University Hospital in Martin

Martin, Slovakia

University Hospital in Martin

Martin, Slovakia
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Simekova K.,University Hospital in Martin | Simekova K.,Commenius University in Bratislava | Szilagyiova M.,University Hospital in Martin | Szilagyiova M.,Commenius University in Bratislava | And 11 more authors.
Vector borne and zoonotic diseases (Larchmont, N.Y.) | Year: 2017

Echinococcosis is a serious parasitic disease that ends lethally in 95% of untreated infected patients. It was first diagnosed in Slovakia in the year 2000. It is caused by the larval stage of a tapeworm belonging to the genus Echinococcus, which was assigned to the group "A" of zoonoses in the year 2004. The number of new infections is rising because of increasing percentage of infected red foxes (Vulpes vulpes). Early and accurate diagnosis of infections with this parasite is essential for proper initiation of adequate therapy. Thanks to professional multidisciplinary efforts and new laboratory procedures, the number of correctly diagnosed cases has increased. Antimicrobial therapeutic approaches can lead to improved quality of life and better prognosis even if radical surgery is refused by the patient.


Jesenak M.,University Hospital in Martin
Advances in Respiratory Therapy Research | Year: 2014

The Book represents an actual view on the current trends in the area of respiratory therapy research. The amount of new information in each field of clinical medicine is astonishing and therefore we considered it very important to catch this exciting movement in the form of monograph dedicated to the advances in therapy research of various respiratory diseases. The chapters analyze the therapeutic strategies and perspectives in the management of the most common chronic diseases, especially in childhood. Due to very rapid progress in this area, it is very important that the authors succeed in summarizing the most knowledge and data about the available and possible future therapies of bronchial asthma, primary ciliary dyskinesia, chronic and acute cough, and obstructive sleep apnea syndrome. Aside from clinical chapters, the readers can also find experimental studies analyzing the possible therapeutic application of different medications and chest physiotherapy. A very important part of each chapter is the current view on the pathogenesis of particular diseases, in which understanding is crucial for better, targeted therapy and research of novel therapeutic modalities. We hope that this book will find its readers and will help physicians and other interested people to understand the most recent trends in the treatment and management of respiratory diseases. © 2015 by Nova Science Publishers, Inc. All rights reserved.


Dzian A.,University Hospital in Martin | Halasova E.,University Hospital in Martin | Matakova T.,University Hospital in Martin | Kavcova E.,University Hospital in Martin | And 4 more authors.
Neoplasma | Year: 2012

Slovak Republic belongs to the countries with high incidence of lung cancer. Gene polymorphisms of the glutathione S-transferases (GSTs) may play a role in individual lung cancer susceptibility. In presented case-control study we investigate the incidence of polymorphism of GSTT1, GSTM1, GSTP1 genes and their combinations as possible predictive factors for identification of individuals with increased risk of formation and development of adenocarcinoma (AC) and squamous cell carcinoma (SCC) of lung in Slovak population. The study was conducted on 520 individuals consisting of 118 patients with adenocarcinoma, 112 patients with squamous cell carcinoma and 290 control individuals. GSTT1, GSTM1, GSTP1 gene polymorphisms were assayed by standard PCR and PCR-RFLP technique. The results of this study indicate that the GSTT1null-genotype and combination GSTT1 null and Ile/Val or Val/Val are associated with increased risk of lung adenocarcinoma. A significant association with 2.13 - fold increased risk was observed between lung adenocarcinoma and GSTT1 null genotype (95% CI = 1.29 - 3.51; p= 0.004). Also it was proved 2.83 times statistically higher risk for development of this histological type of lung cancer (95% CI = 1.34 - 6.01; P = 0.005) in combination of GSTT1null and Ile/Val or Val/Val genotypes. GSTT1, GSTM1, GSTP1 polymorphism did not show any significant association with SCC. Our study suggests that genetic make-up in metabolizing genes may increase susceptibility towards lung cancer development.


Sarlinova M.,Comenius University | Majerova L.,Comenius University | Matakova T.,Comenius University | Musak L.,Comenius University | And 4 more authors.
Advances in Experimental Medicine and Biology | Year: 2014

Chromium is a well known carcinogen involved in the lung cancer development. Polymorphism of some of the DNA repair genes may be associated with elevated risk of cancerous transformation. In the present study, we investigated the polymorphisms of the following selected members of the base and nucleotide excision repair genes: XPC (Lys939Gln), XPD (Lys751Gln), XRCC1(Arg399Gln), and hOGG1 (Ser326Ser), and the risk they present toward the development of lung cancer, with emphasis on the effect of chromium exposure. We analyzed 119 individuals; 50 patients exposed to chromium with diagnosed lung cancer and 69 healthy controls. Genotypes were determined by a PCR-RFLP method. We found a significantly increased risk of lung cancer development in XPD genotype Lys/Gln (OR ¼ 1.94; 95 % CI ¼ 1.10–3.43; p ¼ 0.015) and in the gene combinations: XPD Lys/Gln+XPC Lys/Gln (OR ¼ 6.5; 95 % CI ¼ 1.53–27.49; p ¼ 0.009) and XPD Lys/Gln+XPC Gln/Gln(OR ¼ 5.2; 95 % CI ¼ 1.07–25.32; p ¼ 0.04). In conclusion, gene polymorphisms in the DNA repair genes may underscore the risk of lung cancer development in the chromiumexposed individuals. © Springer International Publishing Switzerland 2014.


Dedinska I.,University Hospital in Martin | Dedinska I.,Comenius University | Laca L.,University Hospital in Martin | Laca L.,Comenius University | And 10 more authors.
Diabetologia Kliniczna | Year: 2014

Background. We define metabolic syndrome as a non-random collective incidence of glucose metabolism disorders related to insulin resistance, central obesity, dyslipidemia, arterial hypertension and other factors which contribute to increased risk of ischemic heart disease and diabetes mellitus type 2. Smoking is one of the most significant risk factors for ischemic heart disease. Objectives and methods. A prospective analysis of 125 patients (75 men and 50 women) with the average age of 57.3 years. A subset of smokers was composed of 59 patients; the average number of cigarettes smoked per day was 18 pieces. A subset of non-smokers was composed of 66 patients. We examined the presence of metabolic syndrome components according to the International Diabetic Federation criteria for the European population throughout the whole set of patients. Results. Percentually higher incidence of metabolic syndrome occurred in the group of non-smokers. The incidence of metabolic syndrome in the group of smokers was significantly influenced by their age. Arterial hypertension and impaired fasting glucose were the most frequent components of metabolic syndrome in the subset of smokers with metabolic syndrome. In the subset of non-smokers with metabolic syndrome arterial hypertension was the most frequently found component. Conclusion. The results of the research did not show statistically significantly increased or decreased incidence of metabolic syndrome in case of smokers. We did not find any relation between the number of cigarettes smoked per day and metabolic syndrome development. Copyright © 2014 Via Medica.


Sarlinova M.,Comenius University | Halasa M.,Libyan Arab Jamahiriya | Mistuna D.,University Hospital in Martin | Musak L.,Occupational Medicine and Toxicology | And 6 more authors.
Anticancer Research | Year: 2016

The Aim of this study was to evaluate the expression levels of miR-21, miR-221, miR-150, let-7a and miR-126a in peripheral blood of 71 patients with colorectal cancer and 80 matched healthy control individuals. We determined expression levels of these microRNAs in peripheral blood samples and used small nucleolar RNA (RNU48) as an internal control. Expression levels of miR-21 (p<0.0001) and miR-221 (p<0.0001) were significantly higher, whereas expression levels of miR-150 (p=0.0054) were significantly lower in the blood samples of patients with colorectal cancer in comparison to the control group. The combination of these three microRNAs enabled us to distinguish patients with colorectal cancer from healthy donors with a sensitivity of 80% and specificity of 74% (p<0.0001). We did not observe any correlation of the studied microRNAs with clinicopathological features of colorectal cancer, indicating that expression of these microRNAs is more likely related to the host response to the tumour than the tumour itself.


PubMed | Comenius University, Slovak Medical University, University Hospital in Martin and Masaryk University
Type: Journal Article | Journal: Anticancer research | Year: 2016

The Aim of this study was to evaluate the expression levels of miR-21, miR-221, miR-150, let-7a and miR-126a in peripheral blood of 71 patients with colorectal cancer and 80 matched healthy control individuals. We determined expression levels of these microRNAs in peripheral blood samples and used small nucleolar RNA (RNU48) as an internal control. Expression levels of miR-21 (p<0.0001) and miR-221 (p<0.0001) were significantly higher, whereas expression levels of miR-150 (p=0.0054) were significantly lower in the blood samples of patients with colorectal cancer in comparison to the control group. The combination of these three microRNAs enabled us to distinguish patients with colorectal cancer from healthy donors with a sensitivity of 80% and specificity of 74% (p<0.0001). We did not observe any correlation of the studied microRNAs with clinicopathological features of colorectal cancer, indicating that expression of these microRNAs is more likely related to the host response to the tumour than the tumour itself.


PubMed | Slovak Academy of Sciences, University Hospital in Martin and Commenius University in Bratislava
Type: | Journal: Vector borne and zoonotic diseases (Larchmont, N.Y.) | Year: 2017

Echinococcosis is a serious parasitic disease that ends lethally in 95% of untreated infected patients. It was first diagnosed in Slovakia in the year 2000. It is caused by the larval stage of a tapeworm belonging to the genus Echinococcus, which was assigned to the group A of zoonoses in the year 2004. The number of new infections is rising because of increasing percentage of infected red foxes (Vulpes vulpes). Early and accurate diagnosis of infections with this parasite is essential for proper initiation of adequate therapy. Thanks to professional multidisciplinary efforts and new laboratory procedures, the number of correctly diagnosed cases has increased. Antimicrobial therapeutic approaches can lead to improved quality of life and better prognosis even if radical surgery is refused by the patient.


PubMed | Comenius University, University Hospital in Martin, Hospital in Zilina and Catholic University in Ruzomberok
Type: | Journal: Advances in experimental medicine and biology | Year: 2016

Phase I enzymes, including cytochrome P450, family 1, subfamily A, and polypeptide 2 (CYP1A2), are involved in the activation of carcinogens to reactive intermediates that are capable of binding covalently to DNA to form DNA adducts, potentially initiating the carcinogenic process. The aim of present study was to investigate the association of CYP1A2 gene polymorphisms and haplotypes with lung cancer risk. A case-control study was carried out on 105 lung cancer patients and 189 controls. To investigate three CYP1A2 polymorphisms: rs2472299, rs2470890, rs11072508 we used a high resolution melting analysis. We found significant allele associations (rs2470890 and rs2422299) with lung cancer risk. We searched for meaningful associations for all variants in the dominant, recessive, and additive genetic models. Genotype associations in the recessive model were of marginal significance for the same single nucleotide polymorphisms. A haplotype analysis included five variants with the frequency higher than 1%. The haplotype acc, present with the highest frequency, was associated with increased lung cancer risk (38.7% vs. 31.5%; OR 1.38; 95 %CI 0.95-2.01). On the contrary, rare haplotype gtc was significantly associated with decreased lung cancer risk in the Slovak population. In conclusion, the present study identified the risk alleles and haploid genotype associations of the CYP1A2 gene in lung cancer.

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