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Alexandroúpoli, Greece

Zarogoulidis P.,Aristotle University of Thessaloniki | Papanas N.,Democritus University of Thrace | Kioumis I.,Aristotle University of Thessaloniki | Chatzaki E.,Democritus University of Thrace | And 2 more authors.
European Journal of Clinical Pharmacology

Background: Macrolides have long been recognised to exert immunomodulary and anti-inflammatory actions. They are able to suppress the "cytokine storm" of inflammation and to confer an additional clinical benefit through their immunomodulatory properties. Methods: A search of electronic journal articles was performed using combinations of the following keywords: macrolides, COPD, asthma, bronchitis, bronchiolitis obliterans, cystic fibrosis, immunomodulation, anti-inflammatory effect, diabetes, side effects and systemic diseases. Results: Macrolide effects are time- and dose-dependent, and the mechanisms underlying these effects remain incompletely understood. Both in vitro and in vivo studies have provided ample evidence of their immunomodulary and anti-inflammatory actions. Importantly, this class of antibiotics is efficacious with respect to controlling exacerbations of underlying respiratory problems, such as cystic fibrosis, asthma, bronchiectasis, panbrochiolitis and cryptogenic organising pneumonia. Macrolides have also been reported to reduce airway hyper-responsiveness and improve pulmonary function. Conclusion: This review provides an overview on the properties of macrolides (erythromycin, clarithromycin, roxithromycin, azithromycin), their efficacy in various respiratory diseases and their adverse effects. © Springer-Verlag 2011. Source

Tsarouhas A.,University of Thessaly | Iosifidis M.,Papageorgiou General Hospital | Kotzamitelos D.,University Hospital of Alexandroupolis | Spyropoulos G.,University of Thessaly | And 4 more authors.
Arthroscopy - Journal of Arthroscopic and Related Surgery

Purpose: To investigate whether anatomic restoration of the anterior cruciate ligament (ACL) functional bundles results in significant reduction in transverse-plane instability compared with the conventional single-bundle technique during a dynamic 60° pivoting maneuver with the supporting knee in extension. Methods: Using an 8-camera optoelectronic system and a force plate, we examined 10 patients with double-bundle ACL reconstruction, 12 patients with single-bundle reconstruction, 10 ACL-deficient subjects, and 10 healthy control individuals. The 4 groups did not differ in terms of age, body mass index, duration of follow-up, and number of meniscectomies performed. Kinematic and kinetic data were collected from these subjects while performing a pivoting maneuver on each side with the supporting knee in extension. Maximum range of motion for internal-external knee rotation and maximum knee rotational moment were examined. Results: There was no significant difference in tibial rotation either between the 4 groups or between sides. The mean knee rotation for the single- and double-bundle groups was lower than the control group. Rotational moment values were substantially reduced on the affected side of the reconstructed and the ACL-deficient groups. However, rotational moment was not found to affect the degree of angular displacement significantly. Conclusions: Double-bundle ACL reconstruction does not reduce knee rotation further compared with the single-bundle reconstruction technique. The affected side of ACL-deficient or -reconstructed individuals is subjected to reduced knee rotational moments compared with the intact side during stressful functional maneuvers. Level of Evidence: Level III, retrospective comparative study. © 2010 Arthroscopy Association of North America. Source

Bantis A.,University Hospital of Alexandroupolis | Grammaticos P.,51 Hermou Str.
Hellenic Journal of Nuclear Medicine

Prostate cancer (PC) is currently the most frequently diagnosed cancer in males and constitutes a major health issue in developed countries. On the other hand, the majority of PC cases are considered clinically not significant and certainly not lethal. These discrepancies highlight the need for the early detection of especially those cases that have aggressive features and call for early and radical intervention. The clinical use of prostatic specific antigen (PSA) towards this end is recognized as inadequate since PSA is prostate specific, but not a PC specific marker, as it is known to increase in other prostate diseases such as benign hyperplasia, inflammations, transrectal ultrasound examination, biopsy and after transurethral prostatectomy. However due to lack of other more specific markers, digital rectal examination combined with serum PSA are suggested for PC screening and diagnosis. With regard to advanced disease where bone involvement is the rule, nuclear medicine bone scan using radioactive bisphosphonates such as technetium-99m methylene-diphosphonate is quite common and reliable technique for detecting and monitoring bone metastases. The major advantage of nuclear scintigraphy is its ability to reveal bone metastases significantly earlier than the conventional X-rays imaging techniques. PSA density, velocity, doubling time and free to total PSA ratio increase the significance of serum PSA in diagnosing PC. The combination of an increased PSA (>20ng/mL) and a high biopsy Gleason score (>8) enhances the possibility of bone metastases (P<0001) and mandates a bone scan. In conclusion, serum PSA testing is currently recommended in symptomatic PC patients, for disease staging and treatment monitoring and in asymptomatic selected population groups aged more than 50 years. It is reasonable to suggest that PSA density, velocity, doubling time and free to total PSA ratio or combining PSA with Gleason score shall greatly increase PSA specificity in detecting PC cases. Radioisotopic bone scan by SPET or PET can demonstrate osseous metastases at later stages of PC, but should also be applied in cases falsely considered as an early stage of PC, for better staging and for periodic follow-up of the disease. Source

Sertaridou E.,University Hospital of Alexandroupolis | Papaioannou V.,University Hospital of Alexandroupolis | Kolios G.,Democritus University of Thrace | Pneumatikos I.,University Hospital of Alexandroupolis
Annals of Gastroenterology

The concept of bacterial translocation and gut-origin sepsis as causes of systemic infectious complications and multiple organ deficiency syndrome in surgical and critically ill patients has been a recurring issue over the last decades attracting the scientific interest. Although gastrointestinal dysfunction seemingly arises frequently in intensive care unit patients, it is usually underdiagnosed or underestimated, because the pathophysiology involved is incompletely understood and its exact clinical relevance still remains controversial with an unknown yet probably adverse impact on the patients’ outcome. The purpose of this review is to define gut-origin sepsis and related terms, to describe the mechanisms leading to gutderived complications, and to illustrate the therapeutic options to prevent or limit these untoward processes. © 2015 Hellenic Society of Gastroenterology. Source

Froudarakis M.E.,Democritus University of Thrace | Froudarakis M.E.,University Hospital of Alexandroupolis

Thoracoscopy is currently the gold standard for the diagnosis and treatment of pleural diseases. Its diagnostic yield is 95% in patients with malignant pleural disease, with approximately 90% successful pleurodesis for malignant pleural effusion and 95% for pneumothorax. At the same time, thoracoscopy constitutes an important tool in the research of pleural pathophysiology and molecular biology. The improvement of technology has provided important tools to thoracoscopy, such as autofluorescence, narrow band imaging, and infrared light, used in clinical and basic research in many disorders involving the pleura. For these reasons, training in thoracoscopy should be considered equally important as training in bronchoscopy for residents in respiratory medicine. © 2011 S. Karger AG, Basel. Source

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