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Stone G.W.,Columbia University Medical Center | Stone G.W.,Cardiovascular Research Foundation | Abizaid A.,Dante Pazzanese Institute of Cardiology | Silber S.,ISaR GmbH | And 12 more authors.
Journal of the American College of Cardiology | Year: 2012

Objectives: This study sought to evaluate the potential utility of a novel polyethylene terephthalate micronet mesh-covered stent (MGuard) in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). Background: Suboptimal myocardial reperfusion after PCI in STEMI is common and results in increased infarct size and mortality. The MGuard is a novel thin-strut metal stent with a polyethylene terephthalate micronet covering designed to trap and exclude thrombus and friable atheromatous debris to prevent distal embolization. Methods: A total of 433 patients with STEMI presenting within 12 h of symptom onset undergoing PCI were randomized at 50 sites in 9 countries to the MGuard (n = 217) or commercially available bare metal or drug-eluting stents (n = 216). The primary endpoint was the rate of complete (<70%) ST-segment resolution measured 60 to 90 min post-procedure. Results: Baseline characteristics were well matched between the groups. The primary endpoint of post-procedure complete ST-segment resolution was significantly improved in patients randomized to the MGuard stent compared with control patients (57.8% vs. 44.7%; difference: 13.2%; 95% confidence interval: 3.1% to 23.3%; p = 0.008). By core laboratory analysis, the MGuard stent compared with control stents also resulted in superior rates of Thrombolysis In Myocardial Infarction 3 flow (91.7% vs. 82.9%, p = 0.006) with comparable rates of myocardial blush grade 2 or 3 (83.9% vs. 84.7%, p = 0.81). Mortality (0% vs. 1.9%, p = 0.06) and major adverse cardiac events (1.8% vs. 2.3%, p = 0.75) at 30 days were not significantly different between patients randomized to the MGuard stent and control stent, respectively. Conclusions: Among patients with acute STEMI undergoing emergent PCI, the MGuard micronet mesh-covered stent compared with conventional metal stents resulted in superior rates of epicardial coronary flow and complete ST-segment resolution. A larger randomized trial is warranted to determine whether these benefits result in reduced infarct size and/or improved clinical outcomes. (Safety and Efficacy Study of MGuard Stent After a Heart Attack [MASTER]; NCT01368471) © 2012 American College of Cardiology Foundation.

Michalowski T.,Cracow University of Technology | Toporek M.,Cracow University of Technology | Michalowska-Kaczmarczyk A.M.,University Hospital in Cracow | Asuero A.G.,University of Seville
Electrochimica Acta | Year: 2013

The paper provides comprehensive, compatible and consistent knowledge on thermodynamics of elec-trolytic redox systems, and referred to aqueous media. A keystone of the overall knowledge are elementalbalances: f(H) for hydrogen (H), and f(O) for oxygen (O). A new approach (Approach II) to a GeneralizedElectron Balance (GEB) formulation is based on a linear combination pr-GEB = 2 f(O) - f(H) of the balances,considered as the primary form of GEB in redox systems. It is proved that the pr-GEB, as the essence of theApproach II, is equivalent to the Approach I to GEB, based on the principle of common pool of electrons.The fundamental advantage of the Approach II is that none prior knowledge on oxidation degree of ele-ments in complex species of definite elemental composition and charge is needed. The GEB is perceivedas the general law of matter conservation, related to electrolytic (aqueous media) redox systems. TheApproaches I and II are illustrated with several redox systems. © 2013 Elsevier Ltd. All rights reserved.

Gorazda K.,Cracow University of Technology | Michalowska-Kaczmarczyk A.M.,University Hospital in Cracow | Asuero A.G.,University of Seville | Michalowski T.,Cracow University of Technology
Talanta | Year: 2013

Some rational functions are considered as the basis for calculation of unknown concentration (x0) of an analyte X determined according to the standard addition method (SAM). The correction for dilution of the sample tested during addition of successive increments of standard(ised) solution of X is involved in the related algorithm applied for calculation of the x 0 value. The formulae derived were put in context with experimental data, obtained according to the AAS method from Cu-measurements in samples obtained by digestion of an ash obtained from incinerated sludge. It was stated that the use of rational functions for modeling purposes strengthens the robustness of the results thus obtained. © 2013 Elsevier B.V.

Michalowski T.,Cracow University of Technology | Michalowska-Kaczmarczyk A.M.,University Hospital in Cracow | Toporek M.,Cracow University of Technology
Electrochimica Acta | Year: 2013

The paper provides a comprehensive, compatible and consistent approach to thermodynamics of electrolytic redox and non-redox systems, referred to aqueous, non-aqueous and mixed-solvent media. It is stated that the linear combination 2·f(O) - f(H) of elemental balances: f(H) for H and f(O) for O is the property distinguishing between redox and non-redox electrolytic systems. Namely, 2·f(O) - f(H) is the linear combination of concentration balances for other components of a non-redox system, of any degree of complexity. It is also proved that 2·f(O) - f(H) is an independent equation when referred to a redox system, of any degree of complexity. The linear combination 2·f(O) - f(H) is a primary form, pr-GEB, of the Generalized Electron Balance (GEB), 2·f(O) - f(H) = pr-GEB, named as the Approach II, and considered as the alternative for the Approach I to GEB, based on the "card game" principle. The equivalency of both approaches to GEB is also proved in this paper. The GEB, considered as a relatively new Law of Nature, is perceived as a turning point in the theory of electrolytic redox systems. © 2013 Elsevier Ltd. All rights reserved.

Michalowska-Kaczmarczyk A.M.,University Hospital in Cracow | Toporek M.,Cracow University of Technology | Michalowski T.,Cracow University of Technology
Electrochimica Acta | Year: 2015

The speciation diagrams are suggested as a reasonable tool for explanation of processes occurred during simulated redox titration, where K2Cr2O7 solution is added into acidified (H2SO4) solution of KI. The related speciation curves log[Xizi] = fi (Φ) for all interesting species Xizi of the system, and the E = E(Φ) and pH = pH(Φ) relationships (Φ-fraction titrated) are plotted and discussed. The calculations made for this purpose are performed in accordance with principles of the Generalized Approach to Electrolytic Systems (GATES) with Generalized Electron Balance (GEB) involved, and realized with use of iterative computer programs offered by MATLAB. The reactions proceeding in this system can be formulated together with their efficiencies, at any stage of the titration. The stoichiometry is considered as the derivative concept when put in context with GATES/GEB. © 2015 Elsevier Ltd. All rights reserved.

Michalowska-Kaczmarczyk A.M.,University Hospital in Cracow | Michalowski T.,Cracow University of Technology
Analytical and Bioanalytical Chemistry | Year: 2015

Researchers investigate the solution to solubility product challenge. The solubility of nickel dimethylglyoximate (NiL2) in water can be described by considering the equations for five equilibrium constants. Investigations reveal that the total ligand (L) concentration is twice that of the total nickel concentration, as an excess of pure NiL2 is introduced into pure water.

Michalowska-Kaczmarczyk A.M.,University Hospital in Cracow | Michalowski T.,Cracow University of Technology
Analytical and Bioanalytical Chemistry | Year: 2015

We would like to invite you to participate in the Analytical Challenge, a series of puzzles to entertain and challenge our readers. This special feature of "Analytical and Bioanalytical Chemistry" has established itself as a truly unique quiz series, with a new scientific puzzle published every other month. Readers can access the complete collection of published problems with their solutions on the ABC homepage at http://www.springer.com/abc. Test your knowledge and tease your wits in diverse areas of analytical and bioanalytical chemistry by viewing this collection. In the present challenge, solubility is the topic. And please note that there is a prize to be won (a Springer book of your choice up to a value of €100). Please read on... © Springer-Verlag 2015.

Duplaga M.,Jagiellonian University | Andrychiewicz A.,University Hospital in Cracow | Danda J.,AGH University of Science and Technology
CIN - Computers Informatics Nursing | Year: 2013

The acceptance of e-health solutions by users representing the main professional groups in the healthcare system is of key importance for the successful development of this field. The attitude of nurses to information technology may influence the process of shaping an e-health environment. This survey was conducted to assess the use of information technologies and opinions about e-health among nurses employed in hospital centers located in an urban area in Poland. The questionnaire included items on the use of computers and the Internet, perception of the importance of e-health systems, and opinions about the roles and benefits of e-health for healthcare stakeholders. The questionnaire was distributed to 215 nurses participating in extension courses. The analysis was performed on 153 questionnaires accepted after quality control. The respondents were convinced about the importance of information technology in the delivery of healthcare services and specifically of e-health systems; however, there was a significant group that expressed skepticism about the need for the development of e-health services in Poland at the moment. The respondents indicated the Ministry of Health, the National Health Fund, and public health specialists as the stakeholders who should have the most important role in initiating e-health development. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Gadek A.,University Hospital in Cracow | Liszka H.,University Hospital in Cracow | Wordliczek J.,Jagiellonian University
Foot and Ankle International | Year: 2015

Background: Several techniques of anesthesia are used in foot surgery. Preemptive analgesia helps to prevent the development of hypersensitivity in the perioperative period. The aim of our study was to assess the role of preemptive local anesthetic infiltration and postoperative pain after hallux valgus surgery. Methods: We evaluated 118 patients who underwent modified chevron and miniinvasive MitchellKramer bunionectomy of the first distal metatarsal. After spinal anesthesia each patient randomly received an infiltration of local anesthetic or the same amount of normal saline 10 minutes before the skin incision. We measured the intensity of pain 4, 8, 12, 16, 24, and 72 hours after the release of the tourniquet using a visual analogue scale (VAS). Rescue analgesia and all other side effects were noted. Results: Preemptive analgesia resulted in less pain during the first 24 hours after surgery. The decrease of AS score was significantly lower in the study group during all the short postoperative periods measured. The rescue analgesia was administered in 11.9% of patients in the injected group and 42.4% in the placebo group (P < .05). In the injected group we did not observe significant difference in VAS score between patients post-chevron and miniinvasive Mitchell-Kramer osteotomy of the first distal metatarsal. No systemic adverse effects were noted. One persistent injury of dorsomedial cutaneous nerve was observed. Conclusion: Preemptive local anesthetic infiltration was an efficient and safe method to reduce postoperative pain after hallux valgus surgery. The analgesic effect was satisfactory in both traditional and minimally invasive techniques. Level of Evidence: Level I, prospective randomized study. © The Author(s) 2014.

Michalowska-Kaczmarczyk A.M.,University Hospital in Cracow | Asuero A.G.,University Hospital in Cracow | Michalowski T.,University Hospital in Cracow
Critical reviews in analytical chemistry / CRC | Year: 2015

The elementary concepts involved with stoichiometry are considered from different viewpoints. Some examples of approximate calculations made according to the stoichiometric scheme are indicated, and correct resolution of the problems involved is presented. The principles of balancing chemical equations, based on their apparent similarities with algebraic equations, are criticized. The review concerns some peculiarities inherent in chemical reaction notation and its use (and abuse) in stoichiometric calculations that provide inconsistent results for various reasons. This "conventional" approach to stoichiometry is put in context with the generalized approach to electrolytic systems (GATES) established by Michałowski. The article contains a number of proposals that could potentially be taken into account and included in the next edition of the Orange Book. Notation of ions used in this article is not, deliberately, in accordance with actual IUPAC requirements in this respect. This article is intended to be provocative with the hope that some critical debate around the important topics treated should be generated and creatively expanded in the scientific community.

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