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Di Renzo L.,University of Rome Tor Vergata | Gratteri S.,University Magna Graecia | Sarlo F.,University of Naples Federico II | Cabibbo A.,University of Rome Tor Vergata | And 3 more authors.
Disease Markers | Year: 2014

Background and Aim. p53 activity plays a role in muscle homeostasis and skeletal muscle differentiation; all pathways that lead to sarcopenia are related to p53 activities. We investigate the allelic frequency of the TP53 codon 72 in exon 4 polymorphism in the Italian female population and the association with appendicular skeletal muscle mass index in normal weight (NW), normal weight obese (NWO), and preobese-obese (Preob-Ob) subjects.Methods. We evaluated anthropometry, body composition, and p53 polymorphism in 140 women distinguished in NW, NWO, and Preob-Ob.Results. Arg/ Arggenotype increases sarcopenia risk up to 20% (Arg/ Arggenotype OR = 1.20; 95% CI = 0.48-2.9; proallelecarriers OR = 0.83; 95% CI = 0.83-2.06). The risk of being sarcopenic for Arg/ Arggenotype in NWO and Preob-Ob is 31% higher than NW carriers of proallele(RR = 0,31, 95% CI = 0,15-0,66, P = 0,0079). We developed a model able to predict sarcopenia risk based on age, body fat, and p53 polymorphism.Conclusion. Our study evidences that genotyping TP53 polymorphism could be a useful new genetic approach, in association with body composition evaluations, to assess sarcopenia risk. © 2014 Laura Di Renzo et al.

Weier K.,McGill University | Weier K.,University of Basel | Banwell B.,University of Pennsylvania | Cerasa A.,National Research Council Italy | And 7 more authors.
Cerebellum | Year: 2015

In multiple sclerosis (MS), cerebellar signs and symptoms as well as cognitive dysfunction are frequent and contribute to clinical disability with only poor response to symptomatic treatment. The current consensus paper highlights the broad range of clinical signs and symptoms of MS patients, which relate to cerebellar dysfunction. There is considerable evidence of cerebellar involvement in MS based on clinical, histopathological as well as structural and functional magnetic resonance imaging (MRI) studies. The review of the recent literature, however, also demonstrates a high variability of results. These discrepancies are, at least partially, caused by the use of different techniques and substantial heterogeneity among the patient cohorts in terms of disease duration, number of patients, and progressive vs. relapsing disease courses. Moreover, the majority of studies were cross-sectional, providing little insight into the dynamics of cerebellar involvement in MS. Some links between the histopathological changes, the structural and functional abnormalities as captured by MRI, cerebellar dysfunction, and the clinical consequences are starting to emerge and warrant further study. A consensus is formed that this line of research will benefit from advances in neuroimaging techniques that allow to trace cerebellar involvement at higher resolution. Using a prospective study design, multimodal high-resolution cerebellar imaging is highly promising, particularly in patients who present with radiologically or clinically isolated syndromes or newly diagnosed MS. © 2015, Springer Science+Business Media New York.

Nigro S.,University Magna Graecia | Pagnotta L.,University of Calabria | Pantano M.F.,University of Calabria
Microfluidics and Nanofluidics | Year: 2012

The literature includes a variety of analytical and semi-analytical models to describe squeeze-film damping in MEMS perforated structures. Even if many of them have been validated by means of numerical simulations, nobody seems to have discussed about the accuracy of numerical approaches in this field. In the present paper, we apply both the main analytical models and a commercial finite element software, COMSOL Multiphysics, to solve a good number of squeeze-film problems. They refer to some cases, which were experimentally investigated during the past by different authors. The tested structures are rigid rectangular plates fabricated with different material, different perforation ratio (i.e., the ratio of the hole side to the holes pitch) and different number of perforations. We compare both the analytical and the numerical results with the available experimental data, in order to have an overview about their effectiveness. Numerical simulations offer in all the considered cases valuable agreement with experiments. © Springer-Verlag 2012.

Belcastro V.,University of Perugia | Maria Cupini L.,S. Eugenio Hospital | Corbelli I.,University of Perugia | Pieroni A.,University of Perugia | And 6 more authors.
Cephalalgia | Year: 2011

Objectives: This study was aimed at investigating the frequency of the visual phenomenon of palinopsia (visual perseveration) in patients with migraine.Methods: We interviewed 63 patients with migraine with aura (MwA), 137 patients with migraine without aura (MwoA) and 226 sex-age-matched healthy control subjects using an ad hoc structured interview/questionnaire. The interview was divided into four classes of variables for statistical testing.Results: Palinopsia occurred in 19/200 patients (9.5%); of them 10/63 had MwA and 9/137 MwoA (14.2% vs 6.6%, chi = 9.7, degrees of freedom = 1, p = 0.002). Patients with palinopsia had a significantly lower migraine attack frequency than those without this visual phenomenon (4.3 ± 0.3 vs 14.4 ± 0.2, z = 7.1, p < 0.0001). No healthy control subjects complained of palinopsia according to the structured interview/questionnaire.Discussion: Palinopsia is probably under-diagnosed in patients with migraine. Further investigations are needed to assess whether migraineurs are particularly susceptible to the development of recurrent episodes of visual perseveration. © International Headache Society 2011 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Donzuso G.,National Research Council Italy | Donzuso G.,University of Catania | Cerasa A.,National Research Council Italy | Gioia M.C.,National Research Council Italy | And 3 more authors.
Brain and Behavior | Year: 2014

Objectives: The State-Trait Anxiety Inventory (STAI) and the Hamilton scale for anxiety (HARS) are two of the most important scales employed in clinical and psychological realms for the evaluation of anxiety. Although the reliability and sensibility of these scales are widely demonstrated there is an open debate on what exactly their scores reflect. Neuroimaging provides the potential to validate the quality and reliability of clinical scales through the identification of specific biomarkers. For this reason, we evaluated the neural correlates of these two scales in a large cohort of healthy individuals using structural neuroimaging methods. Case report: Neuroimaging analysis included thickness/volume estimation of cortical and subcortical limbic structures, which were regressed on anxiety inventory scores with age and gender used for assessing discriminant validity. A total of 121 healthy subjects were evaluated. Despite the two anxiety scales, at a behavioral level, displaying significant correlations among them (HARS with STAI-state (r = 0.24; P = 0.006) and HARS with STAI-trait (r = 0.42; P < 0.001)), multivariate neuroimaging analyses demonstrated that anatomical variability in the anterior cingulate cortex was the best predictor of the HARS scores (all β's ≥ 0.31 and P's ≤ 0.01), whereas STAI-related measures did not show any significant relationship with regions of limbic circuits, but their scores were predicted by gender (all β's ≥ 0.23 and P's ≤ 0.02). Conclusion: Although the purpose of HARS and STAI is to quantify the degree and characteristics of anxiety-like behaviors, our neuroimaging data indicated that these scales are neurobiologically different, confirming that their scores might reflect different aspects of anxiety: the HARS is more related to subclinical expression of anxiety disorders, whereas the STAI captures sub-dimensions of personality linked to anxiety. © 2014 The Authors.

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