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Parker B.,University Institute of Health Sciences
Lupus | Year: 2013

Metabolic syndrome (MetS) is a recently defined clustering of cardiovascular risk factors associated with insulin resistance and an increased risk of future type II diabetes mellitus and cardiovascular disease (CVD). Systemic lupus erythematosus (SLE) patients have an increased prevalence of MetS and an increased prevalence of insulin resistance. Chronic inflammation may predispose to these complications in SLE and there is also evidence that corticosteroid therapy also contributes, although this finding has not been as consistent as would be predicted from the known metabolic effects of corticosteroids. MetS may represent a good model in which to begin to understand how SLE drives an increased risk of CVD. For now, the utility of identifying MetS in patients is to identify a subset in which more focused lifestyle interventions should be targeted and in whom medication review and adjustment (especially corticosteroid doses) should be considered to help modify future CVD risk. Source

Strasser B.,University Institute of Health Sciences
Annals of the New York Academy of Sciences | Year: 2013

Biological aging is typically associated with a progressive increase in body fat mass and a loss of lean body mass. Owing to the metabolic consequences of reduced muscle mass, it is understood that normal aging and/or decreased physical activity may lead to a higher prevalence of metabolic disorders. Lifestyle modification, specifically changes in diet, physical activity, and exercise, is considered the cornerstone of obesity management. However, for most overweight people it is difficult to lose weight permanently through diet or exercise. Thus, prevention of weight gain is thought to be more effective than weight loss in reducing obesity rates. A key question is whether physical activity can extenuate age-related weight gain and promote metabolic health in adults. Current guidelines suggest that adults should accumulate about 60 minutes of moderate-intensity physical activity daily to prevent unhealthy weight gain. Because evidence suggests that resistance training may promote a negative energy balance and may change body fat distribution, it is possible that an increase in muscle mass after resistance training may be a key mediator leading to better metabolic control. © 2012 New York Academy of Sciences. Source

The present invention includes inhibitors of the amino acid transporter ATB

University Institute of Health Sciences | Date: 2011-02-09

The present invention demonstrates for the first time that alpha-methyl-tryptophan is an inhibitor of the enzyme indoleamine diooxygenase (IDO). The present invention includes the use of alpha-methyl-tryptophan in methods of modulating immune responses and treating cancer and infections.

University Institute of Health Sciences | Date: 2012-07-02

An attachment for a wheelchair includes a secondary front-wheel pair that is movable from a disengaged up position, to a deployed down position, and back again. In the disengaged up position, the secondary front wheels are up off the ground, so the primary front wheels of the wheelchair are in contact with the ground and thereby being used. In the deployed down position, the secondary front wheels are down in contact with the ground and are thereby being used, so the primary front wheels are now removed from contact with the ground and are no longer in use. In typical embodiments, the secondary front wheels are relatively larger wheels for traversing rough terrain, the primary front wheels are relatively smaller wheels for traversing smooth terrain, and the secondary front wheels move between the disengaged up position and the deployed down position in a pivoting motion.

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