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Patent
University Los Andes, Hospital Universitario San Ignacio and Hospices Civils De Lyon | Date: 2016-11-14

A computer-based method is herein disclosed, allowing to differentiate automatically between two tissues of interest: an extrinsic and an intrinsic tissue, from a plurality of images, obtaining a quantitative assessment of each of said tissues without requiring the intervention of an expert. Said method involves the definition of a differentiation region in images obtained from a medical imaging acquisition device using a parametric contour, after which differentiation and quantification are carried out based on the photometric characteristics of the different tissues observed in images, evaluating the local neighborhood of each voxel belonging to the differentiation region previously defined in the plurality of images. The disclosed method increases to a great extent precision in differentiation and quantification of tissues, while the shown percentage error is considered tolerable for diagnostic purposes.


Patent
University of Nantes, French National Center for Scientific Research and University Los Andes | Date: 2017-01-11

The invention relates to a system for assessing chloride concentration at one predetermined area of a porous or composite material, such as a reinforced concrete structure, comprising a sensor (1) embedded in the predetermined area of the material, an analyser (2) connected to the sensor, and a processing module (4) connected to the analyser. The sensor (1) comprises two facing or coplanar electrodes (11), called electrodes, an intermediate layer (13) arranged between said electrodes, said intermediate layer being in contact with the material of the first area of the structure and comprising calcium aluminates. The analyser (2) is configured to apply an alternate current between the electrodes and output an impedance value or capacitance value of the intermediate layer. The processing module (4) is configured to compute a chloride concentration assessment in the predetermined area of the material based on the impedance value or capacitance value outputted by the analyser.


Patent
University Los Andes, Hospital Universitario San Ignacio, Hospices Civils De Lyon, Mendoza Leon, Uriza Carrasco, Douek and Hernandez | Date: 2017-03-22

A computer-based method is herein disclosed, allowing to differentiate automatically between two tissues of interest: an extrinsic and an intrinsic tissue, from a plurality of images, obtaining a quantitative assessment of each of said tissues without requiring the intervention of an expert. Said method involves the definition of a differentiation region in images obtained from a medical imaging acquisition device using a parametric contour, after which differentiation and quantification are carried out based on the photometric characteristics of the different tissues observed in images, evaluating the local neighborhood of each voxel belonging to the differentiation region previously defined in the plurality of images. The disclosed method increases to a great extent precision in differentiation and quantification of tissues, while the shown percentage error is considered tolerable for diagnostic purposes.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA | Phase: INFRA-2007-1.2.3;INFRA-2007-1.2-03 | Award Amount: 5.11M | Year: 2008

EELA-2 aims to build, on the current EELA e-Infrastructure, a high capacity, production-quality, scalable Grid Facility providing round-the-clock, worldwide access to distributed computing, storage and network resources for a wide spectrum of applications from European and Latin American scientific communities. The project will provide an empowered Grid Facility with versatile services fulfilling application requirements and ensure the long-term sustainability of the e-Infrastructure beyond the term of the project. The specific EELA-2 objectives are: - Build a Grid Facility by: Expanding the current EELA e-Infrastructure to consist of more production sites mobilising more computing nodes and more storage space, at start of the project and to further grow storage over the duration of the project; Providing, in collaboration with related projects (e.g. EGEE), the full set of Grid Services needed by all types of scientific applications; Supporting applications various types (from classical off-line data processing up to control and data acquisition of scientific instruments), selected against well defined criteria (including grid added value, suitability for Grid deployment, outreach/potential impact); - Ensure the Grid Facility sustainability: Through the already established and new contacts with policy/decision makers, collaborating with RedCLARA and NRENs and supporting the ongoing creation of e-Science Initiatives and/or National Grid initiatives (NGI). Building the support of the e-Infrastructure to provide a complete set of Global Services from a Central Operation Centre and to pave the way for the creation of Regional Operation Centres in Latin America: Attracting new applications; Making available knowledge of EELA-2 Grid Facility to all potential users, developers, and decision makers through an extensive Training and Dissemination program; Creating knowledge repositories federated with the EGEE ones.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-SICA | Phase: HEALTH-2007-2.3.4-1 | Award Amount: 3.75M | Year: 2009

The focus of this multidisciplinary proposal is to elucidate the epidemiology of the genetic lineages of T. cruzi, for improved understanding and prevention of Chagas disease. The project will unite skills in genotyping, genomics, genetics and pathogenesis in Europe with considerable compatible skills in South America, and with key research in endemic areas that have distinct characteristics. The proposal is intended to be high impact in terms of both research progress and fostering of collaborative networks. Aim: Elucidate the epidemiology of the genetic lineages of T. cruzi, for improved understanding and prevention of Chagas disease. Technology development: 1. Develop further and apply MLST; PCR-RFLP and MLMT to the analysis of genetic populations of T. cruzi, 2. Sequence the unresolved genome of T. cruzi I, 3. Develop lineage specific diagnosis, 4. Develop an oligochromatography PCR-dipstick procedure for detection of T. cruzi. Molecular epidemiology: 5. Pilot studies of association between genetic lineage, clinical outcome, and prevalence of congenital infection, 6. Map the silvatic vector, silvatic mammal, human and ecological associations of the T. cruzi genotypes IId,e,b,a. 7. Compare lineage specific pathogenesis and transmissibility of congenital infection in a mouse model, and compare lineage susceptibility to drugs in vitro. Population genetics and phylogenetics: 8. Re-evaluate the population genetics and evolution of T. cruzi lineages. International cryobank and database: 9. Establish in South America an accessible, expanded, international cryobank for T. cruzi, 10. Establish a website and database for outputs of the project. The project encompasses the desirable characteristics prescribed by the call, in that they include: genomics/proteomics; effective, innovative relevance to disease, pathogenesis, drugs, interventions; an integrated multidisciplinarity, and capacity building, networking and training in endemic regions.


Dean T.J.,Louisiana State University | Jerez M.,University Los Andes | Cao Q.V.,Louisiana State University
Forest Science | Year: 2013

A new approach to simulating net forest growth is presented. The model is based on density effects on mean crown dimensions and the stem geometry required to counteract the bending moment generated from wind action on the crown. Stem geometry is based on the constant-stress principle of stem formation. Various structural and growth properties of hypothetical loblolly pine stands growing on a range of site indexes and with a range of initial tree densities are calculated with the model and compared with published values and well-known patterns. Size-density relations calculated with the model are consistent with converging, curvilinear lines reported for slash pine and loblolly pine plotted on log-transformed axes. Linear relationships between mean crown length and mean spacing agree with observations from various coniferous species, and culmination of current annual increment corresponds with the rapid changes in canopy structure reported with Sitka spruce. Overestimations of mean annual increment appear to result from differences in canopy dynamics in the loblolly pine plots used to fit the model's regression equations and the canopy dynamics in the loblolly pine plantations used for comparisons. The model has the potential to create an alternative approach for accessing environmental changes on forest growth and yield to complement extant carbon-balance models. © 2013 by the Society of American Foresters.

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