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University of Technology of Compiègne, France

Misery L.,University of Western Brittany | Bodere C.,University of Western Brittany | Genestet S.,Breton Competence Cen. of Rare Neuro Muscular Dis. and Neuro. with Cutaneous Mucosal Symptoms | Zagnoli F.,University of Western Brittany | And 2 more authors.
European Journal of Dermatology | Year: 2014

Small-fibre neuropathies (SFNs) can be defined as diseases of small nerve fibres. Because their symptoms are mainly located in the skin in the initial stages, dermatologists may frequently be confronted with these diseases. Moreover, skin biopsies and the subsequent measurement of intraepidermal nerve fibre density have become a widely accepted technique to investigate the structural integrity of small nerve fibres. The pathogenesis of injury to small nerve fibres is poorly understood. It probably depends on the cause. SCN9A-gene variants have been reported. Diabetes mellitus is one of the main causes of SFNs. Some causes of SFNs are very well-known to dermatologists: Gougerot-Sjögren syndrome, lupus, sarcoidosis and Fabry disease. We also discuss erythermalgia, prurigo nodularis, nummular eczema, burning mouth syndrome and sensitive skin as SFNs.


Misery L.,University Hospital of Brest | Misery L.,University of Western Brittany
Expert Review of Dermatology | Year: 2011

The World Congress on Itch, previously named the International Workshop for the Study of Itch, is the official workshop of the International Forum for the Study of Itch. The scientific program covered all aspects of research from biology to psychology, from epidemiology to clinics, from physiology to neuroimaging and so on. The contribution of distinguished invited speakers guaranteed a state-of-the art update, while selected free communications and posters provided the newest information. It is not feasible to attempt comprehensive coverage of the conference. We focus on presentations that are most topical, interesting or thought-provoking. © 2011 Expert Reviews Ltd.


Misery L.,University of Western Brittany | Misery L.,University Hospital of Brest
Journal of Investigative Dermatology | Year: 2011

Acne may cause psychological distress that is associated with many psychiatric disorders. In this issue, Halvorsen et al. report suicidal ideation, mental health problems, and affective isolation to be relatively frequent in adolescents with acne. This report suggests that adverse events that have been attributed to therapies for acne, including suicidal ideation and depression, may reflect the burden of substantial acne rather than the effect of medications. © 2011 The Society for Investigative Dermatology.


Sheehan F.T.,U.S. National Institutes of Health | Brochard S.,U.S. National Institutes of Health | Brochard S.,University Hospital of Brest | Brochard S.,French Institute of Health and Medical Research | And 3 more authors.
Journal of Shoulder and Elbow Surgery | Year: 2014

Background: Obstetrical brachial plexus palsy (OBPP) is a common birth injury, resulting in severe functional losses. Yet, little is known about how OBPP affects the 3-dimensional (3D) humeral morphology. Thus, the purpose of this study was to measure the 3D humeral architecture in children with unilateral OBPP. Methods: Thirteen individuals (4 female and 9 male patients; mean age, 11.8 ± 3.3 years; mean Mallet score, 15.1 ± 3.0) participated in this institutional review board approved study. A 3D T1-weighted gradient-recalled echo magnetic resonance image set was acquired for both upper limbs (involved and noninvolved). Humeral size, version, and inclination were quantified from 3D humeral models derived from these images. Results: The involved humeral head was significantly less retroverted and in declination (medial humeral head pointed anteriorly and inferiorly) relative to the noninvolved side. Osseous atrophy was present in all 3 dimensions and affected the entire humerus. The inter-rater reliability was excellent (intraclass correlation coefficient, 0.96-1.00). Discussion: This study showed that both humeral atrophy and bone shape deformities associated with OBPP are not limited to the axial plane but are 3D phenomena. Incorporating information related to these multi-planar, 3D humeral deformities into surgical planning could potentially improve functional outcomes after surgery. The documented reduction in retroversion is an osseous adaptation, which may help maintain glenohumeral congruency by partially compensating for the internal rotation of the arm. The humeral head declination is a novel finding and may be an important factor to consider when one is developing OBPP management strategies because it has been shown to lead to significant supraspinatus inefficiencies and increased required elevation forces. © 2014 .


Kamide R.,Jikei University School of Medicine | Misery L.,University Hospital of Brest | Sibaud V.,Institute Claudius Regaud | Taieb C.,Public Health and Quality of Life
Journal of Dermatology | Year: 2013

Sensitive skin syndrome was first described in 1977; however, no robust study has been carried out to evaluate its prevalence in Japan. A national representative sample of the Japanese population over the age of 18 years was taken. Individuals were questioned by telephone and selected according to the quota method. When asked "Do you have a sensitive skin?", 52.84% of men and 55.98% of women answered "rather sensitive" or "very sensitive". There was no significant difference (P = 0.22) between the two sexes. The non-response rate among respondents was zero, suggesting that the term "sensitive skin" held a meaning for the majority of the population. Concerning questions about the onset of a rash, tingling or irritation in the presence of various factors, such as emotional issues, cold, heat, sun, dry air, air-conditioning, water, air pollution and temperature variations, respondents with rather sensitive or very sensitive skin responded "yes" more often than others: approximately three-times more often for water (18.97%/6.15%), air pollution (39.29%/12.45%) and warm climatic conditions (29.74%/9.8%). To our knowledge, this epidemiological study is the first to focus on sensitive skin among Japanese people of this century. It is of particular interest for two reasons: (i) it was conducted on a representative sample of the Japanese population; and (ii) the methodology used was identical to that used for sensitive skin assessment studies conducted in Europe and the USA, making it possible to draw certain comparisons. © 2012 Japanese Dermatological Association.

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