Albacete University Hospital Complex

Albacete, Spain

Albacete University Hospital Complex

Albacete, Spain

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Garcia de Marcos J.A.,Albacete University Hospital Complex
Journal of oral science | Year: 2010

Peripheral ossifying fibroma (POF) is a lesion of the gingival tissues that predominantly affects women and is usually located in the maxilla anterior to the molars. The definitive diagnosis is established by histological examination, which reveals the presence of cellular connective tissue with focal calcifications. Surgery is the treatment of choice, though the recurrence rate can reach 20%. We present a clinical and histological review - including a detailed immunohistochemical analysis - of four cases of POF diagnosed and treated at our hospital. All four patients were women, and two were pregnant. The immunohistochemical study revealed that the proliferating cells showed myofibroblastic characteristics and did not express estrogen or progesterone receptors. The lesions showed clinically benign behavior. Our results indicate that POF should be considered as a myofibroblastic proliferation, and although the clinical characteristics suggest hormonal influence, we were unable to demonstrate the expression of hormone receptors in the proliferating cellular component.


PubMed | Albacete University Hospital Complex
Type: Case Reports | Journal: Journal of oral science | Year: 2010

Peripheral ossifying fibroma (POF) is a lesion of the gingival tissues that predominantly affects women and is usually located in the maxilla anterior to the molars. The definitive diagnosis is established by histological examination, which reveals the presence of cellular connective tissue with focal calcifications. Surgery is the treatment of choice, though the recurrence rate can reach 20%. We present a clinical and histological review - including a detailed immunohistochemical analysis - of four cases of POF diagnosed and treated at our hospital. All four patients were women, and two were pregnant. The immunohistochemical study revealed that the proliferating cells showed myofibroblastic characteristics and did not express estrogen or progesterone receptors. The lesions showed clinically benign behavior. Our results indicate that POF should be considered as a myofibroblastic proliferation, and although the clinical characteristics suggest hormonal influence, we were unable to demonstrate the expression of hormone receptors in the proliferating cellular component.


PubMed | Albacete University Hospital Complex
Type: Case Reports | Journal: Oral and maxillofacial surgery | Year: 2010

Basal cell nevus syndrome (BCNS), also known as Gorlin-Goltz syndrome, comprises five main pathological features: nevoid basal cell carcinomas, keratocystic odontogenic tumors, congenital skeletal anomalies, calcification of the falx cerebri, and point skin depressions on the palms and/or soles. The disease exhibits a dominant autosomal hereditary trait, with implication of the human homologue of the Drosophila segment polarity Patched (PTCH) gene. BCNS is diagnosed on the basis of clinical and radiological criteria and can be confirmed by genetic study. The patient prognosis is very good, with normal life expectancy in most cases.The present study reports two cases of BCNS with the presence of maxillo-mandibular keratocystic odontogenic tumors.One case was diagnosed according to clinical criteria, while the other required genetic confirmation that revealed a germ line mutation in exon 17 (c.2868delC), not previously described in the databases, which was considered to be responsible for the disease.

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