interrogated by the light coupled into them, acting as reporter elements and exhibiting a specific spectral response. The advantage of this configuration is the highly-efficient cell-light interaction, making it possible to diagnose diseases by measuring and comparing their photonic fingerprint (PIN). This key parameter, newly introduced in LIPHOS, consists of the spectral response of the living photonics and includes the different inherent or acquired bands and peaks (scattering, absorbance and/or fluorescence) directly related to the cell culture under study. This is highly specific, since healthy and non-healthy cell cultures present different PINs. This ground-breaking method will give rise to a powerful analytical tool, which could be applied to study and diagnose a disease at cell culture level. The ultimate aim of the LIPHOS project is the diagnosis of cardiovascular diseases (CVD). This target will be addressed firstly by measuring adherent cell layers cultured under controlled conditions and representing disease or healthy states. At a later stage, the LIPHOS concept will undergo pre-clinical validation as a diagnostic tool for CVD, using arterial segments obtained from patients with known endothelial dysfunction.\nLIPHOS provides a realistic, yet innovative and game-changing opportunity of reducing the impact of CVD in society and in the global economy, as well as providing huge market possibilities to the companies involved.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 4.57M | Year: 2011

The central goal of the COHERENCE network is the training of Early Stage Researchers (ESRs) and Experienced Researchers (ERs) to the highest level of international excellence within the rapidly growing field of electronically highly excited (Rydberg) gases and aggregates. The systems range from single atoms to large mesoscopic ensembles with full control over motional and internal degrees of freedom. Recent scientific progress has primarily been made by a number of European experimental and theoretical groups which are all assembled within the network. The field of Rydberg gases is at the crossroads between various scientific areas, including condensed matter physics, biophysics, molecular physics, quantum optics and quantum information, surface science, plasma physics, and laser technology. As perspective applications of Rydberg systems are already in sight, two optics and laser development companies have joined the network delivering technological expertise and in-depth training in business matters. The elaborate and well-structured training programme includes a schedule of workshops, schools, and conferences. The training will be strongly focused on the individual researchers by assigning each of them an international Thesis Advisory Board and by designing Individual Career Development Plans. Based on the interdisciplinary character of the research, the training content will include a blend of broad scientific, technological, and complimentary skills providing excellent perspectives for successful careers in both academia and industry. ESRs will also profit from the extensive exchage programme among the participating teams based on cotutelles, short- and long-term secondments. The COHERENCE network will thus ensure that Europe maintains the leading role within an important area of research and will stimulate transformation of the generated knowledge into new technologies.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.6.1 | Award Amount: 5.38M | Year: 2014

The consortium behind the SEMIAH project aims to pursue a major technological, scientific and commercial breakthrough by developing a novel Information and Communication Technology (ICT) infrastructure for the implementation of Demand Response (DR) in households. This infrastructure enables the shifting of energy consumption from high energy-consuming loads to off-peak periods with high generation of electricity from Renewable Energy Sources (RES). The projects innovative approach is based on the development of an open ICT framework that will promote an environment for the deployment and innovation of smart grid services in households. A centralised system for DR service provisioning based on aggregation, forecasting and scheduling of electricity consumption will be developed. Furthermore, the project delivers a DR solution for control of electrical loads at a competitive price. The solution consists of a number of smart plugs that can be controlled over a home area network through a gateway connected to a wide area network. The consortium will integrate security and privacy functions to ensure that the system cannot be compromised. Finally, the consortium will develop new business models for electricity players and residential customers to quantify costs and benefits for players in the value chain. SEMIAH will provide benefits to residential customers, energy utilities and the society in general, through lower electricity bills, improved integration of RES and higher stability of the electricity grid. Hereby, the project will enable savings in CO2 emissions and fuel costs and reduce investments in electricity network expansions and electricity peak generation plants. The consortium of 12 partners from 4 different European countries, coming from ICT (Aarhus University, Centre Suisse DElectronique et de Microtechnique, University of Agder and Haute Ecole Specialisee de Suisse Occidentale), Energy (Fraunhofer IWES, Agder Energi Nett, SEIC Teledis, EnAlpin, Misurio and Develco Products) and Telecommunications (Devoteam Solutions and netplus) jointly possess the technological skills and competencies needed to overcome the identified challenges and to drive this ambitious project to successful result.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2010.2.2.1-1 | Award Amount: 9.65M | Year: 2010

EURO-BASIN is designed to advance our understanding on the variability, potential impacts, and feedbacks of global change and anthropogenic forcing on the structure, function and dynamics of the North Atlantic and associated shelf sea ecosystems as well as the key species influencing carbon sequestering and ecosystem functioning. The ultimate goal of the program is to further our capacity to manage these systems in a sustainable manner following the ecosystem approach. Given the scope and the international significance, EURO-BASIN is part of a multidisciplinary international effort linked with similar activities in the US and Canada. EURO-BASIN focuses on a number of key groups characterizing food web types, e.g. diatoms versus microbial loop players; key species copepods of the genus Calanus; pelagic fish, herring (Clupea harengus), mackerel (Scomber scombrus), blue whiting (Micromesistius poutassou) which represent some of the largest fish stocks on the planet; piscivorous pelagic bluefin tuna (Thunnus thynnus) and albacore (Thunnus alalunga) all of which serve to structure the ecosystem and thereby influence the flux of carbon from the euphotic zone via the biological carbon pump. In order to establish relationships between these key players, the project identifies and accesses relevant international databases and develops methods to integrate long term observations. These data will be used to perform retrospective analyses on ecosystem and key species/group dynamics, which are augmented by new data from laboratory experiments, mesocosm studies and field programs. These activities serve to advance modelling and predictive capacities based on an ensemble approach where modelling approaches such as size spectrum; mass balance; coupled NPZD; fisheries; and end to end models and as well as ecosystem indicators are combined to develop understanding of the past, present and future dynamics of North Atlantic and shelf sea ecosystems and their living marine resources.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2008-1.1.1 | Award Amount: 11.53M | Year: 2009

Europe has the largest and most advanced system of synchrotrons and free electron lasers (FELs): 17 operating facilities, several under construction, some 300 beamlines, 25,000-30,000 users per year from many disciplines (materials, chemistry, biology, medicine, physics, technology and others); this is also the worlds largest experimental network. The system is an open resource for all scientists based on merit, without national barriers. The network and its bottom-up approach to transnational access are major factors in the European competitiveness in science and technology. The European Commission had a major role in this accomplishment by providing through different channels resources for joint activities and transnational access. The present proposal is will enhance this role guaranteeing full exploitation of the research infrastructure by European scientists. The specific objectives are: (1) to provide resources for a concrete transnational access independent of the financial situation of the concerned users; (2) to support joint research activities to build new capacities in existing research infrastructures to even better serve the transnational user community and make European synchrotrons and FELs even more competitive with respect to the USA, Japan and others. In addition, (3) networking activities - schools, workshops, documentation, standards and public dissemination - will boost cooperation in the network and its positive effects in Europe and beyond. The requested financial support is much smaller than the overall funding of the network but its impact is major, benefiting some 10,000 scientists in Europe. Transnational access is crucial for researchers from less-favored countries new EU members in particular. The concrete access front-line instruments without emigration and brain drain is a key effect of the open access to the European synchrotrons and FELs. Similarly positive is the impact on junior researchers and women scientists.

Agency: European Commission | Branch: FP7 | Program: NOE | Phase: ICT-2007.1.1 | Award Amount: 20.70M | Year: 2008

Future networks became a central topic with a large debate whether moving towards the new networked society will be evolutionary or disruptive. In the future networked society the physical and the digital worlds will merge based on the massive usage of wireless sensor networks. Objects will be able to identify and locate themselves and to communicate through radio interfaces. Self-organized edge networks will become more and more common. Virtualization and programmability will allow for providing different networking environments over the same infrastructure. Autonomic networking will deal with the increasing complexity of IandC systems. End-users empowerment will increase with his capacity of providing services and content, as well as connectivity support.\nThis new environment forces the scientific community to develop new principles and methods to design/dimension/control/manage future multi-technology architectures. The new paradigms raise new challenging scientific and technological problems embedded in complex policy, governance, and worldwide standards issues. Dealing with the diversity of these scientific and socio-economic challenges requires the integration of a wide range of research capacities; a role that Euro-NF will fulfil.\nIndeed, Euro-NF extends, in scope and duration, the successful Euro-NGI/FGI NoE that has integrated the required critical mass on the networks of the future and is now a major worldwide player in this area. The consortium has evolved in order to have an optimal coverage of the new scope. Euro-NF will therefore cover the integration of a wide range of European research capacities, including researchers and research and dissemination activities. As such Euro-NF will continue to develop a prominent European center of excellence in Future networks design and engineering, acting as a Collective Intelligence Think Tank, representing a major support for the European Society leading towards a European leadership in this area.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 4.30M | Year: 2011

TESIS, Towards an Embodied Science of InterSubjectivity, is an integrated ITN programme to investigate the foundations of human sociality. It brings together the complementary expertise of 13 European research institutes, clinical centres and private enterprises that span the biomedical sciences and the humanities. Thus, TESIS provides critical mass in the fields of philosophy, cognitive neuroscience, developmental psychology, psychiatry and societal outreach. It will advance our understanding of human intersubjectivity based on the following research and training objectives: (1) To investigate the neural underpinnings of affective exchange with others, of shared action spaces and joint object relations, endorsing a novel interactive embodied neuroscience; (2) To investigate the development of social skills in infants in the context of the awareness of others during interaction, yielding an interactive concept of embodied social cognition; (3) To investigate the intersubjective factors affecting psychopathologies, especially schizophrenia, autism and somatoform disorders and to draw implications for treatment; (4) To investigate in toddlers and young children the understanding of toys, objects and cultural artefacts and the links between materiality and sociality; (5) To investigate cultural interactive patterns and shared practices such as group learning, playing, teamwork, distributed cognition, creating applied knowledge for education, management, and organizational development. By integrating state of the art and novel approaches to studying interactive situations, TESIS will significantly extend the individualistic and static paradigm still dominant in social cognition research. The major breakthrough to be expected from TESIS is a comprehensive framework for embodied intersubjectivity applicable in the biomedical sciences, the humanities, and society in general, showing how we become human by embodied interaction with others from the beginning.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2008. | Award Amount: 6.55M | Year: 2009

The broad interdisciplinary consortia assembled in the Arctic Tipping Points (ATP) project will be managed (WP1) to identify the elements of the Arctic marine ecosystem likely to show abrupt changes in response to climate change, and establish the levels of the corresponding climate drivers inducing the regime shift for these tipping elements. ATP will evaluate the consequences of crossing those tipping points, and the associated risks and opportunities for economic activities dependent on the Arctic marine ecosystem. Historical records of Arctic climate change and projections of future changes in Arctic sea climate and ice systems are compiled (WP2), and time series of Arctic ecosystem components analysed using novel statistical tools to detect regime shifts and ecological thresholds and tipping points, and evaluate their sensitivity to climatic forcing (WP3). Experimental manipulations and comparative analyses across broad climatic ranges will be used to detect climatic thresholds and tipping points of Arctic organisms and ecosystems, using genome-wide analyses to develop genomic markers of climate-driven stress useful as early-warning indicators of the proximity of tipping points (WP4). A biological-physical coupled 3 D model will be used to generate future trajectories of Arctic ecosystems under projected climate change scenarios and to identify their consequences for the Arctic ecosystem (WP5). The impacts of abrupt changes in the Arctic ecosystems for activities of strategic importance for the European Arctic and the associated impacts on employment and income will be elucidated, and policies and legislative frameworks to adapt and mitigate these impacts will be analysed (WP 6). The effectiveness of possible alternative, post-Kyoto policies and stabilization targets in avoiding climate-driven thresholds in the Arctic ecosystem will be examined, and the results and projections will be conveyed to policy makers, economic sectors and the public in general (WP7).

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.2-1 | Award Amount: 11.66M | Year: 2014

MARS will support managers and policy makers in the practical implementation of the WFD, of related legislation and of the Blueprint to Safeguard Europes Water Resources by conducting new research and synthesising existing knowledge concerning effects and management of multiple stressors in surface water and groundwater bodies; by advising the 3rd RMBP cycle and the revision of the WFD; and by developing new integrated tools for diagnosing and predicting multiple stressors in water resource management. The consortium includes 19 research institutes and five water boards and environment agencies. MARS will engage with ongoing and finalised European initiatives addressing related topics, thus acting as an integrating project. Work will be organised at the scales of water bodies, river basins and Europe; at each scale there is a direct link to water managers and decision makers. Nested within the scale structure, we will employ a suite of methods: flume and mesocosm experiments to better understand the effects of selected stressor combinations with a focus on extremes and hydrological stress; linkage of abiotic and biotic models to predict effects of stressor combinations at a river basin scale; large-scale data analysis employing existing databases, but including additional variables, to gain a Europe-wide overview of stress, status and ecosystem services. MARS will be composed of eight workpackages (WPs). While WP1 will be responsible for overall coordination, WP2 will provide tools, concepts and scenarios for the other WPs. WPs 3-5 will analyse and predict multiple stressor-impact relationships on three scales: water bodies (WP3), river basins (WP4) and Europe (WP5); the results will be synthesised across scales by WP6. WP7 will generate a wiki information system and produce or improve tools addressing the three scales. WP8 will communicate with river basin districts and Common Implementation Strategy (CIS) groups and will advise the WFD revision.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.3-1 | Award Amount: 13.58M | Year: 2013

SUN (Sustainable Nanotechnologies) is the first project addressing the entire lifecycle of nanotechnologies to ensure holistic nanosafety evaluation and incorporate the results into tools and guidelines for sustainable manufacturing, easily accessible by industries, regulators and other stakeholders. The project will incorporate scientific findings from over 30 European projects, national and international research programmes and transatlantic co-operations to develop (i) methods and tools to predict nanomaterials exposure and effects on humans and ecosystems, (ii) implementable processes to reduce hazard and exposure to nanomaterials in different lifecycle stages, (iii) innovative technological solutions for risk management in industrial settings, and (iv) guidance on best practices for securing both nano-manufacturing processes and nanomaterials ultimate fate, including development of approaches for safe disposal and recycling. In summary, SUN stands for an integrated approach for the long-term sustainability of nanotechnologies through the development of safe processes for production, use and end-of-life processing of nanomaterials and products, as well as methods reducing both adverse effects and exposure to acceptable levels.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.95M | Year: 2015

A diverse, complex, and poorly characterised community of microorganisms lies at the heart of the wine an industry worth over 220 billion globally. These microorganisms play key roles at all stages of the viniculture and vinification processes, from helping plants access nutrients from the soil, driving their health through protection against pathogens, to fermentation processes that transform the must into wine with its complex array of aromas and flavours. Given this importance, an improved understanding of the microbial community and its interplay will have significant effects on the industry. In recent years, Next Generation DNA sequencing has revolutionised many areas of biology, including microbiology, through conferring the ability to characterise microbes on the deep community scale, through both shotgun and deep amplicon sequencing approaches. To exploit this power for the benefit of the wine industry, we propose MICROWINE, a 15 ESR Marie Curie Actions European Training Network. The network is constructed as a close collaboration between industry and academic partners, around the theme of the microbial communitys role in the wine production process. Through combining microbial metagenomic sequencing with powerful computation analyses, with metadata generated using techniques such as metabolomics and geochemistry, we will study the action of microbes from the plant protection and nutrition, through to wine fermentation process, using samples collected from both Europe and beyond. We will further train the ESRs across a wide range of relevant disciplines, and maximise information transfer through multiple host and academic-industry cosupervision and secondments. In this way, we anticipate contributing to the strength and scientific progress of the wine industry through training of a cohort of leading, interdisciplinary and tightly interconnected scientists at the forefront of modern microbiological, genomic, computational and related techniques.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETOPEN-1-2014 | Award Amount: 3.40M | Year: 2016

The main objective of SPICE is to realize a novel integration platform that combines photonic, magnetic and electronic components. Its validity will be shown by a conceptually new spintronic-photonic memory chip demonstrator with 3 orders of magnitude higher write speed and 2 orders of magnitude lower energy consumption than state-of-the-art spintronic memory technologies. This enables, e.g., future petabit-per-second processor-memory bandwidths, required in a decade from now, and highly energy-efficient exascale datacenters with reduced carbon footprint. Such a versatile memory will result in so-called Universal Memory: one technology for all memory applications ranging from cache to storage. The methods to achieve this are based on the recent discovery of magnetization reversal by short optical pulses. SPICE will bring this technique to the integrated circuit level by first developing free magnetic layers that can be optically switched into a magnetic-tunnel-junction layerstack, with optically transparent top contacts. These layers will then be processed into spintronic memory elements that can be electrically read. A novel short-pulse switching architecture will be designed and implemented in a silicon photonic integrated circuit. This photonic switching layer will then be combined with the spintronic memory layer to achieve an optically switched 8-bit memory with write efficiency of 600 fJ per bit: the proof of concept of the technology. The novelty of SPICE is the convergence of the emerging fields of opto-magnetism and spintronics with electronic and photonic integration technologies. The ambition is to develop this technology in such a way that it can be compatible with future mature electronics fabrication processes, for real-world applications beyond 2025, thereby creating a new field. The SPICE platform is therefore foundational as it can be used not only for ultrafast and energy-efficient memory, but also for RF nano-oscillators and sensor technology.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.91M | Year: 2015

The interaction of matter with light is one of the most fundamental processes occurring in nature with countless scientific and technological applications. In recent years, the continuing development of intense, ultrashort, coherent light sources from the mid-infrared (mid-IR) to the extreme ultraviolet (XUV) spectral range has opened new possibilities for the investigation of this interaction in new and complementary domains. In both the IR and XUV regimes, molecules and clusters of atoms interacting with light exhibit (correlated) multi-electron dynamics evolving on the few femtosecond (1 fs=10-15 s) to attosecond (1 as=10-18 s) timescale. Several experimental and theoretical investigations suggest that ultrafast multielectronic processes might be fundamental in determining the behaviour of molecules and clusters, and that understanding these phenomena might offer new perspectives on processes occurring on slower timescales, such as bond-breaking in complex molecules and Coulomb explosion in charged clusters. In this context, the main objectives of the MEDEA network are: 1) to advance attosecond and femtosecond XUV spectroscopy in molecules and clusters 2) to demonstrate the feasibility of nonlinear attosecond XUV spectroscopy, 3) to obtain benchmarks for the validation of attosecond tools and femtosecond XUV pulses for the time-resolved imaging of electron and nuclear dynamics in molecules, 4) to contribute to the development of new technological solutions that will increase the competiveness of the industrial partners 5) to train a group of early stage researchers (ESRs) and contribute to their career prospects, and 6) to increase the interest of young students in the networks core research field (Photonics) by introducing a dedicated experimental kit in several European secondary schools.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: WASTE-6b-2015 | Award Amount: 4.25M | Year: 2016

Europes cities are some of the worlds greatest tourism destinations. The socio-economic impact of tourism is extraordinary and urban tourism, but it brings at the same time a range of negative externalities, including high levels of unsustainable resource consumption and waste production. In comparison with other cities, tourist cities have to face additional challenges related to waste prevention and management due to their geographical and climatic conditions, the seasonality of tourism flow and the specificity of tourism industry and of tourists as waste producers. UrBAN-WASTE will support policy makers in answering these challenges and in developing strategies that aim at reducing the amount of municipal waste production and at further support the re-use, recycle, collection and disposal of waste in tourist cities. In doing so UrBAN-WASTE will adopt and apply the urban metabolism approach to support the switch to a circular model where waste is considered as resource and reintegrated in the urban flow. UrBAN-WASTE will perform a metabolic analysis of the state of art of urban metabolism in 11 pilot cities. In parallel a participatory process involving all the relevant stakeholders will be set up through a mobilization and mutual learning action plan. These inputs will be integrated in the strategies along with a review of the most innovative existing technologies and practices in the field of waste management and prevention. The strategies will then be implemented in the 11 cities and the results will be monitored and disseminated facilitating the transfer and adaptation of the project outcomes in other cases.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2008. | Award Amount: 9.02M | Year: 2009

WISER will support the implementation of the Water Framework Directive (WFD) by developing tools for the integrated assessment of the ecological status of European surface waters (with a focus on lakes and coastal/transitional waters), and by evaluating recovery processes in rivers, lakes and coastal/transitional waters under global change constraints. The project will (1) analyse existing data from more than 90 databases compiled in previous and ongoing projects, covering all water categories, Biological Quality Elements (BQEs) and stressor types and (2) perform targeted field-sampling exercises including all relevant BQEs in lakes and in coastal/transitional waters. New assessment systems will be developed and existing systems will be evaluated for lakes and coastal/transitional waters, with special focus on how uncertainty affects classification strength, to complete a set of assessment methodologies for these water categories. Biological recovery processes, in all water categories and in different climatic conditions, will be analysed, with focus on mitigation of hydromorphological and eutrophication pressures. Large-scale data will be used to identify linkages between pressure variables and BQE responses. Specific case studies, using a variety of modelling techniques, will address selected pressure-response relationships and the efficacy of mitigation measures. The responses of different BQEs and different water categories to human-induced degradation and mitigation will be compared, with special focus on response signatures of BQEs within and among water categories. Guidance for the next steps of the intercalibration exercise will be given by comparing different intercalibration approaches. Stakeholders will be included from the outset, by building small teams of stakeholders and project partners responsible for a group of deliverables, to ensure the applicability and swift implementation of results.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SiS-2010- | Award Amount: 1.48M | Year: 2010

EPOCH aims both to broaden and deepen knowledge of the role of ethics in the governance of science and technology, focusing on ethical aspects of new and emerging bio-, neuro- and nanotechnologies and specifically related to the topic of human enhancement (i.e. any modification of the human body aimed at improving performance and realized by scientific-technological means). On the basis of comparative analyses of current governance and normative frameworks at European and national level (including non-EU countries), a comprehensive approach to the governance of contentious developments in science, technology and society will be outlined. It will include guidance and strategic options for governance activities in Europe, but also specific proposals regarding public policies on selected enhancement technologies, focusing on physical enhancement in sport. The research will cover (i) academic, policy and public discourses; (ii) the institutional landscape of ethical policy advice; (iii) the multi-disciplinary expertise involved in it; (iv) procedures and mechanisms for a participatory, socially inclusive, and reflexive governance of science and technology; and (v) specific ethical and governance challenges raised by the use of new technologies for human enhancement. EPOCH aims to generate new insights into the role of ethical expertise in European policy making on science and technology, coherent with national and other European projects. The comprehensive governance approach adopted will facilitate the integration of emerging technologies in an open, effective and democratic knowledge-based society. It will have a strong and critical participatory element, embedded in a broader multidisciplinary and reflexive governance framework. It will also include suggestions on how to foster, in the European Union and beyond, cross-national reflection and well-informed discussions on ethically contentious scientific and technological developments.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 4.01M | Year: 2016

Large Polycyclic Aromatic Hydrocarbon (PAH) molecules are deeply interwoven in the fabric of the Universe and lock up ~15% of the elemental carbon in the interstellar medium (ISM) of galaxies. They dominate the mid-infrared emission characteristics of galaxies that can be used to trace star formation locally as well as in the early universe, they influence the phase structure of the ISM and the star formation rate of galaxies, and they are the epitome of molecular complexity in space, heralding the importance of top-down chemistry. In spite of the influential role of PAHs in the ISM, their lifecycle, catalytic activity, interaction with interstellar radiation, gas and grains and their role in the organic inventory of solar system bodies is still poorly understood. The EUROPAH ETN aims to change this by creating a highly multidisciplinary network that combines astronomy, molecular physics, molecular spectroscopy, environmental science, quantum chemistry, surface sciences, and plasma physics in a comprehensive research and training program. EUROPAH will train 16 ESRs through cutting edge individual research and innovation projects investigating key physical and chemical processes of PAHs in space and related terrestrial settings and linking directly to R&D needs of our industrial beneficiaries. EUROPAH will engage all ESRs in industry driven innovation activities aimed at R&D of the industrial participants products and services, including outreach activities led by our industrial science communication beneficiary. Research and innovation training is complemented by an extensive program of network-wide training events to expose ESRs to all disciplines in the network and to instill in them a comprehensive set of transferable skills. This will provide the ESRs with a unique learning environment in a multidisciplinary setting aimed at developing a research oriented creative and innovative mind set and will place them well for a future career in academia or in industry.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.87M | Year: 2017

CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particularly in neural tissues, circRNA expression is high, dynamic, and evolutionarily conserved. In aging animal brains the expression of certain circRNAs is strongly elevated, suggesting connections to age-related diseases. The study of circRNAs thus emerges as a novel topic with highest importance for the understanding of such diverse conditions as neurodegenerative diseases, aging, and cancer. Moreover, the highly stable expression and their presence in human blood and exosomes make circRNAs attractive biomarker candidates. The overall aims of circRTrain are to 1. Elucidate the biogenesis and function of circRNAs; 2. Define their role in diseases; 3. Exploit their potential as biomarkers and for medical applications; and 4. Combine cutting-edge technologies and disciplines. Understanding circRNAs and exploring their medical relevance requires to integrate various technologies (sequencing, single-molecule and whole-organism imaging, RNA knockdown/delivery, CRISPR/CAS9), disciplines (biochemistry, computational biology, genetics), model systems (worm, fly, mouse, human) and medical applications (biomarkers, new therapeutic strategies). CircRTrain will combine these diverse approaches and industrial technologies by training 15 early stage researchers (ESR) at two SMEs and seven academic partners, which are all leaders in their respective fields. Additionally, cooperation with four partner organizations, circRNA devoted conferences, winter- and summer schools will extend training for the ESRs, sustaining the critical number of young talented professionals in the field.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2010.2.1.2-1 | Award Amount: 4.46M | Year: 2011

Economic policy instruments (EPI) have received widespread attention over the last three decades, and have increasingly been implemented to achieve environmental policy objectives. However, whereas EPI have been successfully applied in some policy domains (such as climate, energy and air quality), their application to tackle water management issues (drought/water scarcity, floods, water quality control) are beset by many practical difficulties. EPI-Water sets to assess the effectiveness and the efficiency of Economic Policy Instruments in achieving water policy goals, and to identify the preconditions under which they complement or perform better than alternative (e.g. regulatory or voluntary) policy instruments. Using a common multi-dimensional assessment framework, the project will compare the performance of single economic instruments or their apposite combinations with the performance otherwise achievable with regulatory (command & control) interventions (such as water restriction/rationing, licensing or permitting), persuasive instruments or voluntary commitments. Furthermore the project will identify remaining research and methodological issues that need to be addressed, in particular with regards to the further development and use of national accounting, for supporting the design, implementation and evaluation of EPI in the field of water management.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE-2008-2-1-01 | Award Amount: 3.21M | Year: 2009

Obesity has been estimated to cost the EU some 70 annually through health care costs and lost productivity, and additionally over-consumption of salt, sugar and saturated fats and under-consumption of fruit and vegetables cause almost 70,000 premature deaths annually in the UK alone. Member States have initiated a variety of policy interventions to encourage healthy eating including prohibitions on advertising certain foods to children, promotion of fruit and vegetable consumption, nutrition labelling, dialogue with food industry to improve food product composition and regulation of school meals and public sector canteens to ensure healthy food offerings. Rarely have these been evaluated in a systematic manner. The EATWELL project will gather benchmark data on healthy eating interventions in Member States and review existing evaluations of the effectiveness of interventions using a 3 stage procedure: 1. The impact of the intervention on consumer attitudes, consumer behaviour and diets; 2. The impact of the change in diets on obesity and health; 3. The value attached by society to these changes, measured in life years gained, cost savings and QALYs. Where evaluations have been inadequate EATWELL will gather secondary data and analyse them using models mainly from the psychology and economics disciplines. Particular attention will be paid to lessons that can be learned from the private sector that are transferable to the healthy eating campaigns in the public sector. Through consumer surveys and workshops with other stakeholders, EATWELL will assess the acceptability of the range of potential interventions. Armed with scientific quantitative evaluations of policy interventions and their acceptability to stakeholders, EATWELL will recommend most appropriate interventions for Member States and the EU, provide a one-stop guide to methods and measures in intervention evaluation, and outline data collection priorities for the future.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2009.;ENV.2009. | Award Amount: 9.90M | Year: 2010

Understanding how freshwater ecosystems will respond to future climate change is essential for the development of policies and implementation strategies needed to protect aquatic and riparian ecosystems. The future status of freshwater ecosystems is however, also dependent on changes in land-use, pollution loading and water demand. In addition the measures that need to be taken to restore freshwater ecosystems to good ecological health or to sustain priority species as required by EU Directives need to be designed either to adapt to future climate change or to mitigate the effects of climate change in the context of changing land-use. Generating the scientific understanding that enables such measures to be implemented successfully is the principal focus of REFRESH. It is concerned with the development of a system that will enable water managers to design cost-effective restoration programmes for freshwater ecosystems at the local and catchment scales that account for the expected future impacts of climate change and land-use change in the context of the WFD and Habitats Directive. At its centre is a process-based evaluation of the specific adaptive measures that might be taken to minimise the consequences of climate change on freshwater quantity, quality and biodiversity. The focus is on three principal climate-related and interacting pressures, increasing temperature, changes in water levels and flow regimes and excess nutrients, primarily with respect to lowland rivers, lakes and wetlands because these often pose the most difficult problems in meeting both the requirements of the WFD and Habitats Directive. REFRESH will advance our fundamental and applied science in 5 key areas: i) understanding how the functioning of freshwater ecosystems is affected by climate change; ii) new indicators of functional response and tools for assessing vulnerability; iii) modelling ecological processes; iv) integrated modelling; and v) adaptive management.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-2.2.2-3 | Award Amount: 15.91M | Year: 2008

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of biological age and predict the onset of age-related diseases and/or residual lifetime are termed biomarkers of ageing. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (GEHA offspring) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) classical ones for which data from several smaller studies have been published; (b) new ones, based on recent preliminary data, as well as (c) novel ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: SiS-2008- | Award Amount: 1.15M | Year: 2009

This project (duration: 31 months) concerns the experimentation of gender diversity management policies in different kinds of organisations conducting scientific and technological research (STR). It consists of a coordinated set of activities. It will primarily provide for a review on the main areas of risk for gender diversity in research settings as well as on the correspondent regimes to cope with them that will allow the drafting of the provisional version of guidelines to be used for the implementation of experimental activities. These guidelines will be discussed in 3 interactive workshops, involving, representatives of both institutions which promoted some of the experiences previously analysed and research organisations potentially interested in launching programmes on gender diversity management. Special attention will be devoted to promote an exchange among universities, other kinds of public centres and private companies. Starting from the workshops outputs, experimental initiatives will be undertaken in 3 organisations, including both the direct promotion of new programmes and the support to programmes promoted by the organisation. The involved organisations will be provided with advice and technical assistance by the consortium members. During the experimentation, a joint working seminar will be conducted. Special attention will be given to the mutual relationships between the different kinds of actions on gender diversity management as well as on their capacity to generate a real regime for the promotion of gender diversity. On the basis of the experimental initiatives, the guidelines will be revised and presented at a European level conference and then disseminated. Different targets, also including non-scientific actors, will be taken into account, in order to increase the impacts of the project. A website will be created and an electronic newsletter will be published. Moreover, a policy brief on the project will be drafted.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2008-1.1.1 | Award Amount: 7.39M | Year: 2009

The Europlanet RI project will provide the European planetary science community with a unique research infrastructure, combining access to a suite of state of the art facilities while fostering their joint development and integration in terms of capacity and performance. This research infrastructure will include access to laboratory and field site facilities, advanced modelling, simulation and data analysis resources and to data produced by space missions and ground-based telescopes hence maximising the scientific impact of major European space missions and ground-based installations. Access will be provided in two forms. Three coordinated Trans National Access activities will open to many users the unique range of laboratory and field site facilities selected for this project. In parallel, the IDIS e-service will provide a user-friendly web-based access to the available planetary science data, information and software tools. Four Joint Research Activities will broaden the scope of the infrastructure, opening access to new field sites, offering new models and data analysis tools for users and widening the opportunity of remote data access by progressively upgrading IDIS into a Planetary Virtual Observatory. Four complementary networking activities will publicize the objectives and opportunities of Europlanet RI and disseminate project results amongst the scientific community, industries, SMEs, space agencies and the public. They will consolidate the establishment of a European Research Area for planetary science and exploration. Building on the synergies between its services, joint research activities and networking activities, Europlanet RI will provide the ideal scientific and technical environment to fully analyse data from past and present planetary missions and prepare the next generation of missions. In this way it will play a vital role in establishing the European Community as a leading player in planetary and space exploration.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.23. | Award Amount: 8.59M | Year: 2012

CALIPSO coordinates the European synchrotrons and FELs, including the three ESFRI roadmap projects European XFEL, EuroFEL and the ESRF Upgrade Programme, towards a fully integrated network. The consortium is characterised by common objectives, harmonised decisions, transnational open access based on excellence and joint development of new instruments. Innovative networking initiatives address user friendliness and a strengthened industrial interaction. CALIPSO proposes a single entry point ( to simplify access modalities, to coach potential users to find the best beamline for their experiment and to favour interactivity; in addition, targeted education actions will widen and strengthen the community. Transnational Access potentially benefits a community of 10,000 European users represented by the recently formed European Synchrotron User Organisation ( The pivotal EC funding in CALIPSO supports scientists to perform their research at the best facilities, thus promoting equal opportunities for all European researchers. This is particularly important for colleagues from less-favoured countries, early stage and female researchers. The European light sources represent a largely underexploited pool for European industry. To enhance light sourceindustry interactions, CALIPSO proposes a networking activity including specific events to involve industries both as users and instrumentation suppliers, a pan-European Industrial Advisory Board to orient these actions, in preparation for Horizon 2020, and a dedicated task to exploit the innovation potential of the Joint Research Activity. The CALIPSO joint research activity will focus on detectors development, one of the most significant joint challenges for present and future light sources. For Europe to succeed and remain a leader in detectors development, a coordinated action is necessary rather than individual efforts. A close collaboration of the CALIPSO JRA and the industrially-driven action will be setup with the recently signed Detector Consortium initiative, lending an important added dimension with pan-European impact.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.8.2 | Award Amount: 9.14M | Year: 2010

The overall objectives of the AQUTE project are\nA) To develop quantum technologies based on atomic, molecular and optical (AMO) systems for\n* scalable quantum computation;\n* entanglement-enabled technologies like metrology and sensing.\nB) To establish and exploit new interdisciplinary connections, coming from AMO physics, but also including concepts and experimental settings of solid state systems, in order to\n* reinforce interdisciplinary links at the frontiers of quantum information science, and other fields of physics or science in general;\n* conceive and realize novel hybrid systems that couple in a coherent way physically different quantum degrees of freedom.\nObj. A will be pursued along two complementary directions:\n* a bottom-up approach, where individually trapped atomic particles are combined into elementary general-purpose quantum processors including qubit interconnects;\n* a top-down approach, where many-particle atomic systems are employed to realize special-purpose quantum processors, for instance quantum simulators.\nGroundbreaking work in qualitatively new directions is also needed to lay the foundations for the future attainment of scalable fault-tolerant architectures. AQUTE will thus also\n* investigate new experimental systems that have become available in the laboratory and are of direct relevance for QIFT;\n* optimize existing and develop novel theoretical concepts for quantum processing.\nObj. B connects atomic quantum technologies for QIFT to a wider context, by\n* exploring hybrid approaches to QIFT beyond AMO physics;\n* improving connections between QIFT and science in general, following the emergence of a new quantum paradigm at the frontier of nanosciences and information sciences.\nThese research lines determine the structuring of the AQUTE workplan into four deeply interrelated Sub-Projects: Entangling gates and quantum processors, Hybrid quantum systems and interconnects, Quantum Simulators and Quantum Technologies.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH-2009-2.1.1. | Award Amount: 3.32M | Year: 2009

The project will contribute to the goals of the Call showing that it is possible to better address global changes in a long term time perspective (20302050), making a first development of tools new generations of models and indicators with enhanced capabilities to take into account the interaction between the economy and the environment, paradigm shifts in the energy-transport-environment nexus and the land-use and territorial functions. The objectives of PASHMINA will include: 1. production of exploratory scenarios (qualitative storylines) of future global change options up to 2030 and 2050, complemented by a quantitative analysis of key development indicators (GDP, well being, etc.) undertaken by means of global long term meta-models (WP1) 2. analysis of the consequences of the paradigm shifts in the energy-transport-environment nexus related to the urban functions: housing, mobility, recreation, etc. (WP2) 3. analysis of the possible paradigm shifts in the land use and territorial functions related to agriculture, forestry and more in general ecosystem services: e.g. biofuels, biodiversity, ecosystems metabolism, etc. (WP3) 4. first development a new generation of global indicators and models, starting from already existing sustainability accounting and general equilibrium modelling frameworks and adapting these to make them (more) sensitive to paradigm shifts in the long-term perspective (WP4) 5. pilot assessment of possible adaptation and mitigation strategies to tackle with different paradigm shifts, evaluating their trade-offs (WP5). 6. to produce a comparative evaluation of the advancements in modelling tools achieved by PASHMINA, and to disseminate those in the scientific and stakeholders communities by means of innovative dissemination tools (virtual library, wiki-web tools, webGIS application) and other dissemination activities (WP6).

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 4.99M | Year: 2012

The TRAINBIODIVERSE ITN will provide professional skills and training for young scientists covering multi-disciplinary aspects of soil biodiversity, ecosystem services, their economic significance and practical implications and implementation. The researchers will gain access to European educational and network facilities and training aimed at ensuring the wellbeing of human populations and the continued availability of sustainable recourses underpinned by soil microbiology. Practical and theoretical training related to monitoring, evaluating and improving the quality of biodiversity in European soils, in combination with training professionals to ensure enhanced intersectorial skills and communications will help to secure the future of European ecosystem services and agricultural production. TRAINBIODIVERSE will fill the gap between specialists in different institutions and administrative bodies providing information and policy on biodiversity and ecosystem services in Europe. The consortium encompasses different academic, non-academic industrial economic and political professions in different sectors. An understanding of the interrelationships and communications between the different sectors involved will be made available to European researchers for the first time. This will coincide with increases in related governmental policy and actions. The training will cover the process for applying scientific rational to political implementation. Initial training will commence with field and laboratory work then proceeding through interpretation of results to economic evaluation for managerial administrative and decision making processes and application of the information.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: NMP-2008-1.1-2 | Award Amount: 1.66M | Year: 2009

NANOYOU will design and undertake a communication and outreach program in nanotechnology (NT) aimed at European youth. The project will reach 11-18 year olds through school programs to take place in at least 20 EU Member States and Associated States. Additional programs aimed at young adults aged 19-25 will be offered in science centres. The school programs are planned to involve at least 400 schools and reach more than 25,000 students. The science centres program is expected to reach an initial 4,000 young adults during NANOYOU and many more subsequently as more science centres adopt the program. Recent surveys show that most European citizens have poor understanding of NT, its potential and risks. This needs to be rectified if the European public is to contribute positively to future decision-making about the use of NT. In focusing on ages 11-25, NANOYOU recognizes that effective programming needs to be tailored to the educational capabilities and interests of the target population. Programming specialization will be provided for subgroups within this youth population. While some FP6 programs have made an excellent start in informing the public about NT, they have not focused on youth nor have their activities taken places in the schools. NANOYOU will combine temporary exhibitions, innovative computer games, experiments and other online content, with workshops aimed at promoting dialogue that will raise participants awareness of ethical, legal and societal aspects of NT. NANOYOUs content will be balanced and up-to-date, and teacher training materials will be prepared to equip science teachers and other personnel to present the NANOYOU programs. NANOYOU has assembled a strong consortium with partners experienced in nanotechnology, educational methodology and science communication, as well as organizations highly suited and experienced at arranging outreach/communication activities in schools and science centres

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-03-2015 | Award Amount: 6.19M | Year: 2016

Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders, and a highly prevalent somatic disease, obesity. ADHD, a childhood-onset disorder, forms the entry into a lifelong negative trajectory characterized by these comorbidities. Common mechanisms underlying this course are unknown, despite their relevance for early detection, prevention, and treatment. Our interdisciplinary team of experts will integrate epidemiologic/genetic approaches with experimental designs to address those issues. We will determine disease burden of comorbidity, calculate its socioeconomic impact, and reveal risk factors. We will study biological pathways of comorbidity and derive biomarkers, prioritizing two candidate mechanisms (circadian rhythm and dopaminergic neurotransmission), but also leveraging large existing data sets to identify new ones. A pilot clinical trial to study non-pharmacologic, dopamine-based and chronobiological treatments will be performed, employing innovative mHealth to monitor and support patients daily life. Integration of findings will lead to prediction algorithms enhancing early diagnosis and prevention of comorbidity. Finally, we will screen to repurpose existing pharmacological compounds. Integrating complementary approaches based on large-scale, existing data and innovative data collection, we maximize value for money in this project, leading to insight into the mechanisms underlying this comorbidity triad with its huge burden for healthcare, economy, and society. This will facilitate early detection and non-invasive, scalable, and low-cost treatment, creating opportunities for substantial and immediate societal impact.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: ISIB-02-2015 | Award Amount: 1.84M | Year: 2016

The European Fruit Network (EUFRUIT) includes 12 countries focussed on 4 thematic areas of critical for the competiveness and innovation potential of the European Fruit sector: i) new cultivar development and evaluation; ii) minimise residues on fruit and the environment; iii) optimising storage and fruit quality; iv) sustainable production systems. EUFRUIT will coordinate and support innovation through developing a framework for relevant stakeholders and it will establish a systematic approach for knowledge gathering and dissemination. The systematic approach includes: i) scanning & synthesis via 4 expert groups who scan state-of-art knowledge, practises and technologies and synthesise the material to identify key areas of learning and best practise approaches at a European level. ii) showing & sharing will deliver outreach/dialogue at a national level through establishment of local operational groups. An online Knowledge Platform will hold all outreach material, outreach activities include; 100 industry publications, 90 technical bulletins, 25 flyers/newsletters, 60 seminars, 160 field based meetings, 25 conference plus 12 events aimed at the general public. iii) sustaining the network will occur through long-term integration of the assembled EUFRUIT network in future actions. The overall outcome of EUFRUIT will be establishment of a framework and a systematic approach that together builds a bridge across the valley of death. This bridge will secure a direct path for new knowledge in the future and reduce the likelihood of repetition of research at a national level. The European fruit sector will have ready access to up-to-date information to implement and value will be created both for the industry with respect to competitiveness, sustainability and efficiency and society through ensuring the security and safety of fruit; underpinning human health and wellbeing.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: BG-09-2016 | Award Amount: 15.49M | Year: 2016

The overall objective of INTAROS is to develop an integrated Arctic Observation System (iAOS) by extending, improving and unifying existing systems in the different regions of the Arctic. INTAROS will have a strong multidisciplinary focus, with tools for integration of data from atmosphere, ocean, cryosphere and terrestrial sciences, provided by institutions in Europe, North America and Asia. Satellite earth observation data plays an increasingly important role in such observing systems, because the amount of EO data for observing the global climate and environment grows year by year. In situ observing systems are much more limited due to logistical constraints and cost limitations. The sparseness of in situ data is therefore the largest gap in the overall observing system. INTAROS will assess strengths and weaknesses of existing observing systems and contribute with innovative solutions to fill some of the critical gaps in the in situ observing network. INTAROS will develop a platform, iAOS, to search for and access data from distributed databases. The evolution into a sustainable Arctic observing system requires coordination, mobilization and cooperation between the existing European and international infrastructures (in-situ and remote including space-based), the modeling communities and relevant stakeholder groups. INTAROS will include development of community-based observing systems, where local knowledge is merged with scientific data. An integrated Arctic Observation System will enable better-informed decisions and better-documented processes within key sectors (e.g. local communities, shipping, tourism, fisheries), in order to strengthen the societal and economic role of the Arctic region and support the EU strategy for the Arctic and related maritime and environmental policies.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-01-2016-2017 | Award Amount: 10.00M | Year: 2017

Experimentation in mesocosms is arguably the single most powerful approach to obtain a mechanistic quantitative understanding of ecosystem-level impacts of stressors in complex systems, especially when embedded in long-term observations, theoretical models and experiments conducted at other scales. AQUACOSM builds on an established European network of mesocosm research infrastructures (RI), the FP7 Infra project MESOAQUA (2009-2012), where 167 users successfully conducted 74 projects. AQUACOSM greatly enhances that network on pelagic marine systems in at least 3 ways: first by expanding it to 10 freshwater (rivers and lakes), 2 brackish and 2 benthic marine facilities, and by involving 2 SMEs and reaching out to more, thereby granting effective transnational access to world-leading mesocosm facilities to >340 users on >11500 days; second, by integrating scattered know-how between freshwater and marine RI; and third, by uniting aquatic mesocosm science in an open network beyond the core consortium, with industry involved in an ambitious innovation process, to promote ground-breaking developments in mesocosm technology, instrumentation and data processing. A new dimension of experimental ecosystem science will be reached by coordinated mesocosm experiments along transects from the Mediterranean to the Arctic and beyond salinity boundaries. These efforts will culminate in a joint research activity (JRA) to assess aquatic ecosystem responses across multiple environmental gradients to a selected climate-related key stressor with repercussions for ecosystem services. Overall, AQUACOSM will fill a global void by forging an integrated freshwater and marine research infrastructure network. Long-term sustainability is sought through assessing governance models based on science priorities and economic innovation opportunities. Linkages to and synergies with ESFRI RI and other large initiatives are ensured by AQUACOSM partners and Advisory Board members in those programs.

Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 693.00K | Year: 2016

The PEARL project aims at advancing the technologies for manufacturing of high quality Periodically Bent Crystals (PBCr). The PBCr developed in the course of this project will be utilised for the construction of novel light sources of high-energy (h102 keV up to GeV range) monochromatic electromagnetic radiation by means of a Crystalline Undulator (CU) [1]. The technological and experimental part of this project will be accompanied by the complimentary advanced theoretical research utilising modern theoretical, computational and modelling methods accomplished with high performance computing techniques. A broad interdisciplinary, international collaboration has been created in the frame of FP7 PIRSES-CUTE project, which was focused on initial experimental tests of the CU idea and the related theory, for review see [1]. This project has been successfully completed in March 2015 and left the matter experimentally validated to a degree that is tantalising, requiring further experimentation. In particular CUTE elucidated the demand on manufacturing PBCrs of an exceptional lattice quality, their experimental characterisation and exposure against the high quality beams of ultra-relativistic electrons and positrons for the observation of the strong coherent effects in the photon emission process. PEARL will focus on solving the whole complex of the important technological, experimental and theoretical problems aiming to achieve the major breakthrough in this important research area. The PEARL international collaboration is extended with respect to CUTE and involves the new partners with the essential, necessary, complementary expertise and experimental facilities. The PEARL research programme is highly collaborative and requiring numerous exchange visits between the involved laboratories, joint workshops and conferences. Therefore, RISE type of project is the most suitable for strengthening of this very essential, ongoing, international collaborative research.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-16-2015 | Award Amount: 6.03M | Year: 2016

Over 30 million Europeans are blind or visually impaired, leading to reduced quality of life and a tremendous loss of productivity in society. Corneal blindness is the second largest cause of blindness globally and while treatable, millions remain unnecessarily blind due to issues of access to transplantable tissue, lack of standardized treatments, and the lag in translating new regenerative medicine therapies to the clinic. The objective of ARREST BLINDNESS is therefore to develop and validate new regenerative-based therapies addressing a spectrum of blinding disorders of the cornea. These conditions either have no effective current treatments, depend on a scarce supply of donor tissue, or non-standardized methods are hindering validation of promising regenerative treatments. To achieve our objective, we will implant GMP-fabricated collagen-based bioengineered scaffolds to replace or regenerate the corneal stroma in cases of stromal thinning, scarring, dystrophy or trauma; deliver therapeutic epithelial stem and endothelial cells to the cornea to restore its transparency; deliver regenerative factors to promote neural growth and function; and actively maintain corneal immune privilege in high-risk situations by targeted therapeutic approaches to regress blood and lymphatic vessels. We will additionally develop advanced methods to image and monitor therapy throughout the cycle from GMP-compliant cell and scaffold preparation through the pre- and intra-operative stages, to postoperative follow-up and evaluation. After proof-of-concept and preclinical validation of key enabling components, these technologies will be used by one or several partners in preclinical models and in phase I/II human clinical studies. ARREST BLINDNESS directly addresses the translation of regenerative medicine, bio-artificial organs, tissue engineered scaffolds, and advanced cell and gene therapies into clinical use and will help to alleviate the worldwide problem of corneal blindness.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-01-2016-2017 | Award Amount: 10.00M | Year: 2016

The SeaDataNet pan-European infrastructure has been developed by NODCs and major research institutes from 34 countries. Over 100 marine data centres are connected and provide discovery and access to data resources for all European researchers. Moreover, SeaDataNet is a key infrastructure driving several portals of the European Marine Observation and Data network (EMODnet), initiated by EU DG-MARE for Marine Knowledge, MSFD, and Blue Growth. SeaDataNet complements the Copernicus Marine Environmental Monitoring Service (CMEMS), coordinated by EU DG-GROW. However, more effective and convenient access is needed to better support European researchers. The standards, tools and services developed must be reviewed and upgraded to keep pace with demand, such as developments of new sensors, and international and IT standards. Also EMODnet and Copernicus pose extra challenges to boost performance and foster INSPIRE compliance. More data from more data providers must be made available, from European and international research projects and observing programmes. SeaDataCloud aims at considerably advancing SeaDataNet services and increasing their usage, adopting cloud and HPC technology for better performance. More users will be engaged and for longer sessions by including advanced services in a Virtual Research Environment. Researchers will be empowered with a collection of services and tools, tailored to their specific needs, supporting marine research and enabling generation of added-value products. Data concern the wide range of in situ observations and remote sensing data. To have access to the latest cloud technology and facilities, SeaDataNet will cooperate with EUDAT, a network of computing infrastructures that develop and operate a common framework for managing scientific data across Europe. SeaDataCloud will improve services to users and data providers, optimise connecting data centres and streams, and interoperate with other European and international networks.

Agency: European Commission | Branch: H2020 | Program: ERA-NET-Cofund | Phase: SFS-19-2016-2017 | Award Amount: 19.82M | Year: 2016

Organic agriculture is considered to be one of the important development pathways towards a more sustainable agriculture and food production. This development has been and will be dependent on continuous research and innovation. CORE Organic started in 2004 and has been evolving for more than a decade. The present proposal for a CORE Organic Cofund will continue, to update and consolidate the series of transnational research calls that support a focused and coordinated research and innovation effort covering the most important challenges along the organic value chains, for example: increasing the organic production potentials, enhancing resource efficiency, and improving animal welfare. In addition this research and innovation plays a key role in adapting to the new EU regulations on Organic Farming. The new CORE Organic network will be expanded with additional partners from Netherlands and Italy totalling to 25 partners from 19 countries. One joint call with 3-4 topics will be launched with co-funding from the European Commission and another call without EU co-funding is being planned for 2019 as part of the additional activities. Other ERA-NETs with a similar scope will be invited to join this second call. The CORE Organic partners are working to increase innovation potential, knowledge accessibility, alignment of national research and international outreach in support of the ERA-NETs objectives. CORE Organic will closely monitor the funded projects and offer assistance regarding stakeholder involvement and dissemination in order to secure high impact of the research efforts. An impact assessment will be performed after the end of the projects. Looking to the future, the CORE Organic Cofund aims to deliver results that can be used to develop the organic sector throughout Europe and the world, and to continue to be a key player in the European Research Area.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-18-2016 | Award Amount: 2.98M | Year: 2017

More and more data is being generated, and analyzing this data drives knowledge and value creation across society. Unlocking this potential requires sharing of (often personal) data between organizations, but this meets unwillingness from data subjects and data controllers alike. Hence, techniques that protect personal information for data access, processing, and analysis are needed. To address this, the SODA project will enable practical privacy-preserving analytics of information from multiple data assets using multi-party computation (MPC) techniques. For this data does not need to be shared, only made available for encrypted processing. The main technological challenge is to make MPC scale to big data, where we will achieve substantial performance improvements. We embed MPC into a comprehensive privacy approach, demonstrated in an ICT-14.b and a healthcare use case. Our first objective is to enable MPC for big data applications by scaling the performance. We follow a use case-driven approach, combining expertise from the domains of MPC and data analytics. Our second objective is to combine these improvements with a multidisciplinary approach towards privacy. By enabling differential privacy in the MPC setting aggregated results will not leak individual personal data. Legal analysis performed in a feedback loop with technical development will ensure improved compliance with EU data privacy regulation. User studies performed in a feedback loop with our consent control component will make data subjects more confident to have their data processed with our techniques. Our final objective is to validate our approach, by applying our results in a medical demonstrator originating from Philips practice and in a use case arising from the ICT-14.b data experimentation incubators. The techniques will be subjected to public hacking challenges. The technical innovations will be released as open-source improvements to the FRESCO MPC framework.

University of Aarhus and University of Aalborg | Date: 2013-04-12

The present invention relates to an isolated polynucleotide encoding at least a part of calmodulin and an isolated polypeptide comprising at least a part of a calmodulin protein, wherein the polynucleotide and the polypeptide comprise at least one mutation associated with a cardiac disorder. The present invention also relates to a method for determining whether an individual has an increased risk of contracting a cardiac disorder, a method for diagnosing a cardiac disorder, method for treatment of an individual having a cardiac disorder, method for identifying a compound, capable of enhancing the binding of calmodulin to ryanodine receptor 2 and use of such compound in a treatment of an individual having a cardiac disorder. The invention further provides a kit that can be used to detect specific mutations in calmodulin encoding genes.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.4-2 | Award Amount: 7.88M | Year: 2014

The EU population is increasingly exposed to new physical and chemical agents in the environment, some of which may be detrimental to public health. Of these, electromagnetic fields (EMF) are one of the most ubiquitous, with new EMF technologies and novel applications being actively developed and commercialised. To address pertinent questions on EMF and health, GERoNiMO proposes an integrated approach building upon existing European resources (epidemiological studies, exposure assessment techniques, mechanistic and animal models, expert networks), using, where appropriate, novel methods, to better understand potential mechanisms underlying possible health effects of EMF, to characterise population levels of exposure, and to further the state of knowledge on EMF and health. GERoNiMO will focus on radiofrequency fields (RF) as understanding of possible health effects is insufficient and a large proportion of the general population is exposed, with commercial applications continuing to grow and intermediate frequencies (IF) as applications are increasing and information on potential health effects is sparse. GERoNiMO will address all aspects of the call by meeting the following four main objectives: i) evaluate possible health effects (cognitive and behavioural development, cancer risk, and reproductive effects) of exposure to RF and IF in children and adults; ii) better understand mechanisms of biological effects (behavioural and reproductive effects, cancer, ageing, and Alzheimers disease) related to RF and IF; iii) collect better data on population exposure and improve health risk assessment for RF and IF; and iv) underpin policy development in Europe on RF and IF (including non-technological means of reducing exposure and best practices in risk communication to support EU policy makers). GERoNiMO represents a unique and timely opportunity for the development of a truly integrated approach to research into EMF and health in Europe.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: HEALTH.2013.4.1-2 | Award Amount: 662.57K | Year: 2013

REDICLAIM (Understanding the impact of legislation on REduction of DIsease risk CLAIMs on food and drinks) seeks to understand the way in which the European Regulation (EC) No. 1924/2006 of the European Parliament and of the Council of 20 December 2006 on nutrition and health claims made on foods and associated legislation has had and continues to have an impact on the substantiation and use of reduction of disease risk claims on food and drinks. To achieve this REDICLAIM will: (1) Seek to understand the (a) main issues and hurdles concerning substantiation and use of reduction of disease risk claims on food and drinks; (b) level of awareness about legal obligations with regard to reduction of disease risk claims on food and drinks among the relevant stakeholders; and (2) Produce a three-fold study of the impact of nutrition and health claims legislation specific to reduction of disease risk claims on food and drinks on: (a) The claim substantiation process, (b) Health research and/or innovation in the food chain, and (c) Nutrition economic models to determine health impact. REDICLAIM results will contribute to: (1) the development of an evidence base of the process by which health and nutrition claims are made and controlled by regulatory frameworks; (2) the effectiveness of their control by regulation; (3) the establishment of recommendations for government, industry and the scientific community with a view to conducting the necessary research and development of such products. The aim of this will be to achieve both effective compliance with better regulation and, to contribute to the enhancement of innovative and competitive products.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: SiS-2007- | Award Amount: 1.50M | Year: 2008

The project Practising Gender Equality in Science (PRAGES) consists of an action of coordination aimed at comparing the various strategies implemented for promoting the presence of women in decision-making bodies relating to scientific research in public institutions. It pursues the objective of collecting, classifying and evaluating good practices and positive actions (involving those where a positive contribution from men is recorded) that can be found in OECD countries, both at the national level and at the level of the individual institutions, and to make them available, in a usable form, to a number of selected targets, including both decision-makers and other relevant stakeholders. It will be characterized by four particular elements: the attempt to integrate the most important and relevant results deriving from the studies and good practices relating to the fight against vertical segregation in various professional, political and social areas; enhancing the understanding of the exclusion of women as being deeply linked to what may be called the lack of socialisation of gender in science, that is, the resistance of scientific community to recognise and manage social and gender dynamics that drive the production of scientific research and its assessment; the comparative approach, from a geographical point of view, with the inclusion of both European and non-European partners and countries (including, in particular, the United States, Canada and Australia); the orientation to benchmarking, above all in order to concretise the indications in terms of policy-making. These features are translated, at the operational level, into 7 work-packages: WP1- Operational networking; WP2- Monitoring of significant events; WP3- Good practice database; WP4- Benchmarking; WP5- Guidelines; WP6- Public communication and dissemination; WP7- Management. The project will last 18 months. Consortium includes researchers from 8 countries.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2011.2.1.2-1 | Award Amount: 8.88M | Year: 2011

REFORM is targeted towards development of guidance and tools to make river restoration and mitigation measures more cost-effective and to support the 2nd and future River Basin Management Plans (RMBPs) for the WFD. Aims of REFORM are (1) to provide a framework for improving the success of hydromorphological restoration measures and (2) to assess more effectively the state of rivers, floodplains and connected groundwater systems. The restoration framework addresses the relevance of dynamic processes at various spatial and temporal scales, the need for setting end-points, analysis of risks and benefits, integration with other societal demands (e.g. flood protection and water supply), and resilience to climate change. The consortium comprises scientists and practitioners covering a wide range of disciplines (hydrology, hydraulics and geomorphology, ecology, socio-economics). The workplan is organized in three modules: (1) natural processes, (2) degradation, (3) restoration. Data from monitoring programmes and restoration projects will be pooled and linked with landscape-scale hydromorphological and physiographic data and catchment models. Targeted field and experimental studies using common protocols will fill data gaps on the role of scale in restoration success. A wide range of statistical modeling approaches will improve indicators for hydromorphological change and factors determining restoration success. All work packages are multidisciplinary and will feed into products for application in river basin management, e.g. guidelines for successful restoration and a web-based tool for exchanging experiences with river restoration measures facilitated and enhanced through consultation with stakeholders. In addition to its impact on the RBMPs, REFORM will provide guidance to other EU directives (groundwater, floods, energy from renewable resources, habitats) to integrate their objectives into conservation and restoration of rivers as sustainable ecosystems

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.2-09 | Award Amount: 11.84M | Year: 2013

The European aquaculture is a modern industry employing 190,000 people, with a 7 billion ex-farm value. This sector is well situated to be among world leaders in the efficient and sustainable production of safe seafood of the highest quality and nutritional value, taking into account consumer preferences and the large diversity of aquatic products from the wild. DIVERSIFY identified a number of new/emerging finfish species, with a great potential for the expansion of the EU aquaculture industry. The emphasis is on Mediterranean or warm-water cage culture, but also addressed are cold-water, pond/extensive and fresh water aquaculture. These new/emerging species are fast growing and/or large finfishes, marketed at a large size and can be processed into a range of products to provide the consumer with both a greater diversity of fish species and new value-added products. DIVERSIFY focuses on meagre (Argyrosomus regius) and greater amberjack (Seriola dumerili) for warm-water marine cage culture, wreckfish (Polyprion americanus) for warm- and cool-water marine cage culture, Atlantic halibut (Hippoglossus hippoglossus) for marine cold-water culture, grey mullet (Mugil cephalus) a euryhaline herbivore for pond/extensive culture, and pikeperch (Sanders lucioperca) for freshwater intensive culture using RAS. These species were selected based both on their biological and economical potential, and to cover the entire European geographic area and stimulate different aquaculture types. In collaboration with a number of SMEs, DIVERSIFY will build on recent/current national initiatives for species diversification in aquaculture, in order to overcome the documented bottlenecks in the production of these species. The combination of biological, technological and socioeconomic research planned in DIVERSIFY are expected to support the diversification of the aquaculture industry and help in expanding production, increasing aquaculture products and development of new markets.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 5.02M | Year: 2009

There is widespread concern about how production and use of chemicals affect the environment. Yet food production and benefits of chemical products are vital for the functioning of European societies. In order to ensure sustainable use, EU regulations require extensive risk assessment before a chemical is approved for use. Current risk assessments focus on risk at the level of individual organisms, but according to EU directives the protection goal aims at achieving sustainable populations. Population-level effects depend not only on exposure and toxicity, but also on important ecological factors that are impossible to fully address empirically. Mechanistic effect models (MEMs) enable the integration of these factors, thus increasing the ecological relevance of risk assessments as well as providing vital understanding of how chemicals interact with ecosystems. Such understanding is crucial for improving risk mitigation strategies and ecosystem management. So far, however, regulators and industry have lacked understanding of the potential benefits that MEMs can deliver, and academics have been inconsistent in the approaches applied. This has led to scepticism about models, preventing a wider use of MEMs in risk assessment. Examples clearly demonstrating the power of MEMs for risk assessment are urgently needed, and industry, academia and regulatory authorities across Europe need scientists that are trained in both MEMs and regulatory risk assessment. CREAM will develop and experimentally validate a suite of MEMs for organisms relevant for chemical risk assessments. The consortium includes the main sectors involved (industry, academia, regulators) and will formulate Good Modelling Practice that will be followed in all individual projects, thus leading to consistency and transparency. CREAM will provide world class training for the next generation of ecological modellers, emphasizing transparency and rigorous model evaluation as core elements of the modelling process.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.1.2-10 | Award Amount: 8.06M | Year: 2012

European aquaculture production provides direct employment to 65.000 people with a turnover of 3 billion . However, the lack of authorised veterinary medicinal products and the consequent disease outbreaks in farmed fish species costs the sector 20% of the production value. The most appropriate method for disease control, both on economical and ethical grounds, is disease prevention by vaccination. TargetFish will advance the development of existing (but not sufficient) and new prototype vaccines against socio-economically important viral or bacterial pathogens of Atlantic salmon, rainbow trout, common carp, sea bass, sea bream and turbot. The project will develop targeted vaccination strategies for currently sub-optimal and for novel vaccines. Improved vaccines will be brought closer to industrial application by addressing practical issues such as efficacy, safety and delivery route. TargetFish will also establish a knowledge- and technology-base for rational development of next generation fish vaccines. To achieve these challenging tasks, we brought together 29 partners from 11 EU member states, 2 associated countries and 1 International Cooperation Partner Country (ICPC). In this large multidisciplinary consortium an approximate equal number of RTD and SME partners will cooperate closely while keeping an intensive communication with the large vaccine and nutrition industries via an Industry Forum. Specifically, TargetFish will 1) generate knowledge by studying antigens and adjuvants for mucosal routes of administration while analyzing the underpinning protective immune mechanisms; 2) validate this knowledge with response assays for monitoring vaccine efficacy and study safety aspects, including those associated with DNA vaccines; 3) approach implementation of prototype vaccines by optimizing vaccination strategies thus 4) shortening the route to exploitation. Thereby, this project will greatly enhance targeted disease prophylaxis in European fish farming.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: KBBE.2011.2.1-01 | Award Amount: 1.20M | Year: 2011

The objective of the CONNECT4ACTION project is to improve communication between consumers, consumer scientists, food technology developers, and other key players in the food technology development and commercialisation process. Focusing on communication and knowledge exchange between food technologists and consumer scientists, the results of the CONNECT4ACTION project will contribute to improvement of the multidisciplinary dialogue and to increase consumer acceptance of new food products, thereby lower the failure rate of new (food) technologies in Europe. A large group of stakeholders (food scientists and technologists from companies, universities and research institutes, together with consumer scientists, ethical experts, representatives of science media/journalist, and consumers) will be connected with the project and each other via the online CONNECT4ACTION community. This online community strengthens the project with input and feedback during various stages and serves as showcase of improved communication. Based on effective communication strategies identified in the relevant literatures and, subsequently, opinions of experts based on their daily practices and experiences, this project will deliver an improved communication framework, accompanied by tools and training materials that enable food technology developers and other key players to step-by-step improve their food technology development processes. This FP7 experienced consortium, consisting of a broad, multidisciplinary network of key players that are involved in food technology development and commercialisation, has the expertise and experience from the field to disseminate and successfully implement innovative communication strategies into daily life activities. Dissemination of project outcomes receives great attention, even after the project is finished. Finally, the networking effort of CONNECT4ACTION will result in a strengthened European cooperation between public and private stakeholders.

Agency: European Commission | Branch: FP7 | Program: BSG-SME-AG | Phase: SME-2012-2 | Award Amount: 3.19M | Year: 2013

AUTOGRASSMILK is a unique cooperation of SME associations representing close to 100,000 SMEs in Ireland, Denmark, The Netherlands, France, Belgium, and Sweden and the core agricultural RTDs of these countries. AUTOGRASSMILK will analyze, develop, experiment and disseminate concepts for integrating grazing and automatic milking (AM) for dairy farms. By using a network of RTDs, advisory connected to SME-AGs, 20 monitor farms spread over Europe and two partner farms the concepts will be solidly documented and demonstrated. Dairy farming in Europe is a very important agricultural sector, employing over 600,000 professional farm managers (not including their staff), and more than 400,000 in the processing industry. Dairy farming in Europe has adopted AM at an accelerating rate for reasons such as improvement in lifestyle, less physical work, attracting skilled labour and for increased profitability based on higher milk production and lower labour costs. With AM, the cow is milked individually at her own free will, which is an entirely new way of dairy farming. Up to now, indoor feeding systems have been well adapted to AM, however grazing has not. Traditional pasture research does not provide the answers when AM is combined with grazing. Grazing has many advantages for economy, environment, animal welfare and product quality. With the increased focus on sustainability in society, these are very important, and crucially, grass is a low-cost high quality feed if it is managed well. To ensure a wide application among all types of farms, the six partners represent the whole range from extensive family size AM farms to intensive large dairy herds with the latest AM technology. AUTOGRASSMILK has the potential to increase the competitiveness of dairy farming in Europe by developing feeding strategies for dairy cows incorporating grazed grass with AM for various production systems.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.1.3-04 | Award Amount: 5.93M | Year: 2013

Intensive genetic selection in dairy cattle has resulted in a modern cows with very high milk yield but reduced fertility and poor calving performance. The sustainability of dairy cattle farming systems relies in large part on the ability of cows to maintain reproductive performance as they cope with the constraints imposed by environmental conditions and livestock practices. The strategic aim of this project is to unlock the potential for proactive herd management by providing the farmer with improved tools for on-farm reproductive monitoring and management. This will be achieved by a pluridisciplinary approach to eliminate the key scientific/methodological blockages and develop innovative solutions for a robust and sustainable improvement of fertility in cows. The project is structured in four R&D workpackages, one demonstration, one outreach and one management WP. The project will: 1) develop models to support on farm decision at different levels: animal fertility, herd management, and socio-economic impact for the farm and the farmer 2) identify genes and pathways involved in the adaptation of the reproductive function to different environmental conditions, especially low input feeding systems 3) identify the functional quantitative trait nucleotides for days till first luteal activity (based on progesterone measures) and estimate genomic breeding values using whole sequence information on individuals 4) study the adaptative response of animals to different feeding systems and management strategies 5) demonstrate the applicability of the knowledge and tools produced in the PROLIFIC project at the farm level 6) disseminate the knowledge produced in the project to the relevant stakeholders. PROLIFIC is a pluridisciplinary project taking advantage of the skills and expertise (modelling, molecular biology, genomics, phenotypic recording and statistics) of partners from all Europe. Seven research organizations, one industry and four SMEs are involved in the project

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2012.2.1-01 | Award Amount: 3.83M | Year: 2012

Health-related symbols and claims may be potentially influential in supporting informed choice, furthering healthier consumer food choices, and strengthening competitiveness of the European food industry in bringing about food products that support a healthier lifestyle. However, current insights into how health symbols and claims are understood and used in real-world shopping situations are limited, making it difficult to derive recommendations on the wording and design of health claims and symbols, including the context in which these appear on the food label. The objectives of this project are to determine how health-related symbols and claims, in their context, are understood by consumers, and how they affect purchasing and consumption, taking into account both individual differences in needs and wants and country-specific differences with regard to use of health claims and symbols. Guidelines will be developed for EU policy directed towards health-related symbols and claims, and a set of methods will be developed that can be used by policy-makers and industry to assess the effects of health claims and symbols as these appear on the market. The project will draw heavily on the involvement of stakeholders from the whole food sector to ensure results with high practical relevance.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.23M | Year: 2015

The Europlanet 2020 Research Infrastructure (EPN2020-RI) will address key scientific and technological challenges facing modern planetary science by providing open access to state-of-the-art research data, models and facilities across the European Research Area. Its Transnational Access activities will provide access to world-leading laboratory facilities that simulate conditions found on planetary bodies as well as specific analogue field sites for Mars, Europa and Titan. Its Virtual Access activities will make available the diverse datasets and visualisation tools needed for comparing and understanding planetary environments in the Solar System and beyond. By providing the underpinning facilities that European planetary scientists need to conduct their research, EPN2020-RI will create cooperation and effective synergies between its different components: space exploration, ground-based observations, laboratory and field experiments, numerical modelling, and technology. EPN2020-RI builds on the foundations of successful FP6 and FP7 Europlanet programmes that established the Europlanet brand and built structures that will be used in the Networking Activities of EPN2020-RI to coordinate the European planetary science communitys research. It will disseminate its results to a wide range of stakeholders including industry, policy makers and, crucially, both the wider public and the next generation of researchers and opinion formers, now in education. As an Advanced Infrastructure we place particular emphasis on widening the participation of previously under-represented research communities and stakeholders. We will include new countries and Inclusiveness Member States, via workshops, team meetings, and personnel exchanges, to broaden/widen/expand and improve the scientific and innovation impact of the infrastructure. EPN2020-RI will therefore build a truly pan-European community that shares common goals, facilities, personnel, data and IP across national boundaries

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.4.2-2 | Award Amount: 7.95M | Year: 2012

EPIC-CVDs overarching goal is to provide clinicians and policy-makers with a menu of evidence-based options for cost-effective individualised risk assessment that enables the EUs increasingly resource-constrained economies to achieve more personalised predictive medicine in harmony with Europes diverse cultures and healthcare systems. We will achieve this through developing and validating innovative risk scores and efficient screening strategies by studying 75 high priority soluble biomarkers and 215,000 carefully selected genetic variants in the most powerful population-based prospective study ever conducted of incident coronary heart disease, stroke, and type 2 diabetes across 10 diverse European countries. EPIC-CVD will provide the first consideration across Europe of risk scores with information on the interplay of nature and nurture together with biomarkers of lifestyle, biological pathways, vascular injury, and ageing. Our multidisciplinary consortium involves world-leading expertise in population health science, laboratory science (including VITAS, an SME partner, renowned for nutritional biomarker assays), translational science, and implementation science. This rare combination of expertise will enable systematic consideration of the implications of risk scores and screening strategies for predictive accuracy, feasibility, safety, acceptability, and cost-effectiveness. The impact on clinical decision making and clinical outcomes will be demonstrated in a new randomised trial of risk scores in relation to patient-centred outcomes that assess attitudes, behaviours, and biological risk factors. Key stakeholders (eg, healthcare professionals, regulators, industry) will be closely engaged by the project. Policy recommendations mindful of the broader societal implications of targeted screening will be tailored to Europes diverse needs and systematically disseminated to various audiences. This initiative will derive major synergy from related efforts.

Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2011.9.1 | Award Amount: 486.75K | Year: 2012

We seek to bring together all major European and Israeli research centres in Optimal Control of Quantum Information Processing. This project will coordinate ongoing research activities, best practice dissemination, personnel training and public engagement as well as interaction with public stakeholders and policymakers for 17 established research groups from 15 universities in 6 countries a total of about 60 scientists and 30 PhD students, spanning a variety of nationalities, races, cultures, social backgrounds, genders and career stages.The proposed Consortium will join the forces of multiple EU and Israeli research groups to explore a radical alternative to the currently established information processing technologies quantum information processing, where bits are carried by atoms or elementary particles and dramatic acceleration is believed to be possible for several types of computational tasks. Our specific research area within Quantum Information Processing is optimal control of quantum bits a set of technologies that enable extremely accurate manipulation of quantum bits with minimal expenditure of energy.Within this Coordination Action, we aim to create a vibrant, productive and efficient European research community, to deliver value to the society and to grow a new generation of young European physicists.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: ENV.2012.6.1-6 | Award Amount: 2.42M | Year: 2013

The overall objective of this Coordination and Support Action is to coordinate and support the development and the implementation plans of the Joint Programming Initiative Connecting Climate Knowledge for Europe (JPI Climate). The CSA will serve as a tool integrated in JPI Climate to enable it to address the challenges of climate change. Hence, it will contribute to the EU objective of building the European Research Area through enhanced cooperation and coordination of national research programmes. The CSA will coordinate preparatory activities within JPI Climate and will support the capacity-building process, with the aim of shortening the time required to reach the implementation phase. This will be done by further developing the common strategic research agenda and by refining the mapping exercise. With regard to the implementation a general concept for JPI Climate as a whole will be developed with preparing a catalogue of possible joint activities, developing and revising implementation schemes. Another main task of the CSA will be developing of a network strategy and the establishment of JPI Climate as the leading European platform to align policies in the area of climate research. This includes the coordination and development of synergies with the existing research and innovation schemes in the EU. The development of a strategy how to engage with member states not yet involved in JPI Climate and involve international institutions outside of Europe will complement this task. Further, the adaptation of the Framework Conditions will be an important step towards the implementation of JPI Climate. An appropriate use of the research findings requires effective communication strategies (web-sites, conferences, brochures). Therefore, the development of an optimized dissemination strategy will be part of the CSA as well.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2012.2.1-1 | Award Amount: 3.12M | Year: 2013

Social InnovationEmpowering the Young (SocIEtY) for the Common Good will both focus on and integrate disadvantaged young people into the research process to improve their quality of life and to foster social innovation. Therefore SocIEtY will extend the given informational basis for designing and implementing policies to reduce inequalities by giving voice and opportunities for developing aspirations to young people facing multifaceted inequalities while living in deprived city districts. The approach is to bring to the fore young persons concerns and voices about their self-perception and social participation in society. To accomplish these ambitious research tasks, the research strategy will benefit from the complementarities between qualitative and quantitative methodologies, reflected in the close interconnections between the Work Packages (WPs). SocIEtY will refine a coherent theoretical and methodological framework for the whole project on the basis of the Capability Approach. As a second step a documentary analysis and interviews with relevant political stakeholders and a longitudinal analysis of EU-SILC data will be carried out. Additionally, national and regional data for each partner country (WP3) for evaluating existing policies towards inequalities will be analysed. 11 analyses of social support networks (WP4) will be carried out, scrutinizing the strategies and policies of local actors in deprived city districts of each partner country. Finally, SocIEtY will develop an innovative participative research methodology (WP5) bringing different stakeholders and different narratives together. An aim of this empirical instrument is to enable deliberative processes in which every participant has equal opportunity to voice their concerns and aspirations with regard to the common good. Traditional empirical research is combined with a participation methodology, broadening the informational basis for social innovation in public policies.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra-PP | Phase: INFRA-2010-2.2.3 | Award Amount: 6.68M | Year: 2010

Environmental change and climate change in particular, are expected to be most pronounced in the polar regions. For this reason, a multi-disciplinary research infrastructure covering all important elements of the coupled Earth System in the Arctic is a very valuable tool to quantify the ongoing global change and to verify the capability of Earth System models to predict future changes. The proposed EFRI project Svalbard Integrated Arctic Earth Observing System (SIOS) is intended to take this role. The main goal of the SIOS Preparatory Phase (SIOS-PP) project is to define, work out and decide on the formal framework needed to establish and operate the geographically distributed and thematically composed multi-national research infrastructure with a node function in different aspects, that SIOS will manifest. This covers, on one side, aspects common for all ESFRI initiatives, such as legal status, governance structure, financial strategy, a data management and utilization plan, and an (on- and offshore) logistics plan. In addition, SIOS-PP will address topics that are special for this infrastructure: a dedicated remote sensing strategy, an internal scientific and observational, as well as an international integration and cooperation plan, which will link SIOS to regional European Arctic and pan-Arctic scientific infrastructure networks. The SIOS-PP project will be carried out by a consortium of 27 partners from 14 countries including 4 non-EU and non-associated countries; three of the partners are national funding agencies. In addition, 19 associated partners with infrastructure or strong scientific interests on Svalbard will cooperate during the preparatory phase. The project has a duration of 3 years.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE-2007-1-2-08 | Award Amount: 7.11M | Year: 2008

Dairying is an important sector of EU agriculture, but intensification has been accompanied by an increase in N surplus. This has a negative environmental impact on groundwater (pollution with nitrates), surface water (eutrophication) and on the atmosphere (de-nitrification and ammonia volatilisation). The EU seeks to stimulate measures that improve management of nutrients, waste and water as a start to move to management practices beyond usual good-farming practice. The objective of REDNEX is to develop innovative and practical management approaches for dairy cows that reduce nitrogen excretion into the environment through the optimization of rumen function, an improved understanding and prediction of dietary nitrogen utilization for milk production and excretion in urine and faeces. Novel tools for monitoring these processes and predicting the consequences in terms of N losses onfarm will be developed. At the centre of the project is a detailed mathematical model of N utilization by the cow which will act to integrate results from previous work and from new research carried out in the project. This interlinked research aims to improve the supply of amino acids to be absorbed relative to the quantity and quality of amino acids and carbohydrates in feed allowing a reduction in N intake. Research to understand amino acid absorption, intermediary utilization and the processes involved in the transfer of urea N from blood to the gastro-intestinal tract will further underpin model development and indicate strategies to reduce N losses. To predict N losses on-farm and the impact on profitability, a harmonised applied model will be derived from the mechanistic model and will be supported by tools to better describe feeds and biomarkers to indicate N status. Impact of the research will be enabled by dissemination and knowledge interaction using a participatory approach to include the views of stakeholders and recognition of the need to provide support to EU neighbours.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE-2007-2-1-03 | Award Amount: 3.71M | Year: 2008

Nutrition labels are potentially a major instrument for enabling consumers to make healthier food choices, but current insights into how nutrition labels are used by consumers in real-world shopping situations are limited, making the science-based formulation of new labelling policies and the evaluation of existing ones difficult. The objectives of this project are to determine how food nutrition labelling can affect dietary choices, consumer habits and food-related health issues by developing and applying an interpretation framework incorporating both the label and other factors/influences. Based on this, guidelines will be developed on use of nutrition labelling for EU policy and the food industry, especially SMEs, which will include recommendations for assessing the impact of ongoing and future legislative and voluntary food labelling schemes. These objectives will be achieved by a work programme covering an analysis of current penetration of and exposure to nutrition labels in the EU, determinants of attention to and reading of nutrition labels, determinants of consumer liking of nutrition labels, understanding how consumers infer healthiness of food products from label information in combination with other sources, in-store use of labels, and effects of label use on dietary intake. The project will draw heavily on the involvement of stakeholders from the whole food sector to ensure results with high practical relevance.

Agency: European Commission | Branch: H2020 | Program: ERA-NET-Cofund | Phase: ISIB-12a-2014 | Award Amount: 15.15M | Year: 2015

The objective of FACCE SURPLUS is to strengthen the European Research Area in support of different integrated food and non-food biomass production and transformation systems, especially by organising, implementing and cofunding with the EU a joint call for transnational research projects on the topic of sustainable and resilient agriculture. As this topic falls within the scope of the Strategic Research Agenda (SRA) of the Joint Programming Initiative on Agriculture, Food Security and Climate Change (FACCEJPI), this ERA-NET Cofund will contribute substantially to the delivery of the FACCEJPI SRA. It will thereby also contribute to the overall EU objective of building the European Research Area through enhanced cooperation, coordination and alignment of national research programmes. The action FACCE SURPLUS also aims at implementing other joint activities such as organizing workshops, scientific events, clustering of research platforms and infrastructures in the field of food and non-food biomass production and transformation systems, and also additional joint calls without EU cofunding. Launching such joint calls on a regular basis would pave the way to the long term objective of FACCE SURPLUS to establish a self-sustaining joint programme for FACCE-JPI. This will include establishing links with ongoing FACCE-JPI actions as well as related EU and international initiatives. FACCE SURPLUS will also support innovation and value creation from biomass in a sustainable way. The ERA-NET Cofund instrument is appropriate for FACCE-JPI, since it provides additional incentive to participating countries to engage financially on the field of sustainable and resilient agriculture, but also includes the flexibility to implement further activities to contribute to the establishment of a renewable bioeconomy in the ERA.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.00M | Year: 2015

Structural biology provides insight into the molecular architecture of cells up to atomic resolution, revealing the biological mechanisms that are fundamental to life. It is thus key to many innovations in chemistry, biotechnology and medicine such as engineered enzymes, new potent drugs, innovative vaccines and novel biomaterials. iNEXT (infrastructure for NMR, EM and X-rays for Translational research) will provide high-end structural biology instrumentation and expertise, facilitating expert and non-expert European users to translate their fundamental research into biomedical and biotechnological applications. iNEXT brings together leading European structural biology facilities under one interdisciplinary organizational umbrella and includes synchrotron sites for X-rays, NMR centers with ultra-high field instruments, and, for the first time, advanced electron microscopy and light imaging facilities. Together with key partners in biological and biomedical institutions, partners focusing on training and dissemination activities, and ESFRI projects (Instruct, Euro-BioImaging, EU-OPENSCREEN and future neutron-provider ESS), iNEXT forms an inclusive European network of world class. iNEXT joint research projects (fragment screening for drug development, membrane protein structure, and multimodal cellular imaging) and networking, training and transnational access activities will be important for SMEs, established industries and academics alike. In particular, iNEXT will provide novel access modes to attract new and non-expert users, which are often hindered from engaging in structural biology projects through lack of instrumentation and expertise: a Structural Audit procedure, whereby a sample is assessed for its suitability for structural studies; Enhanced Project Support, allowing users to get expert help in an iNEXT facility; and High-End Data Collection, enabling experienced users to take full benefit of the iNEXT state-of-the-art equipment.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.18M | Year: 2016

In the ASPIRE project, whose academic and industrial beneficiaries are world leading in their complementary fields of expertise, the overarching research goal is the measurement of photoelectron angular distributions (PADs) in the molecular frame (MF) of systems of biological relevance. These MF-PADs can be interpreted as electron diffraction patterns, achieved by illuminating the molecule from within, and enable the shapes and motions of individual molecules to be interrogated. Such knowledge is needed for the development of new medicines (the shapes of drug molecules dictate their function) and new materials (efficient solar cells can be constructed if energy dissipation processes in molecules are understood). Progress in this area is highly technologically driven, requiring high repetition rate, short wavelength light sources and fast detectors. The input of private sector beneficiaries is therefore critical to the scientific objectives, as well as to the enhanced training environment. Work packages on advanced light source and detector developments will feed into the overall goal through secondments, regular virtual meetings and face-to-face network meetings. The symbiosis of the developments that will take place in ASPIRE will create a research and training environment that is world-leading and optimally tailored to capitalise, for example, on the investment that has been made in the European XFEL facility. The ESRs will be trained in world-leading laboratories and will benefit from the exchange of best practice among beneficiaries and partners, and from unique training events. ASPIRE will therefore ensure that European research remains competitive in the global market, and that the trained researchers will be uniquely well-placed to contribute to the development of novel instrumentation in the future.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: BG-01-2015 | Award Amount: 9.21M | Year: 2016

ATLAS creates a dynamic new partnership between multinational industries, SMEs, governments and academia to assess the Atlantics deep-sea ecosystems and Marine Genetic Resources to create the integrated and adaptive planning products needed for sustainable Blue Growth. ATLAS will gather diverse new information on sensitive Atlantic ecosystems (incl. VMEs and EBSAs) to produce a step-change in our understanding of their connectivity, functioning and responses to future changes in human use and ocean climate. This is possible because ATLAS takes innovative approaches to its work and interweaves its objectives by placing business, policy and socioeconomic development at the forefront with science. ATLAS not only uses trans-Atlantic oceanographic arrays to understand and predict future change in living marine resources, but enhances their capacity with new sensors to make measurements directly relevant to ecosystem function. The ATLAS team has the track record needed to meet the projects ambitions and has already developed a programme of 25 deep-sea cruises, with more pending final decision. These cruises will study a network of 12 Case Studies spanning the Atlantic including sponge, cold-water coral, seamount and mid-ocean ridge ecosystems. The team has an unprecedented track record in policy development at national, European and international levels. An annual ATLAS Science-Policy Panel in Brussels will take the latest results and Blue Growth opportunities identified from the project directly to policy makers. Finally, ATLAS has a strong trans-Atlantic partnership in Canada and the USA where both government and academic partners will interact closely with ATLAS through shared cruises, staff secondments, scientific collaboration and work to inform Atlantic policy development. ATLAS has been created and designed with our N American partners to foster trans-Atlantic collaboration and the wider objectives of the Galway Statement on Atlantic Ocean Cooperation.

Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 549.00K | Year: 2017

This two-year project involves an international and inter-sector research and training network that focuses on the potential of makerspaces, which are specific spaces that enable creative design and the production of both digital and non-digital artefacts, to foster the digital literacy and creative skills of young children. A key aim of the project is to inform educational policy and practice in this area, enabling formal learning institutions (early years settings and primary schools) to learn from practice in non-formal learning spaces, and vice-versa, and also to foster innovation and entrepreneurship in the makerspace sector, enabling SMEs to develop robust business models and appropriate resources for future work in this area. The project involves 16 academic and non-academic beneficiaries and 10 non-academic, non-beneficiary partners across 6 EU countries (Denmark, Finland, Iceland, Norway, Romania, UK), an Associated Country (Colombia) and 4 Third Countries (Australia, Canada, South Africa and USA). This global network of university scholars, cultural industry partners in makerspaces, early years practitioners, museum educators and librarians will engage in a collaborative research and training programme that addresses 4 objectives, which are to: 1. Conduct a comprehensive review of the role of makerspaces in the formal and non-formal educational experiences of children and young people. 2. Undertake empirical research to determine how makerspaces can foster the digital literacy and creativity skills and knowledge of young children. 3. Develop a conceptual framework for analysing young childrens engagement in makerspaces. 4. Make recommendations for policy and practice that will foster innovation and entrepreneurship in SME makerspaces and facilitate the use of makerspaces for enhancing digital literacy in early childhood educational institutions and non-formal learning spaces.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2008. | Award Amount: 4.73M | Year: 2009

Long-range transport of contaminants to the Arctic, the resulting exposures observed in Arctic human populations, and impacts of such exposures on human health have been the subject of considerable work in recent years, providing a baseline against which to compare future developments. Global climate change has the potential to remobilize environmental contaminants and alter contaminant transport pathways, fate, and routes of exposure in human populations. The Arctic is particularly sensitive to climate change and already exhibits clear impacts. Research into contaminant exposure and its effects on human health in the Arctic, in comparison with other exposed populations in Europe, presents an opportunity to gain insight into changes that may later impact other areas. The influence of climate change on contaminant spreading and transfer and the resultant risk to human populations in the Arctic and other areas of Europe will be studied by: 1) Research on the ways in which climate change will affect the long-range transport and fate of selected groups of contaminants, and possible implications for the re-distribution of contaminants (geographically and between relevant environmental media). This will involve modelling, utilizing the information base that exists on the distribution of such contaminants in the Arctic and other areas of Europe; 2) Research on the impacts that changing pathways and climatic conditions will have on contaminant uptake and transfer within food webs, leading to foods consumed by humans. This will involve experimental work, process studies and targeted analytical studies, the latter focussed on supporting the modelling work and process studies related to human exposure to contaminants; 3) Research focussing on human health, aimed at determining how climate-mediated changes in the environmental fate of selected groups of contaminants will result in changes in exposure of human populations, in the Arctic and in selected areas of Europe.

Agency: European Commission | Branch: FP7 | Program: CP-IP-SICA | Phase: ENV.2010.4.1.3-2 | Award Amount: 9.15M | Year: 2010

The overall goal of the proposed project is to develop a coordinated global observation system for mercury able to provide temporal and spatial distributions of mercury concentrations in ambient air and precipitation over land and over surface waters at different altitudes and latitudes around the world. This will then provide high quality data for the validation and application of regional and global scale atmospheric models, to give to governments, national and international organisations and stakeholders a firm basis for future policy development and implementation. Specific objectives of the proposed project are (a) to establish a Global Observation System for Mercury (GMOS) able to provide ambient concentrations and deposition fluxes of mercury species around the world, by combining observations from permanent ground-based stations, and from oceanographic and tropospheric measurement campaigns; (b) to validate regional and global scale atmospheric mercury modelling systems able to predict temporal variations and spatial distributions of atmospheric mercury entering to and re-emitted from terrestrial and aquatic receptors; (c) to evaluate and identify source-receptor relationships at country scale and their temporal trends for current and projected scenarios of mercury emissions from anthropogenic and natural sources; (d) to develop interoperable tools to allow the sharing of observational and models output data produced by GMOS. The overarching goal of GMOS is to support the achievement of goals set by the GEO / GEOSS, and specifically of the GEO Task HE-09-02d and contribute to the advancement of our scientific understanding in the nine Societal Benefit Areas (SBA) established in GEOSS. The proposed project will rely on the results and knowledge acquired in the framework of past EU projects (i.e., MAMCS, MOE, MERCYMS) and international programs (i.e., UNECE TF HTAP; UNEP F&T partnership area).

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH-2009-1.1.1. | Award Amount: 2.86M | Year: 2009

Making Capabilities Work (WorkAble) will scrutinise strategies to enhance the social sustainability and economic competitiveness of Europe by strengthening the capabilities of young people to actively shape their personal and work lives in knowledge societies and cope with today's economic, cultural, demographic and technological challenges. Bridging quantitative and qualitative methods, WorkAble will assess the potential of innovative European strategies for dealing with local labour-market demands and regional inequalities. Adopting a comparative and interdisciplinary approach, it will systematically analyse whether and how young people are enabled to participate in working life and society. Applying the Capabilities Approach as a common heuristic framework, 12 partners from different disciplines (educational science, sociology, economics, philosophy, political studies and social work) in 10 European countries will collaborate closely in a multidimensional research process. WorkAble will survey whether and how the match between young peoples supply of skills and competencies and changing labour-market needs is sustained and secured, while simultaneously broadening their options for living in and actively shaping European knowledge societies. It will explore how educational strategies are implemented and assess whether they enable young people to convert knowledge, skills and competencies into capabilities to function as fully participating active citizens. This calls for a three-phase research design: 1) a comparative institutional mapping and analysis of vocational and labour-market policies in all educational regimes; 2) case studies to reconstruct the conceptions, aspirations and practices of local actors implementing educational and training programmes; and 3) quantitative secondary analyses of national and European longitudinal data revealing how effectively these strategies enhance economic performance and close the capability gap for young people.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2011-1.1.14. | Award Amount: 7.58M | Year: 2011

The overall objective of the SeaDataNet II project is to upgrade the present SeaDataNet infrastructure into an operationally robust and state-of-the-art Pan-European infrastructure for providing up-to-date and high quality access to ocean and marine metadata, data and data products originating from data acquisition activities by all engaged coastal states, by setting, adopting and promoting common data management standards and by realising technical and semantic interoperability with other relevant data management systems and initiatives on behalf of science, environmental management, policy making, and economy. SeaDataNet is undertaken by the National Oceanographic Data Centres (NODCs), and marine information services of major research institutes, from 31 coastal states bordering the European seas, and also includes Satellite Data Centres, expert modelling centres and the international organisations IOC, ICES and EU-JRC in its network. Its 40 data centres are highly skilled and have been actively engaged in data management for many years and have the essential capabilities and facilities for data quality control, long term stewardship, retrieval and distribution. SeaDataNet II will undertake activities to achieve data access and data products services that meet requirements of end-users and intermediate user communities, such as GMES Marine Core Services (e.g. MyOcean), establishing SeaDataNet as the core data management component of the EMODNet infrastructure and contributing on behalf of Europe to global portal initiatives, such as the IOC/IODE Ocean Data Portal (ODP), and GEOSS. Moreover it aims to achieve INSPIRE compliance and to contribute to the INSPIRE process for developing implementing rules for oceanography.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: SIS-2008- | Award Amount: 5.24M | Year: 2009

Helping teachers raise the quality of science teaching and its educational environment has the potential to increase student engagement, attainment, scientific literacy and science career choices. S-TEAM will achieve this by connecting existing science education research and teacher knowledge to teacher education. This task requires the power of coordinated action across a wide range of institutions and national contexts. The 26 partners and 15 nations engaged in S-TEAM have a unique opportunity to systematically integrate their knowledge of teaching, research and teacher education, and to adapt science education to the diverse needs of citizens and the economy in Europe, focusing on inquiry-based methods. These involve problem-solving, hands-on experimentation, authentic, student-led content and critical dialogue, but they require wider development of teacher skills and knowledge. Many teachers are already competent in these methods, and are thus the best source of learning for others. S-TEAM will achieve its aims by disseminating research on, and teachers' experiences of inquiry-based methods to existing and future science teachers. Its actions will involve listening to teachers, working with teacher educators and researchers, and providing support for better science education. This support will include workshops, training packages, video case-studies, teaching materials and publications. S-TEAM will involve not only teachers, but also teacher educators, researchers, students, parents and policymakers in dialogue, to ensure that this dissemination is effective. S-TEAM is sustainable since learning through teacher collaboration and education can be continually regenerated, but also necessary because science teacher education needs to be shared across Europe. By enabling teachers to deliver more efficient and efficacious learning, S-TEAM will improve the attitudes, motivation and learning of young people, including girls, in science education.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.6.6 | Award Amount: 3.97M | Year: 2011

Reduction of CO2 emissions is the great challenge of the transport sector nowadays. Despite progress in vehicle manufacturing and fuel technology, additional innovative technologies are needed to address this challenge. According to the Int. Assoc. of Public Transport, a significant fraction of CO2 emissions in EU cities is resulting from public transport and other mass transport means, which are commonly organized into multi-modal transport fleets, because their vehicles have, on average, nearly substantial mileage and fuel consumption.The REDUCTION project focuses on advanced ICT solutions for managing multi-modal fleets and reducing their environmental footprint. REDUCTION collects historic and real-time data about driving behaviour, routing information, and emissions measurements, that are processed by advanced predictive analytics to enable fleets enhancing their current services as follows: 1) Optimizing driving behaviour: supporting effective decision making for the enhancement of drivers education and the formation of effective policies about optimal traffic operations (speeding, braking, etc.), based on the analytical results over the data that associate driving-behaviour patterns with CO2 emissions. 2) Eco-routing: suggesting environmental-friendly routes and allowing multi-modal fleets to reduce their overall mileage automatically. 3) Support for multi-modality: offering a transparent way to support multiple transportation modes and enabling co-modality.REDUCTION follows an interdisciplinary approach and brings together expertise from several communities. Its innovative, decentralized architecture allows scalability to large fleets by combining both V2V and V2I approaches. Its planned commercial exploitation, based on its proposed cutting-edge technology, aims at providing a major breakthrough in the fast growing market of services for green fleets in EU and worldwide, and present substantial impact to the challenging environmental goals of EU.

NanoPack will demonstrate a solution for extending food shelf life by using novel smart antimicrobial surfaces, applied in active food packaging products. It will run pilot lines in operational industrial environments to manufacture commercially feasible antimicrobial polymer films, accepted by consumers. It will minimize the amount of preservatives required to maintain freshness, add value and assure safety to the entire supply chain. The project will employ natural Halloysite Nanotubes (HNTs) as reliable and safe carriers of bio-active compounds which are unable to migrate from the food packaging into food. Maximising safety, they slowly release minute amounts of potent, volatile and broad-spectrum natural agents into the packaging headspace. Using nanotechnology enables 1) introducing sensitive molecules into polymer films; 2) anti-microbial functionality without impaired film properties; 3) manufacturing potent antimicrobial surfaces with tunable properties, while creating a pH-triggered gate keeper effect to slow down release of the payload encapsulated. The resulting film will exhibit antimicrobial properties unmet by the current state-of-the-art. The processes across the supply chain will be validated through 5 pilot runs on existing production lines: 1) loading antimicrobials, 2) anti-microbial HNT polymer production, 3) anti-microbial packaging film production and 4-5) using the novel packaging on food products. Commercial feasibility will be assessed, including consumer acceptance and legal, regulatory, safety and environmental aspects. The success of NanoPack will result in validated consumer-accepted nanotechnology-based antimicrobial food packaging that will enhance food safety, prevent foodborne illness outbreaks and reduce food waste caused by early spoilage. Better performing, safer and smarter products will position Europe as the leader in food nanotechnology & smart antimicrobial packaging while increasing competitiveness and industry growth.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC5-11c-2015 | Award Amount: 7.99M | Year: 2016

A key EU policy aims to reduce the Union dependency on raw materials imports, in particular (candidate) Critical Raw Materials that are vital for the EU innovative technologies. Topic SC5-11c-2015 scope focuses on developing new highly-automated technological sustainable solutions for deep mining in the sea bed combined with in-situ processing of minerals. An existing but challenging raw material resource concerns polymetallic nodules. These round to elongated concretions of 115 cm diameter form on sediment-covered deep-sea plains in all oceans between 4-6000m water depth. The challenge to harvest and transport the nodules to the EU shore is taken on by Blue Nodules. The governing project principle is: industrial viability within the context of a realistic and technical, economic and environmentally balanced business case for the complete Polymetallic Nodules value chain of mining, processing and valorisation. Blue Nodules will develop and test to TRL6 maturity a new highly-automated and technologically sustainable deep sea mining system. Key features are: an annual production capability of 2 Million Tons nodules in water depths up to 6000m, in-situ processing of the nodules and intrinsic safe working conditions. Technical WPs are dedicated to subsea harvesting equipment & control technology, in-situ seafloor processing of polymetallic nodules and sea surface, land operations & processes. A dedicated WP focuses on environmental issues and on an Environmental Impact Assessment (EIA). A WP setting requirements and assessing the developed technology controls the entire work plan structure. High credibility is obtained by linking the project work to a nodule field licence owned by a project partner and located in the most promising known nodule deposit: the Clarion Clipperton Zone. The project consortium contains 14 leading industry and research partners from 9 EU member states. The project duration is 48 months, the required funding amounts to 8 Million.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 4.05M | Year: 2013

Finding novel solutions for energy storage is of high societal relevance, since it is a prerequisite for the turnaround from fossil fuels and nuclear power to energy from renewable sources, since these sources mostly are intermittent. Also for providing an ecological friendly mobility, high capacity energy storage solutions are urgently needed. Well trained experts in energy storage are a prerequisite of the necessary technological development. ECOSTORE contributes to these targets by training 12 ESRs and 3 ERs in materials science and use of novel metal hydrides for energy storage chemical, as hydrogen, and electrochemical, in batteries. The fellows will be trained in scientific skills by pursuing own research projects (leading to a PhD in the case of ESR) as well as in complementary skills, important for their future career in academia or industry, like management of scientific and technical projects, science-public communication and development of their own career and personality. ECOSTORE is an international network of partners each with high reputation in the field of hydrogen and electrochemical storage. 9 European research institutions, 3 European industrial companies, and 2 Associated Partners from Japanese Universities form a network of complementary scientific and techno-economical expertise. Novel borohydride- and nitride based materials may allow for high energy storage densities in terms of both hydrogen and electrochemical processes. For commercial introduction, a prerequisite is the cost efficient large scale production from abundant and relatively cheap raw materials, going from extremely pure chemicals and laboratory-scale to less pure raw materials and industrial scale. ECOSTORE aims at the scientific understanding of materials behaviour in hydrogen as well as in electrochemical processes, and, based on this, at scale-up of cost effective materials production, and at prototype testing to perform a techno-economical evaluation of the developments

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2012.1.2-05 | Award Amount: 4.20M | Year: 2012

Healthy seed are key to high crop yields, underpinning European and global food security. A wide range of diseases and pests are carried by seed and as well as spreading and increasing old problems, new problems may be introduced into the European Community countries via this route. There are currently opportunities to improve seed quality control by implementing emerging novel methodologies. The TESTA project will develop a range of novel methods to underpin the control of these diseases and pests, including faster, more accurate methods to assess the mode of seed transmission, economic and practical sampling approaches for the detection of low levels in large seed lots, novel and efficient generic detection methodologies, non-destructive testing methods and improved, effective and sustainable disinfection methods. Target crop and disease/pest combinations have been identified in consultation with EPPO, ISHI-ISF and ISTA. Outcomes from the project will include a comprehensive electronic database of seed transmitted diseases and pests, validated detection methods for target species, a validation protocol for assessing the efficacy of disinfection, as well as many key scientific publications. These will provide supporting methods and sources for the EU seed testing laboratories and plant health services. The consortium comprises experienced researchers who have been involved in key previous research projects funded by the EU and national authorities, representatives of EPPO, ISTA plant health panel and ISHI working groups as well as seed testing laboratories and SMEs involved in seed production. The consortium includes a member from South Africa who is an international expert on seed production in non-EU countries and will provide insight into emerging risks. Involvement of these important players in the management of the project will guarantee that the project plans and outcomes are well-targeted and taken up in a practice so that the project legacy is ensured.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMBP-03-2016 | Award Amount: 4.95M | Year: 2017

Permanent magnets are crucial in modern technology as they allow storing, delivering and converting energy. They are able to transform electrical energy into mechanical and vice versa, which means that improving their performance entails transforming energy in a more efficient and sustainable way. The best magnets are based on rare-earths (RE), however, their status as a Critical Raw Material (CRM) has brought forward the realization that it is of great strategic, geographic, environmental and socio-economic importance to consider alternative magnets that present a reduced amount (or absence) of RE. One of the most sought approaches towards this goal consists on constructing composite magnetic materials magnetically coupled at the interface. In the framework of the success of a previous European Project (FP7-SMALL-NANOPYME-310516), focused on improving ferrite-based magnets, we developed a low-cost novel approach (Patent P201600092) that exploits the magnetostatic interactions within these composites and that yielded extremely promising results in the form of an experimental proof-of-concept. The goal of this project is to implement up-scalable and cost-efficient methods for fabrication of ferrite-based dense anisotropic magnets with a 40% enhanced magnetic performance (energy products above 55 kJ/m3) with respect to commercial ferrites. We aim at producing improved magnets that retain the advantages of ferrites availability, sustainability, cost, recyclability, eco-friendliness- and which have the potential to substitute currently used RE magnets (CRM) in the electric power system. Our targeted application is an electric energy storage device: we will substitute RE magnets by AMPHIBIAN ones in a demonstrator of a flywheel and evaluate its performance against cost, eco-friendliness and resource efficiency criteria.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-2.4.4-1 | Award Amount: 3.92M | Year: 2008

In this proposal, we have mobilized a critical mass of expertise to investigate, on a Europe-wide scale, the natural history and pathophysiology of rare inherited diseases affecting important structures of the kidney. The project will use and develop multiple models (in vitro and in vivo) with the aim to develop preventive, diagnostic and therapeutic interventions that should alleviate the burden of these diseases, particularly in children. A central part of the proposal is the creation of a European registry and a network of genetic laboratories to foster a tight interaction between physicians and researchers, promote clinical and basic research, and ensure the efficient dissemination of knowledge. By increasing our knowledge of these rare diseases, the EUNEFRON project will also yield new insights into basic processes relevant for the general population (progression of renal disease, blood pressure control, prevention of renal stones, effect of gender and ageing, etc), the complex relationship between different nephron segments, and the multi-systemic involvement of renal diseases.

Agency: European Commission | Branch: FP7 | Program: CP-IP-SICA | Phase: KBBE.2010.1.2-01 | Award Amount: 12.67M | Year: 2011

ANIMALCHANGE will provide scientific guidance on the integration of adaptation and mitigation objectives and design sustainable development pathways for livestock production in Europe, in Northern and Sub-Saharan Africa and Latin America. ANIMALCHANGE will inform public policy development in EU27 and propose cooperation programs addressing smallholder livestock farming in selected developing countries. The core analytical spine of the project is a series of coupled biophysical and socio-economic models combined with experimentation. This allows exploring future scenarios for the livestock sector under baseline and atmospheric CO2 stabilization scenarios. These scenarios are first constructed in Component (CP) 1. They are elaborated and enriched by breakthrough mitigation and adaptation options from CP 2 at field and animal scales, integrated and evaluated at farm scale in CP 3 and used to assess policy options and their socio-economic consequences in CP 4. ANIMALCHANGE will: - Quantify and reduce uncertainties in greenhouse gas (GHG) emissions and assess climate change impacts on livestock systems (including grasslands) - Revise estimates of the GHG balance of livestock systems and integrate soil carbon sequestration - Integrate climate variability and extremes into the assessment of impacts, adaptation and vulnerability of livestock systems to climate change - Develop breakthrough technologies for adaptation and mitigation to climate change for both ruminants and monogastrics - Study and quantify trade-offs and synergies between adaptation and mitigation options - Assess the potential societal and sectoral costs and benefits of these options for the livestock sector in Europe and in study regions of Africa and Latin America - Assess climate change vulnerability of animal production and of associated GHG emissions - Provide direct support through the design of an integrated and consistent mitigation and adaptation policy framework for the livestock sector

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2010.2.1.4-4 | Award Amount: 9.99M | Year: 2011

The strategic goal of EcoFINDERS is to provide the EC with tools to design and implement soil strategies aimed at ensuring sustainable use of soils, including: i) Characterisation of European soil biodiversity; ii) Determination of relations between soil biodiversity, soil functions and ecosystem services; iii) Design of policy-relevant and cost-effective indicators for monitoring soil biodiversity. The project will: i) Develop and standardise tools and procedures to measure microbial and faunal diversity; ii) Describe the diversity of soil organisms (microbes and fauna), iii) Decipher the interactions among soil organisms and with plants through foodwebs and iv) Determine the role played by soil organisms in soils ecosystem services (nutrient cycling, carbon storage, water retention, soil structure regulation, resistance to pests and diseases, and regulation of above-ground diversity); iii) Establish cost-effective bioindicators for measuring sustainability of the microbial and faunal diversity and their associated functions (using a combination of metrics and meta-analysis); iv) Evaluate the economic value of ecosystem services, the added value of these bioindicators; v) Develop and implement effective communication strategies to engage the European public around issues associated with the sustainability of soil biodiversity. The overall concept of the project is to develop and integrate the following activities: i) Decipher the links between soil biodiversity, activities, functioning and ecosystem services; ii) Combine three types of approach: observation, experimentation, and computation; iii) Assess the impact of environmental conditions; iv) Integrate information on microbes, fauna and plant communities and analyse how these compartments interact. The general hypotheses are: changes in soil biodiversity indicate the direction and rate of changes in soil functions and associated ecosystem services; application of cost-effective bioindicators brings an economic added value to sustainable soil management.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: NMP.2011.1.3-4 | Award Amount: 2.33M | Year: 2012

NANOPINION will provide a multi-tasking and enlivening online science-technology-social media-based platform for learning, information, outreach, dialogue and monitoring for young people, general public and consumer opinion on NT, realising the need for enhanced communication and dialogue between science and society for successful technology development and societal acceptance. A central dialogue arena of both physical and virtual aspects will be created to establish a dynamic outreach and dialogue model that will address the public in the high street via street knowledge and opinion labs, and other target groups in a variety of interactions in live events, online project portal, and web 2.0 tools. Controversial issues will be discussed on range of channels in order to establish a trustworthy and informed dialogue with the public. The engagements will be monitored continuously, and citizens opinions of NT will be gathered and traced using validated online and offline tools, thus providing clear direction and challenges driven by the citizens opinion regarding communication, NT fields, regulation, governance, research, social implications and education of NT. Past FP6/7 projects will be extensively used as prime knowledge, information and education resources for the project. NANOPINION will contribute to awareness and interest raising in the realm of NT, by engaging all age groups in the wider public in informing and discussion surrounding NT. We aim for the project to serve as an access bridge between FP7 and FP8 thus provides the EC with insights for policy framing concerning NT. The NANOPINION takes the debate to the outdoor arena dealing with tough to reach audience, that usually do not participate in science debates. Also, The project is going to offer experimental NT curriculum for high school that will carried out in EU, Associated countries and Russia. This curriculum will ne used for a future bacaloriate/ A level/ matriculation program of study NT.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.62M | Year: 2012

The proposed ITN (NanoS3) have assembled eight academic groups with complementary expertise in synthesis, modeling and characterization. They are joined by two full industrial partners active in the development of novel luminescent materials (LuminoChem), and in the home and personal care sectors (Procter and Gamble). Two associated partners will contribute to the work of our proposed network: BioTalentum is an SME in the field of stem-cell research and the Institute for Surface Chemistry (YKI) is a world-leading research institute in applied surface chemistry. Our work will focus on three priority areas of research: 1: Organizing Soft Nanoparticles 2: Dynamics of Soft Nanoparticles 3: Soft Nanoparticles at Interfaces These S&T objectives are combined with the ambitious objectives to train and promote qualified research project managers in the field of soft matter nanoscience, capable to work in research or industry together with experts in different disciplines and in different countries. We will accomplish our goal by training early stage researchers in a wide variety of modern bulk and surface techniques, as well as in modelling and synthetic methods. We will organize a series of tutorial courses on specialized topics, organize network workshops, and implement secondments and visits. To develop the complementary skills needed to start a successful career either in academia or in R&D we will organize trainings in e.g. Project management, Proposal writing, Presentation skills, IP and patent rights and Innovation.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2009.3.2.2 | Award Amount: 4.08M | Year: 2010

The Biowalk4Biofuels Project aims to develop an alternative and innovative system for biowaste energy recovery and use of GHG emissions to produce biofuels, using macroalgae as a catalyser, in a multidisciplinary approach. The objectives of the project are: production of a cost-efficient biogas without using cereal crops; optimise the production of biogas per amount of biowaste and CO2 used, with low land use for plant facilities; and increase and optimize the types of biowastes that can be utilised for biogas production. To achieve the underlined objectives, research activities are to be carried out on the selection of adequate macroalgae species that can reach high output biomass yields and high carbohydrate content. Pre-cultivation of protoplasts will allow to obtain easily available biomass for feeding the cultivation open floating ponds within shorter periods, thanks to the rapid proliferation of germplasm, diminishing the life-cycle of macroalgae. In addition, the relationship between growth and energy potential of selected species with the amounts/characteristic of GHG emissions and biowaste introduced in the cultivation medium is to be studied. . After fermenting the algal biomass and other biowastes, the cycle is closed by producing biogas to be used for electricity and heat generation and as a transport fuel. A high quality biogas is expected, hence a purification step will proceed the final product. Furthermore, organic residues output from the methanation biodigestor are to be used as fertilizer after solid/liquid separation. The liquid fraction of the digestate will be treated in a biological oxidation system .A portion of the unseparated outlet effluent from the oxidation system (solids \ liquid) will be fed to the macroalgae cultivation (instead of the enrichment with chemical N-P-K fertilizers). Meanwhile, the other portion will be reused as feeding for the AD plant section. This process solution will permit to feed with several critical biowastes the biodigester, transforming them into a resource. The expected impact is to produce a cost-efficient, low energy-intensive, purified biogas, to reduce negative environmental impacts from industry (GHG emissions) and biowaste. The multidisciplinary approach solution to reduce GHG emission and process biowaste, while producing energy, seeking for the future replications in other locations.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2010.3.2-01 | Award Amount: 3.85M | Year: 2011

The aim of MARINE FUNGI is the demonstration of sustainable exploitation of marine natural resources providing appropriate culture conditions for the underutilised group of marine fungi, thus enabling efficient production of marine natural products in the laboratory and also in large scale cultures, avoiding harm to the natural environment. The focus of MARINE FUNGI are new anti-cancer compounds The project will carry out the characterisation of these compounds to the stage of in vivo proof of concept ready to enter further drug development in order to valorise the results of the project. MARINE FUNGI covers two approaches to gain effective producer strains: a) Candidate strains originating from one partners strain collection will be characterised and optimised using molecular methods. b) New fungi will be isolated from unique habitats, i.e. tropical coral reefs, endemic macroalgae and sponges from the Mediterranean. Culture conditions for these new isolates will be optimised for the production of new anti-cancer metabolites. MARINE FUNGI will develop a process concept for these compounds providing the technological basis for a sustainable use of marine microbial products as result of Blue Biotech. The project will explore the potential of marine fungi as excellent sources for useful new natural compounds. This will be accomplished by the formation of a new strongly interacting research network comprising the scientific and technological actors, including 3 SMEs and 2 ICPC partners, necessary to move along the added-value chain from the marine habitat to the drug candidate and process concept. The generated and existing knowledge will be disseminated widely for the valorisation of the project results.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-1.4-2 | Award Amount: 5.92M | Year: 2008

Direct vaccination cannot prevent diseases that affect neonates in the first days of life. Group B Streptococcus (GBS) is the major cause of neonatal septicemia and meningitis affecting up to one in every thousand live births. Over 80% of cases occur in the first 7 days after birth and the remaining 20% of disease occurs between 8-90 days after birth. Studies carried out in the USA indicate that high titres of maternal antibody to GBS capsular polysaccharides (CPS) correlate with reduced risk of disease in neonates suggesting that maternal immunization may be an effective strategy for delivery of a protective immune response to the child in this early period. The overall objective of this proposal is to design immunization strategies capable of inducing strong durable and placentally transferable protective immune responses against GBS in women in order to fill this gap in early infancy when direct immunization is not possible. Starting with the genome sequence of 8 strains of GBS, Novartis scientists have identified three proteins that confer protection against lethal challenge in neonatal mice from immunized females. Combinations of CPS conjugates plus the recombinant proteins conferred protection against 12 of 12 GBS strains representing the major disease causing serotypes. In order to translate this research into a viable vaccine it will be necessary to identify appropriate adjuvant and delivery systems capable of inducing a protective response which will last through pregnancy. In order to select the serotypes of CPS to include in the vaccine, it will be necessary to understand the serotype distribution of GBS disease in Europe. Furthermore, an immune surrogate of protection will be required to replace efficacy trials. This proposal will address these issues by evaluating adjuvant and delivery in mouse models of disease and by analysis of maternal antibody levels and strain characteristics in cases versus controls obtained from several countries in Europe

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: SPACE | Award Amount: 6.00M | Year: 2014

The main objective of the MyOcean Follow On project will be to operate a rigorous, robust and sustainable Ocean Monitoring and Forecasting component of the pre-operational Copernicus Marine Service delivering ocean physical state and ecosystem information to intermediate and downstream users in the areas of marine safety, marine resources, marine and coastal environment and weather, climate and seasonal forecasting. This is highly consistent with the objective of the HORIZON 2020 Work Programme 2014-2015 establishing the need for interim continuity of the pre-operational services developed by MyOcean 2 before the fully operational services of Copernicus. The project proposes to sustain the current pre-operational marine activities until March 2015 in order to avoid any interruption in the critical handover phase between pre-operational and fully operational services. In effect, any significant interruption in these services could potentially jeopardize several important high-level policy objectives and undermine other related scientific activities. In the period from October 2014 to March 2015, MyOcean-FO will ensure a controlled continuation and extension of the services already implemented in MyOcean and MyOcean2 FP7 projects that have advanced the pre-operational marine service capabilities. To enable the move to full operations, MyOcean-FO is targeting the prototype operations, and developing the management and coordination to continue the provision of Copernicus Marine service products and the link with independent R&D activities. MyOcean-FO will produce and deliver services based upon the common-denominator ocean state variables that are required to help meet the needs for information for environmental and civil security policy making, assessment and implementation. MyOcean-FO is also expected to have a significant impact on the emergence of a technically robust and sustainable Copernicus Service infrastructure in Europe.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.3-2 | Award Amount: 8.50M | Year: 2013

Chronic kidney disease is world wide a major cause of end-stage renal disease (ESRD). 800.000 patients in Europe and in the US, respectively, require long-term treatment initially with peritoneal dialysis, followed by hemodialysis and kidney transplantation. Each ESRD patient on hemodialysis costs 40000 to 80000 per year, has extremely poor quality of life and an average life expectancy of only 4 years. Kidney transplantation totally changes life for an ESRD patient who can then return to normal life, but this treatment is hampered by the low number of available kidney grafts. All these treatments are, however, associated with severe adverse reactions that cause damaging thromboinflammation, triggered by the intravascular innate immune system, which lead to poor results and non-function. The overall aim of this project is to clarify the mechanisms and identify natures own specific control points of regulation in these adverse reactions in order to be able to significantly improve the quality of hemodialysis devices and kidney grafts by applying these concepts of regulation in hemodialysis and kidney transplantation. We envisage that conveying a novel soluble complement inhibitor to the clinical stage via phase 1/2a clinical studies, creation of nano-profiled surfaces with low activating properties and generation of easy-to-apply one step-coatings for treatment of biomaterials (hemodialysis) and endothelial cell surfaces (kidney grafts) will revolutionize the treatment modalities of ESRD. The feasible hemodialysis treatment periods are anticipated to be extended, combined with an improved quality of life and in kidney transplantation attenuation of innate immune reactions will prolong the life expectancy of the graft and make kidneys more accessible for transplantation. All the novel techniques can be applied to other types of implantations, extracorporeal treatments and transplantation and in the future be used in xenotransplantation and stem cell therapies.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.24M | Year: 2013

The research training focuses on the substantive and theoretical challenges posed by universities new role in a global knowledge economy, and especially the contrast between developments in Europe and the Asia Pacific rim. In recent years, massive effort has been put into reforming, managing and marketing universities in Europe and elsewhere in the world. The justification is that universities are to play a new role in the formation of the EHEA and ERA and in driving a knowledge-based economy. The reform processes are, arguably, themselves producing new ways of organising this economy in world regions and reforming the higher education sector itself. This research training project provides ESRs and ERs with the theoretical, methodological and technical skills to analyse these processes in Europe and the Asia Pacific Rim.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: NMP.2011.4.0-4 | Award Amount: 947.59K | Year: 2011

After running a series of events in individual NMP areas, the Commission decided to create a large biannual event to integrate their work across these themes. The first Industrial Technologies event took place in Brussels in 2010 and attracted 1000 participants. The event successfully gathered a high-level group of speakers and attendees including ministers, CEOs of large companies, and the Director General of the Research DG. The next Industrial Technologies event is planned to take place during the Danish Presidency of the European Commission in the first half of 2012. iNANO, Spinverse, and the Center for Industrial Production proposes to host the event in Aarhus from June 12-14th 2012. The event will last for three days and will be expected to again have 1000 participants. Industrial Technologies 2012 will have four objectives: 1. To underline the importance of NMP key enabling technologies in developing solutions to the grand challenges, such as climate change, health, mobility and energy efficiency 2. To spotlight the success stories of NMP under FP7, giving visibility to those projects that combine breakthrough technology innovation with significant industrial impact and communication where FP7 NMP funding is playing a vital role 3. To identify innovative solutions to unfavourable framework conditions which acutely affect industrial technologies, including access to funding, market fragmentation, regulation, by bringing together those affected by such barriers with those best able to effect change 4. To coordinate the activities of stakeholders at local, national and transnational levels to avoid costly duplication of effort and build coherent development strategies.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2010.1.2-05 | Award Amount: 12.35M | Year: 2011

To meet both the worldwide demand for food security and new environmental needs, agriculture must increase food production and quality while decreasing its ecological footprint. Ensuring sustainability and competitiveness with reduced pesticide inputs is a major challenge. PURE will provide integrated pest management (IPM) solutions and a practical toolbox for their implementation in key European farming systems (annual arable and vegetable, perennial, and protected crops) in which reduction of pesticide use and better control of pests will have major effects. PURE will exploit recent advances in emerging technologies, plant-pest-enemies interactions, soil and landscape ecology and pest evolution to feed IPM solutions with innovative diagnostic and decision support systems, physical devices and bio-products, strategies for ecological pest regulation and improved durability of control methods. For each selected farming system, PURE will combine existing methods with new tools and technologies into novel IPM solutions addressing the biological, agronomical and economical diversity in Europe. IPM solutions will range from easy to adopt combinations of tactical control methods to more ambitious solutions involving strategic changes at farm level. PURE will test the efficacy, practicability and relevance of IPM solutions under the agro-ecosystems and farming conditions of the main broad European regions by on-station and on-farm experiments and will perform a comparative assessment of their environmental, economic and social sustainability. By jointly involving researchers and the key actors of pest management (farmers, advisors, policy makers and actors of the food supply chain) in design and assessment, PURE will facilitate the adoption of these innovative IPM solutions. PURE will thereby contribute to reduce the risks to human health and the environment and the dependence on pesticides and will facilitate the implementation of the pesticides package legislation.

Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2011.1.1-2 | Award Amount: 7.99M | Year: 2011

Treatment resistant schizophrenia (TRS) is the most disabling of all psychiatric illnesses, affecting about 1/3 of patients (~1 million Europeans), a considerable economic and social burden. First-line treatments include atypical (e.g. olanzapine) and typical (e.g. haloperidol) antipsychotics. The original atypical, clozapine, is a final option, and although it is the only antipsychotic shown to be effective in TRS, about half of TRS patients are also resistant to clozapine. CRESTAR is an SME-driven projected, focusing on the development of pharmacogenomic biomarkers for schizophrenia. It aims to develop tools to predict i) who will NOT respond to usual antipsychotics, indicating treatment with clozapine as early as possible, ii) the 1% of patients who will develop potentially fatal side effects, agranulocytosis, which is the main factor limiting clozapine use, and diabetic ketoacidosis, occurring in up to 2% of patients, and often fatal. We will also predict patients likely to be non-responders to all antipsychotics, i.e. extreme TRS, so that they can be stratified in clinical trials. CRESTAR will address these questions by examining genome-wide association data, genome sequence, epigenetic biomarkers and epidemiological data in European patient cohorts characterized for treatment response, and adverse drug reaction using data from clozapine therapeutic drug monitoring and linked National population medical and pharmacy databases, alongside existing European projects (e.g. PSYCNVs and EU-GEI) national initiatives (e.g. UK10K genome sequencing) to identify predictive factors. In parallel CRESTAR will perform health economic research on potential benefits, and ethics and patient-centered research with stakeholders. The outcome of CRESTAR will be a genomic test and associated clinical decision making tools, designed to improve pharmacological treatment of schizophrenia in both efficacy and safety, piloted with existing and new clinical trials such as OPTiMiSE.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2012.6.2-3 | Award Amount: 12.05M | Year: 2012

The objectives are to: (i) improve our understanding of human activities impacts (cumulative, synergistic, antagonistic) and variations due to climate change on marine biodiversity, using long-term series (pelagic and benthic). This objective will identify the barriers and bottlenecks (socio-economic and legislative) that prevent the GES being achieved (ii) test the indicators proposed by the EC, and develop new ones for assessment at species, habitats and ecosystems level, for the status classification of marine waters, integrating the indicators into a unified assessment of the biodiversity and the cost-effective implementation of the indicators (i.e. by defining monitoring and assessment strategies). This objective will allow for the adaptive management including (a) strategies & measures, (b) the role of industry and relevant stakeholders (including non-EU countries), and (c) provide an economic assessment of the consequences of the management practices proposed. It will build on the extensive work carried out by the Regional Seas Conventions (RSC) and Water Framework Directive, in which most of the partners have been involved (iii) develop/test/validate innovative integrative modelling tools to further strengthen our understanding of ecosystem and biodiversity changes (space & time); such tools can be used by statutory bodies, SMEs and marine research institutes to monitor biodiversity, applying both empirical and automatic data acquisition. This objective will demonstrate the utility of innovative monitoring systems capable of efficiently providing data on a range of parameters (including those from non-EU countries), used as indicators of GES, and for the integration of the information into a unique assessment The consortium has 23 partners, including 4 SMEs (close to 17% of the requested budget) and 2 non-EU partners (Ukraine & Saudi Arabia). Moreover, an Advisory Board (RSC & scientific international scientists) has been designed,to ensure a good relationship with stakeholders

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: SiS.2011.2.1.1-1 | Award Amount: 4.65M | Year: 2012

STAGES has the general aim of making the most of the unprecedented opportunity, provided for by the EC, to leave the logic of pilot projects behind and launch structural change strategies addressing the many and interconnected layers of the problem of gender inequality in science from an integrated perspective, deeply involving human resources management in research institutions, modifying and gendering its basic tenets. Under the coordination of a national Government, and assisted by a research centre specialised in gender and science, 5 research institutes/universities from Italy, Germany, Denmark, Romania and the Netherlands will each implement a self tailored action plan including activities such as, among others: awareness-raising initiatives in high level institutional bodies; training modules on gender equality for internal decision makers; mentoring programmes for young women scientists; actions to enhance the visibility of women scientists; updated management and research assessment standards; course content development; leadership development; work-life balance measures; gender quotas in committees; promotion and retention policies. Negotiation with all relevant actors will play a key role in order to assure the effectiveness of the action plans and the future sustainability of the actions after the project lifespan. Sharing know how and experience will enhance the planned activities in a real time basis, giving the implementation a more participative and flexible approach. A set of central activities, including technical assistance, evaluation, accompanying research and drafting guidelines has been devised to facilitate the implementation of the action plans. International meetings on Gender and Science will be held and a special attention will be paid to dissemination activities, both at national and European level, also through the creation of national committees in the countries of each consortium member.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2013.1.2-01 | Award Amount: 8.01M | Year: 2014

Agroforestry is the practice of deliberately integrating woody vegetation (trees or shrubs) with crop and/or animal systems to benefit from the resulting ecological and economic interactions. AGFORWARD (AGroFORestry that Will Advance Rural Development) is a four-year project, developed by 23 organisations at the forefront of agroforestry research, practice and promotion in Europe, with the goal of promoting appropriate agroforestry practices that advance sustainable rural development. The project will i) increase our understanding of existing, and new extensive and intensive agroforestry systems in Europe; ii) identify, develop and demonstrate innovations to improve the ecosystem service benefits and viability of agroforestry systems in Europe using participatory research, iii) develop better adapted designs and practices for the different soil and climatic conditions of Europe, and iv) promote the wide adoption of sustainable agroforestry systems. Successful and sustainable agroforestry practices are best developed by farmers and land owners working in partnership with researchers, extension staff, and other rural businesses. AGFORWARD will facilitate 33 participative agroforestry research and development stakeholder groups to improve the resilience of i) existing agroforestry systems of high nature and cultural value such as the dehesa and montado; and ii) olive, traditional orchard, and other high value tree systems, and the sustainability of iii) arable and iv) livestock systems with the integration of trees. Using existing bio-economic models, AGFORWARD will evaluate and adapt the innovations to improve the delivery of positive ecosystem services and business profitability at farm- and landscape-scales across Europe. By using and developing existing European fora, such as the European Agroforestry Federation, AGFORWARD will implement an informative and effective promotion programme to benefit the European economy, environment and society.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.51M | Year: 2011

This network will bridge two very active disciplines in physics, namely the quantum electrodynamics of atoms or ions strongly interacting with light in resonators, and the emerging field of solid-state superconducting circuit quantum electrodynamics. Advanced techniques will be developed jointly with industry partners for the manipulation of a deterministic number of particles - atoms, ions or artificial atoms - with electromagnetic fields covering the microwave and the optical frequency spectrum. The interdisciplinary training of a new generation of young researchers will strengthen the European expertise in those fields, and will allow for a new discipline to emerge that combines single-atom control methods with superconductor micro-chip fabrication. The use of high-quality resonators, whether superconducting transmission lines or highly-reflecting mirrors, coupled to a controlled number of particles will open novel avenues to explore quantum dynamics via hitherto inaccessible physical mechanisms. These new control scenarii will be strengthened by the development of potentially marketable technologies of great multidisciplinary interest. The network groups 10 research centres and 3 companies representing the cutting edge of research in the quantum electrodynamics of fundamental systems in Europe. The network will train 12 ESRs and 2 ERs, with focus on (i) establishing bonds between solid-state and quantum optics physics, (ii) strengthening the communication between theory and experiment, and, (iii) concretizing links between fundamental and applied research. Prominent scientists and industry leaders will contribute to the schools and workshops. Special attention will be given on developing complementary skills, such as communication, presentation, project planning and management.

Agency: European Commission | Branch: FP7 | Program: CP-CSA | Phase: SPA.2011.1.5-01 | Award Amount: 41.18M | Year: 2012

The main objective of the MyOcean2 project will be to operate a rigorous, robust and sustainable Ocean Monitoring and Forecasting component of the GMES Marine Service (OMF/GMS) delivering ocean physical state and ecosystem information to intermediate and downstream users in the areas of marine safety, marine resources, marine and coastal environment and climate, seasonal and weather forecasting. This is highly consistent with the objective of the FP7 Space Work Programme to support a European Space Policy focusing on applications such as GMES (Global Monitoring for Environment and Security), with benefits for citizens, but also other space foundation areas for the competitiveness of the European space industry. In the period from April 2012 to September 2014, MyOcean2 will ensure a controlled continuation and extension of the services and systems already implemented in MyOcean, a previous funded FP7 project that has advanced the pre-operational marine service capabilities by conducting the necessary research and development. To enable the move to full operations as of 2014, MyOcean2 is targeting the prototype operations, and developing the necessary management and coordination environment, to provide GMES users with continuous access to the GMES service products, as well as the interfaces necessary to benefit from independent R&D activities. MyOcean2 will produce and deliver services based upon the common-denominator ocean state variables that are required to help meet the needs for information of those responsible for environmental and civil security policy making, assessment and implementation. MyOcean2 is also expected to have a significant impact on the emergence of a technically robust and sustainable GMES service infrastructure in Europe and significantly contribute to the environmental information base allowing Europe to independently evaluate its policy responses in a reliable and timely manner

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2008-1.1.2 | Award Amount: 9.32M | Year: 2009

Europe possesses several experiment facilities holding the level 3 of bio safety, which is required to study the large majority of zoonoses, emerging diseases and a number of other animal infectious diseases. Most of them are nevertheless loosely connected, leading to redundancy. NAIF has as its strategic aim to realise the potential European leadership in animal infectiology by bringing together 14 L3 animal experiment infrastructures and organising the facilities in order to optimize their investigation and diagnostic/validation tools, achieve economies of scale and use the saved resources to modernise existing facilities in a coordinated manner. To achieve these goals, NADIR will 1) internally, upgrade the collaboration between the partners by setting an Internet-based joint workspace, strengthening the share of knowledge, best practices and ethical considerations, commonly managing biological resources, organising transnational access to the involved infrastructures, and jointly executing research activities designed to improve the services provided by these facilities; 2) externally, enhance access to the networks infrastructures by setting up a electronic portal presenting all the infrastructures and services offered by the network in a unified way, providing access of non-member institutions to these infrastructures, coordinating actions with other relevant initiatives, and jointly presenting safety and ethical recommendations. NADIR is organised around four types of activities: i) three networking activities, consisting of internal and external communication, knowledge and best practices sharing, and biological resources joint management; ii) three research activities, made up of characterising animal lines, improvement of infection monitoring tools, and development of new infection models for emerging diseases; iii) as many transnational access activities as infrastructures involved in the network; iv) one project management work package.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.3.3-4 | Award Amount: 7.82M | Year: 2011

ANTIFLU is to develop innovative drugs against influenza virus infections based on a novel concept that precludes the development of viral resistance and ensures efficacy against upcoming pandemic influenza strains. Viral replication is known to depend on multiple host factors. Whilst traditional anti-influenza treatments usually target viral factors, ANTIFLU will aim at drugs interfering with host-response pathways. The concept of drugs targeting human factors, established in treatment of other diseases, has yet not been sufficiently explored for treatment of viral infections, although it bears compelling advantages over conventional antiviral therapies: (i) the avoidance of viral escape mutants and (ii) the broad coverage against unprecedented viral variants. ANTIFLU aims to fully exploit this potent approach to fill critical gaps in our current treatment and prevention options against seasonal and pandemic influenza virus infections. By building upon an existing panel of potent human targets and firm knowledge derived from FP6 project RIGHT, an interdisciplinary consortium will pursue the identification and validation of small molecule ligands and inhibitory RNA molecules effective against influenza infection. Promising modulators will form the basis to generate lead molecules that will be further refined to yield clinically applicable therapeutics. Initial preclinical studies will aim at providing proof of concept in animal models, safety and toxicology profiles. They will allow initiating complete clinical trials immediately after the phase of FP7 support, thanks to the commitment already taken by investors from the private sector. The consortium includes several SMEs, internationally renowned research groups and clinical institutions with extensive experience in anti-influenza treatment and clinical trials. An already agreed common exploitation model will provide a smooth route to market and optimal use of the project results.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE-2007-3-1-02;KBBE-2007-3-1-01 | Award Amount: 7.66M | Year: 2008

With oil reserves diminishing and the effects of industrial emissions on global climate, there is a need for renewable carbon-neutral industrial feedstocks. First generation biorefineries, producing biofuels and bioplastics by the fermentation of sugar or starch, are seeing a rapid expansion and are adding stress to food supplies. A more sustainable option is to use plant biomass from agricultural by-products, or dedicated biomass crops. Plant biomass is underutilized, abundant and composed mostly of cell wall polysaccharides. Conversion of these polysaccharides to sugars will provide cheap and abundant raw materials for industrial biotechnology. The use of plant biomass in this way is hampered by the high cost of saccharification due to the recalcitrance of cell walls to enzymatic hydrolysis. RENEWALL aims to find ways to overcome this technical bottleneck by identifying and modifying the structural features of plant cell walls that make them difficult to process. Our partnership brings together outstanding biologists, chemists, and enzymologists, as well as industrialists from the plant breeding and biotechnology sectors, from Europe and the USA who can together take an integrated multidisciplinary approach to solving this fundamental problem. Combining genomics, transcriptomics, proteomics, and systems approaches, we will achieve a step-change in our understanding of the biosynthesis of the major components of plant biomass, namely; lignin, cellulose and matrix polysaccharides. Using state-of-the-art and novel analytical methods we will determine the basis of the recalcitrance of plant biomass to saccharification. Combining these approaches, we will identify new genes that can be manipulated to improve the ease and yield of biomass saccharification and will generate rational approaches for improving the quality of plant biomass as an industrial feedstock

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2012.6.1-3 | Award Amount: 7.56M | Year: 2012

Climate change can disrupt ecological, social and economic systems, with some regions and sectors suffering significantly. Therefore, adaptation plays a paramount role in responding to climate change. Progress has been made, but there are still important obstacles. Knowledge of the benefits and costs of adaptation is sparse, unsystematic and unevenly distributed across sectors and countries. Planning suffers from substantial uncertainties in terms of precise impacts. It is also difficult to reconcile the bottom-up nature of adaptation with top-down strategic policy making on adaptation. To address these challenges BASE will: Improve adaptation knowledge availability, integration and utilization Case studies will be used to understand facilitators of, and barriers to, adaptation. Over 20 cases have been selected to cover the diversity of adaptation, simultaneously paying attention to the need for generalization and comparability. The gap between top-down strategic assessments of costs and benefits and empirical context-sensitive bottom-up analyses will be bridged using novel combinations of models and qualitative analyses. Promote and strengthen stakeholder participation in adaptation BASE will support stakeholder involvement through novel participatory and co-design techniques. Successful bottom-up initiatives will be studied, and the use of knowledge, two-way learning, the role of social media and other awareness raising methods and tools will be explored. Support coherent, multi-level, multi-sector integrated adaptation policies BASE will provide policy guidelines by integrating lessons from past experiences, case studies, insights provided by modeling and stakeholder participation. Issues of multilevel, cross sectoral and inter-temporal governance that are presently weakly tackled will be highlighted. Potential conflicts and synergies of adaptation with other important policies will be explored to overcome constraints caused by context-related inertias.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2012.4.1-3 | Award Amount: 4.51M | Year: 2012

This project addresses the design and development of permanent magnets without rare earths but consisting on hybrid nanostructures based on metals and metal ferrite oxides. The metallic nanostructures offers high magnetization values while the ferrite oxide one provides high anisotropy. We intend to design and process novel permanent magnets based on traditional hard ferrites and additional new magnetic phases combined with a soft magnetic phase to achieve high magnetic performance through effective exchange-coupling of both magnetic phases. This phenomenon has been extensively studied in metallic systems but not in oxide nanocomposite permanent magnets, where the studies are very scarce mainly due to the difficulty in optimizing the magnetic properties because of microstructural complexities. In view of practical applications this will guarantee their use in some nowadays applications which are currently covered by more expensive rare-earth permanent magnets, simply because typical ferrites do not fulfill the required magnetic energy product. This no-mans-land applications area - characterized by required energy products between 35 to 100 kJ/m3 - includes fundamental fields such as diverse components for transport and energy applications. As an important consequence, the use of rare-earth based permanent magnets will be reduced to its maximum possible extent by fulfilling the needs for a broad applications range by these newly designed rare-earth free permanent magnets. This project is therefore important from a fundamental as well as from a practical point of view where the complementary expertise areas of the different groups will combine to achieve the proposed objectives.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-10a-2014 | Award Amount: 8.10M | Year: 2015

European aquaculture production provides direct employment to 80,000 people and a 3-billion annual turnover. Parasites cause severe disease outbreaks and high economic losses in finfish aquaculture. The overarching goal of ParaFishControl is to increase the sustainability and competitiveness of European Aquaculture by improving understanding of fish-parasite interactions and by developing innovative solutions and tools for the prevention, control and mitigation of the major parasites affecting Atlantic salmon, rainbow trout, common carp, European sea bass, gilthead sea bream and turbot. To achieve these objectives, ParaFishControl brings together a multidisciplinary consortium comprising 30 partners possessing world-leading, complementary, cross-cutting expertise and drawn from public and private research organisations, and the aquaculture industry. The consortium has access to excellent research facilities, diverse biological resources including host-parasite models, and state-of-the-art vaccinology, genomic, proteomic and transcriptomic technologies. The project will: 1) generate new scientific knowledge on key fish parasites, including genomics, life-cycle, invasion strategy and host-parasite interaction data, with special emphasis on host immunity, pathogen virulence and immunomodulation, providing a scientific basis for improved prophylaxis; 2) determine the transfer of parasites between farmed and wild host populations; 3) develop a wide range of novel prophylactic measures, including vaccines and functional feeds; 4) provide a range of advanced or alternative treatments for parasitic diseases; 5) develop cost-effective, specific and sensitive diagnostic tools for key parasitic diseases; 6) assess the risk factors involved in the emergence, transmission and pathogenesis of parasitic diseases; 7) map the zoonotic risks due to fish helminths and; 8) provide a catalogue of good husbandry practices to obtain safe and high-quality fish products.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH.2013.1.2-1 | Award Amount: 6.38M | Year: 2014

The multi-disciplinary CUPESSE project carries out a comparative analysis of both the demand and supply side of youth unemployment in ten Member States of the EU and Associated Countries (i.e. Austria, Czech Republic, Denmark, Germany, Hungary, Italy, Spain, Switzerland, Turkey, and the United Kingdom). These ten countries represent the main empirical scope of the project, but whenever possible, the analysis is extended to include all European countries. CUPESSE has five main objectives. The first objective is to obtain a more refined understanding of the supply side of young adults employment by concentrating on how the inter-generational accumulation of social capital and cultural capital in the context of family organisation influences the economic self-sufficiency and entrepreneurship of young people in Europe. The second objective is to examine how supply-side factors and demand-side factors affect the unemployment of young adults. In this context we are particularly interested in the degree to which the attitudes and skills of young adults match with employers demands. The third objective is to understand the implications of young adults unemployment in the longer term, including the effects on the unemployed individuals and on society as a whole. The fourth objective is to investigate the degree to which flexicurity policies, policies supporting business start-ups and self-employment, and policies promoting education and training platforms are embraced by the European states and to assess their impacts on young adults unemployment. The fifth objective of the CUPESSE project is to present ideas for new policy measures and formulate strategy for overcoming youth unemployment in Europe. To attain this goal, the project brings together theoretical perspectives and methodological approaches from four academic disciplines, namely economics, political science, psychology, and sociology.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-01a-2014 | Award Amount: 9.93M | Year: 2015

Feed-a-Gene aims to better adapt different components of monogastric livestock production systems (i.e., pigs, poultry and rabbits) to improve the overall efficiency and to reduce the environmental impact. This involves the development of new and alternative feed resources and feed technologies, the identification and selection of robust animals that are better adapted to fluctuating conditions, and the development of feeding techniques that allow optimizing the potential of the feed and the animal. To reach this overall objective, the project will: - Develop new and alternative feeds and feed technologies to make better use of local feed resources, green biomass and by-products of the food and biofuel industry. - Develop methods for the real-time characterization of the nutritional value of feeds to better use and adapt diets to animal requirements. - Develop new traits of feed efficiency and robustness allowing identification of individual variability to select animals that are more adapted to changes in feed and environmental conditions. - Develop biological models of livestock functioning to better understand and predict nutrient and energy utilization of animals along their productive trajectory. - Develop new management systems for precision feeding and precision farming combining data and knowledge from the feed, the animal, and the environment using innovative monitoring systems, feeders, and decision support tools. - Evaluate the overall sustainability of new management systems developed by the project. - Demonstrate the innovative technologies developed by the project in collaboration with partners from the feed industry, breeding companies, equipment manufacturers, and farmers organisations to promote the practical implementation of project results. - Disseminate new technologies that will increase animal production efficiency, whilst maintaining product quality and animal welfare and enhance EU food security to relevant stakeholders.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2012.3.5-04 | Award Amount: 7.76M | Year: 2012

The project GRACE will a) elaborate and sustainably implement a transparent framework for the review of GMOs or GM food and feed effects on environment, socio-economics and health and b) reconsider the design, execution and interpretation of results of animal feeding trials as well as in vitro studies for assessing the safety of GM food and feed. The framework will create high quality reviewing processes for different fields of GMO impact assessment and address the need for a well documented, transparent and sustainable representation of these reviewing processes. This will provide valuable and accessible information addressing the main issues associated with GMOs and enabling risk assessors, managers, scientists and the general public to reiterate and update their evaluations and conclusions on GMOs. It will adapt recently elaborated methodologies for (systematic) reviewing of the risk assessment information of GMOs and derived food and feed. The quality assessment for all reviewed papers and studies as well as the reviews conducted by the consortium, will be referenced by an open access database and one-stop-shop for data and information relevant to GMO risk assessment. Animal feeding trials and in vitro studies will clarify and compare the scientific added value of 90day feeding trials with whole foods with advanced state-of-the-art analytical, in vitro and in-silico tools. Suitable animal GMO-feeding models will be investigated, that are based on European (EFSA) and international guidance, and the project will provide guidance for relevant, alternative in vitro cell-based approaches for specific topics within the overall food and feed safety assessment. Available standard or scientifically approved protocols form the basis of the investigations also in the case of the analytical, in-vitro and second in-silico approaches. GRACE will provide guidance for the use and improvement of existing and suggested assessment tools in the field of food and feed safety.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: KBBE.2013.1.2-11 | Award Amount: 2.15M | Year: 2014

The overall vision of the OrAqua project is the economic growth of the organic aquaculture sector in Europe, supported by science based regulations in line with the organic principles and consumer confidence. OrAqua will suggest improvements for the current EU regulatory framework for organic aquaculture based on i) a review of the relevant available scientific knowledge, ii) a review of organic aquaculture production and economics, as well as iii) consumer perceptions of organic aquaculture. The project will focus on aquaculture production of relevant European species of finfish, molluscs, crustaceans and seaweed. To ensure interaction with all relevant stakeholders throughout the project a multi stakeholder platform will be established. The project will assess and review existing knowledge on fish health and welfare, veterinary treatments, nutrition, feeding, seeds (sourcing of juveniles), production systems, including closed recirculation aquaculture systems (RAS), environmental impacts, socio-economic and aquaculture economic interactions, consumer aspects, legislations and private standards for organic aquaculture. The results will be communicated using a range of media and techniques tailored to involve all stakeholder groups. Further, Multi Criteria Decision Analysis (MCDA) and SWOT analysis will be used to generate relevant and robust recommendations. A wide range of actors from several countries will participate and interact through a participatory approach. The 13 OrAqua project partners form a highly qualified and multidisciplinary consortium that includes four universities, five aquaculture research institutes, three research groups in social science, a fish farmer organisation, a fish farmer and two organic certification/control bodies. The main outcomes of the project will be recommendations on how to improve the EU regulation, executive dossiers and a Policy Implementation Plan (PIP). Further the project will deliver recommendations on how to enhance economic development of the European organic aquaculture sector.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.8 | Award Amount: 10.93M | Year: 2010

In the past two decades spectacular insight into basic principles of life has been obtained from paradigmatic high-resolution structural investigations providing a rational basis for biological experiments. NMR is an indispensable enabling technology for determining such structures and their interactions in solution, the immobilized state and living cells. The power of NMR to link structural, dynamic, kinetic and thermodynamic information makes it an essential component of cutting edge research in medicine and biology. Bio-NMR pools pan-European resources of the most relevant bio-NMR infrastructures. Eleven partners will provide access to researchers involved in structural biology following the EU-NMR I3 project. This initiative successfully responded to the increasing demand for access since 1994. Seven other excellent partners, including the leading NMR manufacturer Bruker, are included in the new consortium. Jointly, they will develop methods aimed at pushing the frontiers of biological NMR and improving the quality of access to allow users to tackle ever more challenging goals in cellular structural biology. Finally, all nineteen partners, amongst them a company specialized in NMR technology dissemination, are involved in the networking activities. These include (1) knowledge transfer among consortium members, Bio-NMR users and other NMR researchers, (2) the demonstration to biologists of the potential of structural biology with NMR , and lowering the barriers to their becoming users, (3) interactions with industrial and medical communities, and (4) raising awareness of the impact of the results achieved through Bio-NMR among society, financing and governing bodies with the final aim of developing a business plan for self-sustainability. The overall project and its management have been conceived in coordination with INSTRUCT, which will contribute to the cultural frame and networking activities of Bio-NMR.

Agency: European Commission | Branch: FP7 | Program: CP-SoU | Phase: ENERGY.2013.8.8.1 | Award Amount: 33.34M | Year: 2014

Based on thorough integrated climate planning the READY project will demonstrate a Whole City Approach including: 1) Demo of a balanced and holistic approach towards affordable retrofitting of residential buildings and offices 2) Development and demo of new solutions for low-temp. district heating, components and management ICT systems 3) Development and demo of flexible combined grid balancing/energy storage solutions for buildings and RES systems including combined heat pumps for heating and cooling, electrical vehicles charging, new PVT systems and 2ndlife reuse of EV batteries in buildings 4) Resource and energy smart solutions for kitchens 5) Solutions for water efficiency and waste water energy recovery 6) Demo of new innovative industrial equipment for use of RES and integration of demand and supply, - based on business plans, and follow-up by promotion and dissemination activities. These measures will demonstrate how the demand of energy and particularly the needs for fossil fuels and release of CO2 can be considerably reduced to nearly zero, and show a sustainable way to go for other European cities. Demonstration will take place in 2 cities; Aarhus (DK - 300,000 inhabitants), which is representative for north western parts of Europe and Vxj (SE - 83,000 inhabitants) representative for the Baltic Sea region. Both cities have a long standing technical experience and for years been frontrunners in respect of setting and carrying out ambitious climate and smart city polices. Kaunas (LT - 300,000 inhabitants) will take part as an observer city in order to bring in Eastern European experience with a most relevant context. The project team consist of internationally well known industrial companies, energy supply companies, SMEs, housing companies, universities, consultants and other organisations that formed the consortium to realise the project. All participants are devoted to improve RES integration in energy supply systems and housing standards towards nZEB

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2013.7.1-1 | Award Amount: 2.98M | Year: 2014

The project POst-CArbon CIties of TOmorrow foresight for sustainable pathways towards liveable, affordable and prospering cities in a world context (POCACITO) will develop an evidence-based 2050 roadmap for EU post-carbon cities. POCACITO facilitates the transition of EU cities to a forecasted sustainable or post-carbon economic model. The project focuses on towns, cities, megacities, metropolitan areas and urban clusters larger than 1 million people as well as small and medium-sized cities. POCACITOs approach uses participatory scenario development as a mutual learning and living lab environment strategy. The project recognises that post-carbon city transitions should improve urban resilience to fluctuating environmental and socio-economic pressure. Pressure in this context includes long-term changes in urban resident demographics, city and rural migration patterns, and potential city health concerns. Further, POCACITO develops innovative long-term outlooks for European post-carbon cities to address climate adaptation and urban environmental metabolism concerns by using a participatory city case study approach. Case study cities include Barcelona, Copenhagen/Malm, Istanbul, Lisbon, Litomerice, Milan/Turin, Offenburg and Zagreb. These cities will develop qualitative post-carbon visions with local stakeholders. Visions will be chosen based on selected best-practice measures and preliminary city assessments. Accompanying studies will yield a typology of post-carbon cities and a post-carbon city index. A marketplace of ideas will spread best practices from other EU cities and global cities in global emerging nations, allowing an international exchange of urban best practices. Related research will produce case study city roadmaps and an evidence-based 2050 roadmap for post-carbon EU cities within a global context. The projects research supports the sustainable development objective of the Europe 2020 strategy and the Innovation Union flagship initiative.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2011.4-01 | Award Amount: 582.96K | Year: 2012

PLATFORM will bring together the European Research Area Networks (ERA-NETs) from FP6 and FP7 in the area of the Knowledge Based Bio-Economy (KBBE) with the aim to improve exchange and cooperation between ERA-NETs and strengthen their contribution to, and impact on, the European Research Area in the Knowledge Based Bio-Economy. Experienced ERA-NET coordinators and managers propose to establish a network that will increase synergies and thus contribute to their effectiveness and impact. The project will not only benefit the coordinators of the ERA-NETs, but all participants, as well as other KBBE actors such as Joint Programming Initiatives (JPI) in this area, SCAR and KBBE-NET Collaborative Working Groups. The project will establish a networking platform with a mutual learning dimension and a strategic dimension. Customized and effective learning will be facilitated by creating an open and inclusive learning environment, through Workshops and a moderated cyber forum and by building on results of ERA-LEARN. PLATFORM will thus make available an extensive body of knowledge to help individual initiatives run their activities more effectively and to support new initiatives throughout their development. PLATFORM will further foster a more effective and harmonized environment for the ERA-NET users and provide guidance based on good practices. PLATFORM will address issues of overarching strategic importance, such as the identity and role of ERA-NETs, the synergy between national, intergovernmental and European research programming, and modalities for collaboration. PLATFORM will deliver a Vision Paper and Roadmap for long-term cooperation and synergy among ERA-NETs, and between ERA-NETs and other research policy actors such as JPIs, SCAR, and KBBE Technology Platforms. PLATFORM will contribute to a common strategic framework for EU research and innovation policy.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: Ocean.2010-2 | Award Amount: 16.58M | Year: 2011

Marine life makes a substantial contribution to the economy and society of Europe. VECTORS will elucidate the drivers, pressures and vectors that cause change in marine life, the mechanisms by which they do so, the impacts that they have on ecosystem structures and functioning, and on the economics of associated marine sectors and society. VECTORS will particularly focus on causes and consequences of invasive alien species, outbreak forming species, and changes in fish distribution and productivity. New and existing knowledge and insight will be synthesised and integrated to project changes in marine life, ecosystems and economies under future scenarios for adaptation and mitigation in the light of new technologies, fishing strategies and policy needs. VECTORS will evaluate current forms and mechanisms of marine governance in relation to the vectors of change. Based on its findings, VECTORS will provide solutions and tools for relevant stakeholders and policymakers, to be available for use during the lifetime of the project. The project will address a complex array of interests comprising areas of concern for marine life, biodiversity, sectoral interests, regional seas, and academic disciplines as well as the interests of stakeholders. VECTORS will ensure that the links and interactions between all these areas of interest are explored, explained, modelled and communicated effectively to the relevant stakeholders. The VECTORS consortium is extremely experienced and genuinely multidisciplinary. It includes a mixture of natural scientists with knowledge of socio-economic aspects, and social scientists (environmental economists, policy and governance analysts and environmental law specialists) with interests in natural system functioning. VECTORS is therefore fully equipped to deliver the integrated interdisciplinary research required to achieve its objectives with maximal impact in the arenas of science, policy, management and society.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: KBBE-2009-1-4-09 | Award Amount: 1.61M | Year: 2010

Organic agriculture and food markets have grown considerably and organic agriculture addresses important challenges of European agriculture, such as sustainable production of high quality food, reducing dependency on high energy inputs, improving environmental and nature conservation, climate change adaptation, animal welfare and rural livelihoods. Organic farming and food systems still have a big potential for innovation and improved solutions. Research activities will be important for this. Coordinated transnational research has the potential to create a less fragmented research area in this fast growing sector. CORE Organic II builds on the outcome of the first CORE Organic to aim at an effective and sustainable transnational research programme. It will identify common research priorities for the organic sector where a transnational approach will give added value, launch at least two transnational calls, initiate research projects, organize project monitoring and dissemination of results, and consider funding models. CORE Organic II will also develop all components to continue the transnational research activities beyond the ERA-NET. The results of CORE Organic II will be a strong and sustainable network of funding bodies, all components for the effective continuation of collaboration, a series of on-going research projects and a plan to support dissemination. The expected benefits for Europe will be to reinforce its leading status and excellence in organic research, enhance the European research area on organic agriculture, increase the efficiency in use of organic research funds and improve the impact of research on the organic sectors development. Initiating projects on topics identified as common priorities will allow the sector to better meet the demand for organic food and products. This will contribute to sustainable development in food production and improve the general competitivity of the European agriculture.

In 2006, the UN General Assembly Resolution (61/105) called upon fisheries management organisations worldwide to: i) assess the impact of bottom fishing on vulnerable marine ecosystems, ii) identify/map vulnerable ecosystems through improved scientific research/data collection, and iii) close such areas to bottom fishing unless conservation and management measures were established to prevent their degradation. In European deep waters, in addition, there is now a need to establish monitoring tools to evaluate the effectiveness of closed areas for the conservation of biodiversity and fish and their impact on fisheries. Currently the tools necessary to achieve these management goals are wholly lacking. CoralFISH aims to support the implementation of an ecosystem-based management approach in the deep-sea by studying the interaction between cold-water coral habitat, fish and fisheries. CoralFISH brings together a unique consortium of deep-sea fisheries biologists, ecosystem researchers/modellers, economists and a fishing industry SME, who will collaborate to collect data from key European marine eco-regions. CoralFISH will: i) develop essential methodologies and indicators for baseline and subsequent monitoring of closed areas, ii) integrate fish into coral ecosystem models to better understand coral fish-carrying capacity, iii) evaluate the distribution of deepwater bottom fishing effort to identify areas of potential interaction and impact upon coral habitat, iv) use genetic fingerprinting to assess the potential erosion of genetic fitness of corals due to long-term exposure to fishing impacts, v) construct bio-economic models to assess management effects on corals and fisheries to provide policy options, and vi) produce as a key output, habitat suitability maps both regionally and for OSPAR Region V to identify areas likely to contain vulnerable habitat. The latter will provide the EU with the tools to address the issues raised by the UNGA resolution.

Agency: European Commission | Branch: FP7 | Program: CP-FP-SICA | Phase: HEALTH.2011.3.4-1 | Award Amount: 3.69M | Year: 2012

In 2008 an estimated 13 million induced abortions were conducted in China. Induced abortions are associated with a high risk of injury or long-term physical and psychological morbidity and a heavy social and economic burden. Most abortions occur in cities and the epidemic affects young and unmarried women as well as rural-to-urban migrant women. The large number of abortions is primarily due to contraceptive failure or no use of contraception. The Chinese Family Planning (FP) program focuses mainly on birth control among married couples and the services are provided by an independent FP system. Young and unmarried women including rural-to-urban migrant women are less likely to access professional FP services. Abortion is a commonly used way to end unwanted pregnancy, however, post-abortion family planning services are often lacking in hospital settings. The INPAC project consortium proposes to integrate post-abortion family planning services into existing abortion services in hospital settings in China and to evaluate the effectiveness of the interventions in terms of reduction of unwanted pregnancies and repeat abortions. Based on the project findings, policy recommendations on health system organization aiming to improve equitable access to reproductive healthcare and FP service will be developed. Context-specific interventions will be developed based on a situation analysis of the effects of the current FP policy and a feasibility assessment of the integration approach. The proposed interventions will be implemented in 30 divisions of mainland China and evaluated with regard to its effectiveness. The project will contribute to standardize the post-abortion family planning services and decrease the long-term costs related to abortion in China. The results of this research will also be of interest to other countries with high abortion rates.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2011.1.1.2-1 | Award Amount: 10.93M | Year: 2011

CLAIRE investigates the ways in which climate change alters the threat of air pollution on European land ecosystems including soils. Based on field observations, experimental data and models, it establishes new flux, concentration and dose-response relationships, as a basis to inform future European policies. Starting with biosphere-atmosphere exchange measurements, CLAIRE quantifies how global warming and altered precipitation will affect emissions of key European primary pollutants (NOx, NH3, VOCs), including interactions with increasing aerosol and hemispheric O3 background concentrations, modifying atmospheric transport and deposition. An ensemble of chemistry transport models will be applied to assess uncertainty in response to harmonized scenarios for climate, emissions and land-use, while high resolution studies will investigate how climate change alters local patterns of pollutant exposure and threshold exceedance. A network of European experiments for contrasting ecosystems and climates, combined with meta-analysis of unpublished datasets, will quantify how climate change alters ecosystem vulnerability to tropospheric O3 and N deposition, including interaction with increased CO2. Combined with special topics on interactions with N form (wet/dry, NHx/NOy), aerosol-exacerbated drought stress and BVOC self-protection of O3 effects, novel threshold and dose-response approaches will be developed. These will be combined with regional atmospheric and biogeochemical models to estimate interactions and feedbacks on plant/soil carbon stocks, greenhouse gas balance and plant species change. The new risk assessment chain to be developed will be applied at the European scale, quantifying how projected climate change will alter damage estimates. Combined with economic valuation of ecosystem services, improved integrated assessment modelling will allow a cost-benefit analysis to inform future mitigation and adaptation strategies on air pollution and climate change.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE-2008-1-4-01 | Award Amount: 4.14M | Year: 2009

Development of accurate identification tools for plant pathogens and pests is vital to support European Plant Health Policies. For this project Council Directive 2000/29/EC is important, listing some 275 organisms for which protective measures against introduction into and their spread within the Community needs to be taken. Those threats are now greater than ever because of the increases in the volumes, commodity types and origins of trade, the introduction of new crops, the continued expansion of the EU and the impact of climate change. Currently identifying pathogens (in particular new emerging diseases) requires a staff with specialised skills in all disciplines (mycology, bacteriology, etc.); which is only possible within big centralised laboratory facilities. Taxonomy, phytopathology and other fields which are vital for sustaining sound public policy on phytosanitary issues are threatened with extinction. Modern molecular identification/detection techniques may tackle the decline in skills since they often require much less specialist skills to perform, are more amenable for routine purposes and can be used for a whole range of different target organisms. Recently DNA barcoding has arisen as a robust and standardised approach to species identification. QBOL wants now to make DNA barcoding available for plant health diagnostics and to focus on strengthening the link between traditional and molecular taxonomy as a sustainable diagnostic resource. Within QBOL collections harbouring plantpathogenic Q-organisms will be made available. Informative genes from selected species on the EU Directive and EPPO lists will be DNA barcoded from vouchered specimens. The sequences, together with taxonomic features, will be included in a new internet-based database system. A validation procedure on developed protocols and the database will be undertaken across worldwide partners to ensure robustness of procedures for use in a distributed network of laboratories across Europe

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.3.3 | Award Amount: 8.15M | Year: 2011

The design of innovative products and services that take advantage of Systems of Systems (SoS) technology is in its infancy. It is hampered by the complexity caused by the heterogeneity and independence of SoS constituent systems and the difficulty of communication between diverse stakeholders. The state of the art in SoS engineering lacks models and tools that help developers to make trade-off decisions during design and evolution, and assist in working out and recording precise contracts between constituents and the global SoS. This leads to sub-optimal design and expensive rework during integration and in service.\nCOMPASS will augment existing industry tools and practice with an underlying modelling language in which SoS architectures and contracts can be expressed. A formal semantic foundation the first to be developed specifically for SoS engineering will enable this language to support analysis of global SoS properties. The language and methods will be supported by an open, extendible tools platform with integrated prototype plug-ins for model construction, dynamic analysis by simulation and test automation, static analysis by model-checking and proof, and links to an established architectural modelling language (SysML). These strengthened foundations and tools will support enhanced methods guidelines that help users embed this new technology in industrial SoS practice.\nTechnical advances in COMPASS are focussed on industry needs evaluated through substantial industry-led case studies in three diverse and complementary areas. These will be augmented by challenge problems solicited from a range of SoS stakeholders and developer organisations through a special interest group. The open platform, tools plug-ins, semantics, development guidelines, industry case study experience and challenge problems will ensure that COMPASSs outputs can be readily exploited by SoS developers and stakeholders as well as in future research and development.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH-2010-3.2-1 | Award Amount: 10.21M | Year: 2011

ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors will be studied through a foresight approach to inform a redesign of effective addictions governance. Ownership will be described by an historical study of addiction through the ages, an analysis of public and private stakeholder views, and through image analyses, of professional and citizenship views. A study of how addictions are classified and defined will be followed by estimates of their health, social and economic impact. Determinants of addiction will be investigated through a coordinated and cohesive social, economic and biological analysis of initiation, transition into problem use and transition into and out of dependence. The business of addiction will be analyzed through studies of revenues, profits and participants in legal and illegal trade, the impact of suppliers on addictive substance use and behaviours, and analyses of webs of influence on policy responses. Addictions governance will be studied by describing the views and forces that determine the ways societies steer themselves and by stock taking of present governance practices to old and emerging addictions. Youth as customers will be analyzed through considering the impacts of new technologies on promoting and mitigating use, by studying the interrelations of culture and biology, and by determining features that promote resilience and nudge young people to reduce problematic use. The programme itself will be professionally managed from a partnership perspective to promote a coordinated and integrated approach to the high volume of research and its policy implications.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2010-IRSES | Award Amount: 210.00K | Year: 2011

Half of the European Unions land is farmed. This fact alone highlights the importance of farming for the EUs economy, employment, energy use and environment. In recent years several factors (climate change, unpredictably outside weather conditions, water shortage, energy crisis, environmental pollution) lead to an increase of agriculture production under controlled environments, (CEA) such as greenhouse and livestock buildings. In greenhouse and livestock production, growth practises, techniques, technologies and methodologies should be addressed to the achievement of stated objectives by modifying and improving the relationship of factors involved in the productive process. However the importance of certain objectives can change over time. Currently, several research groups in Europe are engaged in the areas related to the proposed action, but the information and knowledge obtained is dispersed. Moreover, considerable work was carried out in other countries outside from Europe which faced similar problems probably long time ago before the problems become evident in Europe. Many projects, currently being performed in isolation through national funding, will benefit significantly through the action, since it will eliminate overlaps, facilitate collaboration, and make more efficient use of resources, and thus amplify the value of the research for all European stakeholders. The proposed action brings together an international and interdisciplinary group of research teams from Europe, USA & Korea and relative SMEs for the purpose of forming an excellent centre of synergy in research, innovation and technology transfer in the area of agriculture production in greenhouse and livestock buildings aiming to remove the barriers that presently impede a fluent diffusion and actualization of the knowledge and know-how available in the field of new technologies applied to the CEA sector. Focus will be given on climate change, energy, environment and food safety and quality.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SPA-2007-1.1-01 | Award Amount: 55.01M | Year: 2009

MyOcean is THE PROJECT to set up infrastructures, services and resources to prepare the operational deployment of first Marine Core Services. My Ocean answers to the topic SPA.2007.1.1.01 - development of upgraded capabilities for existing GMES fast-track services and related (pre)operational services. MyOcean is proposed by a consortium of 67 partners spread in maritime countries: - federated around a core team of MCS operators - connected to Key R&D players with independent experts - rich of key intermediate users ready to commit to the service validation and promotion and play the role of beta-testers. My Ocean is not the MCS but shall provide the major building blocks and umbrella to allow the operational deployment of a full MCS in cooperation with external providers (National Met services, EMSA, ). MyOcean proposes to set an incremental logic and a governance to remain sustainable after the project and able to welcome new science and new services. The project includes the following tasks: - The definition of a first set of operational Marine Core Services, first package of an enlarged MCS portfolio - The operational development of European upgraded capacities acting as a common denominator for Member States, EU needs for reference marine information - The pre-operational validation of these MCS infrastructures and services and their formal commissioning - The marketing and promotion of Marine Core Services for use widening - The elaboration of a committed organisation to support at long term MCS operations, evolution and research. My Ocean inherits, benefits and pursues a European operational oceanography strategy started within EUROGOOS networks, and progressively implemented through subsequent projects: MERSEA Strand1, MERSEA, BOSS4. BOSS4 will provide a Version 0 of Marine Core Services fast tracks. MyOcean work plan shall cover the development, validation and pre-operations of the following versions of MCS V1 and V2.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2009. | Award Amount: 4.79M | Year: 2010

Pollinators form a key component of European biodiversity, and provide vital ecosystem services to crops and wild plants. There is growing evidence of declines in both wild and domesticated pollinators, and parallel declines in plants relying upon them. STEP will document the nature and extent of these declines, examine functional traits associated with particular risk, develop a Red List of some European pollinator groups, in particular bees and lay the groundwork for future pollinator monitoring programmes. We will also assess the relative importance of potential drivers of such change, including climate change, habitat loss and fragmentation, agrichemicals, pathogens, alien species, light pollution, and their interactions. We will measure the ecological and economic impacts of declining pollinator services and floral resources, including effects on wild plant populations, crop production and human nutrition. STEP will review existing and potential mitigation options, providing novel tests of their effectiveness across Europe. Our work will build upon existing datasets and models, complemented by spatially-replicated campaigns of field research to fill gaps in current knowledge. We will integrate our findings in a policy-relevant framework, creating Evidence-based Decision Support tools. We will also establish communication links to a wide range of stakeholders across Europe and beyond, including policy makers, beekeepers, farmers, academics and the general public. Taken together, our research programme will make great steps towards improving our understanding of the nature, causes, consequences and potential mitigation of declines in pollinator services at local, national, continental and global scales.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2011-1.1.8. | Award Amount: 7.16M | Year: 2012

The ability to quantitatively analyze plant phenotypic traits (from single cells to plant and stand level) and their dynamic responses to the environment is an essential requirement for genetic and physiological research, and the cornerstone for enabling applications of scientific findings to bioeconomy. Whereas molecular profiling technologies allow today the generation of a large amount of data with decreasing costs largely due to automation and robotics, the understanding of the link between genotype and phenotype has progressed more slowly. Insufficient technical and conceptual capacity of the plant scientific community to probe existing genetic resources and unravel environmental effects limits faster progress in this field. The development of robust and standardized phenotyping applications depends on the availability of specialised infrastructure, technologies and protocols. Europe has become a key driver in defining innovative solutions in academic and industrial settings. However, the existing initiatives at the local or member-state level represent a fragmented research landscape with similar goals. The aim of this project is to create synergies between the leading plant phenotyping institutions in Europe as a nucleus for the development of a strong European Plant Phenotyping Network (EPPN). The project fosters the development of an effective European infrastructure including human resources, expertise and communication needed to support transnational access to user communities. Joint research activities will adapt and develop novel sensors and methods for application in plant phenotyping. Innovative phenotyping concepts integrating mechanistic, medium- and high throughput as well as field phenotyping will be developed and made available to the community. This project will strengthen Europes leading role in plant phenotyping research and application through the creation of a community of research institutes, universities, industry and SMEs.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETPROACT-3-2014 | Award Amount: 4.70M | Year: 2015

Quantum Simulators provide new levels of understanding of equilibrium and out-of-equilibrium properties of many-body quantum systems, one of the most challenging problems in physics. The main objective of the RYSQ project is to use Rydberg atoms for quantum simulations, because their outstanding versatility will allow us to perform a great variety of useful quantum simulations, by exploiting different aspects of the same experimental and theoretical tools. By implementing not only one but a whole family of Rydberg Quantum Simulators, the project will address both the coherent and incoherent dissipative dynamics of many-body quantum systems, with potential applications in the understanding and design of artificial light harvesting systems, large quantum systems with controlled decoherence, and novel materials. This will be achieved by building upon a novel generic approach to quantum simulation, where Rydberg atoms allow both digital (gate) and analog (interaction) simulations. In addition to solving problems in fundamental and applied science, the project will build up core competences for quantum science and technologies in mainstream engineering, by using innovative methods for communication, dissemination and exploitation of results. In summary, RYSQ plans (A) to develop a collection of novel experimental and theoretical tools for Rydberg quantum simulators, and (B) to use them as a basis for implementing many important applications of quantum simulations. The project is structured in such a way to allow for efficient exchanges within the consortium, and to maximize the overall outcome of the work.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 3.10M | Year: 2009

Cardiovascular diseases are the leading cause of death and disability in the European population and represent a great burden of suffering and costs. Their complex etiology originates from different pathological stimuli and involves different cell types, resident in the vascular wall or infiltrating from the blood. The adaptation of the vasculature to physiological and pathophysiological forces depends on both the communication between its cellular components and their interaction with the extracellular matrix (ECM). When subjected to enhanced stretch, cyclic mechanical strain, or shear stress, blood vessels undergo typical transformations in wall shape that are always associated with alterations of the ECM and cellular composition, collectively described as vascular remodelling. Remodelling processes occur specifically in small arteries and arterioles, which show extreme changes in their size and function (microvascular remodelling). This is especially the case in hypertensive or diabetic patients, and contributes to a vicious cycle resulting in organ dysfunction and progression of vascular disease. A multidisciplinary approach is required to better understand vascular remodelling processes. We propose an interdisciplinary ITN to promote excellence in vascular biology, with focus on small vessels/arteries and their ECM. This will enhance the interaction between 8 academic groups and one SME in 7 European countries, specialized in physiology, signalling mechanisms, cell-cell and cell-matrix interactions in vascular endothelium and smooth muscle, as well as in drug discovery and development. The ITN will provide a specialized training ground by connecting investigations of the biology of vascular cells and their surrounding ECM in an innovative manner. It will therefore promote the careers of young investigators by specialising them in a field of vascular biology with a great potential for the future.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: KBBE.2011.2.5-03 | Award Amount: 1.08M | Year: 2011

There is an increasing recognition that innovation is a task for all actors in the food chain, since innovation should add value to the food chain as a whole and lead to sustainable novel applications. RECAPT aims at supporting a process that leads to closer collaborative management of innovations along the food supply chain. The overall objective of this action is to build a platform that strengthens collaboration between food scientists, food industry and the retailing and catering sectors, such that research findings can be effectively integrated into the development of innovative and sustainable products that meet consumer acceptance, thereby contributing to global competitiveness of the European food sector. More specifically, RECAPT has the following strategic objectives: 1. To promote information exchange and facilitate trust building in order to enhance innovation-oriented cooperation among the actors in the food supply chain. 2. To analyze all parameters and provide all necessary inputs for the realization and viability of those collaborations. In order to promote information exchange, facilitate trust building and enhance cooperation among actors in the food chain, a Collaborative Food Innovation Forum (CFIF) for effective dialog and collaboration between the food chain actors will be created. The CFIF will be a unique meeting place that will bring together actors from science, food manufacturing, retailing, catering and consumer organisations. Based on input from the different work packages, the CFIF will discuss issues related to promising novel technologies, consumer acceptance of new products based on novel technologies, retailer and caterer adoption of new products as well as innovation management processes in the food chain based on input from the RECAPT partners. In this way, a comprehensive view of the parameters and inputs necessary for increasing collaborative innovation activities in the European food sector will be developed.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2010.4-01 | Award Amount: 1.25M | Year: 2011

By integrating the key European teams in genomics, bioinformatics, animal health and animal models, EADGENE has enabled: - the gathering of a critical mass of scientists and a unique access of complementary resources across host and pathogen models - the development of innovative functional genomics so that it has become a powerful tool in veterinary molecular medicine and has contributed to a better understanding of host-pathogen interactions, for the improvement of animal health and food safety, Building from these benefits, EADGENE_S will ensure a long-term integration of the European resources in animal disease genomics grouping together the leading institutions. It will strengthen durably the creation of a core group of European research centres of excellence highly committed to integrating their resources and national facilities. To achieve this, EADGENE_S will: (1) Expend, share and upgrade common research tools and platforms for joint research projects (2) Further develop common research methods, standards and protocols (3) Maintain, consolidate and further develop high quality common research projects on animal genomics and genetics in Europe (4) Support strategies for durable integration, particularly by providing opportunities for further funding (5) Consolidate the skills and expertise throughout the partnership with a programme of workshops, training courses, short-term missions, internships and studentships (6) Provide platforms for the development, management and dissemination of knowledge (7) Ensure efficient technology transfer to the industry to ensure timely commercialisation newest developments This integration will be fulfilled under the framework of the European Research Group EADGENE (EADGENE ERG), a co-operation instrument composed of the EADGENE members as represented by their respective participating research departments.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: ISIB-02-2014 | Award Amount: 2.19M | Year: 2015

The overall aim of the thematic network OK-Net Arable is to improve the exchange of innovative and traditional knowledge among farmers, farm advisers and scientists to increase productivity and quality in organic arable cropping all over Europe, in order to satisfy future market demand. To achieve this, OK-Net Arable has three specific objectives: 1) to create a European network of well-functioning farmer innovation groups representing the best examples of co-innovation by farmers and researchers. The network of farmer innovation groups will serve to exchange experiences in the area of arable crop production and test the innovative end-user and education material developed in the project; 2) to digest and synthesize the considerable knowledge available from the reservoir of scientific and practical knowledge in the area of organic arable farming and to identify the best methodology in learning and knowledge exchange. Based on this easily understandable education and end-user material will be developed; 3) to create a platform for knowledge exchange across Europe unique in organic farming, offering both innovative education and end-user material as well as offering opportunities for farmer-to-farmer, advisor-to-advisor or researcher-to-advisor-to-farmer learning. The multi-actor approach is prominent in this proposal: (1) at EU level with scientific partners and farmers associations jointly coordinating the work packages; (2) on the local level with farmers, farm advisors and scientists cooperating in farmer innovation groups. The whole consortium covers in total 13 countries from all corners of Europe giving a well-balanced representation of different climate, geographical and socio-economic conditions.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: IoT-01-2016 | Award Amount: 34.71M | Year: 2017

The IoF2020 project is dedicated to accelerate adoption of IoT for securing sufficient, safe and healthy food and to strengthen competitiveness of farming and food chains in Europe. It will consolidate Europes leading position in the global IoT industry by fostering a symbiotic ecosystem of farmers, food industry, technology providers and research institutes. The IoF2020 consortium of 73 partners, led by Wageningen UR and other core partners of previous key projects such as FIWARE and IoT-A, will leverage the ecosystem and architecture that was established in those projects. The heart of the project is formed by 19 use cases grouped in 5 trials with end users from the Arable, Dairy, Fruits, Vegetables and Meat verticals and IoT integrators that will demonstrate the business case of innovative IoT solutions for a large number of application areas. A lean multi-actor approach focusing on user acceptability, stakeholder engagement and sustainable business models will boost technology and market readiness levels and bring end user adoption to the next stage. This development will be enhanced by an open IoT architecture and infrastructure of reusable components based on existing standards and a security and privacy framework. Anticipating vast technological developments and emerging challenges for farming and food, the 4-year project stays agile through dynamic budgeting and adaptive decision-making by an implementation board of representatives from key user organizations. A 6 M mid-term open call will allow for testing intermediate results and extending the project with technical solutions and test sites. A coherent dissemination strategy for use case products and project learnings supported by leading user organizations will ensure a high market visibility and an increased learning curve. Thus IoF2020 will pave the way for data-driven farming, autonomous operations, virtual food chains and personalized nutrition for European citizens.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: IoT-01-2016 | Award Amount: 20.05M | Year: 2017

SynchroniCity represents the first attempt to deliver a Single Digital City Market for Europe by piloting its foundations at scale in 11 reference zones - 8 European cities & 3 more worldwide cities - connecting 34 partners from 11 countries over 4 continents. Building upon a mature European knowledge base derived from initiatives such as OASC, FIWARE, FIRE, EIP-SCC, and including partners with leading roles in standardization bodies, e.g. ITU, ETSI, IEEE, OMA, IETF, SynchroniCity will deliver a harmonized ecosystem for IoT-enabled smart city solutions where IoT device manufacturers, system integrators and solution providers can innovate and openly compete. With an already emerging foundation, SynchroniCity will establish a reference architecture for the envisioned IoT-enabled city market place with identified interoperability points and interfaces and data models for different verticals. This will include tools for co-creation & integration of legacy platforms & IoT devices for urban services and enablers for data discovery, access and licensing lowering the barriers for participation on the market. SynchroniCity will pilot these foundations in the reference zones together with a set of citizen-centred services in three high-impact areas, showing the value to cities, businesses and citizens involved, linked directly to the global market. With a running start, SynchroniCity will serve as lighthouse initiative to inspire others to join the established ecosystem and contribute to the emerging market place. SynchroniCity takes an inclusive approach to grow the ecosystem by inviting businesses and cities to join through an open call, allowing them to participate on the pioneering market place enabling a second wave of successful pilots. They will strengthen the ecosystem by creating a positive ripple effect throughout Europe, and globally, to establish a momentum and critical mass for a strong European presence in a global digital single market of IoT-enabled solutions.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE-2007-1-1-04 | Award Amount: 8.18M | Year: 2009

QUANTOMICS will deliver a step-change in the availability of cutting edge technologies and tools for the economic exploitation of livestock genomes. We will provide the tools to identify rapidly the causative DNA variation underpinning sustainability in livestock and for industry to exploit high-density genomic information. Our adaptable quantitative and genomic tools each based on cutting-edge technologies and valuable in itself, will together form a powerful integrated pipeline with wide application. To deliver these outcomes we will; i) use comparative genomics to annotate putatively functional features of the genomes of the EUs key farmed animal livestock species; ii) enhance existing molecular genetic tools (to include copy number variation, CNV); iii) deliver computationally optimised tools for genome-wide selection (GWS) to include CNV; iv) apply these tools to important health and welfare traits in commercial populations of dairy cattle and broiler chickens, determining the benefits and constraints; v) use hyper-parallel resequencing of DNA within identified genomic features underlying loci of large effect in significant numbers of animals to catalogue variation; vi) develop new visualisation tools to make this variation publicly available via the Ensembl genome-browser; vii) develop tools to prioritise the likely functionality of identified polymorphisms; viii) validate the utility of the putative causative haplotypes within commercial populations; ix) test the potential advances from combined GWS and gene assisted selection in breeding programmes; x) explore new methods to manage molecular biodiversity; xi) assess the implications of these new tools for breeding programme design, and xii) disseminate results of the project achieving major competitive, animal health and welfare impacts across the EU livestock industry and ultimately consumers. QUANTOMICS will have wide application in all farmed species and leave a legacy of resources for future research.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INT-04-2015 | Award Amount: 3.72M | Year: 2016

This Project aims to address an increasingly pressing global challenge: How to achieve the EUs development goals and the UNs Sustainable Development Goals, while meeting the global target of staying within two degrees global warming and avoid transgressing other planetary boundaries. EU policies must align with sustainable development goals (Article 11 TFEU). The impacts of climate change and global loss of natural habitat undermine the progress achieved by pursuing the Millennium Development Goals and threaten the realisation of EU development policy goals. Our focus is the role of EUs public and private market actors. They have a high level of interaction with actors in emerging and developing economies, and are therefore crucial to achieving the EUs development goals. However, science does not yet cater for insights in how the regulatory environment influences their decision-making, nor in how we can stimulate them to make development-friendly, environmentally and socially sustainable decisions. Comprehensive, ground-breaking research is necessary into the regulatory complexity in which EU private and public market actors operate, in particular concerning their interactions with private and public actors in developing countries. Our Consortium, leading experts in law, economics, and applied environmental and social science, is able to analyse this regulatory complexity in a transdisciplinary and comprehensive perspective, both on an overarching level and in depth, in the form of specific product life-cycles: ready-made garments and mobile phones. We bring significant new evidence-based insights into the factors that enable or hinder coherence in EU development policy; we will advance the understanding of how development concerns can be successfully integrated in non-development policies and regulations concerning market actors; and we provide tools for improved PCD impact assessment as well as for better corporate sustainability assessment.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: HEALTH-2007-4.2-3 | Award Amount: 1.22M | Year: 2008

This proposal aims to review current knowledge and issues related to the economic impact of health at work, to assemble, organise, analyse and synthesise data from national projects and surveys, and to recommend future actions for research and policy development aiming at improving health and safety at work in a changing labour market environment in the European Union in an era of ageing populations, feminised labour markets and increased incidence of Small and Medium Enterprices (SMEs). This is achieved through co-ordinated reviews, the development of common databases regarding indicators of health and safety at work in the participant countries (including the incidence of accidents and illnesses of work, the incidence of absenteeism, and early retirement due to accidents/illnesses at work,) and the associated GIS analysis capability. In addition, a pilot study aiming at designing appropriate data collection protocols is designed to explore the appropriateness of small scale surveys, using purpose-build questionnaire, to determine the preference setting of both employers and employees with regard to health and safety at work and to highlight the cost and benefits of investing in improving the health and safety at work. The above lead to a series of co-ordination meetings and workshops at which the status of health and safety at work, its repercussions for the quality of work and its effects on Europes competitiveness are reviewed and studied. A comparative EU-wide assessment of the structure and dynamics of the health and safety at work is carried out. Policy recommendations aiming at improving the health and safety at work in the context of changing labour market environment are detailed with particular reference to the ageing population, the feminisation of the labour markets and the increased incidence of SMEs.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.19 | Award Amount: 9.36M | Year: 2011

Environmental change and particularly amplified global climate change are accelerating in the Arctic. These changes already affect local residents and feedback from the Arctics land surface to the climate system, will have global implications. However, climate change and its impacts are variable throughout the wide environmental and land use envelopes of the Arctic. Unfortunately, the Arctic is generally remote, sparsely populated and research and monitoring activities are more restricted in time and space than elsewhere. This limitation comes when there is a rapidly expanding need for knowledge as well as increasing technological opportunities to make data collection in the field and accessibility more efficient. INTERACT is a network under the auspices of SCANNET, a circumarctic network of terrestrial field bases. INTERACT specifically seeks to build capacity for research and monitoring in the European Arctic and beyond. Partnerships will be established between Station Managers and researchers within Joint Research Activities that will develop more efficient networks of sensors to measure changing environmental conditions and make data storage and accessibility more efficient through a single portal. New communities of researchers will be offered access to Arctic terrestrial infrastructures while local stakeholders as well as major international organisations will be involved in interactions with the infrastructures. This will lead to increased public awareness of environmental change and methods to adapt to them, increased access to information for education at all levels, and input to major international research and assessment programmes.The whole consortium will form a coherent and integrated unit working within a concept of a wide environmental and land use envelopes in which local conditions determine the directions and magnitudes of environmental change whereas the balance and synergies of processes integrated across the whole region have global impacts.

Nielsen S.B.,University of Aarhus | Nielsen M.B.,Copenhagen University | Rubio A.,University of the Basque Country
Accounts of Chemical Research | Year: 2014

ConspectusIn a charge-transfer (CT) transition, electron density moves from one end of the molecule (donor) to the other end (acceptor). This type of transition is of paramount importance in nature, for example, in photosynthesis, and it governs the excitation of several protein biochromophores and luminophores such as the oxyluciferin anion that accounts for light emission from fireflies. Both transition energy and oscillator strength are linked to the coupling between the donor and acceptor groups: The weaker the coupling, the smaller the excitation energy. But a weak coupling necessarily also causes a low oscillator strength possibly preventing direct excitation (basically zero probability in the noncoupling case). The coupling is determined by the actual spacer between the two groups, and whether the spacer acts as an insulator or a conductor. However, it can be difficult or even impossible to distinguish the effect of the spacer from that of local solvent molecules that often cause large solvent shifts due to different ground-state and excited-state stabilization. This calls for gas-phase spectroscopy experiments where absorption by the isolated molecule is identified to unequivocally establish the intrinsic molecular properties with no perturbations from a microenvironment. From such insight, the effect of a protein microenvironment on the CT excited state can be deduced.In this Account, we review our results over the last 5 years from mass spectroscopy experiments using specially designed apparatus on several charged donor-acceptor ions that are based on the nitrophenolate moiety and π-extended derivatives, which are textbook examples of donor-acceptor chromophores. The phenolate oxygen is the donor, and the nitro group is the acceptor. The choice of this system is also based on the fact that phenolate is a common structural motif of biochromophores and luminophores, for example, it is a constituent of the oxyluciferin anion. A presentation of the setups used for gas-phase ion spectroscopy in Aarhus is given, and we address issues of whether double bonds or triple bonds best convey electronic coupling between the phenolate oxygen and the nitro group, the significance of separating the donor and acceptor spatially, the influence of cross-conjugation versus linear conjugation, and along this line ortho versus meta versus para configuration, and not least the effect of a single solvent molecule (water, methanol, or acetonitrile). From systematic studies, a clear picture has emerged that has been supported by high-level calculations of electronically excited states. Our work shows that CC2 coupled-cluster calculations of vertical excitation energies are within 0.2 eV of experimental band maxima, and importantly, that the theoretical method is excellent in predicting the relative order of excitation energies of a series of nitrophenolates. Finally, we discuss future challenges such as following the change in absorption as a function of the number of solvent molecules and when gradually approaching the bulk limit. © 2014 American Chemical Society.

Tolstikhin O.I.,Moscow Institute of Physics and Technology | Madsen L.B.,University of Aarhus | Morishita T.,University of Electro - Communications
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2014

The weak-field asymptotic theory of tunneling ionization in an external static uniform electric field [Tolstikhin et al., Phys. Rev. A 84, 053423 (2011)PLRAAN1050-294710.1103/PhysRevA.84.053423] is extended to many-electron atomic and molecular systems treated in the frozen-nuclei approximation. The leading-order term in the asymptotic expansion of the ionization rate Γ in the value of the field F for F→0 is obtained. The resulting formulas express Γ in terms of properties of the unperturbed system. The most essential difference from the one-electron case, through which the many-electron character of the present theory reveals itself, is that the structure factor for a given ionization channel, defining the dependence of the ionization rate into this channel on the orientation of the system with respect to the field, is determined by the corresponding Dyson orbital. The theory is illustrated by calculations for several few-electron systems. The asymptotic results are compared with accurate fully correlated calculations of tunneling ionization rates available in the literature. © 2014 American Physical Society.

Pritchard J.D.,Durham University | Adams C.S.,Durham University | Molmer K.,University of Aarhus
Physical Review Letters | Year: 2012

We consider three-level atoms driven by two resonant light fields in a ladder scheme where the upper level is a highly excited Rydberg state. We show that the dipole-dipole interactions between Rydberg excited atoms prevents the formation of single particle dark states and leads to strongly correlated photon pairs from atoms separated by distances large compared to the emission wavelength. For a pair of atoms, this enables realization of an efficient photon-pair source with on average one pair every 30μs. © 2012 American Physical Society.

Happe F.,King's College London | Frith U.,University College London | Frith U.,University of Aarhus
Journal of Child Psychology and Psychiatry and Allied Disciplines | Year: 2014

As a starting point for our review we use a developmental timeline, starting from birth and divided into major developmental epochs defined by key milestones of social cognition in typical development. For each epoch, we highlight those developmental disorders that diverge from the normal developmental pattern, what is known about these key milestones in the major disorders affecting social cognition, and any available research on the neural basis of these differences. We relate behavioural observations to four major networks of the social brain, that is, Amygdala, Mentalizing, Emotion and Mirror networks. We focus on those developmental disorders that are characterized primarily by social atypicality, such as autism spectrum disorder, social anxiety and a variety of genetically defined syndromes. The processes and aspects of social cognition we highlight are sketched in a putative network diagram, and include: agent identification, emotion processing and empathy, mental state attribution, self-processing and social hierarchy mapping involving social 'policing' and in-group/out-group categorization. Developmental disorders reveal some dissociable deficits in different components of this map of social cognition. This broad review across disorders, ages and aspects of social cognition leads us to some key questions: How can we best distinguish primary from secondary social disorders? Is social cognition especially vulnerable to developmental disorder, or surprisingly robust? Are cascading notions of social development, in which early functions are essential stepping stones or building bricks for later abilities, necessarily correct? © 2013 The Authors. Journal of Child Psychology and Psychiatry © 2013 Association for Child and Adolescent Mental Health.

Petersen S.,University of Aarhus | Bundgaard K.W.,Alectia A S
Applied Energy | Year: 2014

This paper investigates the effects of weather forecast uncertainty on the performance of a concept for predictive control of building systems operation. The concept uses a computational physically-based building model and weather forecasts to predict future heating or cooling requirement. This information enables the building systems to respond proactively to keep the operational temperature within the thermal comfort range with the minimum use of energy. The effect of weather forecast uncertainty was assessed using weather data from two different years in a temperate climate in the simulation of 24 building design scenarios. Despite the uncertainty in the weather forecasts, the predictive control concept demonstrated a potential for energy savings and/or improvements in thermal indoor environment when compared to a conventional rule-based control. © 2013 .

Christensen J.,Aarhus University Hospital | Grnoborg T.K.,University of Aarhus | Sroensen M.J.,Aarhus University Hospital | Schendel D.,Centers for Disease Control and Prevention | And 3 more authors.
JAMA - Journal of the American Medical Association | Year: 2013

Importance: Valproate is used for the treatment of epilepsy and other neuropsychological disorders and may be the only treatment option for women of childbearing potential. However, prenatal exposure to valproate may increase the risk of autism. Objective: To determine whether prenatal exposure to valproate is associated with an increased risk of autism in offspring. Design, Setting, and Participants: Population-based study of all children born alive in Denmark from 1996 to 2006. National registers were used to identify children exposed to valproate during pregnancy and diagnosed with autism spectrum disorders (childhood autism [autistic disorder], Asperger syndrome, atypical autism, and other or unspecified pervasive developmental disorders). We analyzed the risks associated with all autism spectrum disorders as well as childhood autism. Data were analyzed by Cox regression adjusting for potential confounders (maternal age at conception, paternal age at conception, parental psychiatric history, gestational age, birth weight, sex, congenital malformations, and parity). Children were followed up from birth until the day of autism spectrum disorder diagnosis, death, emigration, or December 31, 2010, whichever came first. Main Outcomes and Measures: Absolute risk (cumulative incidence) and the hazard ratio (HR) of autism spectrum disorder and childhood autism in children after exposure to valproate in pregnancy. Results: Of 655 615 children born from 1996 through 2006, 5437 were identified with autism spectrum disorder, including 2067 with childhood autism. The mean age of the children at end of follow-up was 8.84 years (range, 4-14; median, 8.85). The estimated absolute risk after 14 years of follow-up was 1.53% (95% CI, 1.47%-1.58%) for autism spectrum disorder and 0.48% (95% CI, 0.46%-0.51%) for childhood autism. Overall, the 508 children exposed to valproate had an absolute risk of 4.42% (95% CI, 2.59%-7.46%) for autism spectrum disorder (adjusted HR, 2.9 [95% CI, 1.7-4.9]) and an absolute risk of 2.50% (95% CI, 1.30%-4.81%) for childhood autism (adjusted HR, 5.2 [95% CI, 2.7-10.0]). When restricting the cohort to the 6584 children born to women with epilepsy, the absolute risk of autism spectrum disorder among 432 children exposed to valproate was 4.15% (95% CI, 2.20%-7.81%) (adjusted HR, 1.7 [95% CI, 0.9-3.2]), and the absolute risk of childhood autism was 2.95% (95% CI, 1.42%-6.11%) (adjusted HR, 2.9 [95% CI, 1.4-6.0]) vs 2.44% (95% CI, 1.88%-3.16%) for autism spectrum disorder and 1.02% (95% CI, 0.70%-1.49%) for childhood autism among 6152 children not exposed to valproate. Conclusions and Relevance: Maternal use of valproate during pregnancy was associated with a significantly increased risk of autism spectrum disorder and childhood autism in the offspring, even after adjusting for maternal epilepsy. For women of childbearing potential who use antiepileptic medications, these findings must be balanced against the treatment benefits for women who require valproate for epilepsy control. ©2013 American Medical Association. All rights reserved.

Madsen L.B.,University of Aarhus | Tolstikhin O.I.,RAS Research Center Kurchatov Institute | Morishita T.,University of Electro - Communications
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2012

The recently developed weak-field asymptotic theory is applied to the analysis of tunneling ionization of a molecular ion (H2+), several homonuclear (H 2, N 2, O 2) and heteronuclear (CO, HF) diatomic molecules, and a linear triatomic molecule (CO 2) in a static electric field. The dependence of the ionization rate on the angle between the molecular axis and the field is determined by a structure factor for the highest occupied molecular orbital. This factor is calculated using a virtually exact discrete variable representation wave function for H2+, very accurate Hartree-Fock wave functions for the diatomics, and a Hartree-Fock quantum chemistry wave function for CO 2. The structure factors are expanded in terms of standard functions and the associated structure coefficients, allowing the determination of the ionization rate for any orientation of the molecule with respect to the field, are tabulated. Our results, which are exact in the weak-field limit for H2+ and, in addition, under the Hartree-Fock approximation for the diatomics, are compared with results from the recent literature. © 2012 American Physical Society.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.6.1 | Award Amount: 4.66M | Year: 2012

SmartHG will develop economically viable Intelligent Automation Software services gathering real-time data about energy usage from residential homes and exploiting such data for intelligent automation pursuing two main goals: minimise energy usage and cost for each home, support the Distribution Network Operator (DNO) in optimising operation of the grid. SmartHG rests on the following four pillars.\n\nFirst, Internet-based open standard protocols enabling effective communication between: i) home devices (e.g., sensors, smart appliances, local generators, electric vehicles, energy storage) and SmartHG services; ii) SmartHG services and DNO software systems; iii) any pair of SmartHG services. This will enable development of hardware device-independent energy services, possibly on the basis of the services already available.\n\nSecond, user-aware SmartHG services focusing on residential homes. Such services will measure home energy usage and local generation (e.g., from renewable sources), forecast it and actuate home devices (both loads and generators) in order to minimise the home energy bill and usage (local optimisation) with respect to a given price policy computed to attain global (grid level) optimisation.\n\nThird, demand-side aware SmartHG services focusing on the grid. Such services will compute individual (yet fair) price policies for each single home taking into account user preferences while optimizing grid operations. Grid safety for such price policies will be formally verified using model-checking-based techniques. Furthermore, such SmartHG services will increase grid reliability by estimating and controlling (using price policies) voltages and currents in internal unmonitored nodes of the grid.\n\nFourth, SmartHG case studies in Kalundborg and Minsk will enable thorough technical, environmental and economical evaluation of project results.\n\nFinally, SmartHG consortium consists of three highly qualified and multidisciplinary clusters comprising: four research institutions focusing on Computer and Electrical Engineering, four Energy Service SMEs, two DNOs and a municipality. The resulting synergies will ensure the success of the project as well as the wide dissemination and the effective exploitation of the project results.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: INFRA-2007-2.1-01 | Award Amount: 2.46M | Year: 2008

Key questions in particle and astroparticle physics can be answered only by construction of new giant underground observatories to search for rare events and to study sources of terrestrial and extra-terrestrial neutrinos. In this context, the European Astroparticle Roadmap of 03/07, via ApPEC and ASPERA, states: We recommend a new large European infrastructure, an international multi-purpose facility of 105-106 ton scale for improved studies of proton decay and low-energy neutrinos. Water-Cherenkov, Liq. Scintillator & Liq. Argon should be evaluated as a common design study together with the underground infrastructure and eventual detection of accelerator neutrino beams. This study should take into account worldwide efforts and converge by 2010... Furthermore, the latest particle physics roadmap from CERN of 11/06 states:A range of very important non-accelerator experiments takes place at the overlap of particle and astroparticle physics exploring otherwise inaccessible phenomena; Council will seek with ApPEC a coordinated strategy in these areas of mutual interest. Reacting to this, uniting scientists across Europe, we propose here a design study, LAGUNA, to produce by 2010 a full conceptual design sufficient to provide policy makers and funding agencies with enough information for a construction decision. Has Europe the technical and human capability to lead future underground science by hosting the next generation underground neutrino and rare event observatory? We aim to answer this question. Certainly construction will exceed the capacity of any single European nation - to compete with the US and Asia unification of our scattered efforts is essential. Failure to plan now risks not only that our picture of Natures laws remain fundamentally incomplete but also that leadership in the field enjoyed by Europe for 20 years falls away. EU FP7 input now is timely and will have major strategic impact, guaranteeing coherence and stimulating national funding.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 3.75M | Year: 2009

This ITN project will train young investigators to enable them make significant advances in the field of in situ sensor technology. It will bring together 15 research groups and 2 industrial partners from across the European Union. The ITN will provide training for 16 PhD students, early stage researchers (ESRs) and 1 Postdoctoral student, experienced researcher (ER). The programme will combine the strengths of the leading marine and engineering research groups in the EU, and through a structured and extensive programme of collaboration and student exchange, will provide a powerful, cohesive marine sensor development programme. Fundamentally, the outcome of this ITN will be to equip Europe with a network of young scientist/engineers, who will share a common technical culture and approach, and who will ultimately enable the monitoring of our fragile yet rapidly changing marine environment.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: ISIB-10-2014 | Award Amount: 499.59K | Year: 2015

PLATFORM brings together ERA-NETs in the area of the bioeconomy. The current proposal will continue and expand the work of FP7 PLATFORM (2012-2014) with the following objectives: to further increase collaboration among actors, to foster inclusiveness, to increase capacities for efficient and effective ERA-NETs, and to inform research policy making. FP7 PLATFORM organised inspiring annual events, dedicated workshops, a master class for call managers, fruitful two-way interaction with the Commission, the EIP AGRI and with the BBI-JU, and produced a comprehensive book about the bioeconomy ERA-NETs and their activities. Surveys, analysis and events also engaged ERA-NETs from neighbouring themes with bioeconomy relevance, JPIs Oceans and FACCE, SCAR WGs, and self-sustained ERA-NETs. PLATFORM2 will build on these activities and will further strengthen mutual learning, maximise synergies and increase coordination. PLATFORM2 will expand the network to new ERA-NET actions (Cofund), to more JPIs and will also seek stronger interaction with SCAR. On the website, a searchable database on bioeconomy ERA-NET joint calls will be constructed, including statistics and impact assessments, such as on leverage. Data may flow into other data repositories, e.g. an EIP Agri database on projects in the area of agriculture. A World Caf workshop is scheduled to ponder new, sustainable and alternative models for cooperation between public research programmes. PLATFORM2 will make an inventory of alignment actions taken by ERA-NETs. The series of Annual Events will be continued and enable actors to discuss emerging cooperation needs, opportunities and tools. PLATFORM2 will foster inclusiveness in all its work, in particular by a master class directed at new Member States and sessions at the Annual Events on improving both involvement and performance. Capacities will be increased by sharing experience and by way of master classes on planning and managing (Cofund) calls, as well as through evaluation and monitoring of ERA-NETs. The reflections and recommendations will be summarised in policy briefs.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2009-2.4.4-1 | Award Amount: 8.05M | Year: 2010

The Collaborative Project on Mendelian Forms of Parkinsons Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinsons disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years it has become increasingly clear that progress in the understanding of the molecular basis of PD, the second most common neurodegenerative disorder, and hence the chance to develop effective disease-modifying treatments, will most likely be brought about by focusing on the rare variants of the disease with known genetic defects. The groups forming the MEFOPA-consortium will therefore analyze the molecular pathways underlying inherited forms of PD with autosomal-dominant and autosomal-recessive inheritance in an integrative way, using cellular and animal models and cutting-edge technology. These two subprojects will provide targets for novel, disease-modifying treatment strategies. In a third subproject, a European registry and biobank for patients with rare Mendelian forms of PD will be established. Body fluids will be collected and systematically analyzed by unbiased proteomic techniques as well as by focussed analysis of candidate proteins, and ex vivo cellular models will be generated, in order to allow validation of disease-related alterations detected in the models analyzed in subprojects 1 and 2. Through this integrated, translational approach combining basic and clinical research groups, the project aims to achieve measurable progress in defining the relevant targets and readouts for disease-modifying therapies and will set the stage for rationally designed drug trials in carefully selected groups of patients and even presymptomatic mutation carriers.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.56M | Year: 2014

Explosive volcanic eruptions are an unavoidable natural hazard: Volcanic ash, the ejected lethal mixture of crystals, lava, glass and older rocks, is the most far-reaching threat. In April 2010, the ash cloud from Eyjafjall volcano in Iceland, a comparatively small event, paralysed large parts of Europe for up to one week in a manner unique in history. The impact was dramatic: several million passengers were grounded due to closed air pace and decelerated or halted industrial production caused several billion Euros of estimated economic loss. This scenario was largely amplified by the quasi-Babylonian lack of understanding and interaction amongst volcanologists, meteorologists, atmospheric researchers, engineers, private sector and politics. This eruption was not a singular accident: Europe has active volcanoes and is surrounded by others and must be prepared for similar future events. This requires a comprehensive and supra-disciplinary approach to allow for an encompassing mechanistic and quantitative understanding of the physico-chemical processes during the lifecycle of volcanic ash: from formation in a volcano, through changes during the dispersal in the atmosphere to the impacts on life and society. VERTIGO will address this challenging issue with a unique and innovative portfolio of partners from academia, research institutes and the private sector from eight European countries. We will offer an unmatched platform for research and training for highly-skilled students with a background in geology/volcanology, petrology/chemistry, informatics, biology, toxicology, fluid dynamics and/or engineering. The research-through-training projects for 13 students accomplish the EUROPE2020 strategy for a modern system of education. They will be educated in scientific and transferable skills, spiced with experience in private sector applications, to qualify for career opportunities in academia, research institutes, civil protection and private sector.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.07M | Year: 2013

DNA Nanotechnology is an emerging interdisciplinary area that will underpin the development of future nanoscience-based technologies for areas such as medicine, diagnostic tools, optics and electronics. DNA nanotechnology is based on the unique self-assembly properties of DNA which allow the rational design and synthesis of complex nanoscale structures with predictable form and function. Many other materials can be integrated in such DNA structures to create highly functional nanodevices. The Marie Curie ITN EScoDNA will establish a sustainable European School of DNA Nanotechnology. By providing high quality training to young scientists, EScoDNA will improve their career prospects in both public and private sectors; it will also strengthen the competitive position of European research and industry in this promising strategic field. A network of leading European researchers, two SMEs and a major commercial research institute will work together to foster the development of a new generation of scientists with the skills required to meet future challenges in DNA nanotechnology, from fundamental science to novel applications. The training program will involve collaborative research projects, including international secondments and exchange of data through a web-based Lab-Wiki Journal, and through summer schools and workshops. The industrial partners will be integrated in the training programme, and the two SMEs will coordinate training related to the commercial exploitation of new technologies, management and entrepreneurial skills. They will also take a lead in managing the protection and commercialization of new technologies arising from research with the ITN. The programme is designed to create a pool of highly qualified researchers prepared for a wide range of careers in bionanotechnology and nanofabrication and, especially, capable of contributing to the development of a strong European centre for the scientific and commercial development of DNA nanotechnology.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.58M | Year: 2010

GeoWeb 2.0 is the geographic embodiment of the Web 2.0 moniker for the next generation Web, i.e., the next generation of geographic information publishing, discovery and use. With the proliferation of the Internet as the primary medium for data publishing and information exchange, we have seen an explosion in the amount of online content available on the Web. In addition to professionally-produced material being offered free on the Internet, the public has also been encouraged to make its content available online to everyone as User-Generated Content (UGC). The goal of the GEOCROWD project is to establish a fertile research environment by means of a training network that will promote the GeoWeb 2.0 vision and advance the state of the art in collecting, storing, analyzing, processing, reconciling, and making large amounts of semantically rich user-generated geospatial information available on the Web. Specifically, activities will be centered on (i) exploiting user-contributed geospatial data, (ii) Web-geodata management and (iii) efficient means for data collection and dissemination, e.g., mobile computing. Our goal is to tame this data explosion, which applied to the geospatial domain translates to massively collecting and sharing knowledge to ultimately digitize the world.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SPA.2012.2.1-01 | Award Amount: 3.22M | Year: 2013

Observations of oscillations on the solar and stellar surfaces have emerged as a unique and extremely powerful tool to gain information on, and understanding of, the processes in the Sun and stars, and the origin of the variability in the solar and stellar output. Through helio- and asteroseismology detailed inferences of the internal structure and rotation of the Sun, and extensive information on the properties of a broad range of stars can be obtained. Space-based observations play a leading role in helio- and asteroseismology, in close synergy with ground-based observations as well as theoretical modelling. Long observing sequences are essential for measuring the oscillation frequencies with the precision required, and to extract the lowest mode frequencies involved. The enormous value of long-term space-based observations has been demonstrated in the solar case by the joint ESA/NASA SOHO mission (Solar and Heliospheric Observatory. This is now being followed by instruments on the NASA Solar Dynamics Observatory (SDO) mission.Large volumes of exquisite data on stellar oscillations of stars with a broad range of masses and ages are being collected by the CNES space mission CoRoT (Convection, Rotation and Transit) and the NASA Kepler mission. Extensive Earth-based observations of solar oscillations have been undertaken with the GONG network (Global Oscillations Network Group) and the Birmingham Oscillation Network (BiSON) to ensure continuous monitoring. A asteroseismic network, SONG (Stellar Observations Network Group) is being established under Danish leadership. Equally important for asteroseismology is the availability of supplementary data on the stars from more traditional observations, to determine their surface temperature, composition, radius, etc. Only through a coordinated use of the space- and ground-based data can the full potential of helio- and asteroseismology be realized.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2010-1.3-1 | Award Amount: 12.48M | Year: 2011

While there are standard procedures for product life cycle analysis, exposure, hazard, and risk assessment for traditional chemicals, is not yet clear how these procedures need to be modified to address all the novel properties of nanomaterials. There is a need to develop specific reference methods for all the main steps in managing the potential risk of ENM. The aim of MARINA is to develop such methods. MARINA will address the four central themes in the risk management paradigm for ENM: Materials, Exposure, Hazard and Risk. The methods developed by MARINA will be (i) based on beyond-state-of-the-art understanding of the properties, interaction and fate of ENM in relation to human health and the quality of the environment and will either (ii) be newly developed or adapted from existing ones but ultimately, they will be compared/validated and harmonised/standardised as reference methods for managing the risk of ENM. MARINA will develop a strategy for Risk Management including monitoring systems and measures for minimising massive exposure via explosion or environmental spillage.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.91M | Year: 2015

We need to increase the crop yield while reducing pesticide and use of inorganic fertiliser to meet the challenges of world population growth and climate change. Plant endophytic microorganisms can improve plant yield and enhance plant tolerance to abiotic stress as well as to pathogens under experimental conditions, but these effects are often not sufficiently stable for practical application. How do we boost the stability and reliability of the positive effects of endophytes on plants? We need to understand the genetic basis of beneficial interactions between crops and endophytes and extent this basis exhibits phenotypic plasticity at all interaction levels from the cellular to the field environment. This requires increasing our knowledge of the molecular mechanisms underlying the effects of endophytes, including intra and inter-kingdom exchange and distribution of resources (nutrients), signalling and possibly regulation between and inside the partners, the mutual induced production of secondary metabolites and the environmental cues which influence crop-endophyte interactions. The genetic variation and its plasticity in host and microbe will be exploited in to establish crop breeding and inoculum production processes for boosting the establishment and stability of plant-microbe mutualisms to benefit crop development, stress tolerance, pathogen resistance and quality. In this project we will provide fundamental biological as well as practical knowledge about interactions between endophytes and plants. This improved understanding will pave the way for increased use of endophytes to improve sustainability and plant productivity in a reliable way. The participants in this project comprise many of the key institutions and industries working with these problems and provide a uniquely strong consortium to address the key issues. Furthermore, the consortium will train a new generation of scientists who have the insight and skills to continue this task in their careers.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.1.2-09 | Award Amount: 7.78M | Year: 2012

Benthic ecosystems provide important goods and services, such as fisheries products and supporting, regulation and cultural services. There is serious concern about the adverse impact of fisheries on benthic ecosystem which may negatively affect the fisheries yield and integrity of the sea bed. To develop an integrated approach to the management of human activities in the marine environment, in particular fishing, there is a need to develop quantitative tools to assess the impact of fisheries on the benthic ecosystem and at the same time collaborate with the fishing industry to develop innovative technologies and new management approaches to reduce the impact on benthic ecosystems. BENTHIS will provide the knowledge to further develop the ecosystem approach to fisheries management as required in the Common Fisheries Policy and the Marine Strategy Framework Directive. It will study the diversity of benthic ecosystem in European waters and the role of benthic species in the ecosystem functioning. Fisheries impacts will be studied on benthic organisms and on the geo-chemistry. The newly acquired knowledge will be synthesized in a number of generic tools that will be combined into a fishing/seabed habitat risk assessment method that will be applied to fisheries in the Baltic, North Sea, Western waters, Mediterranean and Black Sea. Fisheries will be selected with the fishing industry based on the impact on the benthic ecosystem. BENTHIS will integrate fishing industry partners to collaborate in testing the performance of innovative technologies to reduce fishing impact. Finally, in collaboration with the fishing industry and other stakeholders, new management approaches will be developed and tested on their effects on the ecosystem and the socio-economic consequences. As such BENTHIS will the urgently needed scientific basis to integrate the role of marine benthic ecosystems in fisheries management.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP-2010-1.2-2 | Award Amount: 3.62M | Year: 2011

Hernia operations are among the most common surgical procedures performed today with over 20 million cases annually worldwide. Hernia incidents are associated with pain and poor quality-of-life for the patient and lead to enormous healthcare costs, exceeding US $48 billion in the US annually. At present, hernia operations rely heavily on non-degradable polypropylene, polytetrafluoroethylene and nylon meshes. However, these polymers are often associated with foreign body reaction; implant failure; and hernia reoccurrence (over 42%). Moreover, leaking chemicals of these polymers are often deleterious to the surrounding cells and tissue and immobilise post-operative drug treatments. In addition, the process technologies are often associated with environmental risks. Herein, we propose a novel approach that employs recent advances in green nanotechnology and sustainable raw materials for scaffold fabrication that not only will eliminate toxic chemicals from the processes, but will also enhance functional repair due to superior biological properties. Specifically, we aim to fabricate a nano-fibrous mesh with well-defined nano-topography using cellulose; human recombinant collagen, derived from transgenic tobacco plants; and biodegradable polylactic/polyglycolic acid as raw materials. The green credentials of this innovative approach lie in the use of sustainable eco-friendly raw materials that will produce biodegradable waste products and therefore replacing hazardous chemicals currently in use. Thus, this proposal directly fits the call for the substitution of materials or components with green nano-technology.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.4.5-2 | Award Amount: 7.59M | Year: 2010

Autoimmunity in rheumatoid arthritis (RA) is characterised by an antibody response to citrullinated proteins. Periodontitis (PD) is largely caused by infection, in which Porphyromonas gingivalis is a major pathogen. The two diseases combine specific HLA-DRB1alleles and smoking as risk factors, and have a similar pathophysiology characterised by destructive inflammation. A possible causative link between RA and PD is based on the ability of P. gingivalis to citrullinate proteins and thereby generate autoantigens that drive autoimmunity in RA. We hypothesise that anti-citrullinated protein antibodies can be generated, in genetically susceptible individuals, as a consequence of P. Gingivalis-induced citrullination in the gingiva. In the context of genetic risk factors, during chronic exposure to danger signals, such as bacterial lipopolysacharides and DNA, tolerance to citrullinated proteins may be broken, with production of a pathogenic antibody response, which at a later time point cross-reacts with joint proteins and causes chronic RA. We will use a multidisciplinary approach (genetics, epidemiology, molecular immunology and animal models) to study susceptibility factors and immune responses in RA and PD, with an aim to identify novel etiological and pathogenic pathways, forming the basis for new therapies.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: ENV.2009. | Award Amount: 1.14M | Year: 2010

The Deep Sea and Sub-Seafloor Frontier project (DSF) provides a pathway towards sustainable management of oceanic resources on a European scale. It will develop subseafloor sampling strategies for enhanced understanding of deep-sea and subseafloor processes by connecting marine research in life and geosciences, climate and environmental change, with socio-economic issues and policy building. Subseafloor drilling and sampling provide two key aspects for understanding how deep-sea ecosystems presently function and how they may respond to global change: (a) an inventory of current subsurface processes and biosphere, and their links to surface ecosystems, utilising seafloor observation and baseline studies and (b) a high resolution archive of past variations in environmental conditions and biodiversity. For both aspects, an international effort is needed to maximise progress by sharing knowledge, ideas and technologies, including mission-specific platforms to increase the efficiency, coverage and effectiveness of subseafloor sampling and exploration. The deep biosphere has been discovered only within the past two decades and comprises a major new frontier for biological exploration. We lack fundamental knowledge about biomass distribution, diversity and physiological activity of deep biosphere communities at lifes extremes, and their impact on seafloor and deep sea ecosystems. Similarly, the geodynamic processes fuelling biological activity, and how these processes impinge upon the emission of geofuels, hydrocarbon formation and other resources including seafloor ecosystems, need to be understood. This Coordination & Support Action will develop the most efficient use of subseafloor sampling techniques and existing marine infrastructure to study the geosystem, its effects on the deep biosphere and marine ecosystems, and provide a comprehensive white paper and an open access web portal for a sustainable use of the oceans and a Maritime Policy.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2011.1.1-1 | Award Amount: 3.59M | Year: 2012

LLLightinEurope LifeLong Learning, Innovation, Growth and Human capital Tracks in Europe Among all Europeans between 24 and 65 years old who had a tertiary educational degree in 2010, 82.8% were working. In the same age group, 68.3% who completed secondary schooling were working. Only 46% of those who did not complete secondary schooling were working. It is apparent that if Europe wants to be working, higher education is the necessary foundation for being competitive in the labor market. Since this is not only true for generations of future workers currently in school, but equally so for those who are today in their 30s, 40s and 50s, Lifelong Learning must be essential to continued employability. The cumulative investment necessary to generate higher education degrees alone for adults over the next two decades across Europe may be 3.5 trillion euros or about 1.4% of European GDP per year. Even higher investments are required in non-formal and informal Lifelong Learning. To help guide this investment, this research project will find answers to the following urgent questions: 1. How do successful enterprises actively employ Lifelong Learning for their competitive advantage? 2. Which public policy environments facilitate Lifelong Learning for such enterprises and entrepreneurs? 3. How does Lifelong Learning interact with and promote innovativeness on the enterprise level? 4. How much of which skills do European adults actually have? 5. What are the actual learning mechanisms in adult life that lead to these skills? 6. What are the causal effects of these skills on growth, competitiveness and social cohesion? The research consortium includes nine universities and research institutes from four academic disciplines macro-econometrics, innovation dynamics, educational systems, psychometrics to establish empirically proven answers. All outputs of the project (models, reports and tools) are designed to guide, support and facilitate best practice and strategy among public policy officials, enterprise strategists, individual citizens and fellow scientists.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2011.4-04 | Award Amount: 614.55K | Year: 2011

Until now energy efficiency in agriculture has received little attention, except for energy use in greenhouses. Nevertheless, it is considerable, especially when indirect energy use is taken into account. AGREE has the objective of showing the potential of short term energy efficiency gains and the promise of the long term potential. Environmental effects of savings on direct and indirect energy use in agriculture are integrally considered, as energy use efficiency also implies reduction of greenhouse gas emissions. Because energy savings in agriculture depend highly on the agri-environment (climate), AGREE will bring together south-eastern, south-western, north-eastern and north-western agroproduction systems. Evidence from energy saving potential and corresponding environmental and economical effects on country level are brought to the transnational level to identify an agenda for transnational collaboration to increase the learning curve on energy use efficiency. AGREE will set up a participatory process for two reasons. 1. Stakeholders will be involved in the set-up of the agenda which will facilitate the implementation of the results. 2. AGREE needs the opinions and views of stakeholders to produce an agenda that reflects the needs of and opportunities by practice. To ensure implementation, a link has been created with a European network of researchers committed to adopt the issue. This network (ENGAGE) is closely associated with the European Society of Agricultural Engineers (EuAgEng). This link will facilitate the adoption process. To ensure that the results will create relevant and effective R&D programmes, AGREE has established a close link with the Collaborative Working Group on Agriculture and Energy. This group is embedded in SCAR and the KBBE-Net and is thus positioned to translate the AGREE agenda, into commitment for effective R&D on energy efficiency. To this end, it is important that AGREE provides evidence of the added value of such research.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2011.2.1.4-3 | Award Amount: 3.78M | Year: 2011

In order to protect biodiversity, policy makers increasingly require demonstration of its value. BESAFE will use case studies to investigate how much importance people attribute to alternative arguments for the protection of biodiversity and in particular how this relates to ecosystem services. It will focus on the arguments used at different governance levels and in different ecological, socio-economic, spatial and temporal contexts. BESAFE will examine the interactions of environmental protection policies between governance scales. This will lead to an assessment of the transferability of arguments across scales. The Project will consider the contribution that valuing ecosystem services can make in demonstrating the value of biodiversity. The results will be used to produce a framework that will give guidance on the effectiveness of alternative arguments and protection strategies in various contexts. The framework will be made accessible through a web-based public access database with associated toolkit. To ensure practical usability, the toolkit and database interface will be developed in cooperation with stakeholders.

Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.75M | Year: 2017

Cancer is considered as the second leading cause of death worldwide. It is important to develop methodologies that improve understanding of the disease condition and progression. Over the past few years, single cell biology has been performed using micro/nano robotics for exploration of the nanomechanical and electrophysiological properties of cells. However, most of the research so far has been empirical and the understanding of the mechanisms and thus possible for cancer therapy are limited. Therefore, a systematic approach to address this challenge using advanced micro/robotics techniques is timely and important to a wide range of the technologies where micro/nano manipulation and measurement are in demand. The proposed Micro/nano robotics for single cancer cells (MNR4SCell) project focuses on the staff exchange between the 8 world recognised institutions of EU and China, and the share of knowledge and ideas, and further the development of the leading edge technologies for the design, modelling, and control of micro/nano robotics and their applications in single cancer cell measurement, characterisation, manipulation, and surgery. This project meets the objectives and requirements of the Marie Skodowska-Curie Actions: Research and Innovation Staff Exchange (RISE). The ultimate goal of MNR4SCell is to establish long-term international and multidisciplinary research collaboration between Europe and China in the challenging field of micro/nano robotics for single cancer cells in the characterisation, diagnosis and targeted therapy. The synergistic approach and knowledge established by MNR4SCell will serve as the building blocks of the micro/nano robotics and biomedical applications, and thus keep the consortiums leading position in the world for potential major scientific and technological breakthroughs in nanotechnology and cancer therapy.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: BG-07-2015 | Award Amount: 5.51M | Year: 2016

Objectives: 1) to improve the observation and predictions of oil spreading in the sea using novel on-line sensors on-board vessels, fixed structures or gliders, and smart data transfer into operational awareness systems; 2) to examine the true environmental impacts and benefits of a suite of marine oil spill response methods (mechanical collection in water and below ice, in situ burning, use of chemical dispersants, bioremediation, electro-kinetics, and combinations of these) in cold climate and ice-infested areas; 3) to assess the impacts on biota of naturally and chemically dispersed oil, in situ burning residues and non-collected oil using biomarker methods and to develop specific methods for the rapid detection of the effects of oil pollution; 4) to develop a strategic Net Environmental Benefit Analysis tool (sNEBA) for oil spill response strategy decision making. A true trans-disciplinary consortium will carry out the project. Oil sensors will be applied to novel platforms such as ferry-boxes, smart buoys, and gliders. The environmental impacts of the oil spill response methods will be assessed by performing pilot tests and field experiments in the coastal waters of Greenland, as well as laboratory tests in Svalbard and the Baltic Sea with the main focus on dispersed oil, in situ burning residues and non-collected oil. The sNEBA tool will be developed to include and overarch the biological and technical knowledge obtained in the project, as well as integrate with operational assessments being based on expertise on coastal protection and shoreline response. This can be used in establishing cross-border and trans-boundary cooperation and agreements. The proposal addresses novel observation technology and integrated response methods at extreme cold temperatures and in ice. It also addresses the environmental impacts and includes a partner from Canada. The results are vital for the off-shore industry and will enhance the business of oil spill response services.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2010.1.2-02 | Award Amount: 7.75M | Year: 2011

Organic and low-input dairy farming systems are increasingly noted as delivering multifunctional benefits to the agricultural industry and society but technical and economic constraints prevent widespread adoption. SOLID will deliver an innovative toolbox of novel methodologies that will contribute to the competitiveness of the dairy industry and increase the effectiveness with which these benefits are delivered. SOLID facilitates the use of breeds and feeding strategies to maintain productivity, improve animal health and welfare while meeting the market requirement for high quality milk. A multidisciplinary team comprising academic and stakeholder (SME) partners from across Europe, encompassing dairy cows and goats, will identify and apply novel strategies at the farm level and throughout the supply chain. Innovative science and models, combined with a participatory approach, will tackle practical issues, and assess competitive sustainability and integration across a range of scales and geographical contexts. Proteomics combined with genotyping and calorimetry will be used to characterise and quantify dairy cow and goat breed adaptation to organic and low-input systems. Given the reliance of such systems on forage, SOLID will develop novel and sustainable feed resources and design a decision-support model to optimise the management of on-farm forage supply. Life cycle assessment tools will assess environmental sustainability of grassland-based multifunctional dairy systems. Analysis of the supply chain from fork to farm will quantify the acceptability of new strategies and enhance collaboration. An integrated assessment tool and socio-economic modelling will assess innovations on farms and along supply chains, and will predict the impact of more widespread adoption of low-input practises. Effective knowledge dissemination and exchange activities will target key stakeholder groups ensuring exploitation of outputs at animal, farm, region, sector and European levels.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.3.4 | Award Amount: 3.62M | Year: 2010

The efficient design of embedded systems is hampered by the separation of engineering disciplines in current state of the art development approaches. A methodology to address system-level design issues across discipline boundaries is lacking and tool support is poor. This design gap inhibits iterative and concurrent engineering, leading to sub-optimal designs and long development lead times. Moreover, the design gap is widening because of increasing system complexity and increasing capabilities of the system artifacts used.DESTECS will create a methodology and supporting open tools platform for the collaborative and multidisciplinary development of dependable embedded real-time control systems. We will develop a methodology combining continuous time and formal discrete event modeling with support for iterative design evolution.Model analysis will be based on co-simulation and the framework will support explicit modeling of faults and fault-tolerance mechanisms from the outset. Tool support is crucial: the methodology will be supported by an open, extendible tools platform, populated with plug-ins supporting co-simulation, test and code generation. DESTECS does not replace current industry practice but it will facilitate and support the cross-discipline design dialogue by integration of domain-specific best practices. The methods and tools development is driven by industry-led case studies which also provide evaluation of the emerging technology.The novel aspects of this proposal are the use of a systems-level modeling approach based on co-simulation of formal models, the explicit modeling of faults and fault-tolerance at this level and the support for lightweight trade-off analysis between design alternatives on the basis of extra-functional properties, especially resilience. In particular, the development of an open tools framework for co-simulation will encourage greater industrial uptake.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.3-02 | Award Amount: 7.76M | Year: 2014

Global apiculture is facing an unprecedented crisis of increasing parasite pressure and a loss of hon-eybee biodiversity. SMARTBEES unites a team of experts with the necessary skills to build a bright and sustainable future. The SMARTBEES concept is low risk and high impact, using established protocols and state-of-the-art methods. Including world leading researchers from outwith the traditional honeybee sphere (e.g. acarology, genetic breeding and insect immunology). We will identify crucial facets of honeybee resistance to colony losses, Varroa and viruses. We will provide a step-change in the current mechanistic understanding of these traits, and will characterise the genetic background of the resistance mechanisms in honeybees. We will develop breeding strategies to increase the frequencies of these valuable traits in local honeybee populations, considering the variable need of both common and endangered subspecies and local beekeeping practises. Breeding efforts concentrating on very few races may endanger genetic diversity, to avoid this SMARTBEES will promote multiple local breeding efforts, to conserve local resilient populations and will develop molecular tools for describing and safeguarding future populations. SMARTBEES recognizes responsibility to protect our natural honeybee heritage. SMARTBEES will commission extension science, and work in cooperation with stakeholders to attain conservation by utilisation. SMARTBEES will establish a network of apiaries for performance testing, to encourage local uptake of resistant traits. These will be run mainly by beekeepers, thereby improving the local acceptability and dissemination, and support the long-term sustainability of the apicultural sector. SMARTBEES recognises the need to horizon scan for new threats, and the consortium includes the current EU reference laboratory to that end. SMARTBEES is an opportunity to make a lasting difference to the health, resilience and genetic diversity of our honeybees.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.82M | Year: 2012

NEUTRINOS AND DARK MATTER are the most abundant particles in the universe and yet they remained unnoticed -invisible- for a long time, due to their tenuous couplings to the ordinary matter we are composed of. Neutrino masses inferred from neutrino oscillations and the existence of dark matter constitute the first evidence ever of particle physics beyond the Standard Model. A wide experimental program focused on the properties of both type of particles is imminent and major breakthroughs are expected soon. The road to build the New Standard Model of particle physics is open: the theory must encompass the nature and properties of neutrinos and dark matter, besides those of ordinary matter. The mission of INVISIBLES ITN is to form the new generation of young researchers which will accomplish this task. It will focus on neutrino and dark matter phenomenology and their connection, with the indispensable link to experiment and a deep understanding of theoretical and astroparticle issues. It will be the first transnational program on these topics, exploiting the capital investment in new experimental facilities and overcoming the fragmentation of the research effort. INVISIBLES ITN is uniquely placed to achieve its goal: i) World-leadership in all relevant scientific areas; ii) A novel multidisciplinary approach fostering the neutrino-dark matter synergy; iii) In addition to theorists, inclusion of key experimentalists; theory-experiment cross training is a unique characteristic of this ITN; iv) Outstanding training record; v) CERN, Fermilab, XENON and SuperKamiokande -the four major experimental players- as partners; vi) Partnership with the world-leader research-related industry and cutting-edge technology transfer; vii) Strong outreach and communication program, with two dedicated companies; viii) Top-quality expertise from emergent countries; ix) Optimal in gender balance and role models, with over 60% female and mostly junior international leaders as coordinators.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-02b-2015 | Award Amount: 7.63M | Year: 2016

European crop production is to remain competitive while reducing environmental impacts, requiring development and uptake of effective soil improving cropping systems. The overall aim of SOILCARE is to identify and evaluate promising soil-improving cropping systems and agronomic techniques increasing profitability and sustainability across scales in Europe. A trans-disciplinary approach will be used to evaluate benefits and drawbacks of a new generation of soil improving cropping systems, incorporating all relevant bio-physical, socio-economic and political aspects. Existing information from literature and long term experiments will be analysed to develop a comprehensive methodology for assessing performance of cropping systems at multiple levels. A multi-actor approach will be used to select promising soil-improving cropping systems for scientific evaluation in 16 study sites across Europe covering different pedo-climatic and socio-economic conditions. Implemented cropping systems will be monitored with stakeholder involvement, and will be assessed jointly with scientists. Specific attention will be paid to adoption of soil-improving cropping systems and agronomic techniques within and beyond the study sites. Results from study sites will be up-scaled to the European level to draw general lessons about applicability potentials of soil-improving cropping systems and related profitability and sustainability impacts, including assessing barriers for adoption at that scale. An interactive tool will be developed for end-users to identify and prioritize suitable soil-improving cropping systems anywhere in Europe. Current policies and incentives will be assessed and targeted policy recommendations will be provided. SOILCARE will take an active dissemination approach to achieve impact from local to European level, addressing multiple audiences, to enhance crop production in Europe to remain competitive and sustainable through dedicated soil care.

Agency: GTR | Branch: EPSRC | Program: | Phase: Training Grant | Award Amount: 4.34M | Year: 2014

This world-leading Centre for Doctoral Training in Bioenergy will focus on delivering the people to realise the potential of biomass to provide secure, affordable and sustainable low carbon energy in the UK and internationally. Sustainably-sourced bioenergy has the potential to make a major contribution to low carbon pathways in the UK and globally, contributing to the UKs goal of reducing its greenhouse gas emissions by 80% by 2050 and the international mitigation target of a maximum 2 degrees Celsius temperature rise. Bioenergy can make a significant contribution to all three energy sectors: electricity, heat and transport, but faces challenges concerning technical performance, cost effectiveness, ensuring that it is sustainably produced and does not adversely impact food security and biodiversity. Bioenergy can also contribute to social and economic development in developing countries, by providing access to modern energy services and creating job opportunities both directly and in the broader economy. Many of the challenges associated with realising the potential of bioenergy have engineering and physical sciences at their core, but transcend traditional discipline boundaries within and beyond engineering. This requires an effective whole systems research training response and given the depth and breadth of the bioenergy challenge, only a CDT will deliver the necessary level of integration. Thus, the graduates from the CDT in Bioenergy will be equipped with the tools and skills to make intelligent and informed, responsible choices about the implementation of bioenergy, and the growing range of social and economic concerns. There is projected to be a large absorptive capacity for trained individuals in bioenergy, far exceeding current supply. A recent report concerning UK job creation in bioenergy sectors concluded that there may be somewhere in the region of 35-50,000 UK jobs in bioenergy by 2020 (NNFCC report for DECC, 2012). This concerned job creation in electricity production, heat, and anaerobic digestion (AD) applications of biomass. The majority of jobs are expected to be technical, primarily in the engineering and construction sectors during the building and operation of new bioenergy facilities. To help develop and realise the potential of this sector, the CDT will build strategically on our research foundation to deliver world-class doctoral training, based around key areas: [1] Feedstocks, pre-processing and safety; [2] Conversion; [3] Utilisation, emissions and impact; [4] Sustainability and Whole systems. Theme 1 will link feedstocks to conversion options, and Themes 2 and 3 include the core underpinning science and engineering research, together with innovation and application. Theme 4 will underpin this with a thorough understanding of the whole energy system including sustainability, social, economic public and political issues, drawing on world-leading research centres at Leeds. The unique training provision proposed, together with the multidisciplinary supervisory team will ensure that students are equipped to become future leaders, and responsible innovators in the bioenergy sector.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2009. | Award Amount: 9.23M | Year: 2010

Past4Future will combine multidisciplinary paleoclimate records from ice cores, marine cores, speleothems, pollen and other records, concentrating on a global distribution of the records, to reconstruct climate change and variability during the present interglacial (the Holocene) and the last interglacial (known as the Eemian in northwestern Europe and as marine isotope stage 5e in the marine sediment records). The records will be combined in integrated analyses aided by proxy modeling and assimilation, to gain understanding of the climate processes involved in the dynamics of interglacial climates. Earth system models (ESM) including physical and biogeochemical processes will be applied to simulate the past and present interglacial climate, and to confront and intercompare the simulations with climate changes as observed from the palaeodata; this will both advance the models and our understanding of the dynamics and predictability of the climate system. Focus will be on the most recent two interglacial periods, as these provide the highest-resolved most comprehensive data records. Moreover the last interglacial represents a situation where the mean state was warmer than at present in large regions due to orbital forcing, thereby allowing tests of climate system sensitivity to constrain projections of potential future ice sheet, sea-level, circulation and biogeochemical changes. The data and Earth system model results will be used improve our capabilities to project future global and regional warming from a better understanding of relevant paleoclimates, especially in relation to sea level changes, sea ice changes and thermohaline circulation changes. The Past4Future program will draw together a world leading team of European and international partners in a concerted effort to advance our knowledge on the causes, processes and risks of abrupt changes in warm periods, such as those projected for the current and the next century. The program will inform the international debate on climate system stability and the dissemination of results will be targeted to both citizens and governmental and non-governmental stakeholders. It will leave a legacy of improved understanding of past drivers of sea level changes, changes of sea ice, and of greenhouse gas concentrations, and it will train a new generation of young climate researchers to further advance research and improved future predictions for the benefit of society and our capacity to mitigate and adapt to climate changes.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.2-4 | Award Amount: 10.92M | Year: 2013

Although there is a large body of knowledge available on soil threats in Europe, this knowledge is fragmented and incomplete, in particular regarding the complexity and functioning of soil systems and their interaction with human activities. The main aim of RECARE is to develop effective prevention, remediation and restoration measures using an innovative trans-disciplinary approach, actively integrating and advancing knowledge of stakeholders and scientists in 17 Case Studies, covering a range of soil threats in different bio-physical and socio-economic environments across Europe. Within these Case Study sites, i) the current state of degradation and conservation will be assessed using a new methodology, based on the WOCAT mapping procedure, ii) impacts of degradation and conservation on soil functions and ecosystem services will be quantified in a harmonized, spatially explicit way, accounting for costs and benefits, and possible trade-offs, iii) prevention, remediation and restoration measures selected and implemented by stakeholders in a participatory process will be evaluated regarding efficacy, and iv) the applicability and impact of these measures at the European level will be assessed using a new integrated bio-physical and socio-economic model, accounting for land use dynamics as a result of for instance economic development and policies. Existing national and EU policies will be reviewed and compared to identify potential incoherence, contradictions and synergies. Policy messages will be formulated based on the Case Study results and their integration at European level. A comprehensive dissemination and communication strategy, including the development of a web-based Dissemination and Communication Hub, will accompany the other activities to ensure that project results are disseminated to a variety of stakeholders at the right time and in the appropriate formats to stimulate renewed care for European soils.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.91M | Year: 2013

Cardiovascular disease remains a major cause of morbidity and mortality in Europe. Small arteries form a key element in the pathogenesis. Thus, these vessels dictate local perfusion and blood pressure by adaptation of their caliber. Structural changes towards smaller caliber, small artery remodelling, cause hypertension and decreased organ perfusion, leading to acute events and chronic end organ dysfunction. Despite this role, these vessels are poorly studied and therapeutic options based on these arteries are lacking. SmArteR (Small Artery Remodelling) collects 13 academic and SME partners who have set up a training programme for 12 ESRs and 3 ERs. We address the interaction between cells, extracellular matrix and mechanical loading in an integrative way, taking advantage of the multidisciplinary partnership. Thus, we will unravel the processes in small artery remodelling at the molecular, cellular and integrative physiology level, and we will develop novel and marketable technology aimed at studying these vessels in vitro under the right biomechanical conditions. The ESRs and ERs are trained in not only cardiovascular R&D, but also in a range of skills required to form the new generation of frontrunners in biomedical research in academia and industry.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH-2007-2.1-02 | Award Amount: 1.98M | Year: 2008

CONSENSUS aims to improve our understanding of trade-offs and synergies between economic, environmental and social aspects of sustainable development. In so doing, the project applies a selective focus in order to shed light on several issues that are of particular relevance in this respect both in practical and analytical terms. First, the project places particular emphasis on a systematic analysis of the interlinkage between different levels of economic pressure and social and environmental policy. Second, in line with the political emphasis on better regulation and deregulation, the project applies a highly innovative perspective on policy change and sustainable development. Third, this interlinkage between economic pressure on the one side, and environmental and social sustainability on the other, is analyzed on the basis of a systematic comparison across 25 OECD countries over a period of thirty years (1975-2005) Fourth, this focus offers the opportunity for a comparison of regulatory adjustments across different policy areas. The focus on two crucial policy fields social and environmental policy allows us to study whether regulatory responses to economic pressures differ between these areas. Fifth, with regard to environmental and social policy, we focus on those subfields that have been identified as priority areas of sustainable development The projects proceeds in the following steps. In the first step, the theoretical framework will be further elaborated. In the second step, a quantitative analysis of the major driving forces of policy dismantling will be acrried out. For this purpose, cross-national data on social and environmental policy dismantling for the period from 1975 to 2005 will be collected. In the third part of the study, theoretiaccly interesting cases will be selected and subject to an in-depth qualitative analysis. The final part refers to the publication of the research reprot and the dissemination of the results.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE-2009-1-2-01 | Award Amount: 4.10M | Year: 2010

This research will deliver knowledge and technology for the optimisation of the use of legumes in European agricultural systems and promote the partnerships needed to support the public policy outcomes sought. By integrating the Consortiums extensive set of existing field case studies, modelling and knowledge base, the project will test, validate and deliver novel cropping systems. This network of 18 case studies, in 12 countries, will be the focus of interaction with farmers, SMEs, other businesses, and policy makers. Outputs will include system-optimised cropping plans for each pedo-climatic region, input into existing farm-planning tools, local on-farm demonstrations, a socio-economic analysis that will enable local economic assessment of cropping systems, and an ecological assessment of the effects of relevant farming system changes on greenhouse gas and nitrogen budgets, biodiversity and soil health from the farm to the continental scale. A book on legume-supported eco-efficient farming systems covering all aspects of the use of legumes in Europe will be published. The research is planned around the appreciation of how nitrogen fertilisation and the production and use of plant protein lie at the heart of many of the global, regional and local environmental challenges arising from agriculture. The project will take a novel strategic approach to knowledge interaction and delivery, in order to enhance and pool existing knowledge platforms and databases. It will then deliver the results into the farming community, commercial use, and policy practice beyond the life of the project. The project will facilitate wide access to new and existing knowledge and technologies and it will promote awareness of the role of legumes in the development of sustainable supply chains and consumption patterns. All research results and products will be put in the public domain, and partnership with all the agents of change, including policy makers, will be a key element of the work.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2013-1 | Award Amount: 1.22M | Year: 2013

This project is addressed to improve the capacity and effectiveness of constructed wetland (CW) systems as sustainable wastewater (WW) treatment technology. HIGHWET project aims to develop and validate new configurations of CWs to obtain high rate CWs for treating different types of WW. HIGHWET system approach will enhance the implementation of these treatment technologies not only due to their low operation and maintenance cost but also due to their high organic and hydraulic loading rate capacity. The HIGHWET project aims to perform and validate new approaches of vertical and horizontal CWs including innovative materials as gravel bed, aeration devices for increasing biological development and hybrid configurations (hydrolysis anaerobic reactor and CW systems) for decreasing required surface of conventional CWs. The outcomes of the project will be the performance of holistic HIGHWET systems capable of operating at high loading rates treating municipal and industrial WW. Furthermore, new operation strategies will be carried out in order to avoid the gravel bed clogging and extend the lifetime of the systems. Three European SMEs with a extended know-how in natural WW treatments will collaborate with two RTD performers with high experience in anaerobic digestion and CWs to obtain new WW plant configurations in order to uptake new markets: small towns (2,000 to 5,000 p.e.), industrial (food and beverage sector) and livestock farm sectors (Farms with more than 100 heads). Furthermore, a food sector company and regional water agency will be involved in the project as end-user and stakeholder, respectively. SMEs involved in HIGHWET project will have the opportunity to extend their market share since they will obtain innovative and novel products: sustainable and competitive WW treatments; novel aeration and micro-aeration systems to be implemented in WW treatment sector; and specific aggregate /material to be used in CW as gravel bed.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.1.1-03 | Award Amount: 8.04M | Year: 2012

The objective of the FIGARO project is to significantly reduce the use of fresh water on farm level through developing a cost-effective, precision irrigation management platform. The platform will be structured for data acquisition from monitoring devices and forecasting tools, data interpretation, system control, and evaluation mechanisms enabling full decision support for end users at farm scale. These tools will be integrated with multiple state-of-the-art irrigation technologies and strategies as well as newly adapted devices leading to further increased water productivity. The flexibility, cost-effectiveness, ease of use, minimal maintenance of the system and often, increases in crop yield, will boost its acceptance and up-take by the end-users (the farmers, extension workers). In addition, as added value the system will enable reduction of fertilizer use, further supporting sustainable use of natural resources and adaptation of agricultural practice to climate change. To achieve this, the FIGARO project will develop a holistic and structured precision irrigation platform which will offer farmers flexible, crop-tailored irrigation scheduling protocols for their specific fields taking into account spatial variability management.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH-2010-5.2-1 | Award Amount: 2.20M | Year: 2011

The EUCROSS project examines the relationship between the manifold activities of EU residents (nationals, mobile EU citizens, and third-country nationals) across the borders of nation states and their collective identities. Specifically, the project will: 1) map out individuals cross-border practices as an effect of European integration and globalisation; 2) assess the impact of these practices on collective identifications (also controlling for the inverse causal process). Which cross-border practices are more likely to foster some form of identification with the EU e.g., contacts with foreign friends and/or unwanted foreigners, periods of labour mobility abroad, buying property abroad, business and tourist travel, or consumer relations with international companies? Under which contextual and individual conditions do these experiences promote a higher sensitivity to Europe rather than the local or the global as an identity catalyst? Which social groups are more prone to adopt a European mindset in the wake of the Europeanisation of everyday life? To disentangle empirically the factors and mechanisms that link together the cross-border practices facilitated by European integration, globalisation and/or other dimensions of collective identity, we adopt a two-stage, mixed quantitative/qualitative approach. In the first stage, we will carry out a quantitative survey among nationals, intra-EU movers (Romanian citizens) and third-country nationals (Turkish citizens) who reside in six European countries (Denmark, Germany, Italy, Romania, Spain and the United Kingdom). In the second stage, we will interrogate, via in-depth interviews, the meaning given by individuals to cross-border practices, their collective identifications, and the role that the European Union, globalisation, and the nation play in these personal narratives, among a select typology of respondents to the quantitative survey.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH-2009-3.3.1. | Award Amount: 3.44M | Year: 2010

In recent times, Europe has experienced increasing tensions between national majorities and ethnic or religious minorities, more particularly with marginalised Muslim communities. In some countries challenges relate more to immigrant groups while in other countries they refer to native minority claims. It is in this geopolitical context that the ACCEPT project responds to Topic 3.3.1 and notably in the quest for investigating whether European societies have become more or less tolerant during the past 20 years and in the necessity to clarify: (a) how is tolerance defined conceptually, (b) how it is codified in norms, institutional arrangements, public policies but also social practices, (c) how tolerance can be measured and how the degree of tolerance of a society across time or of several countries at the same time can be compared (whose tolerance, who is tolerated, and what if degrees of tolerance vary with reference to different minority groups). The project starts from a distinction between liberal tolerance (not interfering with practices or forms of life of a person even if one disapproves of them) and egalitarian tolerance referring to institutional arrangements and public policies that fight negative stereotyping, promote positive inclusive identities and re-organise the public space in ways that accommodate diversity. It reviews critically past empirical research and the scholarly theoretical literature on the topic. It conducts original empirical research on key events of national and European relevance that thematise different understandings and practices of tolerance. Bringing together empirical and theoretical findings, ACCEPT generates a State of the Art on Tolerance and Cultural Diversity in Europe targeting policy makers, NGOs and practitioners, a Handbook on Ideas of Tolerance and Cultural Diversity in Europe aimed to be used at upper high school level and with local/national policy makers, a Tolerance Indicators Toolkit where qualitative and quantitative indicators may be used to score each countrys performance on tolerating cultural diversity. These indicators will inform the evaluation and development of public policies in this area. Last but not least the ACCEPT project will produce a book manuscript on Tolerance, Pluralism and Cultural Diversity in Europe. The project includes direct communication and feedback mechanisms with civil society, political and media actors for the dissemination and exploitation of its findings.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: PEOPLE-2007-1-1-ITN | Award Amount: 2.86M | Year: 2009

This ITN will continue and enhance the success of a recent RTN The Emergence of European Communities (2-2001-00366): Several PhDs have been educated and new knowledge has been unearthed concerning the economic and political foundations of intercultural interaction in Bronze Age Europe a golden epoch between 3000 and 500 BC with new patterns of social identification, specialised production, complex polities and wide-reaching interaction networks across Europe. However, new questions have been evoked: 1. How did cultural mobility impact on the social life of settlements? 2. How did the movement of people, animals, plants, things, ideas, and knowledge take place and on what scale? 3. How were European and regional identities forged through interaction? These and other questions grown out of the preceding RTN will be researched by building on a continued European network and by using a similar cross-disciplinary methodology combining archaeology, natural science and sociology. This shared platform shall create knowledge of the mobility of people and culture including the new metal bronze and insight into the forging of European and regional identities that shaped this remarkable period. The ITN is expected to change current archaeological perspectives from national traditionalism towards transnational and cross-disciplinary engagements. It consists of 7 network partners and 11 associated partners. Network partners have considerable capacities in research training and will provide supervision and facilities for the employed ESRs and ERs. They will cooperate with each other in organising workshops, training courses, and summer schools. Associated partners will provide extra supervision, field sites, data, and secondments offering specific training facilities in archaeology and front-line sciences. Field schools will take place each summer.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-19-2014 | Award Amount: 4.86M | Year: 2015

A good functioning of the European food system is key to deliver food and nutrition security for all Europeans. However, that system faces many economic, environmental and social challenges as well as opportunities following socio-economic and technological developments, that are not equally distributed throughout the EU. Future policymaking aiming at healthy and resilient systems needs to take into account this differentiation and diversity of approaches, which necessitate foresight activities that take into account both the development of important driving forces as well as the social and spatial diversity. Primary productionthat is agriculture, fisheries and aquacultureforms the foundation of the food system. Its structure and performance is influenced by various conditions shaped by both the public and the private sector. As economic agents, primary producers aim at generating a sufficient amount of income, but their financial conditions are highly dependent on public and private actors, such as government regulators (including the EUs agricultural and fisheries policies), the financial sector, suppliers, the food industry, retailers, etc. In other words, the web of policy requirements as well as input and output market imperfections greatly shape farmers and fishermens livelihoods. Knowledge on the conditions of primary producers and the driving forces influencing these conditions exists, but in a fragmented way: not all primary producers and regions are covered, not all driving forces have been investigated, cross-linkages between them have been insufficiently analysed, future opportunities are not well integrated, etc. The purpose of SUFISA is to identify sustainable practices and policies in the agricultural, fish and food sectors that support the sustainability of primary producers in a context of multi-dimensionsal policy requirements, market uncertainties and globalisation.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP-2010-1.2-2 | Award Amount: 3.73M | Year: 2011

The overall objective of the STEELCOAT project is to reduce the use of toxic and hazardous compounds in, and extend the service life of, anticorrosion coatings for steel. The project aims to develop novel green, environmentally friendly, anticorrosion coatings with extended durability for steel protection. We will develop both high solids (HS) solvent-borne and water-borne anticorrosion maintenance coatings. The corrosion protection in these novel coatings will be achieved by combining green nanoparticles, conductive polymers and binders. Steel is an excellent material with high strength and outstanding mechanical properties and it has been used for centuries. Exposing bare steel surfaces to a corrosive environment will lead to corrosion of the steel surfaces and thus pose a potential danger to the whole steel structure, reducing its service life. The cost of corrosion is 3-4 % of GDP worldwide and is therefore a very important issue for all modern societies. Many compounds that are used in the corrosion protection of steel today are hazardous to the environment and to human health. For example, hexavalent chromium has been used in inhibitive pigments but these pigments are being phased out due to environmental and health concerns. Thus, there is an urgent need to replace current paint systems with new effective systems that are more environmental friendly and not hazardous to human health. In the STEELCOAT project we will develop new HS solvent-borne and water-borne anticorrosion maintenance coating systems for steel protection through the combination of nanoceria, nanoclay, conductive polymers and binders. In order to optimize the corrosion protection of the novel systems we will devote a part of the project to increased fundamental understanding of the mechanisms of corrosion protection. Furthermore, in the development of the coating formulations we will investigate and optimize the mechanical properties of the coating and the adhesion to the steel surface.

So far, there are no effective treatments for neuropathic pain (NP), and current treatments suffer from serious unwanted side effects. The NGF ligand-receptor system has recently emerged as a novel target for NP of great therapeutic potential, a master regulator, controlling both neuropathic and inflammatory components. Besides being a multi-component system, it also modulates the endocannabinoid (EC) signalling. Blocking the NGF signaling system is therefore a rational and thoroughly validated approach to pain therapy. Extensive evidence for potent analgesic efficacy of antiNGF mAbs has been obtained in preclinical models and in clinical trials,showing remarkable analgesic efficacy and creating great expectations for this new class of analgesic compounds.However, potential safety concerns related to off-target side effects have been raised and recently the FDA called for more preclinical research. To fully exploit the huge therapeutic potential of NGF system, we built a consortium of leading researchers in the NGF, EC and pain scientific arena.The innovative proposal will investigate new strategies for the treatment of different NP forms, based on the NGF system and its interplay with EC signalling, focussing at different levels of the pain transmission and perception systems. The project results will provide solid, mechanism-based grounds for the development of already identified second-generation therapeutics, based on the NGF target system, as well as for the identification and validation of new druggable targets emerging from the elucidated mechanisms. It will also identify biomarkers for NP, validated in animal models and clinical samples, that could result in future clinical benefits, for the stratification of patients suffering from different neuropathies and their treatment. The project will contribute to the understanding and controlling NP mechanisms, with an interdisciplinary approach, leading to the development of next-generation NGF targeting drugs.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SEC-2013.6.1-2 | Award Amount: 3.59M | Year: 2014

The PRIME project will support the design of technologies (counter-measures and communication measures) for the prevention, interdiction and mitigation of lone actor extremist events (LOEEs), which are hard to anticipate, yet can be highly damaging to local and national communities and therefore must be addressed. Given the difficulty in detecting LOEEs, prevention-based strategies must be complemented by interdiction- and mitigation-based measures, to minimize harm in the event of detection failure. These measures must be accompanied by communication strategies aimed at a range of audiences, including extremists and the general public. The PRIME project will deliver a knowledge-base to inform the design of measures to defend against LOEEs, by achieving the following objectives: 1): Characterising a) the risk posed by lone actor extremists, and b) the context in which measures to defend against LOEEs may be implemented; 2) Producing a cross-level risk analysis framework within which to articulate the key factors and processes implicated in LOEEs, across all stages of the event (radicalisation, attack preparation, attack). 3): Translating the risk analysis framework into a meta-script of lone actor extremist events, and developing methodologies and techniques to produce empirically-supported scripts of each stage. 4): Producing an integrated, cross-level script of LOEEs, and identifying categories of intervention points or pinch points. 5): Delivering a portfolio of requirements for the design of measures for the prevention, interdiction and mitigation of lone actor extremist events across levels of intervention, informed by the analysis of the event script and an understanding of the context in which these measures may be implemented. 6): Delivering a portfolio of requirements for communication measures directed at a diverse audience at each stage of the script, in coordination with the portfolio of counter-measures.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2012.1.3-2 | Award Amount: 1.28M | Year: 2013

Nano-sized materials are a common element in many industrial processes mainly due to their unique properties that lead to the production of high technology products. The widespread use of nanotechnology requires the consideration of the environmental and human health risks that may result from the introduction of engineered nanoparticles (eNPs) into the environment. Although toxic effects for certain types of eNP have been recently reported, there is still a lack of knowledge about their possible long-term effects in biological systems. The project focuses on the understanding of the processes governing the interactions of nanoparticles with biological systems and their associated mechanisms of toxicity, which are essential for eNP safety assessment. Information on the effects of well characterized eNPs will be obtained from literature and other data repositories. Targeted in vivo and in vitro experiments will be also carried out to overcome the limitations of data availability and for model validation. Computational methods will be applied to model both nanostructure-property relationships and the complex and highly non-linear nano-bio interactions and to diminishing the need for animal testing. The main goal of MODERN is to establish new modeling approaches suitable for relating nanotoxicity with the intrinsic molecular and physicochemical properties of eNPs at environmental exposure levels and to implement safe-by-design nanoparticle design strategies. This implies three specific objectives: (i) To apply computational models for the characterization of the structural and physicochemical properties leading to QNPRs and safe-by-design strategies for eNPs; (ii) To develop in silico models (QNAR) of biological activity of eNPs in the body and in the environment; (iii) To establish a categorization and hazard ranking protocol for eNPs based on structural similarity principles and in the analysis of their toxicological profiles.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 4.90M | Year: 2010

The overarching aim of the SMALL ITN project is to train Early Stage Researchers in the field of molecular recognition at surfaces from fundamental science to novel applications. For this task, SMALL combines European experts from surface science, nanotechnology, theory, chemical synthesis, physics, biology and industry, and thus takes a highly integrated approach to the training. The researchers will work within a well-structured scientific programme aimed at molecular recognition, underpinning the next generation of molecular sensors, catalysis, biomimetics, and molecular electronics. The programme of training will foster scientists who, in addition to being specialists in particular branches of molecular nanotechnology, have broad interdisciplinary experience in the experimental and theoretical techniques of molecular nanotechnology. Their hands-on training will be substantiated by a well-developed network training programme which will address both scientific and complementary skills. In their projects, the Early Stage Researcher will explore the nature of the interactions responsible for molecular and atomic recognition and the role that these play in the massively parallel self-assembly of supramolecular nanostructures, using a collaboration of cutting edge experimental and theoretical techniques. They will investigate how to achieve chemical selectivity at surfaces, including enantioselective recognition, by molecular and atomic surface modification as a route to novel catalysis and nanoscale sensors, drawing on expertise across different scientific disciplines and pioneering industrial partnerships.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: PEOPLE-2007-1-1-ITN | Award Amount: 5.04M | Year: 2008

The objective of this project is to set up an Initial Training Network on advanced techniques for ultrafast manipulation of atoms and molecules by strong femtosecond laser pulses. The project comprises a diverse range of applications of strong-field coherent control to ultrafast spectroscopy and microscopy; nuclear and electron wavepacket dynamics; alignment of molecules with applications to collisions, high harmonic generation and adsorption; characterization and control of dissipation; stabilization of cold atoms and molecules; quantum state and process tomography; and ultrafast information processing. The use of strong shaped femtosecond laser pulses opens a novel avenue to control of quantum dynamics via hitherto inaccessible physical mechanisms. The new control scenarios require the development of novel versatile femtosecond sources in the UV and VUV range of high shaping capabilities, to which a part of the research will be dedicated, with anticipated spin-offs of great multidisciplinary interest, e.g. in chemistry and biology. The combined expertise of the network - a joint effort of 10 universities and 3 industrial companies - represents the cutting edge of research and training in femtosecond light-matter interactions in Europe. The network will train 18 doctoral students and about 11 young postdoctoral researchers. The training activities will combine several dedicated instruments of network-wide training, capitalizing on their synergy with a backbone of specialized training inside the groups. The training program will be adapted to the ESRs, with elementary, advanced and expert phases initiated at the network schools and workshops. Prominent scientists from Europe and overseas, and industry leaders from the companies in the network and from outside, will contribute to the schools and workshops. Special attention will be focused on developing important complementary skills, such as communication, presentation, project planning and management.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2012-1 | Award Amount: 1.76M | Year: 2012

The CareStore project wishes to create a shared and open marketplace, similar to Apples App Store, for easier deployment of applications and device drivers within the healthcare domain. We wish to extend and adapt existing open source assisted living platforms for nursing homes to integrate the CareStore. These will be investigated and extended with a reliable and secure recognition and identification hardware and software platform to work in a Pan-European context. The envisaged solution is considerably more flexible, cost-competitive and efficient than current state-of-the-art solutions. The CareStore will allow private and public organisations and institutions to select independent vendors and combine hard- and software from several providers. The solution allows nursing homes (via their public or private provider) to establish an independent CareStore through the general setup of the already existing Open-Care based Sekoia platform. Today, a large number of assisted living technologies coexist without a common language between them. They have different user interfaces, communication infrastructures and maintenance plans, which limit the inclusion of efficiency-enhancing solutions in the homecare and elderly sector. The deployment of applications and devices are overly complex, and cannot be handled by healthcare staff or citizens themselves, but require support from technical personnel, thus increasing cost and reducing feasibility of implementing new technology solutions. By developing an open-source platform and CareStore, based on standardised user-interface and recognition technology, where all technologies and devices can be seamlessly installed and connected, we would most likely increase the incentive to implement assisted living technologies in the homecare and elderly sector and open up a significant market potential for this SME consortium, targeting a potential market of 11,5 billion and a total increased consortium turnover of 41 million.

The requirement for sustainable food production is a global issue to which the EU contributes as a major livestock producer. It is critical to improve animal production efficiency while sustaining environmentally friendly milk production. More profitable dairy production requires increased milk yield, cow health, longevity and fertility; reduced environmental footprint and optimised use of inputs. These are multifactorial problems to achieve. GplusE aims to identify the genotypes controlling biological variation in the important phenotypes of dairy cows, to appreciate how these are influenced by environmental and management factors and thus allow more informed and accurate use of genomic selection. GplusE will link new genomic data in dairy cows to a comprehensive array of phenotypic information going well beyond those existing traits recorded by dairy breeding organisations. It will develop systems that will focus herd and cow management on key time points in production that have a major influence on the rest of the productive cycle including efficiency, environment, physiological status, health, fertility and welfare. This will significantly advance the science, efficiency and management practices in dairy production well beyond the current state-of-the art. The major bioinformatics element of the proposal will illuminate the bovine genome and ensure a reverse flow of information to annotate human and other mammalian genomes; it will ensure training of animal scientists (PhDs & Postdocs) to a high skill level in the use of bioinformatics. The end result of this project will be a comprehensive, integrated identification of genomic-phenotypic associations relevant to dairy production. This information will be translated into benefits for animal breeding and management that will considerably improve sustainable dairy production. It will provide basic biological information into the mechanisms by which genotype, environment and their interaction influence performance.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2011.1.2-01 | Award Amount: 3.75M | Year: 2011

Farming practices that lead to declining returns and inputs of carbon (C) to soils pose a threat to soil functions by reducing availability of organic matter for soil microbes and by affecting soil structure, and soil C stocks that are key to regulating greenhouse gas emissions. SmartSOIL focuses on arable and mixed farming systems in Europe and will develop an innovative approach using the soil C flow and stocks concept to assess the impact of C management on crop productivity, soil organic C (SOC) stocks and other ecosystem services. SmartSOIL will identify and develop options to increase C stocks and optimise C use (flows) whilst maintaining sustainable SOC stocks. The flow and stocks concept will delineate short- versus long-term management effects on vital soil functions through meta-analyses of data from European long-term experiments (LTEs), as well as new measurements within LTEs. The new understanding will be used to improve existing soil and crop simulation models and test the models against independent LTE data. The models will then be used to derive a simplified model to estimate the short- and long-term effects of management on crop productivity and SOC storage. Scenarios of future management systems in Europe for improved productivity and enhanced SOC sequestration will be evaluated under current and future climate. The cost-effectiveness of alternative policy measures and options for managing SOC flows and stocks for improved productivity and SOC storage will be assessed based on the simplified model. SmartSOIL will develop a decision support tool (DST) to enable farmers, advisors and policy makers to discuss and select the most appropriate and cost-effective practices for particular farming systems, soils and climates. SmartSOIL will engage key stakeholders in case study regions and the wider EU in the development of the DST, guidelines and policy recommendations, and will inform the scientific and user community on progress and results.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.8.0 | Award Amount: 3.03M | Year: 2010

In the quest for the realization of quantum information processors, trapped ions occupy a prominent position. The challenge of realizing large-scale processors and quantum simulators based on ions will, however, require that one deals with more complex structures, which may include mesoscopic ordered ion ensembles, i.e., ion Coulomb crystals. In this regime, it is expected that the effect of noise will grow in importance and the control techniques, which have been so successfully applied to small numbers of ions, will be inefficient. This raises the timely issue of identifying novel and efficient strategies for controlling the quantum dynamics and manipulating the quantum state of ion Coulomb crystals.\n\nThe PICC proposal represents a joint theoretical and experimental effort whose aims are (i) to identify tools for controlling ion crystals as their size is scaled up, (ii) to develop strategies for implementing controlled quantum dynamics of mesoscopic ion Coulomb crystals in a noisy environment and (iii) to explore the capability of ion Coulomb crystals as quantum simulators. The long-term vision underlying this proposal is to engineer quantum correlations and entanglement in ion Coulomb crystals in order to exploit them for technological purposes of different kinds.\n\nIt is expected that this effort will pave the way for what could be the realization of the first specific-purpose, large scale quantum processors, complementing existing efforts with the alternative system of neutral atoms in optical lattices.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.1.5 | Award Amount: 10.47M | Year: 2013

The traditional computing paradigm is experiencing a fundamental shift: organizations no longer completely control their own data, but instead hand it to external untrusted parties - cloud service providers, for processing and storage. There currently exist no satisfactory approach to protect data during computation from cloud providers and from other users of the cloud.\n\nPRACTICE has assembled the key experts throughout Europe and will provide privacy and confidentiality for computations in the cloud. PRACTICE will create a secure cloud framework that allows the realization of advanced and practical cryptographic technologies providing sophisticated security and privacy guarantees for all parties in cloud-computing scenarios. With PRACTICE users no longer need to trust their cloud providers for data confidentiality and integrity: Due to its computation on encrypted data, even insiders can no longer disclose secrets or disrupt the service. This opens new markets, increases their market share, and may allow conquering foreign markets where reach has been limited due to confidentiality and privacy concerns. PRACTICE enables European customers to safe cost by globally outsourcing to the cheapest providers while still maintaining guaranteed security and legal compliance.\n\nPRACTICE will deliver a Secure Platform for Enterprise Applications and Services (SPEAR) providing application servers and automatic tools enabling privacy-sensitive applications on the cloud. SPEAR protects user data from cloud providers and other users, supporting cloud-aided secure computations by mutually distrusting parties and will support the entire software product lifecycle. One goal of SPEAR is to support users in selecting the right approach and mechanisms to address their specific security needs. Our flexible architecture and tools that allow seamless migration from execution on unchanged clouds today towards new platforms while gradually adding levels of protection.\n\nPRACTICE is strongly industry-driven and will demonstrate its results on two end-user defined use cases in statistics and collaborative supply chain management. PRACTICE is based on real-life use cases underpinning the business interest of the partners. Our focus is on near-term and large-scale commercial exploitation of cutting-edge technology where project results are quickly transferred into novel products. PRACTICE is the first project to mitigate insider threats and data leakage for computations in the cloud while maintaining economies of scale. This goes beyond current approaches that can only protect data at rest within storage clouds once insiders may misbehave. Moreover, it will investigate economical and legal frameworks, quantify the economic aspects and return on security investment for SMC deployment as well as evaluate its legal aspects regarding private data processing and outsourcing.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.1.4 | Award Amount: 4.73M | Year: 2008

Development of hardware devices and software products is facilitated by a design flow, and a set of tools (e.g., compilers and debuggers), which automate tasks normally performed by experienced, highly skilled developers. However, in both hardware and software examples the tools are generic since they seldom provide specific support for a particular domain. The goal of this project is to design, develop and deploy a toolbox that will support the specific domain of cryptographic software engineering. Ordinarily, development of cryptographic software is a huge challenge: security and trust is mission critical and modern applications processing sensitive data typically require the deployment of sophisticated cryptographic techniques. The proposed toolbox will allow non-experts to develop high-level cryptographic applications and business models by means of cryptography-aware high-level programming languages and compilers. The description of such applications in this way will allow automatic analysis and transformation of cryptographic software to detect security critical implementation failures, e.g., software and hardware based side-channel attacks, when realizing low level cryptographic primitives and protocols. Ultimately, the end result will be better quality, more robust software at much lower cost; this provides both a clear economic benefit to the European industry in the short term, and positions it better in dealing with any future roadblocks to ICT development in the longer term.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2010.2.1.1-2 | Award Amount: 9.06M | Year: 2010

VOLANTE aims to develop a new European land management paradigm, providing an integrated conceptual and operational platform which allows policy makers to develop pro-active and context-sensitive solutions to the challenges for the future, rather than to react on largely autonomous external land systems developments. Objective of VOLANTE is to provide European policy and land management with critical pathways defining the band width of possible land management policies for future European land use. Policy options will therefore be identified in time and space and their consequences in terms of states of the land system (provisioning of ecosystem goods and services) will be evaluated, leading to a ROADMAP FOR FUTURE LAND RESOURCES MANAGEMENT IN EUROPE. To realise this, VOLANTE is designed in three Modules to gain better understanding of the PROCESSES underpinning land use change in Europe, to exploit ASSESSMENT tools that are capable of identifying critical pathways for land management in a variety of environmental and management regimes across Europe, and to provide insight into the role of land management decisions on future sustainability: VISIONS. VOLANTE brings together researchers with experience and expertise on land use change at various spatial and temporal scales enabling a focus on vision development. Module Processes identifies land use change and the processes causing these, testing unproven hypotheses by extensively using the experience gained in earlier projects and studying crucial missing links. Problem orientation is the basis for the Module Assessment, which will narrow down the infinite spectrum of policy decisions possible. Module Visions establishes interaction with decision makers at regional and European level, to enhance an evidence based and problem oriented science-policy interface. A special, professional and consistent effort will be made to gather the views of a broad set of stakeholders and to include them in all steps of the process.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2007-2.2-01 | Award Amount: 6.37M | Year: 2008

The Life Watch e-Science and Technology Infrastructure for biodiversity data and observatories will be a large-scale European research infrastructure bringing together: -a system of marine, terrestrial and freshwater observatories; -common access to a huge amount of interlinked, distributed data from databases and monitoring sites; -computational facilities in virtual laboratories with analytical and modelling tools; -targeted user and training support and a programme for public services. The biodiversity research infrastructure will open up new and exciting research opportunities, and will help to enhance the understanding and sustainable management of our natural environment. This preparatory project brings together the interested EU Member and Associated States with the objective to prepare a cooperation agreement on the construction and maintenance of the Life Watch research infrastructure. In addition, the leading networks in biodiversity science and stakeholder institutes are preparing the organisation and logistics for the following construction phase. The current project delivers the technical, legal and financial preparations required for entering and managing the Construction Phase. A range of policy issues are resolved with respect the organisation of the distributed infrastructure, its legal implications, construction logistics, user service, cost analysis and planning. In addition the project makes the necessary preparations in the domain of risk management and quality control. The project is planned to take three years. A Policy and Science Board, populated by the representatives of fourteen potentially interested partner countries and eight cooperating scientific networks, oversees the progress of the preparations. The individual members of the Board act as the liaison with their political domains and the research communities, respectively.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.3-2 | Award Amount: 7.79M | Year: 2014

Immune system response is the most complex barrier to long-term success of tissue transplants/implants from allogeneic and bio-artificial sources. While newly developed tissue transplant procedures are not yet performed frequently enough for robust analysis of adverse immune responses in humans, corneal transplantation (CT) is a well-established allogeneic tissue transplant with >100,000 full- and partial-thickness procedures performed annually. Adverse immune responses occur in up to 30% of CT recipients causing rejection and failure. The high levels of CT clinical activity and immune complications create an ideal opportunity to comprehensively profile immune responses associated with adverse tissue transplant outcomes and to develop new approaches for their prevention or early diagnosis. VISICORT is a multi-disciplinary project with expertise in basic immunology, bio-sampling, systems biology/immune profiling, bioinformatics, clinical tissue transplantation and cell therapy. It will complete the first systematic immune profiling of biological samples from animal and human CT recipients with diverse outcomes. Clinical data and bio-specimens from over 700 CT recipients at 5 leading transplant centres will be centrally collated and distributed to cutting-edge university- and SME-based laboratories for multi-platform profiling and integrated bioinformatics analyses. Profiling data will generate better understanding of adverse immune reactions to tissue transplants. This knowledge will be used to develop novel biomarker-based surveillance strategies and, coupled with SME-based expertise in cell product development, will also inform the design and initiation of an optimised clinical trial strategy of immunomodulatory stromal stem cell therapy in high-risk human CT recipients. VISICORT research will strongly impact multiple EU research/scientific communities, patient cohorts and SMEs and will have high commercialisation value for the biopharmaceutical and biotechnology industries.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: WATER-1b-2015 | Award Amount: 8.43M | Year: 2016

Taking into account the current global water scarcity and the expensive operation and maintenance cost of wastewater treatment, INCOVER concept has been designed to move wastewater treatment from being primarily a sanitation technology towards a bio-product recovery industry and a recycled water supplier. A wastewater specific Decision Support System methodology will be tailored to the INCOVER technologies and provide data and selection criteria for a holistic wastewater management approach. Three added-value plants treating wastewater from three case-studies (municipalities, farms and food and beverage industries) will be implemented, assessed and optimised concurrently. INCOVER plants will be implemented at demonstration scale in order to achieve Technology Readiness Level(TRL) of 7-8 to ensure straightforward up scaling to 100,000 population equivalents (PE). INCOVER added-value plants will generate benefits from wastewater offering three recovery solutions: 1) Chemical recovery (bio-plastic and organic acids) via algae/bacteria and yeast biotechnology; 2) Near-zero-energy plant providing upgraded bio-methane via pre-treatment and anaerobic co-digestion systems; 3) Bio-production and reclaimed water via adsorption, biotechnology based on wetlands systems and hydrothermal carbonisation. To improve added-value production efficiency, INCOVER solutions will include monitoring and control via optical sensing and soft-sensors. INCOVER solutions will reduce at least a 50% overall operation and maintenance cost of wastewater treatment through the use of wastewater as a source for energy demand and added-value production to follow UE circular economy strategy. In addition, strategies to facilitate the market uptake of INCOVER innovations will be carried out in order to close the gap between demonstration and end-users. An estimated turnover of 188 million for INCOVER lead-users is expected after the initial exploitation strategy of 5 years implementing 27 INCOVER solutions.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETOPEN-1-2014 | Award Amount: 4.00M | Year: 2015

Diagnostic tests are essential to provide a targeted treatment of infectious diseases and to contain the further spread of multidrug resistant pathogens. Current methods are based either on cultivation or on PCR and have significant limitations concerning the clinical requirements to characterise pathogens including their resistance mechanisms within 3 hours. In MARA, we will develop and combine three radically novel technologies that will lead to substantial breakthroughs in science, medicine and industry and, as proof-of principle, use them to create a DNA-based molecular toolkit characterising pathogens. First, the detection of pathogen-associated antigens will be performed by Autonomous Detection Nucleic Acids (AUDENA) that are independent of any laboratory instruments and sophisticated processing. The realisation of the AUDENA concept will lead to an autonomous, stable, simple and very economic novel sensor class applicable for any water-soluble substances. The second revolutionary technology in MARA employs a novel approach in protein mimicry and creation of artificial enzymes, which represents a breakthrough in several disciplines, such as biotechnology, biomedical manufacturing and the energy sector. The third breakthrough in this project represents the development of a Molecular Robot (MORO) that can specifically identify target cells and destroy them. In MARA, the MORO will be used for the lysis of bacterial cells to release intracellular antibiotic resistance associated antigens, but the long-term vision anticipates an application as antibiotic replacement for infectious diseases and a therapeutic agent for cancer treatment, which would represent one of the most important breakthroughs in medicine in the recent years. To meet the highly ambitious objectives pointed out in this proposal, MARA is driven by a complementary, multidisciplinary team of leading experts, with a young, high-profile scientist in the lead.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: ISSI-5-2015 | Award Amount: 3.50M | Year: 2016

STAR BIOS 2 (Structural Transformation to Attain Responsible BIOSciences),coordinated by the University of Tor Vergata (IT), has been designed to respond to the Topic ISSI 5 (Workprogramme Science With And For Society). The general aim of project is that of contributing to the advancement of the Responsible Research and Innovation (RRI) strategy, which underpins Horizon 2020, by promoting 6 Action Plans (APs) oriented to attain a RRI structural change in research institutions from Europe and developing 3 further APs in non-european entities, all active in the field of biosciences. This strategy is geared to cope more in general with one of the main risk, for European research, i.e., its inadequate connection with society, by promoting its increasing alignment, in terms of both process and outcomes, with the needs and values of European society. This entails, in the RRI perspective, an increasing involvement of stakeholders at any level of the research and innovation process. The project has three main focuses: 1) Develop RRI-oriented structural change processes in the already mentioned institutions involved in biosciences research. This aim will be pursued through designing, implementing and evaluating RRI Action Plans. In order to secure the results emerging from the APs, a sustainability strategy will be developed and implemented during the project lifespan. APs will be supported by a central technical assistance and the project will be monitored and assessed. 2) Develop a learning process concerning: a) resistances and barriers to RRI (which are they, how they manifest themselves, which impact they have, etc.); b) key factors favouring or supporting RRI; c) strategic options and RRI-oriented tools. 3) Develop a sustainable model for RRI in biosciences.

observatoryNANO brings together leading EU organizations who collectively have expertise in the technological; economic; societal/ethical; health, safety, and environmental analysis of nanotechnologies. Its primary aim is to develop appropriate methodologies to link scientific and technological development of nanotechnologies with socio-economic impacts. Both of these aspects will be enhanced by expert opinion, making this project unique in providing relevant web-based reports in a common format across all sectors, considered by all criteria, and widely publicized. observatoryNANO will become an industry leading and opinion forming catalyst for nanotechnology in the EU. The purpose is to avoid the exaggerated socio-economic impact of nanotechnologies and place developments in a realistic time-frame. It will present a reliable, complete, and responsible science-based and economic expert analysis of peer-reviewed literature, patents, national funding strategies, investment trends, and markets; in combination with information derived from questionnaires, interviews and workshops with academic and industry leaders, investors, and other key stakeholders. It will place these developments in the context of potential ethical and societal issues, and risks to human health and the environment, through its own analysis and through engagement with other actors, to ensure that its recommendations are balanced and contribute to the safe and responsible development of nanotechnologies. It will collaborate with all appropriate organizations including the EPO, OECD, industry associations, ETPs, and other EU-funded projects. Through these activities observatoryNANO will form a balanced governing board of key EU stakeholders. It will react to advice and input from these stakeholders, and advise on potential opportunities, barriers, and risks. This will allow decision-makers to take appropriate action to ensure that nanotechnology developments are realized as socio-economic benefits.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-1 | Award Amount: 1.37M | Year: 2010

The consortium behind AGROBIOFILM project a group of European SME suppliers and users of agricultural plastics wishes to address a major market opportunity through the development and performance demonstration of mulch films that would be able to fulfill the three main following requirements: to be more environmentally friendly (i.e; biodegradable in soil without containing a high content in fossil carbon); to be compliant with common farming methods; and to match or improve crops performance as expected in the case of conventional plastic films and other biodegradable mulch films available in the market. Specifically, the consortium wants to enhance mulch films based on biodegradable raw materials, which will be customized to specific crops and regions, with a possible positive effect on crop yield and quality, pests and/or disease control, soil preparation and fertilization. The goal of this project is to use a very recent Mater-Bi formulation characterized by a higher content in renewable feedstocks as compared to the other biodegradable mulch films currently used, the Novamonts Mater-Bi CF04P grade (which is not widely widespread), in order to produce, through a be-spoke optimization of processing conditions, customized and enhanced biodegradable mulch films (BMF) that should be more competitive and more sustainable, at both the technical and the economic point-of-view. These new mulches will be tested on four selected crops (muskmelon, bell-pepper, grapevine, strawberry open field and strawberry in greenhouse) known to require different specific expectations in terms of mulching lifetime. A full life cycle analysis is therefore fundamental in order to measure the economic viability of this new product AGROBIOFILM will significantly promote the uptake of highly productive and environmentally friendly farming practices among end-users, who are currently facing a number of competitive challenges threatening the economic stability of the sector. The project will also increase the competitiveness of the participating SME manufacturers by providing them with a state-of-the-art platform to develop competitive biodegradable mulch films, and therefore widening the applicability of their biodegradable products to new markets. Agrobiofilm project runs from 01 April 2010 to 28 March 2013, but the effective duration of the project is 30 months.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH-2007-3.2-01 | Award Amount: 1.85M | Year: 2008

This project will investigate post-compulsory educational pathways among young people who spent at least one of their childhood years in the care of public authorities or child protection agencies. Young men and women from a public care background are among the most economically and socially excluded groups in European nations yet the pathways by which they might overcome their childhood disadvantages through further and higher education are virtually unknown. The high level of social exclusion among young people from a public care background, coupled with some evidence of their heterogeneity and resourcefulness, makes this discreet group a valuable case for investigating the educational prospects for, achievements of, and barriers facing all socially excluded young people. The overall aim of the proposed project is to contribute to the knowledge and policy development and changes in practice that may lead to the retention of many more young men and women from a public care background in education after the end of compulsory schooling and to open up the prospect of further and higher education to them. Specific objectives are to: i) map current knowledge about educational participation among young people from a public care background; ii) track and evaluate the educational plans and pathways of a sample of 19-21 year-olds from a public care background; iii) identify the conditions within the care and education systems that facilitate or inhibit entry to and continuation in post-compulsory education; and iv) explore young peoples constructions of educational identities and trajectories in terms of class, gender, race, ethnicity and care responsibilities both from the perspective of young men and women themselves and of carers and staff in services designed to support them. Using a highly experienced five EU country research team, and a combination of quantitative and qualitative methods, the project will provide a national overview and in-depth analysis.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2012.6.6-1 | Award Amount: 2.37M | Year: 2012

At a time with an urgent need to conserve water resources, efficient sanitation systems play a key role in sustainability. They can ensure that the vital resource Water is recovered from waste and can be re-used at the same time as protecting human health and the environment. The SWINGS project consortium will establish an optimal methodology for nutrient and energy recovery from wastewater (WW) at the same time as making the water safe for reuse, all in a manner conducible to rural communities in developing countries, with India as the concrete example. In particular, the SWINGS project will enlist already optimized municipal WW treatment concepts and combine green and sustainable technologies. The result will be enhances water recycling and re-use, decreased energy consumption, and production of useful by-products from the process as secondary resources. Thus, treated WW will be transformed to soil enrichment resource, to irrigation water, to aquaculture farm feed, via sustainable sanitation that safeguards the local drinking water supply in India. The starting point of the SWINGS project will be anaerobic digestion (AD) and constructed wetlands (CW) that will be configured with environmentally sustainable disinfection technologies, like water solar disinfection. Pilot plants will be designed and constructed in India that combine the treatment methods mentioned above, after which the new systems will be established in steady-state operation, and then, the AD-CW configurations optimized. Systems for disinfection of the effluent will be implemented and on-line monitoring of pathogen load attempted. Finally, life cycle assessment of several treatment configurations will be used to develop a decision support system for future selection of sustainable and efficient treatment technologies in developing countries like India. The project will publish articles and hold workshops in order to disseminate its results, especially to SMEs and to public authorities.

Larsen K.G.,University of Aarhus | Pagh R.,IT University of Copenhagen
Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms | Year: 2012

Motivated by information retrieval applications, we consider the one-dimensional colored range reporting problem in rank space. The goal is to build a static data structure for sets C 1, . . . , C m ⊆ {1, . . . , σ} that supports queries of the kind: Given indices a, b, report the set ∪ a≤i≤b C i. We study the problem in the I/O model, and show that there exists an optimal linear-space data structure that answers queries in O(1 + k/B) I/Os, where k denotes the output size and B the disk block size in words. In fact, we obtain the same bound for the harder problem of three-sided orthogonal range reporting. In this problem, we are to preprocess a set of n two-dimensional points in rank space, such that all points inside a query rectangle of the form [x 1, x 2] x (-∞, y] can be reported. The best previous bounds for this problem is either o(n lg B 2 n) space and O(1 + k/B) query I/Os, or O(n space and O(lg B (h) n + k/B) query I/Os, where lg B (h) n is the base B logarithm iterated h times, for any constant integer h. The previous bounds are both achieved under the indivisibility assumption, while our solution exploits the full capabilities of the underlying machine. Breaking the indivisibility assumption thus provides us with cleaner and optimal bounds. Our results also imply an optimal solution to the following colored prefix reporting problem. Given a set S of strings, each O(1) disk blocks in length, and a function c : S → 2 {1,...,σ}, support queries of the kind: Given a string p, report the set ∪ x∈S∩p* c(x), where p*denotes the set of strings with prefix p. Finally, we consider the possibility of top-k extensions of this result, and present a simple solution in a model that allows non-blocked I/O. Copyright © SIAM.

Food security, environmental sustainability and food safety are pressing global challenges. Smart Farming, which intelligently combines sensor-based data services and ICT applications, can contribute significantly to meeting these challenges. However, developments in smart farming are hampered by roadblocks such as lack of data sharing beyond national/regional borders, interoperability issues and lack of infrastructure investment. The FI-PPP phase 1 project programme SmartAgriFood1 developed a conceptual, cloud-based architecture for Smart Farming based on FI-Ware Generic Enablers. The Phase 2 project FIspace delivered a fully-functional FI platform for business collaboration with a small number of Apps showcasing how this will work. The aim of SmartAgriFood2 is to further leverage the ecosystem that was established in these projects to support SMEs and web-entrepreneurs in developing a large number of smart farming FI services and applications with high end user takeup. This will be achieved through an open call (4M) for application development, in particular for the arable, livestock and horticulture farming subsectors. The call will be jointly coordinated with ICT-AGRI ERA-NET through which additional European regional funds will be leveraged (>1.5M). SMEs and web entrepreneurs will be assisted in the commercialisation and development of European wide end-user markets for their new applications. The focus of the project will be on the implementation of a milestone and mentoring programme involving guidance of SMEs by FI-PPP, agri-ICT and exploitation experts. This programme consists of three progressive stages, where only the most successfully evaluated SMEs will proceed and secure funding for subsequent stages. Optimal impact will be achieved by utilising partners expertise in open call management, their excellent networks in the agri-food sector and particularly the EBN network reaching >65.000 innovative start-ups and >250.000 SMEs across Europe.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE-2007-1-2-14 | Award Amount: 3.90M | Year: 2008

Although exploited fishes have traditionally been managed on a geographic basis, for conservation purposes they should be managed at the population level: the extent and dynamics of population structuring underlies resilience and sustainability. More effective enforcement and conservation demands a focus on identification and monitoring of wild fish populations and traceability of products. FishPopTrace brings together expertise in fish traceability projects (Fish and Chips, FishTrace, FISH-BOL) to: 1.Integrate data from European fish species traceability projects, and to generate a single compatible database and tissue archive managed by the Joint Research Centre of the European Commission. 2. Examine single nucleotide polymorphisms (SNPs) and otolith microchemistry and morphometrics in widely distributed populations of cod, hake, herring and sole. Outputs will comprise population-level signatures associated with fish origins in early life and representative spawning groups. 3. Undertake validation of traceability tools in relation to end-user technology. 4. Develop a population monitoring system based on genetic and otolith data that will assess population stability in a temporal and spatial framework. 5. Test the utility of additional novel traceability systems (fatty acid profiles, proteomics, gene expression, microarray platform for SNP genotyping). 6. Facilitate technology transfer in relation to enforcement and conservation policies of the EU Common Fisheries Policy (CFP) and associated socio-economic consequences. Outputs from FishPopTrace will improve the traceability of fish and fish products and protection of consumer interests through enhanced understanding of the dynamics, temporal stability and distribution of major populations of four key exploited fish species. Central elements of the output will be the development and evaluation of end-user tools, a Cost Benefit Analysis and a final report setting FishPopTrace in the context of the CFP.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-09-2016 | Award Amount: 6.75M | Year: 2017

The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4\ T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planned novel strategy is to successfully combine immune-based therapies, including therapeutic vaccines and broadly neutralizing antibodies with latency reversing agents, in a proof-of-concept phase IIa clinical trial. HIVACAR project will lead to a reduction of the actual costs related to HIV treatment and management and of the social public health as well as an improvement in the patients quality of life. HIVACAR project has been conceived under the framework of responsible research and innovation, so patients and other stakeholders will have a key role from the inception of the project until obtaining the results. Patients will be perfectly aware of how this therapy has been conceived and the real impact and change in their actual quality of life, as well as how the clinical trial has been designed and the consequences of participating in it. In addition, patients (and the general population) will tailor the project and its results dissemination and communication. This patient engagement will not be limited to the clinical trial but also to the rest of the activities of the project, so patients and the general society will be aware of how the research is developed and can include the patients point of view in the research activities. In addition, the socio-economic and psycho-social impact of the new treatment will be also analysed so overwhelming data on the benefits and impact of the new treatment will be obtained and shown to all the stakeholders.

News Article | December 15, 2016

Genomic analysis of the Iberian lynx confirms that it is one of the species with the least genetic diversity among individuals, which means that it has little margin for adaptation Spanish scientists have sequenced the genome of the Iberian lynx (Lynx pardinus), currently one of the world's most endangered felines. They have confirmed the "extreme erosion" suffered by its DNA. The Iberian lynx has one of the least genetically-diverse genomes. It is even less diverse than other endangered mammals, such as the cheetah or Tasmanian devil, or birds, like the crested ibis or osprey. The study, being published today in the scientific journal Genome Biology, has been coordinated by scientists from the Doñana Biological Station (CSIC). The Centre for Genomic Regulation (CRG) contributed to this research project from the very beginning including several groups and facilities. In particular, the laboratories of Roderic Guigó, Cedric Notredame, and Toni Gabaldón at the Bioinformatics and Genomics Programme as well as the CRG Bioinformatics unit. This is the first mammal genome of reference generated entirely in Spain. The project, financed by Banco Santander and managed by the Fundación General CSIC, has integrated the efforts of 50 scientists from research groups of 12 institutions, two of them from outside Spain, that cover a broad range of disciplines, including bioinformatics, genomics, oncology, evolution and conservation. The scientists have managed to read and organize 2.4 billion letters of DNA from Candiles, a male lynx born in the Sierra Morena lynx population, who now forms part of a program for breeding in captivity. To do so, they have used new sequencing techniques and developed innovative procedures to generate a high-quality draft genome on a limited budget. A total of 21,257 genes were identified, a number similar to that of human beings and other mammals, and they have been compared to those of cats, tigers, cheetahs and dogs. Specifically, Toni Gabaldón's group at the Centre for Genomic Regulation in Barcelona has compared the Iberian lynx genome with those of other species, attempting to identify genes that have lost their function because they have remained isolated and the existence of a small population of specimens of this species. Researchers have found evidence of modifications in genes related with the senses of hearing, sight and smell to facilitate the adaptation of the lynx to its en