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Khatami M.,University of Bonn | Schmidt-Wilcke T.,Bergmannsheil University Hospital Bochum | Sundgren P.C.,Lund University | Sundgren P.C.,University of Michigan | And 3 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

We present BundleMAP, a novel method for extracting features from diffusion MRI (dMRI), which can be used to detect disease with supervised classification. BundleMAP uses manifold learning to aggregate measurements over localized segments of nerve fiber bundles, which are natural anatomical units in this data. We obtain a fully integrated machine learning pipeline by combining this idea with mechanisms for outlier removal and feature selection. We demonstrate that it increases accuracy on a clinical dataset for which classification results have been reported previously, and that it pinpoints the anatomical locations relevant to the classification. © Springer International Publishing Switzerland 2015.

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