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Poznań, Poland

Renata M.,Poznan University of Medical Sciences | Ewa I.,Poznan University of Medical Sciences | Ewa I.,University Medyczny znaniu
Polski Merkuriusz Lekarski | Year: 2010

Trans-resveratrol (3,5,4'-trihydroxy-trans-stilbene), a natural polyphenol, displays diversified bioactivities that are crucial in chemoprevention of cancer and cardiovascular diseases. Equally promising action is exerted by resveratrol analogues, mainly pterostilbene (3,5dimethoxy-4'-hydroxy-trans- stilbene) and piceatannol (3,5,3',4'-tetrahydroxy-trans-stilbene). Although fruits and their products are the main natural source of resveratrol and their analogues, recently these polyphenols have been commercially available in numerous pharmaceutical preparations and diet supplements. The aim of this review is to present the status of clinical studies on chemopreventive/ chemotherapeutic effect of resveratrol and its analogues. Source

Czarnecka-Operacz M.,University Medyczny znaniu
Przeglad Dermatologiczny | Year: 2011

Urticaria is a frequent dermatose of complex and diverse etiology. Generally it is easy to diagnose but identification of elicitating factors still presents a great challenge for physicians. Each patient requires an individually tailored panel of diagnostic procedures including basic ones as well as specific provocations, which need to be selected according to the clinical characteristic of the case. Provocation tests require hospitalization because serious systemic side effects may be induced during the diagnostic procedure and anaestesiologic intervention may be necessary. Acute type of urticaria is usually allergic in origin and diagnostic approach is not as complex as in the case of chronic type of the disease. Recently published guideline on definition, classification and diagnosis of urticaria is a very useful document containing selection of rules and advices which should be implemented in the daily practice of dermatologists, allergologists, paediatritians as well as general practitioners. Source

Oestrogen deficiency after the cessation of the ovarian function in women causes many subjective ailments as well as serious health problems. In Poland, similarly to other developed countries, cardiovascular diseases are the main cause of death in women after 50 years of age. Menopause not only induces an increase of blood pressure, but is also an independent risk factor of cardiovascular complications, especially strokes when hypertension coexists. The analysis of patients after 64 years of age revealed the prevalence of hypertension in 81% of women and 66% of men. Hypertension is one of the most important risk factors of coronary artery disease; in hypertensive women, the risk of development of different cardiovascular complications is 4 times higher than in coeval men. Menopause provokes also increased development of atherosclerosis. Cardiovascular risk factors become more often assessed as the elements of the metabolic syndrome. Some of previous clinical trials undermined the positive influence of the treatment of mild hypertension in women because of a lower relative risk in this group. The INDANA analysis showed a great absolute benefit of treatment of hypertension in older women as well as in black people in comparison to men. The decision concerning therapy in younger women, especially in Caucasians, has to be made individually depending on the level of the cardiovascular risk. Diuretics are preferably used in treatment of hypertensive women because of their additional advantage; they have a positive impact on calcium balance that is impaired during menopause. On the other hand, usage of renin-angiotensin-aldosterone system blockers results from the patomechanism of hypertension at the menopausal age and their advantages are revealed in clinical trials. Source

The process of atherogenesis can be conditioned by the imbalance between the tendency to oxidative modification of the lipoproteins containing apoprotein B100 and antioxidant plasma properties. The paper discusses the situations leading to disruption of oxidative homeostasis on the basis of available data. Copyright © Polskie Towarzystwo Kardiologiczne. Source

Schizotypy, perceived as a personality trait, has both positive and negative aspects. Schizotypal disorder, as a diagnostic category, has been included in schizophrenia spectrum disorders in the American Diagnostic and Statistical Manual (DSM-5) as well as in the International Classification of Diseases (ICD-10). A number of genetic, biological, and neuropsychological similarities between persons with schizotypy and patients with schizophrenia have been shown. Schizotypal features occur in greater frequency in bipolar disorder (BD) compared with healthy subjects. A popular tool for measuring schizotypy is the Schizotypal Personality Questionnaire created by Raine in 1991 as well as scales created by Chapman and by Venables. This article presents the origins of the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) created by Claridge and co-workers and describes its stucture, consisting of four dimensions: unusual experiences, cognitive disorganisation, introvertive anhedonia and impulsive nonconformity. Studies using O-LIFE demonstrated both internal consistency and reliability of the scale. Connections between the O-LIFE dimensions and cognitive processes in patients with schizophrenia and creativity in bipolar patients have been demonstrated. In patients with BD treated with lithium carbonate, a significant negative correlation between the quality of response to long-term treatment and schizotypal traits (particularly cognitive disorganisation) was found. In genetic studies, associations between O-LIFE dimensions and polymorphisms of dopaminergic system and circadian rhythm genes were observed. The O-LIFE is an important tool for measuring schizotypy. Studies using this scale may expand the knowledge on neuropsychological and neurobiological mechanisms in psychiatric disorders and in healthy subjects. Source

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