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Ferrara P.,University Hospital Complex of Albacete | Domingo-Chiva E.,University Hospital Complex of Albacete | Selva-Sevilla C.,University of Castilla - La Mancha | Campos-Garcia J.,University Hospital Complex of Albacete | Geronimo-Pardo M.,University Hospital Complex of Albacete
World Neurosurgery | Year: 2016

Background The general inhalation anesthetic sevoflurane can be used for the topical treatment of complicated wounds. It is applied in liquid form and may be used to irrigate the inside of cavities. Sevoflurane also exhibits in vitro antimicrobial activity. Therefore, sevoflurane may be used as an alternative to typical antibiotic or surgical treatment of complicated, localized infections. Case Description The case of a 61-year-old male patient who suffered a cranioencephalic trauma 18 years previously is presented. The patient underwent surgeries related to the trauma on numerous occasions. To date, he has suffered various recurrent epidural abscesses, which have been treated with surgical cleaning and antibiotic treatment. In the most recent episode, he presented a frontal epidural abscess 25 mm in diameter with fistulization of the skin. The patient gave written informed consent to be treated with sevoflurane irrigation, and the Pharmacy Service authorized the off-label use. Sevoflurane was applied via a catheter placed inside the cavity during weekly outpatient procedures. The procedures began 8 weeks after the clinically and radiologically verified recovery of the abscess. By avoiding surgery and the associated hospital admission, this novel alternative may prevent patient morbidity and, furthermore, may produce important economic savings. Conclusions The treatment of complicated wounds with liquid sevoflurane may be an effective and economically efficient clinical alternative for some patients. © 2016 Elsevier Inc. All rights reserved.

Romero M.C.C.,University Hospital Complex of Albacete | Hoyo R.G.,Genomics Laboratory | Calvente M.,Genomics Laboratory | Cano M.B.,University Hospital Complex of Albacete | And 2 more authors.
American Journal of Medical Genetics, Part A | Year: 2012

A newborn boy with broad forehead, mild microretrognathia, large hands and feet, arachnodactyly and a cortical thumb also had left renal agenesis, dysgenesis of corpus callosum with psychomotor delay. After olignucleotide array comparative genomic hybridization (array-CGH) analysis, we detected a 900kb duplication in cytoband 5p13.2, apperently a first clinical description. © 2012 Wiley Periodicals, Inc.

Castro-Garcia P.,University of Castilla - La Mancha | Gil-Gas C.,University of Castilla - La Mancha | Honrubia-Gomez P.,University of Castilla - La Mancha | Alvarez-Simon C.B.,University of Castilla - La Mancha | And 11 more authors.
Journal of Analytical Oncology | Year: 2013

The cancer stem cell hypothesis suggests that cancer contains cancer cells with stemness characteristics, and also in immortalised cancer cell lines. This work analyzes the characteristics of the "cancer stem cell" population in C6 tumour cell line. We found a small population defined by the expression of two biomarkers, previously reported in both stem and cancer stem cells, with an aggressive phenotype injected in nude mice. We found 0.6% BCRP1+ cells, the principal protein responsible for the Side Population (SP). On the other hand, we found a small CD133+ positive population, a self-renewal related protein. Moreover, the entire CD133+ population matched with part of BCRP1+ cells suggesting that CD133+ cells could be a subpopulation of BCRP1+ cells, and therefore, a more specific cancer stem cell population than previously described for glioma C6 cell line. These CD133+/BCRP1+ cells display an aggressive phenotype when injected into NOD/SCID mice. We also eventually found this cancer stem cell like population (BCRP1+/CD133+) in other types of cancer, even in a brain tumour patient sample with aggressive disease, but not in patient sample with good prognosis. Besides, the important finding in this study is that inhibition of cancer stem cell self renewal could reflex a decrease in resistance to chemotherapy. IC50 and percentage of resistant cells is reported after treatment with a stem cell self renewal inhibitor. © 2013 Lifescience Global.

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