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Housni A.,University hospital of Fez | Boujraf S.,University of Fez
Neurosciences | Year: 2013

Multimodal MRI has an important contribution to cancer research. This technique is completely non-invasive and non-ionizing, it provides major information for diagnosis, and answers the questions of therapists before, during, and after treatment. Hence, in this paper we review the interest of these MRI modalities and their impact on the diagnosis, during and after therapeutic care of brain tumors. The MRI modalities allow specifying the localization of the expanding pathological tumoral process, the differential diagnosis between brain tumors and confined lesions of different categories, the diagnosis of the tumoral type of the lesion, assessing the histological grade in cases of glial tumor, and its local extension as well as the therapeutic follow-up. The multimodal MRI approach has a major contribution to the advanced care of brain tumors. Source

Sennou A.S.,University hospital of Fez | Boujraf S.,Clinical Neurosciences Laboratory | Belahsen M.F.,University hospital of Fez | Messouak O.,University hospital of Fez | Messouak O.,Clinical Neurosciences Laboratory
Journal of Neurosciences in Rural Practice | Year: 2014

Previous research indicates that the onset of psychiatric disorders is sometimes associated with multiple sclerosis (MS) evolving several years later. However, information on why this might occur, and on the outcomes of such patients, is still lacking. We aim to discuss these limitations with the current paper. We describe a 51-year-old female who demonstrated severe anxiety disorder and depression years before developing MS neurological symptoms. The patient was treated for these psychiatric disorders over 20 years. In the last 3 years of her treatment, the patient demonstrated a choreic-type of movement disorder in all her limbs. This disorder is consistent with relapsing-remitting MS. Clinical and magnetic resonance imaging (MRI) examinations demonstrated aspects of MS, without MS being diagnosed conclusively. The visual evoked potential indicated a diagnosis of conduction abnormalities. The established diagnosis was slow relapsing MS. The patient underwent methylprednisolone bolus (1 g/day). This case-study suggests that health professionals should conduct a full neurological assessment when they find atypical psychiatric symptoms in a patient. This would make sure that patients receive a better standard of care, and thus experience a better quality of life. © 2014 Journal of Neurosciences in Rural Practice. Source

Souirti Z.,University hospital of Fez | Messouak O.,University hospital of Fez | Belahsen F.,University hospital of Fez
Pan African Medical Journal | Year: 2014

Cerebral venous thrombosis (CVT) is a rare origin of stroke, the clinical presentation and etiologies vary. The prognosis is shown to be better compared to arterial thrombosis. Magnetic Resonance Imaging (MRI) and MR Venograpgy (MRV) are currently important tools for the diagnostic. We studied 30 cases of CVT diagnosed in the department of neurology of the University Hospital of Fez (Morocco). Patients diagnosed with CVT signs between January 2003 and October 2007 were included in the study. Cerebral CT-scan was performed in 27 cases (90%) while the MRI examination was done in 18 patients (67%); and most patients (90%) received anticoagulant therapy. The mean age of our patients was of 29 years (age range between 18 days and 65 years). A female predominance was observed (70%). The clinical presentation of patients was dominated by: headache in 24 cases (80%), motor and sensory disability in 15 cases (50%), seizures in 10 cases (33%), consciousness disorder in 10 cases (33%). CVT was associated to post-partum in 10 cases (33%), infectious origin in 8 cases (26%), Behcet disease in 2 cases (7%), pulmonary carcinoma in 1 case, thrombocytemia in 1 case and idiopathic in 7 cases (23%). The evolution was good in 20 cases (67%), minor squelaes were observed in 6 patients (20%), while major squelaes was observed in 2 cases. Two cases of death were registered. The CVT is a pathology of good prognosis once the diagnosis is promptly established and early heparin treatment initiated. © Zouhayr Souirti et al. Source

Labib S.,University hospital of Fez | Berdai A.,University hospital of Fez | Harandou M.,University hospital of Fez
Saudi Journal of Anaesthesia | Year: 2014

Colchicine is an alkaloid extracted from autumnal Colchicum plant which is used primarily for its anti-inflammatory therapy effect. Acute intoxication with colchicine is uncommon but often severe and results in multiple visceral organ dysfunctions. The intoxication severity and mortality are directly depending on the ingested dose. The treatment is manly symptomatic. However, the development of specific anti-colchicine immunotherapy would offer a new therapeutic perspective. Authors report a case of a young patient that ingested 40 tablets colchicine, which caused a multiple organ failure and with fatal outcome. Source

Oudghiri B.,University hospital of Fez | Benzagmout M.,University hospital of Fez | Boujraf S.,Clinical Neurosciences Laboratory | Belahcen F.,University hospital of Fez | Ibrahimi A.,University hospital of Fez
Journal of Global Infectious Diseases | Year: 2012

Sarcoidosis is a chronic multisystemic granulomatous disease that is triggered by an autoimmune process. Nowadays, this pathology represents a well-recognized but uncommon complication for antiviral treatment in hepatitis C virus (HCV) infection. Herein, we report a remarkable case of 47-year-old woman treated for chronic HCV infection; the patient has developed interferon alfa-induced sarcoidosis involving the central nervous system. The evolution was fatal despite disrupting the antiviral therapy and initiating a high-dose corticotherapy. This complication of interferon alfa treatment was reported in the literature in only one case. Through this case and a review of the literature, we aim to underline the importance of screening for sarcoidosis before and during the follow-up of HCV patients undergoing antiviral therapy. Source

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