Grenoble University Hospital and Grenoble Alpes University

www.chu-grenoble.fr.
Grenoble, France
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PubMed | Grenoble University Hospital and Grenoble Alpes University, Aix - Marseille University and Charles University
Type: | Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology | Year: 2016

Initial results with the Elecsys Toxo IgG Avidity assay showed some potential for interpretation of a very low or very high index result. We aimed to examine these new insights into interpretation using a large panel of serum samples and to define the optimal thresholds. A total of 741 patient serum samples with known date of infection (from a few weeks to more than 9months after infection), were analysed with the Elecsys Toxo IgG Avidity assay. Values 80% (threshold defined by the manufacturer) were reported in 289 sera; 288 sera were sampled more than 4months after infection. Thus, avidity values 80% excluded an infection less than 4months. Avidity values 90% were reported in 112 sera sampled more than 9months after infection. Thus, avidity values 90% excluded infection less than 9months. Moreover avidity values 15% were reported in the 62 sera sampled less than 3months after infection. Thus avidity values 15% excluded infection more than 3months.

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